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https://www.readbyqxmd.com/read/30342124/extracellular-biopolymers-produced-by-dictyosphaerium-family-chemical-and-immunomodulative-properties
#1
Michal Halaj, Ema Paulovičová, Lucia Paulovičová, Soňa Jantová, Vladislav Cepák, Jaromír Lukavský, Peter Capek
Many microalgal species produce a wide range of highly-value products which are interesting for biotechnological applications. Cultivation of microalgal species Dictyosphaerium pulchellum and Dictyosphaerium tetrachotomum, strains Růžicka and Fott resulted yields of 0.2, 0.7 and 1.8 g/L of extracellular biopolymers (EPSs), respectively. All biopolymers were shown to be anionic proteoglycans. The sugar composition analyses of all EPSs showed high contents of hexoses and the presence of partially methylated monosaccharide residues, i...
October 17, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30341487/real-world-data-on-the-utilization-pattern-and-safety-profile-of-infliximab-originator-versus-biosimilars-in-italy-a-multiregional-study
#2
Cristina Scavone, Maurizio Sessa, Emilio Clementi, Giovanni Corrao, Roberto Leone, Alessandro Mugelli, Francesco Rossi, Edoardo Spina, Annalisa Capuano
BACKGROUND: In recent years, several biosimilar drugs, including those of infliximab, have obtained marketing authorization from the European Medicines Agency (EMA). Given the peculiarity of the safety profile of biological medical products (originator and biosimilars), the evaluation of their tolerability represents an important component of pre-marketing and post-marketing clinical development. For example, infliximab products may cause adverse drug reactions (ADRs) including acute infusion reactions, delayed hypersensitivity reactions, and loss of efficacy, as a direct consequence of immunogenicity...
October 20, 2018: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/30340515/expression-of-renal-cell-markers-and-detection-of-3p-loss-links-endolymphatic-sac-tumor-to-renal-cell-carcinoma-and-warrants-careful-evaluation-to-avoid-diagnostic-pitfalls
#3
Rachel Jester, Iya Znoyko, Maria Garnovskaya, Joseph N Rozier, Ryan Kegl, Sunil Patel, Tuan Tran, Malak Abedalthagafi, Craig M Horbinski, Mary Richardson, Daynna J Wolff, Razvan Lapadat, William Moore, Fausto J Rodriguez, Jason Mull, Adriana Olar
Endolymphatic sac tumor (ELST) is a rare neoplasm arising in the temporal petrous region thought to originate from endolymphatic sac epithelium. It may arise sporadically or in association with Von-Hippel-Lindau syndrome (VHL). The ELST prevalence in VHL ranges from 3 to 16% and may be the initial presentation of the disease. Onset is usually in the 3rd to 5th decade with hearing loss and an indolent course. ELSTs present as locally destructive lesions with characteristic computed tomography imaging features...
October 19, 2018: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/30336389/end-of-day-reports-of-daily-hassles-and-stress-in-men-and-women-with-opioid-use-disorder-relationship-to-momentary-reports-of-opioid-and-cocaine-use-and-stress
#4
Kenzie L Preston, Jennifer R Schroeder, William J Kowalczyk, Karran A Phillips, Michelle L Jobes, Megan Dwyer, Massoud Vahabzadeh, Jia-Ling Lin, Mustapha Mezghanni, David H Epstein
BACKGROUND AND AIMS: Stress can be validly assessed "live" or by a summary evaluation of the very recent past. Using smartphone-based ecological momentary assessment (EMA) combined with end-of-day (EOD) entries, we assessed the association between daily hassles, stressful events and use of opioids and cocaine, in opioid- and cocaine-using men and women. METHODS: For up to 16 weeks, 161 outpatients in opioid-agonist treatment who reported cigarette smoking carried smartphones on which they reported stressful events (SEs) and drug use (DU) and completed an EOD questionnaire to report hassles encountered throughout the day, current perceived stress, cigarettes/day, and current mood...
