keyword
https://read.qxmd.com/read/32557169/in-vivo-detection-of-ctc-and-ctc-plakoglobin-status-helps-predict-prognosis-in-patients-with-metastatic-breast-cancer
#21
JOURNAL ARTICLE
Ning Xie, Zheyu Hu, Can Tian, Huawu Xiao, Liping Liu, Xiaohong Yang, Jing Li, Hui Wu, Jun Lu, Jianxiang Gao, Xuming Hu, Min Cao, Zhengrong Shui, Quchang Ouyang
This study aims to detect the prognostic value of circulating tumour cell (CTC) in patients with metastatic breast cancer. In this study, 38 patients with metastatic breast cancer were enrolled. The in vivo CellCollector® method was used to detect the number of CTC in patients. Single CTC and CTC clusters were counted, and the expression of plakoglobin was also analysed. At baseline, 73.7% (28/38) of the patients were positive for ≥ 1 CTC (range, 1-14 cells). No CTC-like events were observed in the control group...
June 18, 2020: Pathology Oncology Research: POR
https://read.qxmd.com/read/32382352/increased-expression-of-plakoglobin-is-associated-with-upregulated-mapk-and-pi3k-akt-signalling-pathways-in-early-resectable-pancreatic-ductal-adenocarcinoma
#22
JOURNAL ARTICLE
Ekene Nweke, Monde Ntwasa, Martin Brand, John Devar, Martin Smith, Geoffrey Candy
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancer types, and it is associated with a 5-year survival rate of <10% due to limited early detection methods and ineffective therapeutic options. Thus, an improved understanding of the mechanisms involved in the early stages of PDAC tumorigenesis is crucial in order to identify potential novel diagnostic and therapeutic targets. The most common signalling aberrations in PDAC occur in the Wnt/Notch signalling pathway, as well as within the epidermal growth factor receptor (EGFR) pathway and its associated ligands, EGF and transforming growth factor-β...
June 2020: Oncology Letters
https://read.qxmd.com/read/32049581/the-rho-guanine-nucleotide-exchange-factor-solo-decelerates-collective-cell-migration-by-modulating-the-rho-rock-pathway-and-keratin-networks
#23
JOURNAL ARTICLE
Yusuke Isozaki, Kouki Sakai, Kenta Kohiro, Katsuhiko Kagoshima, Yuma Iwamura, Hironori Sato, Daniel Rindner, Sachiko Fujiwara, Kazunari Yamashita, Kensaku Mizuno, Kazumasa Ohashi
Collective cell migration plays crucial roles in tissue remodeling, wound healing, and cancer cell invasion. However, its underlying mechanism remains unknown. Previously, we showed that the RhoA-targeting guanine nucleotide exchange factor Solo (ARHGEF40) is required for tensile force-induced RhoA activation and proper organization of keratin-8/keratin-18 (K8/K18) networks. Here, we demonstrate that Solo knockdown significantly increases the rate at which Madin-Darby canine kidney cells collectively migrate on collagen gels...
April 1, 2020: Molecular Biology of the Cell
https://read.qxmd.com/read/31671643/mechanical-property-changes-in-breast-cancer-cells-induced-by-stimulation-with-macrophage-secretions-in-vitro
#24
JOURNAL ARTICLE
Hyonchol Kim, Kenta Ishibashi, Tomoko Okada, Chikashi Nakamura
The contribution of secretions from tumor-associated macrophage (TAM)-like cells to the stimulation of mechanical property changes in murine breast cancer cells was studied using an in vitro model system. A murine breast cancer cell line (FP10SC2) was stimulated by adding macrophage (J774.2) cultivation medium containing stimulation molecules secreted from the macrophages, and changes in mechanical properties were compared before and after stimulation. As a result, cell elasticity decreased, degradation ability of the extracellular matrix increased, and the expression of plakoglobin was upregulated...
