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Mycobacterium bovis

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https://www.readbyqxmd.com/read/27926825/mycobacterium-malmesburyense-sp-nov-a-novel-non-tuberculous-mycobacterium-species-revealed-by-multiple-gene-sequence-characterization
#1
Nomakorinte Gcebe, Victor Rutten, Nicolaas Gey van Pittius, Brendon Naicker, Anita Michel
Non-tuberculous mycobacteria (NTM) are ubiquitous in the environment and an increasing number of NTM species have been isolated and characterized from both humans and animals, highlighting the zoonotic potential of these bacteria. Host exposure to NTM may impact on cross-reactive immune responsiveness which may affect diagnosis of bovine tuberculosis and may also play a role in the variability of the efficacy of Mycobacterium bovis BCG vaccination against tuberculosis. In this study we characterized 10 NTM isolates originating from water, soil, nasal swabs of cattle and African buffalo as well as bovine tissue samples...
December 5, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27914739/infection-by-mycobacterium-bovis-in-a-dog-from-brazil
#2
Vivianne Cambuí Figueiredo Rocha, Salomão Cambuí de Figueiredo, Cesar Alejandro Rodriguez Rosales, Camila Dias Porto, Julio Lopes Sequeira, José Soares Ferreira Neto, Antônio Carlos Paes, Vanessa Riesz Salgado
Tuberculosis (TB) is a chronic disease caused by bacteria belonging to the Mycobacterium tuberculosis complex (MtbC). This disease rarely affects dogs. Canine infections are usually caused by M. tuberculosis. Mycobacterium bovis infections are rare in dogs and associated with consumption of raw milk or contaminated products. Here, we report a Boxer dog who had a M. bovis infection and was admitted to a Brazilian veterinary hospital with a presumptive diagnosis of chronic ehrlichiosis. Despite receiving treatment for chronic ehrlichiosis, it progressed to death...
October 3, 2016: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/27903467/arterio-cutaneous-fistula-associated-with-bilateral-femoral-pseudoaneurysms-caused-by-bacillus-calmette-gu%C3%A3-rin-apropos-of-a-case-and-review-of-literature
#3
Álvaro Torres-Blanco, Francisco Gómez-Palonés, Gemma Edo-Fleta
Vascular complications of intravesical instillation of bacillus Calmette-Guérin (BCG) are rare. BCG is an attenuated strain of Mycobacterium bovis (M. Bovis) that was initially developed for vaccination against tuberculosis, but it has also been used as an adjuvant treatment for bladder transitional carcinoma. We report a patient with a history of instillation of BCG two years before, who underwent surgical treatment of 2 pseudoaneurysms. The first, located in the left superficial femoral artery (SFA), was resected and the artery was ligated because he had a history of femoropopliteal occlusion...
November 26, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27902779/differential-cytokine-gene-expression-in-granulomas-from-lungs-and-lymph-nodes-of-cattle-experimentally-infected-with-aerosolized-mycobacterium-bovis
#4
Mitchell V Palmer, Tyler C Thacker, W Ray Waters
The hallmark lesion of tuberculosis in humans and animals is the granuloma. The granuloma represents a distinct host cellular immune response composed of epithelioid macrophages, lymphocytes, and multinucleated giant cells, often surrounding a caseous necrotic core. Within the granuloma, host-pathogen interactions determine disease outcome. Factors within the granulomas such as cytokines and chemokines drive cell recruitment, activity, function and ultimately the success or failure of the host's ability to control infection...
2016: PloS One
https://www.readbyqxmd.com/read/27893793/field-trial-of-an-aerially-distributed-tuberculosis-vaccine-in-a-low-density-wildlife-population-of-brushtail-possums-trichosurus-vulpecula
#5
Graham Nugent, Ivor J Yockney, E Jackie Whitford, Martin L Cross, Frank E Aldwell, Bryce M Buddle
Oral-delivery Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccine in a lipid matrix has been shown to confer protection against M. bovis infection and reduce the severity of tuberculosis (TB) when fed to brushtail possums (Trichosurus vulpecula), the major wildlife vector of bovine TB in New Zealand. Here we demonstrate the feasibility of aerial delivery of this live vaccine in bait form to an M. bovis-infected wild possum population, and subsequently assess vaccine uptake and field efficacy. Pre-trial studies indicated a resident possum population at very low density (<0...
