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Mycobacterium bovis

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https://www.readbyqxmd.com/read/28209712/mycobacterium-tuberculosis-esxl-inhibit-mhc-ii-expression-by-promoting-hypermethylation-in-class-ii-transactivator-loci-in-macrophages
#1
Srabasti Sengupta, Saba Naz, Ishani Das, Abdul Ahad, Avinash Padhi, Sumanta Naik, Geetanjali Ganguli, Kaliprasad Patnaik, Sunil Kumar Raghav, Vinay Nandicoori, Avinash Sonawane
Mycobacterium tuberculosis (Mtb) is known to modulate the host immune responses to facilitate its persistence inside the host cells. One of the key mechanisms includes repression of class-II transactivator (CIITA) and MHC-II expression in infected macrophages. However, the precise mechanism of CIITA and MHC-II down-regulation is not well studied. Mtb 6-kDa early secretory antigenic target (ESAT-6) is a known potent virulence and antigenic determinant. Mtb genome encodes 23 such ESAT-6 family proteins. We herein report that Mtb and M...
February 16, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28209138/using-whole-genome-sequencing-to-investigate-transmission-in-a-multi-host-system-bovine-tuberculosis-in-new-zealand
#2
Joseph Crispell, Ruth N Zadoks, Simon R Harris, Brent Paterson, Desmond M Collins, Geoffrey W de-Lisle, Paul Livingstone, Mark A Neill, Roman Biek, Samantha J Lycett, Rowland R Kao, Marian Price-Carter
BACKGROUND: Bovine tuberculosis (bTB), caused by Mycobacterium bovis, is an important livestock disease raising public health and economic concerns around the world. In New Zealand, a number of wildlife species are implicated in the spread and persistence of bTB in cattle populations, most notably the brushtail possum (Trichosurus vulpecula). Whole Genome Sequenced (WGS) M. bovis isolates sourced from infected cattle and wildlife across New Zealand were analysed. Bayesian phylogenetic analyses were conducted to estimate the substitution rate of the sampled population and investigate the role of wildlife...
February 16, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28207828/the-wide-spectrum-high-biocidal-potency-of-bioxy-formulation-when-dissolved-in-water-at-different-concentrations
#3
Dori Dagher, Ken Ungar, Richard Robison, Fadi Dagher
Traditional surface disinfectants that have long been applied in medicine, animal husbandry, manufacturing and institutions are inconvenient at best and dangerous at worst. Moreover, some of these substances have adverse environmental impacts: for example, quaternary ammonium compounds ("quats") are reproductive toxicants in both fish and mammals. Halogens are corrosive both to metals and living tissues, are highly reactive, can be readily neutralized by metals, and react with organic matter to form toxic, persistent by-products such as dioxins and furans...
2017: PloS One
https://www.readbyqxmd.com/read/28201585/patterns-and-processes-of-mycobacterium-bovis-evolution-revealed-by-phylogenomic-analyses
#4
José S L Patané, Joaquim Martins, Ana Beatriz Castelão, Christiane Nishibe, Luciana Montera, Fabiana Bigi, Martin J Zumárraga, Angel A Cataldi, Antônio Fonseca Junior, Eliana Roxo, Ana Luiza, A R Osório, Kláudia S Jorge Ufms, Tyler C Thacker, Nalvo F Almeida, Flabio R Araújo, João C Setubal
No abstract text is available yet for this article.
February 13, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28199374/a-novel-mycobacterial-in-vitro-infection-assay-identifies-differences-of-induced-macrophage-apoptosis-between-cd4-and-cd8-t-cells
#5
Vanesa Nkwouano, Sven Witkowski, Nidja Rehberg, Rainer Kalscheuer, Norman Nausch, Ertan Mayatepek, Marc Jacobsen
Macrophages are natural host cells for pathogenic mycobacteria, like Mycobacterium tuberculosis (M.tb). Immune surveillance by T cells and interaction with M.tb infected macrophages is crucial for protection against M.tb reactivation and development of active tuberculosis. Several factors play a role in the control of M.tb infection but reliable biomarkers remain elusive. One major obstacle is the absence of functional in vitro assays which allow concomitant determination of i) mycobacterial eradication; ii) cytotoxic effects on host macrophages; and iii) effector T-cell functions...