October 30, 2019: Micromachines
https://read.qxmd.com/read/31258788/high-expression-of-plakoglobin-promotes-metastasis-in-invasive-micropapillary-carcinoma-of-the-breast-via-tumor-cluster-formation
#25
JOURNAL ARTICLE
Lan Huang, Hongfei Ji, Lei Yin, Xingjian Niu, Yiran Wang, Yang Liu, Qijia Xuan, Liru Li, Han Zhang, Xiaoping Zhou, Jingtong Li, Chengwei Cui, Yue Yang, Weiwei An, Qingyuan Zhang
Invasive micropapillary carcinoma of the breast (IMPC) is a rare subtype of breast cancer that has a high frequency of lymph node (LN) involvement and metastasis to distant organs. IMPC is characterized by distinct histomorphology and unfavorable prognosis when compared with invasive ductal carcinoma no special type (IDC-NST). However, the underlying molecular mechanisms remain unclear. We reported here that plakoglobin, as a key component in cell adhesion, can promote collective metastasis through facilitating IMPC clusters formation...
2019: Journal of Cancer
https://read.qxmd.com/read/30846515/the-potential-clinical-implications-of-circulating-tumor-cells-and-circulating-tumor-microemboli-in-gastric-cancer
#26
JOURNAL ARTICLE
Emne A Abdallah, Alexcia C Braun, Bianca C T C P Flores, Laís Senda, Ana Cláudia Urvanegia, Vinicius Calsavara, Victor Hugo Fonseca de Jesus, Maria Fernanda Arruda Almeida, Maria Dirlei Begnami, Felipe J F Coimbra, Wilson Luiz da Costa, Diana Noronha Nunes, Emmanuel Dias-Neto, Ludmilla T Domingos Chinen
BACKGROUND: Gastric adenocarcinoma (GAC) is the third deadliest malignant neoplasm worldwide, mostly because of late disease diagnosis, low chemotherapy response rates, and an overall lack of tumor biology understanding. Therefore, tools for prognosis and prediction of treatment response are needed. Quantification of circulating tumor cells (CTCs) and circulating tumor microemboli (CTM) and their expression of biomarkers has potential clinical relevance. Our aim was to evaluate CTCs and CTM and their expression of HER2 and plakoglobin in patients with nonmetastatic GAC, correlating the findings to clinicopathological data...
September 2019: Oncologist
https://read.qxmd.com/read/30634453/spectrum-of-epithelial-mesenchymal-transition-phenotypes-in-circulating-tumour-cells-from-early-breast-cancer-patients
#27
JOURNAL ARTICLE
Aleksandra Markiewicz, Justyna Topa, Anna Nagel, Jaroslaw Skokowski, Barbara Seroczynska, Tomasz Stokowy, Marzena Welnicka-Jaskiewicz, Anna J Zaczek
Circulating tumour cells (CTCs) can provide valuable prognostic information in a number of epithelial cancers. However, their detection is hampered due to their molecular heterogeneity, which can be induced by the epithelial-mesenchymal transition (EMT) process. Therefore, current knowledge about CTCs from clinical samples is often limited due to an inability to isolate wide spectrum of CTCs phenotypes. In the current work, we aimed at isolation and molecular characterization of CTCs with different EMT status in order to establish their clinical significance in early breast cancer patients...
January 9, 2019: Cancers
https://read.qxmd.com/read/30628670/histone-deacetylase-7-inhibits-plakoglobin-expression-to-promote-lung-cancer-cell-growth-and-metastasis
#28
JOURNAL ARTICLE
Yi Sang, Longhua Sun, Yuanzhong Wu, Wenxin Yuan, Yanyan Liu, Si-Wei Li
Plakoglobin is a tumor suppressor gene in lung cancer; however, the mechanism by which it is downregulated in lung cancer is largely unknown. The aim of the present study was to investigate whether histone deacetylases (HDACs) regulate plakoglobin expression in lung cancer. The effects of overexpression or knockdown of HDAC7 on plakoglobin were determined using stably transfected lung cancer cell lines. Chromatin immunoprecipitation assays were performed to elucidate the mechanisms underlying the HDAC7‑induced suppression of plakoglobin...
