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Preterm formula

Evandro Brandelero, Bibiana Paula Dambrós, Elenice Messias do Nascimento Gonçalves, Vera Lucia Pagliusi Castilho, Amarildo Moro Ribas, Maribel Emília Gaio
OBJECTIVE: To describe an uncommon case of infection by Strongyloides stercoralis (S. stercoralis) in a 4-month-old child and to highlight the importance of early diagnosis. CASE DESCRIPTION: The patient was a male child from the city of Videira, State of Santa Catarina, Southern Brazil, who was born preterm by Cesarean-section, weighing 1,655 g, and stayed in the neonatal intensive care unit for 20 days. At four months of age, the child started presenting blood in stools and the possibility of cow's milk protein allergy was considered, given the symptoms and the use of infant formula in his 1st semester of life, which was then replaced by infant formula with hydrolyzed protein...
July 26, 2018: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
Ficara Monica, Pietrella Elisa, Spada Caterina, Della Casa Muttini Elisa, Lucaccioni Laura, Iughetti Lorenzo, Berardi Alberto
There is increasing evidence that the intestinal microbiota plays a pivotal role in the maturation of the immune system and in the prevention of diseases occurring during the neonatal period, childhood and adulthood. A number of nonphysiological conditions during the perinatal period (ie caesarean section, prolonged hospitalization, formula feeding, low gestational age) may negatively affect the normal development of the microbiota, leading to decreased amounts of lactobacilli and bifidobacteria and increased amounts of Clostridia ...
July 29, 2018: Journal of Maternal-fetal & Neonatal Medicine
Jason L Robinson, Victoria A Smith, Barbara Stoll, Umang Agarwal, Muralidhar H Premkumar, Patricio Lau, Stephanie M Cruz, Rodrigo Manjarin, Oluyinka O Olutoye, Douglas G Burrin, Juan C Marini
Necrotizing enterocolitis (NEC) is associated with low plasma arginine and vascular dysfunction. It is not clear whether low intestinal citrulline production, the precursor for arginine synthesis, occurs before and thus predisposes to NEC or if it results from tissue damage. This study was designed to test the hypothesis that whole-body rates of citrulline, arginine and nitric oxide synthesis are low in premature pigs and that they precede NEC. Piglets delivered by cesarean-section at 103-d (Preterm, PT), 110-d (Near-Term, NT), or 114-d of gestation (Full-Term, FT) were given total parenteral nutrition and after 2 days, orogastrically fed infant formula for 42h to induce NEC...
July 26, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
Barbara K Kościelniak, Nina Mól, Przemko Kwinta, Krystyna Sztefko, Przemysław J Tomasik
BACKGROUND/AIMS: The objective of the study was to evaluate the circulating concentrations of plasma free fatty acids (FFA), fatty acid binding proteins: FABP-1 and FABP-4 in preterm infants depending on different feeding protocol. METHODS: A total of 43 premature infants (≤34 weeks) were enrolled in the study, and divided into 3 subgroups: nursed while staying in the department (53%), breast-fed only during the first 24 h (16%), and formulafed from the beginning (31%)...
July 25, 2018: Annals of Nutrition & Metabolism
Bronwyn Dervyla Power, Mary Isabel O'Dea, Michael Joseph O'Grady
BACKGROUND: Over the past decade, where mother's own milk (MOM) is unavailable, the use of donor human milk has become increasingly common in preterm and very low birth weight (VLBW) neonates. Limited literature exists regarding donor human milk practices in neonatal units. AIMS: To examine practices and opinions regarding use of donor human milk in neonatal units in the Republic of Ireland. METHODS: Cross-sectional postal survey of all neonatologists and paediatricians working in each of the 19 neonatal units in the Republic of Ireland...
July 24, 2018: Irish Journal of Medical Science
Shreyas K Roy, Qinghe Meng, Benjamin D Sadowitz, Michaela Kollisch-Singule, Natesh Yepuri, Joshua Satalin, Louis A Gatto, Gary F Nieman, Robert N Cooney, David Clark
OBJECTIVE: To develop an animal model which replicates neonatal NEC and characterizes the importance of bacterial fermentation of formula and short chain fatty acids (SCFAs) in its pathogenesis. BACKGROUND: NEC is a severe form of intestinal inflammation in preterm neonates and current models do not reproduce the human condition. METHODS: Three groups of newborn piglets: Formula alone (FO), Bacteria alone (E.coli: BO) and E.coli-fermented formula (FF) were anesthetized, instrumented and underwent post-pyloric injection of formula, bacteria or fermented-formula...
