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https://www.readbyqxmd.com/read/30317730/-gastrointestinal-inflammatory-myofibroblastic-tumor-a-clinicopathologic-study
#1
Q P Wang, M F Gan, J W Zhang, S X Weng, L N Zhang
Objective: To study the clinicopathologic characteristics, immunophenotype and ALK gene alterations of gastrointestinal inflammatory myofibroblastic tumor. Methods: Clinical data, histological features and immunohistochemical results were analyzed in 7 cases of gastrointestinal inflammatory myofibroblastic tumor at Zhejiang Province Taizhou Hospital from January 2005 to December 2016. ALK gene status was investigated by ALK fluorescence in situ hybridization. Results: There were 4 female and 3 male patients...
October 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/30317729/-clinicopathologic-features-of-cronkhite-canada-syndrome-and-the-significance-of-igg4-positive-plasma-cells-infiltration
#2
Y Li, H Q Luo, D Wu, X W Xue, Y F Luo, Y M Xiao, J Chen, W X Zhou
Objective: To analyze the clinical and pathological features of Cronkhite-Canada syndrome (CCS), and to investigate the significance of IgG4 positive plasma cell infiltration. Methods: Clinical presentations, endoscopic appearances and morphological features of 18 patients diagnosed with CCS at Peking Union Medical College Hospital during 2000-2016 were included in the study.There were 11 male and 7 female patients. IgG4 and IgG immunohistochemical stains were performed in total of 55 biopsies from the patients (36 polyps, 10 adenoma and 9 surrounding mucosa) and a control group of 58 cases (19 colonic mucosa, 7 colonic hyperplastic polyps, 9 inflammatory bowel disease and 23 adenoma)...
October 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/30317666/effects-of-hydration-status-during-heat-acclimation-on-plasma-volume-and-performance
#3
Wendy A Pethick, Holly J Murray, Paula McFadyen, Ryan Brodie, Catherine A Gaul, Trent Stellingwerff
The impact of hydration status was investigated during a 5-day heat acclimation (HA) training protocol versus mild/cool control conditions on plasma volume (PV) and performance (20km time-trial (TT)). Sub-elite athletes were allocated to one of two heat training groups (90 min/day): 1) dehydrated to ~2% body weight (BW) loss in heat (35°C; DEH; n=14); 2) euhydrated heat (35°C; EUH; n=10), where training was isothermally clamped to 38.5°C core temperature (Tc). A euhydrated mild control group (22°C; CON; n=9) was later added, with training clamped to the same relative heart rate (~75% HRmax) as elicited during DEH and EUH; thus all groups experienced the same internal training stress (%HRmax)...
October 13, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/30317434/medial-forebrain-bundle-deep-brain-stimulation-reverses-anhedonic-like-behavior-in-a-chronic-model-of-depression-importance-of-bdnf-and-inflammatory-cytokines
#4
Manoj P Dandekar, Ashwini Saxena, Giselli Scaini, Joo Hyun Shin, Agata Migut, Vijayasree Vayalanellore Giridharan, Yuzhi Zhou, Tatiana Barichello, Jair C Soares, Joao Quevedo, Albert J Fenoy
Deep brain stimulation (DBS) of the medial forebrain bundle (MFB) displays a promising antidepressant effects in patients with treatment-refractory depression; however, a clear consensus on underlying mechanisms is still enigmatic. Herein, we investigated the effects of MFB-DBS on anhedonic-like behavior using the Froot Loops® consumption in a chronic unpredictable mild stress (CUS) model of depression, biochemical estimation of peripheral and central inflammatory cytokines, stress hormone, and brain-derived neurotrophic factor (BDNF)...
October 13, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/30317401/effect-of-light-emitting-diodes-platelet-rich-plasma-and-their-combination-on-the-activity-of-sheep-tenocytes
#5
Jihad A M Alzyoud, Saleh A Al Najjar, Seham Talat, Basha'er Abu-Irmaileh, Yasser Bustanji, Abd Al-Rahman S Al-Shudiefat
Healthy tendons play an important role in joint movements and subjected to a group of pathologies called tendinopathy due to multiple factors. Tendons have a slowly repairing process due to the low vascularity and cellularity. Treatment options aimed at potentiating the healing response and relieving symptoms. Phototherapy and platelet-rich plasma were novel treatment modalities in tendons based on photobiomodulation and growth factors during healing, and the results were encouraging suggesting calibrating treatment parameters...
