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https://www.readbyqxmd.com/read/29719626/identification-of-specific-and-common-diagnostic-antibody-markers-for-gastrointestinal-cancers-by-serex-screening-using-testis-cdna-phage-library
#1
Sohei Kobayashi, Takaki Hiwasa, Takahiro Arasawa, Akiko Kagaya, Sayaka Ishii, Hideaki Shimada, Masaaki Ito, Masae Suzuki, Masayuki Kano, Bahityar Rahmutulla, Kouichi Kitamura, Yuji Sawabe, Hideo Shin, Masaki Takiguchi, Fumio Nomura, Hisahiro Matsubara, Kazuyuki Matsushita
The present study was planned to identify novel serum antibody markers for digestive organ cancers. We have used screening by phage expression cloning and identified novel fourteen antigens in this experiment. The presence of auto-antibodies against these antigens in serum specimens was confirmed by western blotting. As for auto-antibodies against fourteen antigens, AlphaLISA (amplified luminescence proximity homogeneous assay) assay was performed in the sera of gastrointestinal cancers patients to confirm the results...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29660836/final-results-of-a-phase-2-open-label-study-of-indisulam-idarubicin-and-cytarabine-in-patients-with-relapsed-or-refractory-acute-myeloid-leukemia-and-high-risk-myelodysplastic-syndrome
#2
Rita Assi, Hagop M Kantarjian, Tapan M Kadia, Naveen Pemmaraju, Elias Jabbour, Nitin Jain, Naval Daver, Zeev Estrov, Taisuke Uehara, Takashi Owa, Jorge E Cortes, Gautam Borthakur
BACKGROUND: Indisulam possesses anticancer properties through down-regulation of various cell-cycle checkpoint molecules, thereby blocking the phosphorylation of retinoblastoma protein and inducing p53 and p21. Indisulam exhibits synergy with nucleoside analogs and topoisomerase inhibitors. METHODS: The authors designed a phase 2 study of indisulam in combination with idarubicin and cytarabine in patients who had relapsed/refractory acute myeloid leukemia AML and high-risk myelodysplastic syndrome...
July 1, 2018: Cancer
https://www.readbyqxmd.com/read/28546157/erratum-for-the-research-article-anticancer-sulfonamides-target-splicing-by-inducing-rbm39-degradation-via-recruitment-to-dcaf15-by-t-han-m-goralski-n-gaskill-e-capota-j-kim-t-c-ting-y-xie-n-s-williams-d-nijhawan
#3
https://www.readbyqxmd.com/read/28437394/selective-degradation-of-splicing-factor-caper%C3%AE-by-anticancer-sulfonamides
#4
Taisuke Uehara, Yukinori Minoshima, Koji Sagane, Naoko Hata Sugi, Kaoru Ogawa Mitsuhashi, Noboru Yamamoto, Hiroshi Kamiyama, Kentaro Takahashi, Yoshihiko Kotake, Mai Uesugi, Akira Yokoi, Atsushi Inoue, Taku Yoshida, Miyuki Mabuchi, Akito Tanaka, Takashi Owa
Target-protein degradation is an emerging field in drug discovery and development. In particular, the substrate-receptor proteins of the cullin-ubiquitin ligase system play a key role in selective protein degradation, which is an essential component of the anti-myeloma activity of immunomodulatory drugs (IMiDs), such as lenalidomide. Here, we demonstrate that a series of anticancer sulfonamides NSC 719239 (E7820), indisulam, and NSC 339004 (chloroquinoxaline sulfonamide, CQS) induce proteasomal degradation of the U2AF-related splicing factor coactivator of activating protein-1 and estrogen receptors (CAPERĪ±) via CRL4DCAF15 mediated ubiquitination in human cancer cell lines...
June 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28302793/anticancer-sulfonamides-target-splicing-by-inducing-rbm39-degradation-via-recruitment-to-dcaf15
#5
Ting Han, Maria Goralski, Nicholas Gaskill, Emanuela Capota, Jiwoong Kim, Tabitha C Ting, Yang Xie, Noelle S Williams, Deepak Nijhawan
Indisulam is an aryl sulfonamide drug with selective anticancer activity. Its mechanism of action and the basis for its selectivity have so far been unknown. Here we show that indisulam promotes the recruitment of RBM39 (RNA binding motif protein 39) to the CUL4-DCAF15 E3 ubiquitin ligase, leading to RBM39 polyubiquitination and proteasomal degradation. Mutations in RBM39 that prevent its recruitment to CUL4-DCAF15 increase RBM39 stability and confer resistance to indisulam's cytotoxicity. RBM39 associates with precursor messenger RNA (pre-mRNA) splicing factors, and inactivation of RBM39 by indisulam causes aberrant pre-mRNA splicing...
April 28, 2017: Science
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