January 9, 2019: International Journal of Oncology
https://read.qxmd.com/read/30411850/identification-of-proteomic-markers-in-head-and-neck-cancer-using-maldi-ms-imaging-lc-ms-ms-and-immunohistochemistry
#29
JOURNAL ARTICLE
Franziska Hoffmann, Claudia Umbreit, Thomas Krüger, Daniela Pelzel, Günther Ernst, Olaf Kniemeyer, Orlando Guntinas-Lichius, Alexander Berndt, Ferdinand von Eggeling
PURPOSE: The heterogeneity of squamous cell carcinoma tissue greatly complicates diagnosis and individualized therapy. Therefore, characterizing the heterogeneity of tissue spatially and identifying appropriate biomarkers is crucial. MALDI imaging (MSI) is capable of analyzing spatially resolved tissue biopsies on a molecular level. EXPERIMENTAL DESIGN: We used MALDI MSI on snap frozen and formalin-fixed and paraffin-embedded (FFPE) tissue samples from patients with head and neck cancer (HNC) to analyze m/z values localized in tumor and non-tumor regions...
November 9, 2018: Proteomics. Clinical Applications
https://read.qxmd.com/read/29997230/altered-cell-cycle-control-inflammation-and-adhesion-in-high-risk-persistent-bronchial-dysplasia
#30
JOURNAL ARTICLE
Daniel T Merrick, Michael G Edwards, Wilbur A Franklin, Michio Sugita, Robert L Keith, York E Miller, Micah B Friedman, Lori D Dwyer-Nield, Meredith A Tennis, Mary C O'Keefe, Elizabeth J Donald, Jessica M Malloy, Adrie van Bokhoven, Storey Wilson, Peter J Koch, Charlene O'Shea, Christopher Coldren, David J Orlicky, Xian Lu, Anna E Baron, Greg Hickey, Timothy C Kennedy, Roger Powell, Lynn Heasley, Paul A Bunn, Mark Geraci, Raphael A Nemenoff
Persistent bronchial dysplasia is associated with increased risk of developing invasive squamous cell carcinoma (SCC) of the lung. In this study, we hypothesized that differences in gene expression profiles between persistent and regressive bronchial dysplasia would identify cellular processes that underlie progression to SCC. RNA expression arrays comparing baseline biopsies from 32 bronchial sites that persisted/progressed to 31 regressive sites showed 395 differentially expressed genes [ANOVA, FDR ≤ 0...
September 1, 2018: Cancer Research
https://read.qxmd.com/read/29660231/plakoglobin-restores-tumor-suppressor-activity-of-p53-r175h-mutant-by-sequestering-the-oncogenic-potential-of-%C3%AE-catenin
#31
JOURNAL ARTICLE
Mahsa Alaee, Kristina Nool, Manijeh Pasdar
Tumor suppressor/transcription factor p53 is mutated in over 50% of all cancers. Some mutant p53 proteins have not only lost tumor suppressor activities but they also gain oncogenic functions (GOF). One of the most frequently expressed GOF p53 mutants is Arg175His (p53R175H ) with well-documented roles in cancer development and progression. Plakoglobin is a cell adhesion and signaling protein and a paralog of β-catenin. Unlike β-catenin that has oncogenic function through its role in the Wnt pathway, plakoglobin generally acts as a tumor/metastasis suppressor...
June 2018: Cancer Science
https://read.qxmd.com/read/29541473/correction-to-circulating-tumor-cell-clusters-associated-gene-plakoglobin-is-a-significant-prognostic-predictor-in-patients-with-breast-cancer
#32
W Goto, S Kashiwagi, Y Asano, K Takada, K Takahashi, T Hatano, T Takashima, S Tomita, H Motomura, M Ohsawa, K Hirakawa, M Ohira
[This corrects the article DOI: 10.1186/s40364-017-0099-2.].