2017: PloS One
https://www.readbyqxmd.com/read/28187776/mycobacterium-bovis-in-a-european-bison-bison-bonasus-raises-concerns-about-tuberculosis-in-brazilian-captive-wildlife-populations-a-case-report
#6
Cristina Kraemer Zimpel, Juliana Sperotto Brum, Antônio Francisco de Souza Filho, Alexander Welker Biondo, João Henrique Perotta, Cristina Corsi Dib, Marcelo Bonat, José Soares Ferreira Neto, Paulo Eduardo Brandão, Marcos Bryan Heinemann, Ana Marcia Sa Guimaraes
BACKGROUND: Tuberculosis caused by Mycobacterium bovis is an important worldwide zoonosis and has been reported to cause clinical disease in several animal species, including captive wildlife. This report describes a case of M. bovis infection in a European bison from a Brazilian zoo and compiles a number of literature reports that raise concern regarding tuberculosis among captive wildlife in Brazil. CASE PRESENTATION: A 13 year-old captive-born male bison (Bison bonasus) from a Brazilian zoo began presenting weight loss, diarrhea and respiratory symptoms, which inevitably led to his death...
February 10, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28177046/stable-expression-of-mycobacterium-bovis-antigen-85b-in-auxotrophic-m-bovis-bacillus-calmette-gu%C3%A3-rin
#7
Caroline Rizzi, Ana Carolina Peiter, Thaís Larré Oliveira, Amilton Clair Pinto Seixas, Karen Silva Leal, Daiane Drawanz Hartwig, Fabiana Kommling Seixas, Sibele Borsuk, Odir Antônio Dellagostin
BACKGROUND: Bovine tuberculosis (TB) is a zoonotic disease caused by Mycobacterium bovis, responsible for causing major losses in livestock. A cost effective alternative to control the disease could be herd vaccination. The bacillus Calmette-Guérin (BCG) vaccine has a limited efficacy against bovine TB, but can improved by over-expression of protective antigens. The M. bovis antigen 85B demonstrates ability to induce protective immune response against bovine TB in animal models. However, current systems for the construction of recombinant BCG expressing multiple copies of the gene result in strains of low genetic stability that rapidly lose the plasmid in vivo...
February 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28174695/the-effect-of-oral-vaccination-with-mycobacterium-bovis-bcg-on-the-development-of-tuberculosis-in-captive-european-badgers-meles-meles
#8
Mark A Chambers, Frank Aldwell, Gareth A Williams, Si Palmer, Sonya Gowtage, Roland Ashford, Deanna J Dalley, Dipesh Davé, Ute Weyer, Francisco J Salguero, Alejandro Nunez, Allan K Nadian, Timothy Crawshaw, Leigh A L Corner, Sandrine Lesellier
The European badger (Meles meles) is a reservoir host of Mycobacterium bovis and responsible for a proportion of the tuberculosis (TB) cases seen in cattle in the United Kingdom and Republic of Ireland. An injectable preparation of the bacillus Calmette-Guérin (BCG) vaccine is licensed for use in badgers in the UK and its use forms part of the bovine TB eradication plans of England and Wales. However, there are practical limitations to the widespread application of an injectable vaccine for badgers and a research priority is the development of an oral vaccine deliverable to badgers in bait...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28168855/vaccination-of-calves-with-mycobacterium-bovis-bacillus-calmette-guerin-reduces-the-frequency-and-severity-of-lesions-of-bovine-tuberculosis-under-a-natural-transmission-setting-in-ethiopia
#9
G Ameni, K Tafess, A Zewde, T Eguale, M Tilahun, T Hailu, A Sirak, F J Salguero, S Berg, A Aseffa, R G Hewinson, H M Vordermeier
Bovine tuberculosis (bTB) is highly prevalent in intensive dairy farms of the urban "milk-sheds" in Ethiopia, and vaccination could be a cost-effective disease control strategy. In the present study, the efficacy of Bacillus Calmette-Guerin (BCG) to protect against bTB was assessed in Holstein-Friesian calves in a natural transmission setting. Twenty-three 2-week-old calves were subcutaneously vaccinated with BCG Danish SSI strain 1331, and matched 26 calves were injected with placebo. Six weeks later, calves were introduced into a herd of M...
February 6, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28159234/immunohistochemical-detection-of-pro-inflammatory-and-anti-inflammatory-cytokines-in-granulomas-in-cattle-with-natural-mycobacterium-bovis-infection
#10
Ana M Canal, Natalia Pezzone, Angel Cataldi, Martín Zumarraga, Mariano Larzabal, Sergio Garbaccio, Analía Fernandez, Lucas Dominguez, Alicia Aranaz, Antonio Rodriguez-Bertos
Cellular immune response was evaluated in lymph nodes and lung with different granulomatous lesions from cattle naturally infected with Mycobacterium bovis. For this purpose, we assessed pro-inflammatory and anti-inflammatory cytokines by immunohistochemical assays. Immunoreaction was observed for all the cytokines analyzed. Fourteen animals displayed advanced stage IV granulomas, with intense immunoreactivity to IFN-γ and TGF-β in areas of caseous necrosis, macrophages and lymphocytes. Seven animals showed stage III granuloma, with high immunoreactivity to IFN-γ (average of 44...