2018: PloS One
Mengnan Yu, Gang Liu, Zhichun Feng, Liuming Huang
PURPOSE: To evaluate whether plasma white blood cell count (WBC), platelet count (PLT), and C-reactive protein level (CRP) can be used to differentiate surgical necrotizing enterocolitis (NEC) from medical NEC. METHODS: Preterm infants admitted between January 1, 2011 and July 31, 2015 were stratified by the need of surgery as surgical NEC (n = 41) and medical NEC (n = 43). The values of WBC, PLT and CRP were collected at time before NEC occurred (T0 ), at onset of NEC (T1 ) and when surgical assessment was required (T2 )...
July 19, 2018: Pediatric Surgery International
Qian-Qian Li, Qian Liu, Jun-Mei Yan, Xian Wang
OBJECTIVE: To investigate the growth and development of very low birth weight (VLBW)/extremely low birth weight (ELBW) preterm infants within the corrected age of 6 months and the effect of different feeding patterns on growth and development. METHODS: A total of 109 VLBW/ELBW preterm infants who were discharged from January 2016 to April 2017 and who had completed regular follow-up were enrolled, and their growth and development within the corrected age of 6 months were monitored...
July 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
Yvan Vandenplas, Silvia Salvatore, Carmen Ribes-Koninckx, Eva Carvajal, Hania Szajewska, Koen Huysentruyt
OBJECTIVE: The Cow's Milk-related Symptom Score (CoMiSSTM) was developed as an awareness tool to recognize possible manifestations of cow's milk protein allergy (CMPA). Arbitrarily, a cut-off value of ≥12 was defined as a "positive score." The aim of this study was to determine an age-related CoMiSS in healthy infants to minimize the risk of false reassurance or over-diagnosis of CMPA in case of a negative or positive score, respectively. METHODS: General pediatricians determined the CoMiSS in presumed healthy infants aged ≤6 months during a routine visit...
2018: PloS One
Maria Dalva Barbosa Baker Méio, Letícia Duarte Villela, Saint Clair Dos Santos Gomes Júnior, Camilla Morcelli Tovar, Maria Elisabeth Lopes Moreira
This paper aims to evaluate the prevalence of breastfeeding among premature infants following hospital discharge. Cohort (< 33 gestation weeks) followed up to 12 months (adjusted age). VARIABLES: breastfeeding, anthropometric measurements, social and family information. The proportion of breastfeeding during follow-up was calculated. Survival analysis was conducted to estimate breastfeeding duration. In total, 242 of the 258 infants (93.7%) returned to follow-up; 170 (69.9%) at 6 months and 139 (57...
July 2018: Ciência & Saúde Coletiva
James G Huang, Shi Hua Chan, Le Ye Lee
INTRODUCTION: We studied the effects of ethnicity on early infant growth patterns in exclusively breast-fed (EBF) infants from a Singaporean multiethnic population. This was a prospective cohort study conducted in National University Hospital, Singapore. MATERIALS AND METHODS: Healthy, EBF infants born at-term completing 37 weeks and above, and whose birthweight was appropriate for gestational age (>10th centile, <90th centile) were recruited. Infants were required to be EBF at least until the minimum age of weaning...
June 2018: Annals of the Academy of Medicine, Singapore
Elizabeth A Reznikov, Sarah S Comstock, Jennifer L Hoeflinger, Mei Wang, Michael J Miller, Sharon M Donovan
Background: Bovine lactoferrin (bLf) reduces Staphylococcus aureus infection in premature infants and promotes the growth of Bifidobacterium infantis , a predominant infant gut species. We hypothesized that bLf in combination with B. infantis would reduce the severity of systemic S. aureus infection. Objective: The aim was to determine the effects of oral administration of bLf and B. infantis on the course of systemic S. aureus infection. Methods: Colostrum-deprived piglets were fed formulas containing 4 g whey/L (CON group) or bLf (LF group)...
April 2018: Current developments in nutrition
Line Hedegaard Toftlund, Susanne Halken, Lone Agertoft, Gitte Zachariassen
BACKGROUND: Breastfeeding promotes healthy growth in very-preterm-born infants (VPI), but extra nutritional supply is needed to ensure catch-up growth and brain development. OBJECTIVES: To investigate how different types of post-discharge nutrition affect growth until 6 years of age in children born VPI. METHODS: This was a 6-year follow-up study of 281 VPI. Median gestational age (GA) was 30 + 0 weeks (range 24-32 weeks). When breastfed at discharge, they were randomized to unfortified human milk (UHM) or fortified human milk (FHM)...