October 11, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/30335438/mood-reactivity-and-affective-dynamics-in-mood-and-anxiety-disorders
#5
Femke Lamers, Joel Swendsen, Lihong Cui, Mathilde Husky, Jordan Johns, Vadim Zipunnikov, Kathleen R Merikangas
The application of ecological momentary assessment (EMA) in community settings provides a powerful opportunity to obtain measures of emotional reactivity to daily life events, as well as emotional dynamics in real time. This investigation examines the association between emotional reactivity to daily events and emotional experience in mood and anxiety disorders in a large community-based sample. Two-hundred and 87 participants with a lifetime history of bipolar I disorder (BPI; n = 33), bipolar II disorder (BPII; n = 37), major depression (MDD; n = 116), anxiety disorders without a mood disorder (ANX; n = 36), and controls without a lifetime history of mood, anxiety, or substance use disorder (n = 65) completed a 2-week EMA evaluation period concerning mood states and daily events...
October 2018: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/30335197/regulatory-aspects-of-the-development-of-drugs-for-metabolic-bone-diseases-fda-and-ema-perspective
#6
REVIEW
Theresa Kehoe, Eberhard Blind, Heidi Janssen
Regulation of medicines involves complex scientific and public health policies which are reflected in the regulatory approaches used by the European Medicines Agency and the United States Food and Drug Administration for the approval of products developed for metabolic bone diseases. For osteoporosis therapies, utilized by many patients, approaches and existing guidance for product development of both Agencies are similar; confirmatory studies for the approval of osteoporosis products can rely on well-defined efficacy outcome parameters...
October 18, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/30335057/-comparative-morphological-characteristics-and-immunophenotype-of-urothelial-carcinomas-of-the-renal-pelvis-and-bladder
#7
Yu I Osmanov, Zh A Gaibov, E A Kogan, S G Radenska-Lopovok, Kh Z Tursunov
Urothelial carcinoma is one of the most frequently diagnosed malignant tumors of the bladder and upper urinary tract, which ranks seventh in the pattern of cancer. Urothelial carcinoma of the renal pelvis is less common; but has a more aggressive clinical course and a worse prognosis than that of the bladder. This is due to the clinical and morphological features of this form of cancer, which, unlike bladder cancer, have not been studied enough. OBJECTIVE: To comparatively analyze the morphological and immunophenotypic parameters of urothelial carcinomas of the renal pelvis and bladder...
2018: Arkhiv Patologii
https://www.readbyqxmd.com/read/30318637/latent-trait-shared-parameter-mixed-models-for-missing-ecological-momentary-assessment-data
#8
John F Cursio, Robin J Mermelstein, Donald Hedeker
Latent trait shared-parameter mixed models for ecological momentary assessment (EMA) data containing missing values are developed in which data are collected in an intermittent manner. In such studies, data are often missing due to unanswered prompts. Using item response theory models, a latent trait is used to represent the missing prompts and modeled jointly with a mixed model for bivariate longitudinal outcomes. Both one- and two-parameter latent trait shared-parameter mixed models are presented. These new models offer a unique way to analyze missing EMA data with many response patterns...
October 14, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/30316010/third-line-nivolumab-monotherapy-in-recurrent-small-cell-lung-cancer-checkmate-032
#9
Neal Ready, Anna F Farago, Filippo de Braud, Akin Atmaca, Matthew D Hellmann, Jeffrey G Schneider, David R Spigel, Victor Moreno, Ian Chau, Christine L Hann, Joseph Paul Eder, Nicola L Steele, Anne Pieters, Justin Fairchild, Scott J Antonia
INTRODUCTION: For patients with recurrent small cell lung cancer (SCLC), topotecan remains the only FDA-approved or EMA-approved second-line treatment, and outcomes are poor. CheckMate 032 is a phase 1/2, multicenter, open-label study of nivolumab or nivolumab plus ipilimumab in SCLC or other advanced/metastatic solid tumors previously treated with ≥1 platinum-based chemotherapies. We report results of third- or later-line (3L+) nivolumab monotherapy treatment in SCLC. METHODS: In this analysis, patients with limited-stage or extensive-stage SCLC and disease progression after ≥2 chemotherapy regimens received nivolumab monotherapy 3 mg/kg every 2 weeks until disease progression or unacceptable toxicity...