October 13, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/30316989/the-clinical-value-of-assays-detecting-antibodies-against-domain-i-of-%C3%AE-2-glycoprotein-i-in-the-antiphospholipid-syndrome
#6
REVIEW
Dongmei Yin, Bas de Laat, Katrien M J Devreese, Hilde Kelchtermans
As the clinical symptoms of the antiphospholipid syndrome (APS) frequently occur irrespective of the syndrome, diagnosis predominantly depends on the laboratory assays measuring the level or function of antiphospholipid antibodies (aPLs). β2-glycoprotein I (β2GPI) is increasingly accepted as the most important target of aPLs. Anti-β2GPI antibodies constitute a heterogeneous population, but current in vivo and in vitro evidence show that especially the first domain (DI) of β2GPI contains an important pathogenic epitope...
October 11, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30316893/sex-specific-deficits-in-biochemical-but-not-behavioral-responses-to-delay-fear-conditioning-in-prenatal-alcohol-exposure-mice
#7
Kevin K Caldwell, Elizabeth R Solomon, Jane J W Smoake, Chrys D Djatche de Kamgaing, Andrea M Allan
BACKGROUND: Studies in clinical populations and preclinical models have shown that prenatal alcohol exposure (PAE) is associated with impairments in the acquisition, consolidation and recall of information, with deficits in hippocampal formation-dependent learning and memory being a common finding. The glucocorticoid receptor (GR), mineralocorticoid receptor (MR), and extracellular signal-regulated kinase 2 (ERK2) are key regulators of hippocampal formation development, structure and functioning and, thus, are potential mediators of PAE's effects on this brain region...
October 11, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/30316779/cardiac-glutathione-levels-increase-in-response-to-glucose-in-diabetic-rats
#8
Max A Thorwald, Jose A Godoy-Lugo, Gema J Rodriguez, Marco Antonio Rodriguez, Mostofa Jamal, Hiroshi Kinoshita, Daisuke Nakano, Akira Nishiyama, Henry Jay Forman, Rudy M Ortiz
Diabetic hearts are susceptible to damage from inappropriate activation of the renin angiotensin system (RAS) and hyperglycemic events both of which contribute to increased oxidant production. Inappropriately elevated oxidants impair mitochondrial enzyme function, further contributing to metabolic derangement. Nuclear factor erythriod-2-related factor 2 (Nrf2) induces antioxidant genes including those for glutathione (GSH) synthesis following translocation to the nucleus. We hypothesized that an acute elevation in plasma glucose facilitates Nrf2 nuclear translocation and subsequent expression of Nrf2-associated genes...
October 11, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/30316696/evaluation-and-comparison-of-postoperative-analgesic-effects-of-dexketoprofen-and-methadone-in-dogs
#9
Álvaro J Gutiérrez-Bautista, Juan Morgaz, María Del Mar Granados, Rafael J Gómez-Villamandos, Juan M Dominguez, José A Fernandez-Sarmiento, Daniel Aguilar-García, Rocío Navarrete-Calvo
OBJECTIVE: To evaluate and compare the analgesic efficacy and adverse effects of dexketoprofen and methadone using a noninferiority trial, during the first 24 postoperative hours in dogs undergoing orthopaedic surgery. STUDY DESIGN: Randomized, blinded clinical study. ANIMALS: A total of 38 healthy dogs undergoing orthopaedic surgery. METHODS: Dogs were premedicated with dexmedetomidine [1 μg kg-1 intravenously (IV)] followed by dexketoprofen (1 mg kg-1 IV; group DK) or methadone (0...
August 11, 2018: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/30316401/suspected-frequent-relapsing-igg4-related-lung-disease-in-kidney-transplant-patient-a-case-report
#10
A J Kim, H Ro, J H Chang, J Y Jung, W K Chung, Y H Park, H H Lee
Besides the initial description of IgG4-related pancreatic disease, other sites are now commonly involved. However, occurrence of IgG4-related disease is rare in organ transplanted patients. A 57-year-old man who received a kidney transplantation presented with recurrent dyspnea on exertion. A computed tomography scan of the chest revealed bilateral interlobular septal thickening and multiple tubular and branching small nodular lesions in the right upper lobe, and mass-like consolidation of the left middle lobe...