2016: PloS One
https://www.readbyqxmd.com/read/27893591/endophthalmitis-in-a-patient-treated-with-bacillus-calmette-gu%C3%A3-rin-immunotherapy
#6
Julie Vadboncoeur, Sébastien Olivier, Hafid Soualhine, Annie-Claude Labbé, Marie-Lyne Bélair
BACKGROUND: Intravesical Bacillus Calmette-Guérin (BCG) instillation has become one of the mainstays of adjunctive therapy in the treatment of superficial bladder cancer. Ophthalmologic complications are rare, but few cases are reported in the literature. METHODS: Retrospective observational case report. RESULTS: The authors report a case of unilateral Mycobacterium bovis BCG endophthalmitis after intravesical BCG instillations. Despite appropriate systemic antituberculous and corticosteroid therapy, the patient almost completely lost sight in the affected eye...
November 23, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27892856/co-infection-with-mycobacterium-bovis-does-not-alter-the-response-to-bovine-leukemia-virus-in-bola-drb3-0902-genetically-resistant-cattle
#7
Claudia M Lützelschwab, Agustina Forletti, Rosana Cepeda, Eduardo N Esteban, Omar Confalonieri, Silvina E Gutiérrez
High proviral load (HPL) profile in bovine leukemia virus infected animals poses increased risk of transmission, and development of HPL or low proviral load (LPL) profile may be attributed to host genetics. Genetic resistance and susceptibility has been mapped to the Major Histocompatibility Complex class II DRB3 gene (BoLA DRB3). The aim of this work was to determine the effect of Mycobacterium bovis infection on certain virological and host immunological parameters of BLV experimental infection. Twenty-six Argentinian Holstein calves carrying the resistance-associated marker allele BoLA DRB3*0902, susceptibility-associated marker allele BoLA DRB3*1501, or neutral BoLA DRB3 alleles, exposed to M...
September 9, 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27879332/mucosal-bcg-vaccination-induces-protective-lung-resident-memory-t-cell-populations-against-tuberculosis
#8
Carolina Perdomo, Ulrike Zedler, Anja A Kühl, Laura Lozza, Philippe Saikali, Leif E Sander, Alexis Vogelzang, Stefan H E Kaufmann, Andreas Kupz
: Mycobacterium bovis Bacille Calmette-Guérin (BCG) is the only licensed vaccine against tuberculosis (TB), yet its moderate efficacy against pulmonary TB calls for improved vaccination strategies. Mucosal BCG vaccination generates superior protection against TB in animal models; however, the mechanisms of protection remain elusive. Tissue-resident memory T (TRM) cells have been implicated in protective immune responses against viral infections, but the role of TRM cells following mycobacterial infection is unknown...
November 22, 2016: MBio
https://www.readbyqxmd.com/read/27867377/over-expression-of-the-mycobacterial-trehalose-phosphate-phosphatase-otsb2-results-in-a-defect-in-macrophage-phagocytosis-associated-with-increased-mycobacterial-macrophage-adhesion
#9
Hao Li, Mei Wu, Yan Shi, Babak Javid
Trehalose-6-phosphate phosphatase (OtsB2) is involved in the OtsAB trehalose synthesis pathway to produce free trehalose and is strictly essential for mycobacterial growth. We wished to determine the effects of OtsB2 expression on mycobacterial phenotypes such as growth, phagocytosis and survival in macrophages. Mycobacterium bovis-bacillus calmette-guerin (BCG) over-expressing OtsB2 were able to better survive in stationary phase. Over-expression of OtsB2 led to a decrease in phagocytosis but not survival in THP-1 macrophage-like cells, and this was not due to a decrease in general macrophage phagocytic activity...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27863556/oral-vaccination-of-cattle-with-heat-inactivated-mycobacterium-bovis-does-not-compromise-bovine-tb-diagnostic-tests
#10
Gareth J Jones, Sabine Steinbach, Iker A Sevilla, Joseba M Garrido, Ramon Juste, H Martin Vordermeier
In this study we investigated whether oral uptake of a heat inactivated M. bovis wildlife vaccine by domestic cattle induced systemic immune responses that compromised the use of tuberculin or defined antigens in diagnostic tests for bovine TB. Positive skin test and blood-based IFN-γ release assay (IGRA) results were observed in all calves vaccinated via the parenteral route (i.e. intramuscular). In contrast, no positive responses to tuberculin or defined antigens were observed in either the skin test or IGRA test when performed in calves vaccinated via the oral route...