2018: Biomarker Research
https://read.qxmd.com/read/29107109/lox-1-activation-by-oxldl-triggers-an-epithelial-mesenchymal-transition-and-promotes-tumorigenic-potential-in-prostate-cancer-cells
#33
JOURNAL ARTICLE
I González-Chavarría, E Fernandez, N Gutierrez, E E González-Horta, F Sandoval, P Cifuentes, C Castillo, R Cerro, O Sanchez, Jorge R Toledo
Obesity is related to an increased risk of developing prostate cancer with high malignancy stages or metastasis. Recent results demonstrated that LOX-1, a receptor associated with obesity and atherosclerosis, is overexpressed in advanced and metastatic prostate cancer. Furthermore, high levels of oxLDL, the main ligand for LOX-1, have been found in patients with advanced prostate cancer. However, the role of LOX-1 in prostate cancer has not been unraveled completely yet. Here, we show that LOX-1 is overexpressed in prostate cancer cells and its activation by oxLDL promotes an epithelial to mesenchymal transition, through of lowered expression of epithelial markers (E-cadherin and plakoglobin) and an increased expression of mesenchymal markers (vimentin, N-cadherin, snail, slug, MMP-2 and MMP-9)...
February 1, 2018: Cancer Letters
https://read.qxmd.com/read/28507762/circulating-tumor-cell-clusters-associated-gene-plakoglobin-is-a-significant-prognostic-predictor-in-patients-with-breast-cancer
#34
JOURNAL ARTICLE
Wataru Goto, Shinichiro Kashiwagi, Yuka Asano, Koji Takada, Katsuyuki Takahashi, Takaharu Hatano, Tsutomu Takashima, Shuhei Tomita, Hisashi Motomura, Masahiko Ohsawa, Kosei Hirakawa, Masaichi Ohira
BACKGROUND: Circulating tumor cells (CTCs) are linked to metastatic relapse and are regarded as a prognostic marker for human cancer. High expression of plakoglobin, a cell adhesion protein, within the primary tumor is positively associated with CTC clusters in breast cancer. In this study, we investigated the correlation between plakoglobin expression and survival of breast cancer. METHODS: We evaluated 121 breast cancer patients treated with neoadjuvant chemotherapy...
2017: Biomarker Research
https://read.qxmd.com/read/28351370/erratum-to-loss-of-plakoglobin-promotes-cell-cell-contact-increased-invasion-and-breast-cancer-cell-dissemination-in-vivo
#35
JOURNAL ARTICLE
Ingunn Holen, Jacob Whitworth, Faith Nutter, Alyson Evans, Hannah K Brown, Diane V Lefley, Ivana Barbaric, Mark Jones, Penelope D Ottewell
No abstract text is available yet for this article.
March 28, 2017: Breast Cancer Research: BCR
https://read.qxmd.com/read/27571934/modification-of-cysteine-457-in-plakoglobin-modulates-the-proliferation-and-migration-of-colorectal-cancer-cells-by-altering-binding-to-e-cadherin-catenins
#36
JOURNAL ARTICLE
Suhee Kim, Sun Hee Ahn, Hee-Young Yang, Jin-Sil Lee, Hyang-Gi Choi, Young-Kyu Park, Tae-Hoon Lee
OBJECTIVES: In tissue samples from patients with colorectal cancer (CRC), oxidation of C420 and C457 of plakoglobin (Pg) within tumor tissue was identified by proteomic analysis. The aim of this study was to identify the roles of Pg C420 and C457. METHODS: Human CRC tissues, CRC and breast cancer cells, and normal mouse colon were prepared to validate Pg oxidation. MC38 cells were co-transfected with E-cadherin plus wild type (WT) or mutant (C420S or C457S) Pg to evaluate protein interactions and cellular localization, proliferation, and migration...