October 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30316100/targeted-metabolomics-to-understand-the-association-between-arsenic-metabolism-and-diabetes-related-outcomes-preliminary-evidence-from-the-strong-heart-family-study
#11
Miranda J Spratlen, Maria Grau-Perez, Jason G Umans, Joseph Yracheta, Lyle G Best, Kevin Francesconi, Walter Goessler, Teodoro Bottiglieri, Mary V Gamble, Shelley A Cole, Jinying Zhao, Ana Navas-Acien
BACKGROUND: Inorganic arsenic exposure is ubiquitous and both exposure and inter-individual differences in its metabolism have been associated with cardiometabolic risk. A more efficient arsenic metabolism profile (lower MMA%, higher DMA%) has been associated with reduced risk for arsenic-related health outcomes. This profile, however, has also been associated with increased risk for diabetes-related outcomes. OBJECTIVES: The mechanism behind these conflicting associations is unclear; we hypothesized the one-carbon metabolism (OCM) pathway may play a role...
September 27, 2018: Environmental Research
https://www.readbyqxmd.com/read/30315666/sperm-quality-during-extra-gonadal-sperm-reserve-depletion-in-stallions
#12
J Len, D Beehan, B Eilts, S Lyle
To estimate when during stallions' extra-gonadal reserves (EGR) depletion period sperm quality would reach its highest quality, six light breed sexually rested stallions were collected daily for seven days to deplete EGR. On collections day 1, 3, 5 and 7, sperm output, total (TM) and progressive (PM) motility, morphology and plasma membrane (PLM) integrity was evaluated. Sperm output decreased as EGR depletion advanced, stabilizing on days 5 - 7. Sperm motility (TM and PM) and morphology was not different during EGR depletion...
October 13, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/30315653/different-phenotypes-of-non-classical-monocytes-associated-with-systemic-inflammation-endothelial-alteration-and-hepatic-compromise-in-patients-with-dengue
#13
Juan S Naranjo-Gómez, Andrés Castillo, Mauricio Rojas, Bertha N Restrepo, Francisco J Diaz, Paula A Velilla, Diana Castaño
Although dengue can progress to severe stages, the exact causes of this phenomenon are unknown; however, the possibility of monocyte participation is acknowledged. It has been suggested that monocyte subsets (classical, intermediate and non-classical) play differential roles in dengue immunopathology. Therefore, we determined the count of monocyte subsets and obtained the clinical information of patients with dengue. We noted a significant decrease in the count of non-classical monocytes in patients than in controls...
October 13, 2018: Immunology
https://www.readbyqxmd.com/read/30315511/urinary-and-plasma-metabolomics-identify-the-distinct-metabolic-profile-of-disease-state-in-chronic-mouse-model-of-multiple-sclerosis
#14
J Singh, M Cerghet, L M Poisson, I Datta, K Labuzek, H Suhail, R Rattan, Shailendra Giri
Identification of non-invasive biomarkers of disease progression in multiple sclerosis (MS) is critically needed for monitoring the disease progression and for effective therapeutic interventions. Urine is an attractive source for non-invasive biomarkers because it is easily obtained in the clinic. In search of a urine metabolite signature of progression in chronic experimental autoimmune encephalomyelitis (EAE), we profiled urine at the chronic stage of the disease (day 45 post immunization) by global untargeted metabolomics...
October 12, 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/30315508/diagnostic-value-of-energy-dispersive-hand-held-x-ray-fluorescence-spectrometry-in-determining-trace-element-concentrations-in-ovine-liver
#15
Daniël E van Loggerenberg, Pete N Laver, Jan G Myburgh, Christo J Botha
There are no data available on the use of hand-held X-ray fluorescence (XRF) spectrometry to determine trace element concentrations in veterinary diagnostics. The hand-held XRF spectrometer is easy to use and does not require extensive training for the operator. In Sub-Saharan Africa with few centralised analytical laboratories equipped with expensive apparatus or mass spectrometry capabilities, trace element analysis using the hand-held XRF spectrometer provides an alternative. The objective of this study was to compare ovine hepatic copper (Cu), iron (Fe), manganese (Mn), molybdenum (Mo), selenium (Se) and zinc (Zn) concentrations as obtained with the hand-held XRF spectrometer to those of a reference laboratory using inductively coupled plasma mass spectrometry (ICP-MS)...
