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Mycobacterium bovis

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https://www.readbyqxmd.com/read/28541150/evaluation-of-pathogen-specific-biomarkers-for-the-diagnosis-of-tuberculosis-in-white-tailed-deer-odocoileus-virginianus
#1
Sylvia I Wanzala, Mitchell V Palmer, Wade R Waters, Tyler C Thacker, Michelle Carstensen, Dominic A Travis, Srinand Sreevatsan
OBJECTIVE To develop a noninvasive biomarker-based detection system specific for Mycobacterium bovis for monitoring infection in wild animals. SAMPLE Serum samples from 8 experimentally infected yearling white-tailed deer (Odocoileus virginianus) and 3 age-matched control deer and from 393 Minnesota Department of Natural Resources hunter-harvested white-tailed deer in northwest Minnesota. PROCEDURES 8 yearling deer were inoculated with 2 × 10(8) CFUs of virulent M bovis strain 1315 (day 0), and sera were obtained on days 0, 19, 48, and 60; sera were obtained from 3 uninoculated control deer on those same days...
June 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28532992/assessment-of-concurrent-infection-with-bovine-viral-diarrhoea-virus-bvdv-and-mycobacterium-bovis-a-herd-level-risk-factor-analysis-from-northern-ireland
#2
A W Byrne, M Guelbenzu-Gonzalo, S A J Strain, S McBride, J Graham, A Lahuerta-Marin, R Harwood, D A Graham, S McDowell
Bovine viral diarrhoea virus (BVDV) is a significant pathogen of cattle, leading to severe economic and animal-welfare impacts. Furthermore, the pathogen has been associated with impacting the progression or spread of other pathogens (e.g. Mycobacterium bovis, the causative agent of bovine tuberculosis (bTB)). During this study we investigated (i) risk factors for BVDV at a herd-level and (ii) whether there was any association between BVDV and herd-level bTB risk. The data for this study were gathered from a voluntary BVDV control programme in Northern Ireland (2013-2015) based on the identification of virus positive animals through tissue tag testing of calves...
June 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28529930/the-central-role-of-ifi204-in-ifn-%C3%AE-release-and-autophagy-activation-during-mycobacterium-bovis-infection
#3
Liu Chunfa, Sun Xin, Li Qiang, Srinand Sreevatsan, Lifeng Yang, Deming Zhao, Xiangmei Zhou
Mycobacterium bovis (M. bovis) is the pathogen of animals and humans that can replicate in the phagosomes of myeloid cells. Cytosolic detection of bacterial products plays a crucial role in initiating the innate immune response, including autophagy activation and interferon-β (IFN-β) release. Although IFN-β release and autophagy activation have been reported during mycobacterium infection, the mechanisms underlying remains poorly defined. Here, we demonstrated that IFN-β release increases in macrophages exposed to M...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28507027/mycobacterium-tuberculosis-lipoprotein-mpt83-induces-apoptosis-of-infected-macrophages-by-activating-the-tlr2-p38-cox-2-signaling-pathway
#4
Lin Wang, Mianyong Zuo, Hao Chen, Siyu Liu, Xiangyang Wu, Zhenling Cui, Hua Yang, Haipeng Liu, Baoxue Ge
Tuberculosis caused by Mycobacterium tuberculosis continues to pose a serious global health threat. The attenuated Mycobacterium bovis bacillus Calmette-Guérin, as the only licensed vaccine, has limited protective efficacy against TB. The development of more effective antituberculosis vaccines is urgent and demands for further identification and understanding of M. tuberculosis Ags. MPT83 (Rv2873), a secreted mycobacterial lipoprotein, has been applied into subunit vaccine development and shown protective effects against M...
May 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28499455/bovis-bacillus-calmette-guerin-bcg-infection-induces-exosomal-mirna-release-by-human-macrophages
#5
Shamila D Alipoor, Esmaeil Mortaz, Payam Tabarsi, Parissa Farnia, Mehdi Mirsaeidi, Johan Garssen, Masoud Movassaghi, Ian M Adcock
BACKGROUND: Tuberculosis (TB) remains a significant global health concern and its diagnosis is challenging due to the limitations in the specificity and sensitivity of the current diagnostic tests. Exosomes are bioactive 30-100 nm vesicles produced by most cell types and are found in almost all human body fluids. Exosomal microRNAs (miRNAs) can transfer biological information between cells and tissues and may act as potential biomarkers in many diseases. In this pilot study, we assessed the miRNA profile of exosomes released from human monocyte-derived macrophages upon infection with Mycobacterium bovis Bacillus Calmette-Guerin (BCG)...
