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Imogen H Bell, Sarah F Fielding-Smith, Mark Hayward, Susan L Rossell, Michelle H Lim, John Farhall, Neil Thomas
Common approaches to the psychological treatment of distressing voice hearing experiences, such as cognitive behavioural therapy, aim to promote more adaptive cognitive, emotional and behavioural responses to these experiences. Digital technologies such as smartphones show promise for supporting and enhancing these treatments by linking immediate therapeutic settings to the context of daily life. Two promising technologies include ecological momentary assessment and intervention (EMA/I), which may offer a means of advanced assessment and support in daily life, and inform the tailoring of interventions to suit individual needs...
December 2018: Internet Interventions: the Application of Information Technology in Mental and Behavioural Health
Chen Heng, Tan Wei, Tu Yingbing, Liu Hanzhong
Two middle-aged females presented with a mass located in the lateral quadrant of the breast. Both patients received modified radical surgery for breast cancer, radiotherapy, and chemotherapy and have been living without evidence of disease for more than one year. Under the microscope, we observed that the tumour cells were organised in a solid nest-like or leafy distribution and comprised sebaceous gland cells and oval or fusiform cells. The differences between the two cases are as follows: First, the mass in the first case had a mixed echo pattern on ultrasound, whereas that in the second case had a hypoechoic pattern...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
Kathleen M McIntyre, Jacqueline A Mogle, Jennifer M Scodes, Martina Pavlicova, Peter A Shapiro, Ethan E Gorenstein, Felice A Tager, Catherine Monk, David M Almeida, Richard P Sloan
OBJECTIVE: Negative affect (NA) reactivity to daily stressors may confer health risks over and above stress exposure, especially in chronically angry adults. This randomized controlled trial tests the hypothesis that a 12-week cognitive-behavioral therapy (CBT) anger-reduction treatment would decrease NA reactivity to daily stressors assessed via ambulatory diary for those in treatment, but not on a wait-list for treatment. METHOD: Healthy adults (N = 158, aged 20-45 years, 53...
December 3, 2018: Journal of Consulting and Clinical Psychology
R Ross MacLean, Aaron L Pincus, Joshua M Smyth, Charles F Geier, Stephen J Wilson
The Balloon Analogue Risk Task (BART) is a behavioral measure that is commonly used to assess risk taking propensity. The primary goal of the present study was to introduce a mobile version of the BART (mBART) that can be included within ambulatory assessment protocols to assess risk taking in daily life. Study 1 compared common BART indices (i.e., total money earned, adjusted average pumps, balloon explosions, and coefficient of variability [CV]) on a single administration of the laboratory BART on a computer and the mBART on a smartphone ( n = 78)...
March 2018: Journal of Psychopathology and Behavioral Assessment
Ege Ülgen, Pınar Kuru Bektaşoğlu, M Aydın Sav, Özge Can, Ayça Erşen Danyeli, Deniz Baycın Hızal, M Necmettin Pamir, Koray Özduman
BACKGROUND: Meningiomas are heterogenous with differences in anatomical, histopathological and clinical characteristics. Such spatial variability in meningioma biology is thought to be due to differences in expression
of critical developmental regulators. We hypothesized that variability in meningioma biology follows gradients as in embryology and tested a cohort of 366 meningiomas for histopathological and immunohistochemical gradients. METHODS: Medical records of 366 patients operated for meningiomas between 2003 and 2016 were retrospectively analyzed for age, gender, anatomical localization, recurrence-free survival, overall survival, histopathological diagnosis and immunohistochemistry findings for six markers: epithelial membrane antigen (EMA), progesterone receptor (PR), CD34, S100, P53 and Ki-67 labeling index (Ki-67)...
November 29, 2018: World Neurosurgery
Kohei Kawaguchi, Juma Obayashi, Takuya Kawaguchi, Junki Koike, Yasuji Seki, Kunihide Tanaka, Kei Ohyama, Hideki Nagae, Shigeyuki Furuta, Masayuki Takagi, Kevin C Pringle, Hiroaki Kitagawa
BACKGROUND: The kidney develops from an intimate interaction between the ureteric bud and the metanephric mass. We attempted to differentially stain the derivatives of the ureteric bud and the metanephric mass in ovine fetuses. METHODS: After appropriate approval, 47 fetal lambs' kidneys at 50 (4), 60 (6), 70 (5), 80 (4), 100 (10), 110 (8), 145 (10) days' gestation (term is 140-145 days) were obtained. After confirming the pregnancy, the sheep were anesthetized, and the fetuses sacrificed...