October 13, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/30315406/iohexol-measured-glomerular-filtration-rate-in-children-and-adolescents-with-chronic-kidney-disease-a-pilot-study-comparing-venous-and-finger-stick-methods
#16
Amy Staples, Craig Wong, George J Schwartz
BACKGROUND: Measurement of glomerular filtration rate by iohexol disappearance (iGFR) has become a gold standard in the pediatric chronic kidney disease (CKD) population. The need for serial phlebotomy can be difficult and minimizing venipunctures would be beneficial. Furthermore, finger stick collection for dried blood spot (DBS) may be more tolerable in the pediatric population, and equivalence between these two methods may further simplify the process. METHODS: This was a cross-sectional study in children and adolescents 1 to 21 years with stages I-IV CKD...
October 12, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/30315245/a-dimeric-fluorescent-protein-yields-a-bright-red-shifted-gevi-capable-of-population-signals-in-brain-slice
#17
Bumjun Yi, Bok Eum Kang, Sungmoo Lee, Sophie Braubach, Bradley J Baker
A bright, red-shifted Genetically Encoded Voltage Indicator (GEVI) was developed using a modified version of the fluorescent protein, tdTomato. Dimerization of the fluorescent domain for ArcLight-type GEVIs has been shown to affect the signal size of the voltage-dependent optical signal. For red-shifted GEVI development, tdTomato was split fusing a single dTomato chromophore to the voltage sensing domain. Optimization of the amino acid length and charge composition of the linker region between the voltage sensing domain and the fluorescent protein resulted in a probe that is an order of magnitude brighter than FlicR1 at a resting potential of -70 mV and exhibits a ten-fold larger change in fluorescence (ΔF) upon 100 mV depolarization of the plasma membrane in HEK 293 cells...
October 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30312801/characterization-of-hemostasis-in-mice-lacking-the-novel-thrombosis-susceptibility-gene-slc44a2
#18
Julia Tilburg, Reheman Adili, Thankam S Nair, Megan E Hawley, David C Tuk, Madeline Jackson, Henri M Spronk, Henri H Versteeg, Thomas E Carey, Bart J M van Vlijmen, Chrissta X Maracle, Michael Holinstat
INTRODUCTION: Recent genome wide association studies (GWAS) identified a novel susceptibility locus for thrombosis, harbouring the SLC44A2 gene which encodes the Solute Carrier Family 44 Member 2 protein (SLC44A2). Thus far, SLC44A2 has not been studied in the context of thrombosis, and may be a unique contributor to thrombotic disease. Here we utilize mice lacking SLC44A2 (Slc44a2-/- ) to evaluate a possible role of SLC44A2 in hemostasis. METHODS: Slc44a2-/- mice were evaluated in key aspects of normal hemostasis including a challenge of vascular damage by applying laser induced injury to the cremaster muscle arteriole...
September 26, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/30312536/diagnostic-application-of-kidney-allograft-derived-absolute-cell-free-dna-levels-during-transplant-dysfunction
#19
J B Whitlam, L Ling, A Skene, J Kanellis, F L Ierino, H R Slater, D L Bruno, D A Power
Graft-derived cell-free DNA (donor-derived cell-free DNA) is an emerging marker of kidney allograft injury. Studies examining the clinical validity of this biomarker have previously used the graft fraction, or proportion of total cell-free DNA that is graft-derived. The present study evaluated the diagnostic validity of absolute measurements of graft-derived cell-free DNA, as well as calculated graft fraction, for the diagnosis of graft dysfunction. Plasma graft-derived cell-free DNA, total cell-free DNA and graft fraction were correlated with biopsy diagnosis as well as individual Banff scores...
October 12, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/30312306/cardiac-leptin-overexpression-in-the-context-of-acute-mi-and-reperfusion-potentiates-myocardial-remodeling-and-left-ventricular-dysfunction
#20
David Kain, Amos J Simon, Avraham Greenberg, Danny Ben Zvi, Boris Gilburd, Jacob Schneiderman
BACKGROUND: Acute MI induces leptin expression in the heart, however the role of myocardial leptin in cardiac ischemia and reperfusion (IR) remains unknown. To shed light on the effects of elevated levels of leptin in the myocardium, we overexpressed cardiac leptin and assessed local remodeling and myocardial function in this context. METHODS AND RESULTS: Cardiac leptin overexpression was stimulated in mice undergoing IR by a single intraperitoneal injection of leptin antagonist (LepA)...
2018: PloS One
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