May 12, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28499434/development-of-a-novel-immunochromatographic-lateral-flow-assay-specific-for-mycobacterium-bovis-cells-and-its-application-in-combination-with-immunomagnetic-separation-to-test-badger-faeces
#6
Linda D Stewart, Nuria Tort, Paul Meakin, Jose M Argudo, Ruramayi Nzuma, Neil Reid, Richard J Delahay, Roland Ashford, W Ian Montgomery, Irene R Grant
BACKGROUND: The European badger is an important wildlife reservoir of Mycobacterium bovis implicated in the spread of bovine tuberculosis in the United Kingdom and Ireland. Infected badgers are known to shed M. bovis in their urine and faeces, which may contaminate the environment. To aid bovine tuberculosis control efforts novel diagnostic tests for detecting infected and shedding badgers are needed. We proposed development of a novel, rapid immunochromatographic lateral flow device (LFD) as a non-invasive test to detect M...
May 12, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28497727/using-white-tailed-deer-odocoileus-virginianus-in-infectious-disease-research
#7
Mitchell Palmer, Rebecca J Cox, W Ray Waters, Tyler C Thacker, Diana L Whipple
Between 1940 and 2004, more than 335 emerging infectious disease events were reported in the scientific literature. Themajority (60%) of these events involved zoonoses, most of which (72%) were of wildlife origin or had an epidemiologically important wildlife host. Because this trend of increasing emerging diseases likely will continue, understanding the pathogenesis, transmission, and diagnosis of these diseases in the relevant wildlife host is paramount. Achieving this goal often requires using wild animals as research subjects, which are vastly different from the traditional livestock or laboratory animals used by most universities and institutions...
May 11, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28487681/etha-r-independent-killing-of-mycobacterium-tuberculosis-by-ethionamide
#8
Michelle L T Ang, Siti Z Zainul Rahim, Paola Florez de Sessions, Wenwei Lin, Vanessa Koh, Kevin Pethe, Martin L Hibberd, Sylvie Alonso
Ethionamide (ETH) is part of the drug arsenal available to treat multi-drug resistant tuberculosis. The current paradigm of this pro-drug activation involves the mycobacterial enzyme EthA and the transcriptional repressor, EthR. However, several lines of evidence suggest the involvement of additional players. The ethA/R locus was deleted in Mycobacterium bovis BCG and three Mycobacterium tuberculosis (MTB) strains. While complete resistance to ETH was observed with BCG ethA/R KO, drug susceptibility and dose-dependent killing were retained in the ethA/R KO MTB mutants, suggesting the existence of an alternative pathway of ETH bio-activation in MTB...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28487230/assessment-of-antigenic-supplementation-of-bovine-purified-protein-derivative-for-diagnosis-of-subclinical-infection-with-mycobacterium-bovis-in-cattle
#9
A H Alvarez, A Gutiérrez-Ortega, V Gómez-Entzin, G Pérez-Mayorga, J Naranjo-Bastién, V González-Martínez, F Milián-Suazo, M Martínez-Velázquez, S Herrera-Rodríguez, E Hinojoza-Loza
Bovine tuberculosis (bTB) is usually diagnosed in vivo and ex vivo on the basis of delayed hypersensitivity reactions with a complex pool of antigens named bovine tuberculin (PPDB). The IFN-γ release assay (IGRA) for bTB is a blood-based assay that improves detection of infected cattle at early stages that escape skin testing. Improvements to IFN-γ testing with specific proteins have been performed to increase sensitivity. DosR regulon-related antigens are well known mycobacterial proteins expressed during the non-replicative phases of infection, this has been useful to improve the diagnosis of subclinical forms of TB in suspected individuals...
May 6, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28485632/mycobacterium-tuberculosis-infection-in-a-domesticated-korean-wild-boar-sus-scrofa-coreanus
#10
Min-Goo Seo, In-Ohk Ouh, Munki Kim, Jienny Lee, Young-Hoan Kim, Jae-Cheul Do, Dongmi Kwak
Tuberculosis, a chronic progressive disease, has been reported in bovine, swine, and primate species. Here, we report the first case of Mycobacterium tuberculosis infection in a Korean wild boar ( Sus scrofa coreanus). The owners this domesticated boar brought it to the Gyeongbuk Veterinary Service Laboratory in Korea after it was found dead and severely emaciated. Demarcated yellowish white nodules were found around the larynx and retropharyngeal lymph node during necropsy. The lungs had diffuse fibrinous pleuritis, severe congestion, and scattered nodules...