December 2018: Journal of Pediatric Surgery
Ting Ting Li, Yar Muhammad Jalbani, Gui Lan Zhang, Zhi Yong Zhao, Zhi Ying Wang, Xiao Yan Zhao, Ai Liang Chen
Economically motivated adulteration (EMA) has become one of the most concerned food safety issues. However, existing mainstream PCR methods could neither achieve qualitative detection purposes, nor detect all possible meat species involved in adulteration. When meat has been adulterated with unidentified species but the result indicates no adulteration, it is a false negative; when meat has not been adulterated deliberately but has somehow been polluted during its processing or packaging, a false positive emerges...
March 30, 2019: Food Chemistry
Yujie Zhang, Liansheng Liu, Yu Peng, Datong Liu
Electro-Mechanical Actuators (EMA) have attracted growing attention with their increasing incorporation in More Electric Aircraft. The performance degradation assessment of EMA needs to be studied, in which EMA motor voltage is an essential parameter, to ensure its reliability and safety of EMA. However, deviation exists between motor voltage monitoring data and real motor voltage due to electromagnetic interference. To reduce the deviation, EMA motor voltage estimation generally requires an accurate voltage state equation which is difficult to obtain due to the complexity of EMA...
November 29, 2018: Sensors
Danica C Slavish, Nichole M Scaglione, Brittney A Hultgren, Robert Turrisi
College women experience more consequences (e.g., blacking out, unprotected/unwanted sex) on days when they engage in their heaviest drinking. To inform prevention efforts, research is needed to understand decision-making processes that influence women's drinking behaviors at the event level. The present study used ecological momentary assessment (EMA) methods to examine: (1) associations between positive affect (PA) and negative affect (NA) and decision-making processes on days leading up to, during, and following heavy drinking events; and (2) mental health symptoms as moderators of these associations...
November 29, 2018: Prevention Science: the Official Journal of the Society for Prevention Research
Meriem Regragui, Mehdi Karkouri, Khadija Ibahioin, Abdessamad El Azhari
Astroblastoma is a rare neuroepithelial tumor most commonly seen in children and young adults. Due to its rarity, this tumor can be easily misdiagnosed as its classification, histogenesis and therapeutic management are still being discussed. We report the case of a 21 year old man, who presented at the Emergency Room for loss of consciousness. He reported a history of headaches, vomiting and decreased visual acuity. The CT and MRI showed a left temporoparietal solid-cystic mass with heterogeneous enhancement and perilesional edema...
December 2018: Annales de Pathologie
X J Sun, H Y Li, D P Li, Y Z Liu, J Y Zhang, Y K Yin, M H Su, H Pan, Q L Li, B Hu, H Liu, J Shi
Objective: To investigate the relationship between the erythrocyte membrane protein gene mutations and the clinical severity of hereditary spherocytosis (HS). Methods: Targeted sequencings were performed on 25 HS patients, correlation between HS mutations and patients' clinical characteristics were evaluated. Results: A total of 25 HS patients were enrolled, including 13 males and 12 females with median age of 20 (4-55) years, including 9 compensatory hemolysis patients, 9 patients with mild anemia, 3 patients with moderate anemia and 4 patients with severe anemia...
November 14, 2018: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
Johanna Mielke, Franz Innerbichler, Martin Schiestl, Nicolas M Ballarini, Byron Jones
Establishing comparability of the originator and its biosimilar at the structural and functional level, by analyzing so-called quality attributes, is an important step in biosimilar development. The statistical assessment of quality attributes is currently in the focus of attention because both the FDA and the EMA are working on regulatory documents for advising companies on the use of statistical approaches for strengthening their comparability claim. In this paper, we first discuss "comparable" and "not comparable" settings and propose a shift away from the usual comparison of the mean values: we argue that two products can be considered comparable if the range of the originator fully covers the range of the biosimilar...
November 27, 2018: AAPS Journal
Tanja Legenbauer, Anne Kathrin Radix, Nick Augustat, Sabine Schütt-Strömel
Eating disorders (EDs) are characterized by marked cognitive distortions and maladaptive schemas. Cognitive models of EDs highlight the direct impact of cognitive dysfunctions on eating-related disturbances, insofar as specific cognitive contents such as thoughts about diet rules and food or loss of control may trigger disturbed eating behavior. Moreover, early maladaptive schemas that reflect perfectionist standards and relate to achievement and performance seem to be associated with disturbed eating, e.g...