November 2017: Redox Report: Communications in Free Radical Research
https://read.qxmd.com/read/27216146/vitronectin-and-dermcidin-serum-levels-predict-the-metastatic-progression-of-ajcc-i-ii-early-stage-melanoma
#37
JOURNAL ARTICLE
Idoia Ortega-Martínez, Jesús Gardeazabal, Asier Erramuzpe, Ana Sanchez-Diez, Jesús Cortés, María D García-Vázquez, Gorka Pérez-Yarza, Rosa Izu, Jose Luís Díaz-Ramón, Ildefonso M de la Fuente, Aintzane Asumendi, María D Boyano
Like many cancers, an early diagnosis of melanoma is fundamental to ensure a good prognosis, although an important proportion of stage I-II patients may still develop metastasis during follow-up. The aim of this work was to discover serum biomarkers in patients diagnosed with primary melanoma that identify those at a high risk of developing metastasis during the follow-up period. Proteomic and mass spectrophotometry analysis was performed on serum obtained from patients who developed metastasis during the first years after surgery for primary tumors and compared with that from patients who remained disease-free for more than 10 years after surgery...
October 1, 2016: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/27144941/plakoglobin-reduces-the-in-vitro-growth-migration-and-invasion-of-ovarian-cancer-cells-expressing-n-cadherin-and-mutant-p53
#38
JOURNAL ARTICLE
Mahsa Alaee, Ghazal Danesh, Manijeh Pasdar
Aberrant expression of cadherins and catenins plays pivotal roles in ovarian cancer development and progression. Plakoglobin (PG, γ-catenin) is a paralog of β-catenin with dual adhesive and signaling functions. While β-catenin has known oncogenic function, PG generally acts as a tumor/metastasis suppressor. We recently showed that PG interacted with p53 and that its growth/metastasis inhibitory function may be mediated by this interaction. Very little is known about the role of PG in ovarian cancer. Here, we investigated the in vitro tumor/metastasis suppressor effects of PG in ovarian cancer cell lines with mutant p53 expression and different cadherin profiles...
2016: PloS One
https://read.qxmd.com/read/27132080/cd66-and-cd49f-expressing-cells-are-associated-with-distinct-neoplastic-phenotypes-and-progression-in-human-cervical-cancer
#39
JOURNAL ARTICLE
Aswathy Ammothumkandy, Tessy Thomas Maliekal, Mayil Vahanan Bose, Thangarajan Rajkumar, Sundersingh Shirley, B Thejaswini, Venkat G Giri, Sudhir Krishna
BACKGROUND: In this study, building on our recent work identifying a subset of CD66+ve cells with distinctive tumourigenic properties in human cervical cancers, we examine patterns of expression and function of these cells; to generate insights into the process of metastasis. METHODS: Our broad approach in this study has been to compare the expression and function of two subsets marked by CD66 and CD49f. We use a combination of histopathology, immunostaining and flow cytometry, functional analysis of an established cervical cancer cell line and a retrospective analysis of a cohort of cervical cancer...
June 2016: European Journal of Cancer
https://read.qxmd.com/read/26490105/hepatitis-b-virus-x-protein-induces-epithelial-mesenchymal-transition-by-repressing-e-cadherin-expression-via-upregulation-of-e12-e47
#40
JOURNAL ARTICLE
Soo Shin Kim, Sujeong Yeom, Juri Kwak, Hyung-Jun Ahn, Kyung Lib Jang
Previous reports have demonstrated that hepatitis B virus (HBV) X protein (HBx) represses E-cadherin expression to induce epithelial-mesenchymal transition (EMT), an essential component of cancer progression to more aggressive phenotypes characterized by tumour invasion, migration and metastasis; however, the underlying mechanism for this phenomenon is still unclear. In this study, we found that ectopic expression of HBx in human hepatocytes using overexpression and 1.2-mer WT HBV replicon systems upregulated levels of the transcriptional repressors E12 and E47, resulting in inactivation of the E-cadherin promoter, containing three E-box motifs, and subsequent repression of its expression...
January 2016: Journal of General Virology
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