May 9, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28482960/tuberculosis-disease-among-mexico-born-individuals-living-in-new-york-city-2001-2014
#11
N L Stennis, J S Meissner, D Bhavnani, B Kreiswirth, S Desai Ahuja
SETTING: Tuberculosis (TB) has decreased substantially in New York City (NYC), but progress has slowed in recent years. Continued declines will require novel approaches tailored to foreign-born populations. OBJECTIVE: To describe TB epidemiology among the Mexico-born population of NYC to inform interventions in this community. DESIGN: The study included NYC patients with TB disease identified from 2001 to 2014. Incidence rates were compared by country of birth groupings...
June 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28476145/disseminated-bacillus-calmette-gu%C3%A3-rin-bcg-infections-in-infants-with-immunodeficiency
#12
Suleiman Al-Hammadi, Ahmed R Alsuwaidi, Eman T Alshamsi, Ghassan A Ghatasheh, Abdul-Kader Souid
BACKGROUND: The Bacillus Calmette-Guérin (BCG) preparations are live-attenuated derivatives of Mycobacterium bovis. These products are used to vaccinate infants at birth, a practice that may result in a disseminated infection in those patients who have an unidentified immunodeficiency. CASE PRESENTATION: Patients who were immunized at birth with BCG and who developed a disseminated infection are reported here to emphasize the importance of taking an extensive medical history before ‎giving the BCG vaccine...
May 5, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28475618/first-time-detection-and-identification-of-the-mycobacterium-tuberculosis-complex-members-in-extrapulmonary-tuberculosis-clinical-samples-in-south-tunisia-by-a-single-tube-tetraplex-real-time-pcr-assay
#13
Mariam Siala, Salma Smaoui, Wafa Taktak, Salma Hachicha, Asma Ghorbel, Chema Marouane, Sana Kammoun, Dhikrayet Gamara, Leila Slim, Radhouane Gdoura, Férièle Messadi-Akrout
INTRODUCTION: Tunisia has one of the highest burdens of extrapulmonary tuberculosis (EPTB) among tuberculosis (TB) cases but the contribution of MTBC-mediated human EPTB is unknown. EPTB diagnosis is challenging due to the paucibacillary nature of clinical samples. Therefore, a need of a simplified molecular method for sensitive and specific TB detection and differentiation of MTBC members caused EPTB remains a priority to an early diagnosis, optimize successful anti-TB treatment and minimize transmission...
May 5, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28465507/the-role-of-hydrophobicity-in-tuberculosis-evolution-and-pathogenicity
#14
Monika Jankute, Vijayashankar Nataraj, Oona Y-C Lee, Houdini H T Wu, Malin Ridell, Natalie J Garton, Michael R Barer, David E Minnikin, Apoorva Bhatt, Gurdyal S Besra
The evolution of tubercle bacilli parallels a route from environmental Mycobacterium kansasii, through intermediate "Mycobacterium canettii", to the modern Mycobacterium tuberculosis complex. Cell envelope outer membrane lipids change systematically from hydrophilic lipooligosaccharides and phenolic glycolipids to hydrophobic phthiocerol dimycocerosates, di- and pentaacyl trehaloses and sulfoglycolipids. Such lipid changes point to a hydrophobic phenotype for M. tuberculosis sensu stricto. Using Congo Red staining and hexadecane-aqueous buffer partitioning, the hydrophobicity of rough morphology M...
May 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28460744/the-performance-of-the-interferon-gamma-assay-when-used-as-a-diagnostic-or-quality-assurance-test-in-mycobacterium-bovis-infected-herds
#15
T A Clegg, M Good, M Doyle, A Duignan, S J More, E Gormley
There are two different contexts in the Irish bTB eradication programme in which the interferon-gamma assay (IFN-γ) is applied. Firstly, the IFN-γ assay is applied routinely to high risk cohorts in herds with four or more reactors to the SICTT. The IFN-γ test is then carried out on blood samples submitted to the laboratory within 8h of collection (diagnostic testing). Secondly, the use of the IFN-γ assay has recently been extended to test SICTT reactors as part of a general quality assurance (QA) scheme to monitor the performance of the SICTT...