October 10, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/30314563/menopause-and-diabetes-emas-clinical-guide
#10
Radoslaw Slopien, Ewa Wender-Ozegowska, Anita Rogowicz-Frontczak, Blazej Meczekalski, Dorota Zozulinska-Ziolkiewicz, Jesse D Jaremek, Antonio Cano, Peter Chedraui, Dimitrios G Goulis, Patrice Lopes, Gita Mishra, Alfred Mueck, Margaret Rees, Levent M Senturk, Tommaso Simoncini, John C Stevenson, Petra Stute, Pauliina Tuomikoski, Stavroula A Paschou, Panagiotis Anagnostis, Irene Lambrinoudaki
INTRODUCTION: Whether menopause increases the risk of type 2 diabetes mellitus (T2DM) independently of ageing has been a matter of debate. Controversy also exists about the benefits and risks of menopausal hormone therapy (MHT) in women with T2DM. AIMS: To summarise the evidence on 1) the effect of menopause on metabolic parameters and the risk of T2DM, 2) the effect of T2DM on age at menopause, 3) the effect of MHT on the risk of T2DM, and 4) the management of postmenopausal women with T2DM...
November 2018: Maturitas
https://www.readbyqxmd.com/read/30312539/effective-mechanical-advantage-allometry-of-felid-elbow-and-knee-extensors
#11
Christine M Harper, Adam D Sylvester
Larger terrestrial mammals have generally been found to use more extended limb postures, a mechanism which maintains muscular requirements at larger sizes by improving the effective mechanical advantage (EMA) of limb musculature. Felids, however, have been documented to maintain joint angles across body sizes. If felid morphology scales isometrically, it would mean larger felids have relatively weaker muscles, compromising locomotor activities. Here we examine the allometric relationships between the EMA of the elbow and knee extensors and body mass, finding that the EMA of the triceps brachii and quadriceps muscles scale with positive allometry...
October 12, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/30311156/prevalence-and-clinical-features-of-celiac-disease-in-healthy-school-aged-children
#12
Omer Faruk Beser, Emine Gulluelli, Fugen Cullu Cokugras, Tulay Erkan, Tufan Kutlu, Rasit Vural Yagci, Firuze Erbek Alp, Gulten Ercal, Nuray Kepil, Mine Kucur
BACKGROUND/AIMS: The aim of this study was to determine the prevalence of celiac disease (CD) in healthy school-aged children in the northern region of Cyprus and to investigate the existence of potential markers that may accompany CD. This is the first study to measure the prevalence of CD in the northern region of Cyprus. METHODS: This study included 3792 school-aged children who were between the ages of 6 and 10 years between January 2015 and October 2016. CD was screened using total serum IgA, IgA anti-tissue transglutaminase (tTG), and IgA antiendomysial (EMA) antibodies...
October 12, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/30309015/the-epidemiology-of-transition-into-adulthood-of-rare-diseases-patients-results-from-a-population-based-registry
#13
Monica Mazzucato, Laura Visonà Dalla Pozza, Cinzia Minichiello, Silvia Manea, Sara Barbieri, Ema Toto, Andrea Vianello, Paola Facchin
Background : Despite the fact that a considerable number of patients diagnosed with childhood-onset rare diseases (RD) survive into adulthood, limited information is available on the epidemiology of this phenomenon, which has a considerable impact both on patients' care and on the health services. This study describes the epidemiology of transition in a population of RD patients, using data from the Veneto Region Rare Diseases Registry (VRRDR), a web-based registry monitoring since 2002 a consistent number of RD in a defined area (4...
October 10, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/30308937/miniature-spectroscopes-with-two-dimensional-guided-mode-resonant-metal-grating-filters-integrated-on-a-photodiode-array
#14
Yoshiaki Kanamori, Daisuke Ema, Kazuhiro Hane
A small spectroscope with 25 color sensors was fabricated by combining metamaterial color filters and Si photodiodes. The metamaterial color filters consisted of guided-mode resonant metal gratings with subwavelength two-dimensional periodic structures. Transmittance characteristics of the color filters were designed to obtain peak wavelengths proportional to grating periods. For each color sensor, a peak wavelength of the spectral sensitivity could be tuned in the range of visible wavelengths by adjusting each grating period...
October 10, 2018: Materials
https://www.readbyqxmd.com/read/30308287/daily-factors-driving-daily-substance-use-and-chronic-pain-among-older-adults-with-hiv-an-exploratory-study-using-ecological-momentary-assessment
#15
Alexis Kuerbis, M Carrington Reid, Jordan E Lake, Suzette Glasner-Edwards, Jessica Jenkins, Diana Liao, Jury Candelario, Alison A Moore
BACKGROUND: Adults 50 and older make up approximately 50% of persons living with HIV. Multiple co-morbidities are common among this group, including chronic pain and substance abuse, yet little is known about the daily factors that either enhance or inhibit these experiences or behaviors. This study explored daily drivers of substance use, pain, and relief from pain among older adults living with HIV utilizing ecological momentary assessment (EMA). METHOD: Participants (N=55), ages 49-71, completed seven consecutive days of daily EMA online surveys prior to treatment initiation within a randomized controlled trial...