July 16, 2018: Neonatology
Yangmei Li, Xinxue Liu, Neena Modi, Sabita Uthaya
OBJECTIVE: To investigate the impact of breast milk (BM) intake on body composition at term in very preterm infants. DESIGN: Preplanned secondary analysis of the Nutritional Evaluation and Optimisation in Neonates Study, a 2-by-2 factorial randomised controlled trial of preterm parenteral nutrition (PN). SETTING: Four National Health Service hospitals in London and South-East England. PATIENTS: Infants born at <31 weeks of gestation; infants with life-threatening congenital abnormalities and those unable to receive trial PN within 24 hours of birth were ineligible...
July 14, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
Ufuk Cakir, Cuneyt Tayman, Utku Serkant, Halil Ibrahim Yakut, Esra Cakir, Ufuk Ates, Ismail Koyuncu, Eyyup Karaogul
ETHNOPHARMACOLOGICAL RELEVANCE: Necrotizing enterocolitis (NEC) is the most important gastrointestinal emergency affecting especially preterm infants and causes severe morbidities and mortality. However, there is no cure. Oxidant stress, inflammation, apoptosis, as well as prematurity are believed to responsible in the pathogenesis of the disease. Ginger and its compounds have anti-inflammatory, antimicrobial, anti-oxidant properties and immunomodulatory, cytoprotective/regenerative actions...
October 28, 2018: Journal of Ethnopharmacology
Anna Parra-Llorca, María Gormaz, Cristina Alcántara, María Cernada, Antonio Nuñez-Ramiro, Máximo Vento, Maria C Collado
Preterm microbial colonization is affected by gestational age, antibiotic treatment, type of birth, but also by type of feeding. Breast milk has been acknowledged as the gold standard for human nutrition. In preterm infants breast milk has been associated with improved growth and cognitive development and a reduced risk of necrotizing enterocolitis and late onset sepsis. In the absence of their mother's own milk (MOM), pasteurized donor human milk (DHM) could be the best available alternative due to its similarity to the former...
2018: Frontiers in Microbiology
Marta Cabrera Lafuente, M Teresa Montes Bueno, Natividad Pastrana, Cristina Segovia, Rosario Madero Jarabo, Camilia R Martin, Felix Omeñaca Teres, Miguel Sáenz de Pipaón Marcos
BACKGROUND: Mothers of preterm (PT) infants have difficulty providing adequate quantities of human milk (HM) for their babies during their hospital stay. The macronutrient content in HM changes over time, varying across and within individual mothers. Research aim: To describe the intake of mothers' own milk (MOM) and its composition according to gestational (GA) and postnatal age (PNA) in infants born <32 weeks' GA and to correlate them with neonatal weight, length and morbidities...
July 10, 2018: Journal of Perinatal Medicine
Jing Sun, Yanqi Li, Xiaoyu Pan, Duc Ninh Nguyen, Anders Brunse, Anders M Bojesen, Silvia Rudloff, Martin S Mortensen, Douglas G Burrin, Per T Sangild
BACKGROUND: Fortification of donor human milk (DHM) is required for optimal growth of very preterm infants, but there are concerns of more gut dysfunction and necrotizing enterocolitis (NEC) when using formula-based fortifiers (FFs), especially soon after birth. Intact bovine colostrum (BC) is rich in nutrients and bioactive factors, and protects against NEC in preterm pigs. We hypothesized that fortification of DHM with BC is superior to FFs to prevent gut dysfunction and infections when provided shortly after preterm birth...
July 10, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
Deborah S Levy, Erika Osborn, Kathryn A Hasenstab, Saira Nawaz, Sudarshan R Jadcherla
BACKGROUND: A common osmolality threshold for feedings is to stay <450 mOsm/kg for normal infants. Preterm formulas are frequently modified to improve growth, modify nutrition, and manage gastroesophageal reflux (GER) or dysphagia. Relationships between osmolality and additives to ready-to-feed preterm formulas are unclear. Our aims were to evaluate and compare the effects of caloric density, thickening agent recipes, and supplements to ready-to-feed preterm formula on osmolality...
July 10, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
Hyo-Jeong Jang, Jae Hyun Park, Chun Soo Kim, Sang Lak Lee, Won Mok Lee
Purpose: We investigated fecal calprotectin (FC) levels in preterm infants with and without feeding intolerance (FI), and compared the FC levels according to the type of feeding. Methods: The medical records of 67 premature infants were reviewed retrospectively. The fully enteral-fed infants were classified into two groups; the FI group (29 infants) and the control group (31 infants). Seven infants with necrotizing enterocolitis, sepsis, and perinatal asphyxia were excluded...
July 2018: Pediatric Gastroenterology, Hepatology & Nutrition
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