February 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28152056/transmission-dynamics-and-elimination-potential-of-zoonotic-tuberculosis-in-morocco
#11
Mahamat Fayiz Abakar, Hind Yahyaoui Azami, Philipp Justus Bless, Lisa Crump, Petra Lohmann, Mirjam Laager, Nakul Chitnis, Jakob Zinsstag
Bovine tuberculosis (BTB) is an endemic zoonosis in Morocco caused by Mycobacterium bovis, which infects many domestic animals and is transmitted to humans through consumption of raw milk or from contact with infected animals. The prevalence of BTB in Moroccan cattle is estimated at 18%, and 33% at the individual and the herd level respectively, but the human M. bovis burden needs further clarification. The current control strategy based on test and slaughter should be improved through local context adaptation taking into account a suitable compensation in order to reduce BTB prevalence in Morocco and decrease the disease burden in humans and animals...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28145400/molecular-detection-of-m-tuberculosis-and-m-bovis-and-hematological-and-biochemical-analyses-in-agricultural-sprayers-exposed-to-pesticides-a-cross-sectional-study-in-punjab-pakistan-during-2014-2016
#12
Saffora Riaz, Farkhanda Manzoor, Nasir Mahmood, Saman Shahid
We determined the correlation between a pesticide exposure, physical health and susceptibility toward tuberculosis along with hematological indices and liver enzymes' alterations in sprayers exposed to pesticides. Molecular detection of Mycobacterium tuberculosis and Mycobacterium bovis was detected by targeting histone-like protein (hupB) gene. The WBC (white blood cells) and RBC (red blood cells) levels of male sprayers and non-sprayers were significantly different (P<0.05). In female spray workers, the WBC and neutrophils levels were significantly different as compared with non-sprayers...
February 1, 2017: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/28142116/a-novel-benzothiazinethione-analogue-sklb-tb1001-displays-potent-antimycobacterial-activities-in-a-series-of-murine-models
#13
Chao Gao, Ting-Hong Ye, Cui-Ting Peng, Yao-Jie Shi, Xin-Yu You, Lu Xiong, Kai Ran, Li-Dan Zhang, Xiu-Xiu Zeng, Ning-Yu Wang, Luo-Ting Yu, Yu-Quan Wei
New chemotherapeutic compounds and regimens are needed to combat multidrug-resistant Mycobacterium tuberculosis. Here, we used a series of murine models to assess an antitubercular lead compound SKLB-TB1001. In the Mycobacterium bovis bacillus Calmette-Guérin and the acute M. tuberculosis H37Rv infection mouse models, SKLB-TB1001 significantly attenuated the mycobacterial load in lungs and spleens. The colony forming unit counts and histological examination of lungs from H37Rv infected mice revealed that the benzothiazinethione analogue SKLB-TB1001 as a higher dose level was as effective as isoniazid...
January 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28138411/granulomatous-prostatitis-after-intravesical-immunotherapy-mimicking-prostate-cancer
#14
Waldemar Białek, Sławomir Rudzki, Paweł Iberszer, Lech Wronecki
Intravesical immunotherapy with attenuated strains of Mycobacterium bovis is a widely used therapeutic option in patients with non-muscle-invasive transitional cell carcinoma of the bladder. A rare complication of intravesical therapy with the Bacillus Calmette-Guérin vaccine is granulomatous prostatitis, which due to increasing levels of prostate-specific antigen and abnormalities found in transrectal examination of the prostate may suggest concomitant prostate cancer. A case of extensive granulomatous prostatitis in a 61-year-old patient which occurred after the first course of a well-tolerated Bacillus Calmette-Guérin therapy is presented...
December 2016: Journal of Ultrasonography
https://www.readbyqxmd.com/read/28126017/ruptured-aortic-aneurysm-due-to-mycobacterium-bovis-bcg-with-a-delayed-bacteriological-diagnosis-due-to-false-negative-result-of-the-mpb-64-immunochromatographic-assay
#15
J Simar, L Belkhir, B Tombal, E André
BACKGROUND: Adjuvant therapy with bacillus Calmette-Guerin (BCG), a live attenuated strain of Mycobacterium bovis, has become the treatment of choice for low-risk superficial bladder carcinoma following transurethral resection of the bladder. Complications following vesical BCG instillations are uncommon but, in some cases, severe side-effects can occur such as sepsis or mycotic aneurysm. Besides usual laboratory techniques used for the diagnosis of Mycobacterium tuberculosis complex (MTBC) infections (smear microscopy and cultures), commercial immunochromatographic assays detecting MBP64, a 24 kDa M...