October 8, 2018: Alcohol
https://www.readbyqxmd.com/read/30308169/neuroethics-questions-to-guide-ethical-research-in-the-international-brain-initiatives
#16
REVIEW
Karen S Rommelfanger, Sung-Jin Jeong, Arisa Ema, Tamami Fukushi, Kiyoto Kasai, Khara M Ramos, Arleen Salles, Ilina Singh
Increasingly, national governments across the globe are prioritizing investments in neuroscience. Currently, seven active or in-development national-level brain research initiatives exist, spanning four continents. Engaging with the underlying values and ethical concerns that drive brain research across cultural and continental divides is critical to future research. Culture influences what kinds of science are supported and where science can be conducted through ethical frameworks and evaluations of risk. Neuroscientists and philosophers alike have found themselves together encountering perennial questions; these questions are engaged by the field of neuroethics, related to the nature of understanding the self and identity, the existence and meaning of free will, defining the role of reason in human behavior, and more...
October 10, 2018: Neuron
https://www.readbyqxmd.com/read/30303927/tissue-expander-complications-do-not-preclude-a-second-successful-implant-based-breast-reconstruction
#17
Louis H Poppler, Minh-Bao Mundschenk, Andrew Linkugel, Ema Zubovic, Utku C Dolen, Terence M Myckatyn
BACKGROUND: Implant based breast reconstruction is the most common method of breast reconstruction in the United States but the outcomes of subsequent implant based reconstruction after a tissue expander (TE) complication are rarely studied. The purpose of this study is to determine the long term incidence of implant loss in patents with a previous TE complication. METHODS: This is a retrospective review of the long term outcomes of all patients with TE complications at a large academic medical center from 2003-2013...
October 9, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/30303166/extensive-trophoblastic-differentiation-in-case-of-an-endometrial-carcinoma
#18
Surekha Yadav, Nishant Sagar, Varuna Mallya, Sharmana Mandal, Nita Khurana, Sangeeta Gupta
Trophoblastic differentiation of endometrial carcinoma is extremely rare, till date 18 cases reports are there in the literature. A 68-year-old postmenopausal female presented with abnormal vaginal bleeding. Histopathologically, there were areas of serous carcinoma with trophoblastic differentiation (~90%). On immunohistochemistry, the trophoblastic component was positive for β-human chorionic gonadotropin (hCG), HPL and EMA. IHC confirmed the diagnosis of serous carcinoma with trophoblastic differentiation...
October 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/30302494/-immunotherapy-for-locally-advanced-and-metastasized-bladder-cancer
#19
REVIEW
W Loidl, F Luger
Urothelial carcinoma of the bladder is difficult to treat in advanced and metastatic stages. Several factors play a role: age, multimorbidity including impaired renal function and neuropathy make access to life-prolonging chemotherapy impossible in many cases. Improvements of response rates and overall survival in the second-line setting are not much different compared to best supportive care. However, the therapeutic landscape has changed dramatically during the last 2 years. Immunotherapies represented by checkpoint inhibitors have showed positive trial outcomes and have been approved by EMA (European Medicines Agency)...
October 9, 2018: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/30301713/-defining-daily-doses-and-total-doses-for-the-measurement-of-antibiotic-usage-in-swiss-pig-production
#20
T Echtermann, C R Müntener, P R Torgerson, X Sidler, D Kümmerlen
A significant Antibiotic-Monitoring-System is essential to analyse the use of antibiotics and to a better understanding of trends in resistance development. In human and veterinary medicine, for example, a system based on defined daily and treatment doses (Defined Daily Dose: DDD and Defined Course Dose: DCD) is applied. These definitions can be used to estimate the number of treatment days and treatments with antimicrobial agents in a population. For veterinary medicine, the European Medicines Agency (EMA) has published the European values DDDvet and DCDvet in the farm animal sector...
October 2018: Schweizer Archiv Für Tierheilkunde
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