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Bipolar Disorders

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https://www.readbyqxmd.com/read/28806578/klotho-dysfunction-a-pathway-linking-the-aging-process-to-bipolar-disorder
#1
Izabela Guimarães Barbosa, Natalia Pessoa Rocha, Gokay Alpak, Erica Leandro Marciano Vieira, Rodrigo Barreto Huguet, Fabio Lopes Rocha, Breno Satler de Oliveira Diniz, Antonio Lucio Teixeira
AIM: Although accelerated aging profile has been described in bipolar disorder (BD), the biology linking BD and aging is still largely unknown. Reduced levels and/or activity of a protein named Klotho is associated with decreased life span, premature aging and occurrence of age-related diseases. Therefore, this study was designed to evaluate plasma levels of Klotho in BD patients and controls. METHODS: Forty patients with type 1 BD and 30 controls were enrolled in this study...
August 11, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28806363/clinical-epidemiology-of-single-versus-multiple-substance-use-disorders-polysubstance-use-disorder
#2
Ish P Bhalla, Elina A Stefanovics, Robert A Rosenheck
OBJECTIVE: While research on substance abuse has largely focused on people who have a single substance use disorder (SUD), many people abuse multiple substances. Studies have yet to examine the distinctive characteristics of patients diagnosed with more than 1 SUD and how those with polysubstance use disorder (PSUD) differ from those with a single SUD. METHODS: National Veterans Health Administration data from fiscal year 2012 were used to compare veterans diagnosed 1 SUD to veterans diagnosed with 2-3, and >3 SUDs on demographic characteristics, psychiatric and medical diagnoses, medical and psychiatric service utilization, and psychotropic medication fills...
September 2017: Medical Care
https://www.readbyqxmd.com/read/28805813/analysis-of-genome-wide-association-data-highlights-candidates-for-drug-repositioning-in-psychiatry
#3
Hon-Cheong So, Carlos Kwan-Long Chau, Wan-To Chiu, Kin-Sang Ho, Cho-Pong Lo, Stephanie Ho-Yue Yim, Pak-Chung Sham
Knowledge of psychiatric disease genetics has advanced rapidly during the past decade with the advent of genome-wide association studies (GWAS). However, less progress has been made in harnessing these data to reveal new therapies. Here we propose a framework for drug repositioning by comparing transcriptomes imputed from GWAS data with drug-induced gene expression profiles from the Connectivity Map database and apply this approach to seven psychiatric disorders. We found a number of repositioning candidates, many supported by preclinical or clinical evidence...
August 14, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28805697/multiple-sclerosis-and-schizophrenia
#4
REVIEW
Borros M Arneth
The psychiatric and neurological aspects of health may present methodological challenges in the diagnosis and treatment of disease. This is especially true for patients whose symptoms indicate the coexistence of multiple sclerosis (MS) and schizophrenia (SCZ). These cases raise critical questions regarding the relationship between the mind and the brain. Studies have noted that patients with MS have an increased risk of developing SCZ or bipolar disorder (BD). It is suggested here that MS and a subgroup of SCZ have similar etiologies...
August 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28804990/characterizing-the-experience-of-auditory-verbal-hallucinations-and-accompanying-delusions-in-individuals-with-a-diagnosis-of-bipolar-disorder-a-systematic-review
#5
REVIEW
L M Smith, L C Johns, Rlc Mitchell
OBJECTIVES: The aim of the current study was to inform ongoing attempts to identify clinically meaningful subcategories of auditory verbal hallucination (AVH), and to evaluate evidence that might pertain to the suitability of current psychological interventions for people with bipolar disorder (BD) who experience psychotic symptoms. METHODS: A comprehensive synthesis of findings on the phenomenology of AVH and delusions in BD is included, alongside a critical review of clinical and cognitive correlates...
August 14, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28803680/corrigendum-to-analysis-of-association-between-common-snps-in-erbb4-and-bipolar-affective-disorder-major-depressive-disorder-and-schizophrenia-in-the-han-chinese-population-prog-neuro-psychopharmacol-biol-psychiatry-36-2012-17-21
#6
P Chen, J Chen, K Huang, W Ji, T Wang, T Li, Y Wang, H Wang, L He, G Feng, Y Shi
No abstract text is available yet for this article.