January 26, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28122192/prevalence-and-risk-factors-for-mycobacterium-bovis-infection-in-african-lions-panthera-leo-in-the-kruger-national-park
#16
Tashnica Taime Sylvester, Laura Elizabeth Rosen Martin, Peter Buss, Andre Gareth Loxton, Guy Anton Hausler, Leana Rossouw, Paul van Helden, Sven David Charles Parsons, Francisco Olea-Popelka, Michele Ann Miller
Mycobacterium bovis, the causative agent of bovine tuberculosis (BTB), is endemic in the Kruger National Park (KNP), South Africa. African lions ( Panthera leo ) are susceptible to BTB, but the impact of the disease on lion populations is unknown. In this study, we used a novel gene expression assay for chemokine (C-X-C motif) ligand 9 (CXCL9) to measure the prevalence of M. bovis infection in 70 free-ranging lions that were opportunistically sampled in the southern and central regions of the KNP. In the southern region of the KNP, the apparent prevalence of M...
January 25, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28121981/oral-vaccination-of-free-living-badgers-meles-meles-with-bacille-calmette-gu%C3%A3-rin-bcg-vaccine-confers-protection-against-tuberculosis
#17
Eamonn Gormley, Deirdre Ní Bhuachalla, James O'Keeffe, Denise Murphy, Frank E Aldwell, Tara Fitzsimons, Paul Stanley, Jamie A Tratalos, Guy McGrath, Naomi Fogarty, Kevin Kenny, Simon J More, Locksley L McV Messam, Leigh A L Corner
A field trial was conducted to investigate the impact of oral vaccination of free-living badgers against natural-transmitted Mycobacterium bovis infection. For a period of three years badgers were captured over seven sweeps in three zones and assigned for oral vaccination with a lipid-encapsulated BCG vaccine (Liporale-BCG) or with placebo. Badgers enrolled in Zone A were administered placebo while all badgers enrolled in Zone C were vaccinated with BCG. Badgers enrolled in the middle area, Zone B, were randomly assigned 50:50 for treatment with vaccine or placebo...
2017: PloS One
https://www.readbyqxmd.com/read/28110868/quinolidene-based-monocarbonyl-curcumin-analogues-as-promising-antimycobacterial-agents-synthesis-and-molecular-docking-study
#18
Dnyaneshwar D Subhedar, Mubarak H Shaikh, Laxman Nawale, Dhiman Sarkar, Vijay M Khedkar, Bapurao B Shingate
A series of quinoline incorporated monocarbonyl curcumin analogues was efficiently synthesized using [HDBU][HSO4] as catalyst via Knoevenagel type condensation and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37Ra (MTB) and Mycobacterium bovis BCG in dormant state. The analogues 3e, 3h, 4a and 4e exhibited very good antitubercular activity. The antiproliferative activity of the analogues against MCF-7, A549 and HCT-116 cell lines was evaluated using modified MTT assay and these compounds were found to be non-cytotoxic...
January 5, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28107879/disease-transmission-in-animal-transfer-networks
#19
Dejene W Sintayehu, H H T Prins, I M A Heitkönig, W F de Boer
Infectious diseases transmission is strongly determined by who contacts whom. Bovine tuberculosis (bTB) caused by Mycobacterium bovis is a worldwide burden for animal populations. One of the major transmission mechanism between herd is the transfer of infectious animal. In East Africa, pastoralists may receive or bestow livestock to create and strengthen social relationships. Here, we used a network approach to examine the relative importance of such cattle transfer in the transmission of bTB. First, a total of 2550 cattle from 102 herds were tested using the comparative intradermal tuberculin test to assess the presence of bTB infected cattle in the herd...
February 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28105923/mosaic-structure-of-mycobacterium-bovis-bcg-genomes-as-a-representation-of-phage-sequences-mobility
#20
Olga L Voronina, Marina S Kunda, Ekaterina I Aksenova, Andrey N Semenov, Natalia N Ryzhova, Vladimir G Lunin, Alexandr L Gintsburg
BACKGROUND: The control of genome stability is relevant for the worldwide BCG vaccine preventing the acute forms of childhood tuberculosis. BCG sub-strains whole genome comparative analysis and revealing the triggers of sub-strains transition were the purpose of our investigation. RESULTS: Whole genome sequencing of three BCG Russia seed lots (1963, 1982, 2006 years) confirmed the stability of vaccine sub-strain genome. Comparative analysis of three Mycobacteruim bovis and nine M...
December 28, 2016: BMC Genomics
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