Samantha Schildroth, Birgit Claus Henn, Anissa I Vines, Ruth J Geller, Sharonda M Lovett, Chad M Coleman, Traci N Bethea, Julianne Cook Botelho, Antonia M Calafat, Chad Milando, Donna D Baird, Ganesa Wegienka, Lauren A Wise
BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) are endocrine-disrupting chemicals with neurotoxic properties. PFAS have been associated with depressive symptoms in women in some studies, but little research has evaluated the effects of PFAS mixtures. Further, no study has investigated interactions of PFAS-depression associations by perceived stress, which has been shown to modify PFAS effects on other health outcomes. OBJECTIVE: In a prospective cohort study of reproductive-aged Black women, we investigated associations between PFAS and depressive symptoms and the extent to which perceived stress modified these associations...
April 18, 2024: Science of the Total Environment