December 2016: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/27863555/test-performance-of-three-serological-assays-for-the-detection-of-mycobacterium-bovis-infection-in-common-warthogs-phacochoerus-africanus
#11
Eduard O Roos, Peter Buss, Lin-Mari de Klerk-Lorist, Jennie Hewlett, Guy A Hausler, Leana Rossouw, Alicia J McCall, David Cooper, Paul D van Helden, Sven D C Parsons, Michele A Miller
Sporadic cases of bovine tuberculosis (bTB) have been reported in warthogs in Southern Africa and confirmed through mycobacterial culture. However, there are no validated ante-mortem tests currently available for bTB in warthogs. In this study, we evaluated the use of three serological assays for the detection of Mycobacterium bovis infection in warthogs; an indirect enzyme-linked immunosorbent assay (ELISA) using bovine purified protein derivative (PPDb) as a capture antigen (indirect PPD ELISA), as well as two commercial assays, the TB ELISA-VK(®) and DPP(®) VetTB Assay...
December 2016: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/27855077/long-chain-fatty-acyl-coa-ligase-fadd2-mediates-intrinsic-pyrazinamide-resistance-in-mycobacterium-tuberculosis
#12
Brandon C Rosen, Nicholas A Dillon, Nicholas D Peterson, Yusuke Minato, Anthony D Baughn
Pyrazinamide (PZA) is a first-line tuberculosis (TB) drug that has been in clinical use for sixty years yet still has an unresolved mechanism of action. Based upon the observation that the minimum concentration of PZA required to inhibit growth of Mycobacterium tuberculosis is approximately 1000-fold higher than for other first-line drugs, we hypothesized that M. tuberculosis expresses factors that mediate intrinsic resistance to PZA. To identify genes associated with intrinsic PZA resistance, a library of transposon mutagenized Mycobacterium bovis BCG was screened for strains showing hyper-susceptibility to the active form of PZA, pyrazinoic acid (POA)...
November 14, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27853698/primary-tuberculosis-of-hand-soft-tissue
#13
Mohd Altaf Mir, Imran Ahmad, Mihd Yaseen
The musculoskeletal extrapulmonary tuberculosis is uncommon, the upper extremity tuberculosis is not common and the mycobacterial involvement of skin of hands and synovial sheath of tendons is rare. This prospective observational study was undertaken between August 2014 and December 2015 in a tertiary referral hospital. Patients attending with suspected primary tuberculosis of soft tissue of the hand were included. Anteroposterior and lateral radiographs of the hand, wrist and lung and MRI were undertaken. A diagnosis of tuberculosis was made based on histology, and positive culture for Mycobacterium...
September 2016: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/27847173/enhanced-protective-efficacy-against-tuberculosis-provided-by-a-recombinant-urease-deficient-bcg-expressing-heat-shock-protein-70-major-membrane-protein-ii-having-pest-sequence
#14
Yumiko Tsukamoto, Yumi Maeda, Toshiki Tamura, Tetsu Mukai, Satoshi Mitarai, Saburo Yamamoto, Masahiko Makino
Enhancement of the T cell-stimulating ability of Mycobacterium bovis BCG (BCG) is necessary to develop an effective tuberculosis vaccine. For this purpose, we introduced the PEST-HSP70-major membrane protein-II (MMPII)-PEST fusion gene into ureC-gene depleted recombinant (r) BCG to produce BCG-PEST. The PEST sequence is involved in the proteasomal processing of antigens. BCG-PEST secreted the PEST-HSP70-MMPII-PEST fusion protein and more efficiently activated human monocyte-derived dendritic cells (DCs) in terms of phenotypic changes and cytokine productions than an empty-vector-introduced BCG or HSP70-MMPII gene-introduced ureC gene-depleted BCG (BCG-DHTM)...
December 7, 2016: Vaccine
https://www.readbyqxmd.com/read/27847008/detection-of-mycobacterium-bovis-in-artisanal-cheese-in-the-state-of-pernambuco-brazil
#15
Renata D S Cezar, Norma Lucena-Silva, Jonas M Borges, Vania L A Santana, José W Pinheiro Junior
OBJECTIVE/BACKGROUND: The present study was aimed at detecting Mycobacterium bovis in artisanal cheese using real-time quantitative polymerase chain reaction. METHODS: One hundred seven cheese samples (250g) were purchased in 107 commercial establishments including neighborhood grocery stores, bakeries, and open-air markets from 19 municipalities of the state of Pernambuco, Brazil. Ten grams of each cheese sample were macerated with sterile saline solution in a sterile bag and DNA was extracted from 20mg of the macerated material using the Wizard SV Genomic DNA Purification System...