May 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28460600/comparison-of-the-bbl-mycobacteria-growth-indicator-tube-the-bactec-12b-and-solid-media-for-the-isolation-of-mycobacterium-bovis
#16
Gary F Yates, Marian Price-Carter, Kirstie Bland, Maree A Joyce, Farina Khan, Melissa Surrey, Geoffrey W de Lisle
We compared different methods for their ability to isolate Mycobacterium bovis from tissue samples from animals with lesions resembling bovine tuberculosis. In the first trial, M. bovis was isolated from 86 of 200 tissue samples that were cultured using 2 liquid media, BACTEC 12B and BBL mycobacteria growth indicator tube (MGIT), and a solid medium, Middlebrook 7H11 supplemented with pyruvate (7H11P). M. bovis was isolated from 2 samples with MGIT but not BACTEC 12B. M. bovis was isolated from 9 samples with BACTEC but not MGIT; these 9 samples came from the North Canterbury/Marlborough region of New Zealand...
April 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28454655/toll-like-receptor-tlr-diversity-influences-mycobacterial-growth-in-african-buffalo
#17
Nikki le Roex, Anna Jolles, Brianna Beechler, Paul van Helden, Eileen Hoal
Understanding the role of wildlife in the maintenance or spread of emerging infectious diseases is a growing priority across the world. Bovine tuberculosis (BTB) is a chronic, infectious disease caused by Mycobacterium bovis (M. bovis). BTB is widespread within game reserves in southern Africa, and within these ecosystems the primary wildlife host of this disease is the African buffalo. We used a modified bacterial killing assay for mycobacteria to investigate the effect of Toll-like receptor (TLR) genetic diversity and demographic parameters on the ability of African buffalo to restrict mycobacterial growth...
May 2017: Tuberculosis
https://www.readbyqxmd.com/read/28454647/genotyping-and-rifampicin-and-isoniazid-resistance-in-mycobacterium-bovis-strains-isolated-from-the-lymph-nodes-of-slaughtered-cattle
#18
Marília Masello Junqueira Franco, Márcio Garcia Ribeiro, Fernando Rogério Pavan, Marcelo Miyata, Marcos Bryan Heinemann, Antonio Francisco de Souza Filho, Rosilene Fressatti Cardoso, Aryadne Larissa de Almeida, Ricardo Ichiro Sakate, Antonio Carlos Paes
In developing nations, 10-20% of the human cases of tuberculosis are caused by Mycobacterium bovis. However, this percentage may be underestimated because most laboratories in developing countries do not routinely perform mycobacterial cultures, and only a few have the systems in place to identify M. bovis. There are few studies investigating genotypic diversity and drug resistance in M. bovis from animal and/or human infections. The genotypic diversity of M. bovis strains obtained from bovine lymph nodes were investigated by spacer oligonucleotide typing (spoligotyping) and mycobacterial interspersed repetitive unit-variable-number tandem repeat typing (MIRU-VNTR)...
May 2017: Tuberculosis
https://www.readbyqxmd.com/read/28453114/-tuberculosis-caused-by-mycobacterium-bovis-in-workers-of-bovine-tuberculosis-sanitation-farms-in-antioquia-boyac%C3%A3-and-cundinamarca
#19
Andrés F Leal-Bohórquez, Claudia M Castro-Osorio, Luz M Wintaco-Martínez, Rafael Villalobos, Gloria M Puerto-Castro
Objective: To perform classic and molecular epidemiological surveillance of human tuberculosis caused by Mycobacterium bovis in bovine supply chains at farms with PPD positive bovines in the departments of Antioquia, Boyacá and Cundinamarca during a one-year period. Methods: Livestock farms with PPD positive bovines or buffalos were visited in the study departments according to information obtained in the "Programa Nacional de Tuberculosis bovina" (National program on bovine Tuberculosis) released by ICA (Colombian Agriculture and Livestock Institute)...
September 2016: Revista de Salud Pública
https://www.readbyqxmd.com/read/28450867/p2x7-receptor-in-bone-marrow-derived-cells-aggravates-tuberculosis-caused-by-hypervirulent-mycobacterium-bovis
#20
Caio César Barbosa Bomfim, Eduardo Pinheiro Amaral, Alexandra Dos Anjos Cassado, Érika Machado Salles, Rogério Silva do Nascimento, Elena Lasunskaia, Mario Hiroyuki Hirata, José Maria Álvarez, Maria Regina D'Império-Lima
Tuberculosis (TB) remains a serious public health problem despite the great scientific advances in the recent decades. We have previously shown that aggressive forms of TB caused by hypervirulent strains of Mycobacterium tuberculosis and Mycobacterium bovis are attenuated in mice lacking the P2X7 receptor, an ion channel activated by extracellular ATP. Therefore, P2X7 receptor is a potential target for therapeutic intervention. In vitro, hypervirulent mycobacteria cause macrophage death by a P2X7-dependent mechanism that facilitates bacillus dissemination...
2017: Frontiers in Immunology
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