2018: Frontiers in Psychology
Krzysztof Piotr Malinowski, Paweł Kawalec, Wojciech Trabka, Christoph Sowada, Andrzej Pilc
Objective: To assess shares of reimbursed orphan drugs and agreement in reimbursement decision-making in different European Union member states as well as to define odds for reimbursement influenced by the presence of conditional approval or exceptional circumstances granted by the European Medicines Agency (EMA) or by type of the disease. Methods: The list of authorized drugs with current orphan designations was collected from the website of the EMA. For each drug, the information regarding conditional approval or approval under exceptional circumstances was collected...
2018: Frontiers in Pharmacology
Ryoichi Ema, Momoka Suzuki, Emi Kawaguchi, Itaru Saito, Ryota Akagi
The current study tested the hypothesis that voluntary activation during maximal voluntary contraction (MVC) conditionally depends on sex and joint action. Twenty-eight healthy adults (14 of each sex) performed knee extensor MVC and plantar flexor MVC at extended and flexed knee positions. Voluntary activation during MVC was assessed using a twitch interpolation technique. The voluntary activation during plantar flexor MVC at the extended knee position was significantly lower ( P  = 0.020, 95% confidence interval 1...
2018: PeerJ
Rinneu Elias Borges, Lia Raquel de Souza Santos, Rhayane Alves Assis, Marcelino Benvindo-Souza, Lilian Franco-Belussi, Classius de Oliveira
Amphibians are considered to be excellent bioindicators to their morphophysiological characteristics and life cycle. In this context, the present study investigated the morphological integrity of anuran larvae collected in preserved environments in the Emas National Park, in the municipality of Mineiros (Goiás state, Brazil), and in environments representative of the agricultural matrix of the Rio Verde region, also in Goiás, where there is a long history of the use of agricultural pesticides. Samples of water from temporary ponds, permanent dams, and veredas were analyzed for the presence of pesticides and, especially atrazine (5350 μg/L), found at significantly higher concentrations in the agricultural matrix...
November 24, 2018: Environmental Science and Pollution Research International
M G Montes Cortés, J L Fernández-García, M Á Habela Martínez-Estéllez
Two haemoparasites, Theileria equi and Babesia caballi, cause equine piroplasmosis (EP), one of the most prevalent tick-borne diseases in horses. The main aim of the present study was to develop and evaluate a multinested PCR (mn-PCR) for simultaneous detection of the equine piroplasmids T. equi and B. caballi, by amplification of five genetic markers (18S rRNA, β-tubulin, cytB, EMA-1 and RAP-1). This novel assay detected a high prevalence of equine piroplasmids in 235 horse blood samples collected in Castilla-León and Extremadura, Spain...
November 13, 2018: Ticks and Tick-borne Diseases
Maria R Cooper, Kathleen R Case, Emily T Hébert, Elizabeth A Vandewater, Kristen A Raese, Cheryl L Perry, Michael S Businelle
INTRODUCTION: Ecological Momentary Assessment (EMA) allows for assessment of electronic nicotine delivery systems (ENDS) use in real-time. This EMA study aimed to 1) describe study participation rates; 2) evaluate the concordance of EMA and survey items measuring frequency and quantity of ENDS use; and 3) assess the relationships between EMA items measuring frequency and quantity of ENDS use with ENDS dependence, measured at baseline and with saliva cotinine collected at follow-up. METHODS: Fifty young adult ENDS users completed baseline surveys, EMAs (i...
November 17, 2018: Addictive Behaviors
Alexander А Soldatov, Jeanne I Avdeeva, Nickolay A Kryuchkov, Elena S Skosyreva
Currently, biotherapeutic medicines are the most effective options for the treatment of many severe and chronic diseases. For faster market entry of biotherapeutic products and their cost reduction, the principles of "biosimilarity" have been developed. Development and licensing of biosimilars is allowed only after the end of patent exclusivity of the original preparation period. Biosimilar medicines of human growth hormones, follicle stimulating hormones and insulins were registered in EMA. During development of biosimilar hormone medicines, differences in the profile of glycosylation between biosimilar and reference preparations were revealed...
November 23, 2018: Current Medical Research and Opinion
Andrew Jones, Danielle Remmerswaal, Ilse Verveer, Eric Robinson, Ingmar H A Franken, Cheng K Fred Wen, Matt Field
BACKGROUND AND AIMS: Whilst there are considerable benefits to Ecological Momentary Assessment (EMA), poor compliance with assessment protocols has been identified as a limitation, particularly in substance users. Our aim was to identify the pooled compliance rate of EMA studies in substance users and examine variables that may influence compliance with EMA protocols; such as the length and frequency of assessments. DESIGN: A meta-analysis and meta-regression of all possible studies (randomised controlled trials and longitudinal) which incorporated EMA protocols, examining substance use...
November 21, 2018: Addiction
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