September 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/27836043/management-of-on-farm-risk-to-livestock-from-bovine-tuberculosis-in-michigan-usa-white-tailed-deer-predictions-from-a-spatially-explicit-stochastic-model
#16
David S L Ramsey, Daniel J O'Brien, Rick W Smith, Melinda K Cosgrove, Stephen M Schmitt, Brent A Rudolph
The eradication of bovine tuberculosis (bTB), caused by Mycobacterium bovis, from cattle in many locations worldwide is complicated by endemic foci of the disease in free-ranging wildlife. Recent simulation modeling of the bTB outbreak in white-tailed deer (WTD) in Michigan, USA, suggests current management is unlikely to eradicate bTB from the core outbreak area (DMU 452) within the next three decades. However, some level of control short of eradication might sufficiently reduce transmission from deer to cattle to a point at which the negative effects of bTB on the cattle industry could be reduced or eliminated, while minimizing the negative consequences of reducing deer numbers...
November 1, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/27834714/draft-genome-sequence-of-mycobacterium-bovis-strain-d-10-02315-isolated-from-wild-boar
#17
Maxime Branger, Amandine Hauer, Lorraine Michelet, Claudine Karoui, Thierry Cochard, Krystel De Cruz, Sylvie Henault, María Laura Boschiroli, Franck Biet
Mycobacterium bovis is the etiologic agent of bovine tuberculosis, a chronic infectious disease, affecting livestock, wild animals, and sometimes humans. We report the draft genome sequence of a Mycobacterium bovis strain isolated from wild boar of spoligotype SB0120 (or BCG-like) also present in wildlife-livestock multi-host systems.
November 10, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27834374/trna-mediated-codon-biased-translation-in-mycobacterial-hypoxic-persistence
#18
Yok Hian Chionh, Megan McBee, I Ramesh Babu, Fabian Hia, Wenwei Lin, Wei Zhao, Jianshu Cao, Agnieszka Dziergowska, Andrzej Malkiewicz, Thomas J Begley, Sylvie Alonso, Peter C Dedon
Microbial pathogens adapt to the stress of infection by regulating transcription, translation and protein modification. We report that changes in gene expression in hypoxia-induced non-replicating persistence in mycobacteria-which models tuberculous granulomas-are partly determined by a mechanism of tRNA reprogramming and codon-biased translation. Mycobacterium bovis BCG responded to each stage of hypoxia and aerobic resuscitation by uniquely reprogramming 40 modified ribonucleosides in tRNA, which correlate with selective translation of mRNAs from families of codon-biased persistence genes...
November 11, 2016: Nature Communications
https://www.readbyqxmd.com/read/27833923/low-dose-bcg-infection-as-a-model-for-macrophage-activation-maintaining-cell-viability
#19
Leslie Chávez-Galán, Dominique Vesin, Denis Martinvalet, Irene Garcia
Mycobacterium bovis BCG, the current vaccine against tuberculosis, is ingested by macrophages promoting the development of effector functions including cell death and microbicidal mechanisms. Despite accumulating reports on M. tuberculosis, mechanisms of BCG/macrophage interaction remain relatively undefined. In vivo, few bacilli are sufficient to establish a mycobacterial infection; however, in vitro studies systematically use high mycobacterium doses. In this study, we analyze macrophage/BCG interactions and microenvironment upon infection with low BCG doses and propose an in vitro model to study cell activation without affecting viability...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/27833091/divergent-macrophage-responses-to-mycobacterium-bovis-among-naturally-exposed-uninfected-and-infected-cattle
#20
Omar A Alcaráz-López, Cindy García-Gil, Claudia Morales-Martínez, Gonzalo López-Rincón, Ciro Estrada-Chávez, José A Gutiérrez-Pabello, Hugo Esquivel-Solís
Mycobacterium bovis, the causative agent of bovine tuberculosis (BTB), is a successful pathogen that remains an important global threat to livestock. Cattle naturally exposed to M. bovis normally become reactive to the M. bovis-purified protein derivative (PPD; tuberculin) skin test; however, some individuals remain negative, suggesting they may be resistant to infection. To better understand host innate resistance to infection, 26 cattle from herds with a long history of high tuberculosis prevalence were included in this study...
November 11, 2016: Immunology and Cell Biology
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