August 10, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28803247/potential-gender-related-aging-processes-occur-earlier-and-faster-in-the-vermis-of-patients-with-bipolar-disorder-an-mri-study
#7
Marta Serati, Giuseppe Delvecchio, Giulia Orsenigo, Cinzia Perlini, Marco Barillari, Mirella Ruggeri, Alfredo Carlo Altamura, Marcella Bellani, Paolo Brambilla
BACKGROUND: In the last decades, there has been increasing interest in investigating the role of the vermis in bipolar disorder (BD), especially because of its involvement in cognitive processes. The main aims of this study were to explore the integrity of the vermis and elucidate the role of demographic and clinical variables on vermis volumes in BD patients, stratified according to gender. METHODS: T1-weighted images were obtained for 38 BD patients and 38 healthy controls using a 1...
August 12, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/28803094/brief-psychoeducation-for-bipolar-disorder-evaluation-of-trophic-factors-serum-levels-in-young-adults
#8
Carolina David Wiener, Mariane Lopez Molina, Fernanda Pedrotti Moreira, Miguel Bezerra Dos Passos, Karen Jansen, Ricardo Azevedo da Silva, Luciano Dias de Mattos Souza, Jean Pierre Oses
The aim of this study was to evaluate the impact of psychoeducation in serum levels of BDNF, NGF and GDNF in young adults presenting bipolar disorder (BD). This is a randomized clinical trial including 39 young adults (18-29 years) diagnosed with BD through the Structured Clinical Interview for DSM-IV (SCID-CV). Participants were randomized in two treatment groups: usual treatment (medication) and combined intervention (medication plus psychoeducation). Depressive symptoms were assessed using the Hamilton Depression Rating Scale (HDRS) and severity of manic and hypomanic symptoms was evaluated through the Young Mania Rating Scale (YMRS)...
July 31, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28803030/neurofeedback-sham-neurofeedback-and-cognitive-behavioural-group-therapy-in-adults-with-attention-deficit-hyperactivity-disorder-a-triple-blind-randomised-controlled-trial
#9
Michael Schönenberg, Eva Wiedemann, Alexander Schneidt, Jonathan Scheeff, Alexander Logemann, Philipp M Keune, Martin Hautzinger
BACKGROUND: Many studies suggest that electroencephalographic (EEG) neurofeedback might be beneficial in the treatment of attention-deficit hyperactivity disorder (ADHD). However, numbers of well controlled studies are low and neurofeedback techniques are regarded as highly controversial. The present trial examined the efficacy (compared with sham neurofeedback) and efficiency (compared with meta-cognitive therapy) of a standard EEG neurofeedback protocol in adults with ADHD. METHODS: We did a concurrent, triple-blind, randomised, controlled trial using authorised deception in adults with ADHD from one centre (University of Tübingen) in Tübingen, Germany...
August 9, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28802938/impulse-control-and-related-disorders-in-parkinson-s-disease
#10
Daniel Weintraub, Daniel O Claassen
Impulse control disorders (ICDs), such as compulsive gambling, buying, sexual, and eating behaviors, are a serious and increasingly recognized complication in Parkinson's disease (PD), occurring in up to 20% of PD patients over the course of their illness. Related behaviors include punding (stereotyped, repetitive, purposeless behaviors), dopamine dysregulation syndrome (DDS) (compulsive medication overuse), and hobbyism (e.g., compulsive internet use, artistic endeavors, and writing). These disorders have a significant impact on quality of life and function, strain interpersonal relationships, and worsen caregiver burden, and are associated with significant psychiatric comorbidity...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28802897/the-different-effects-of-lithium-and-tamoxifen-on-memory-formation-and-the-levels-of-neurotrophic-factors-in-the-brain-of-male-and-female-rats
#11
Samira S Valvassori, Cenita Borges, Roger B Varela, Daniela V Bavaresco, Guilherme Bianchini, Edemilson Mariot, Camila O Arent, Wilson R Resende, Josiane Budni, João Quevedo
Lithium (Li) is a mood-stabilizing drug used in the treatment of bipolar disorder (BD). Recently, preclinical studies have demonstrated the potential of tamoxifen (TMX) in the treatment of acute episodes of BD. However, the prolonged use of TMX for mood disorders treatment is controversial. In this study, we evaluated the effects of TMX or Li on cognitive behavior, as well as the levels of neurotrophic factors in the brain of male and female rats. Male and female Wistar rats received administrations of water (control group), TMX or Li via gavage for a period of 28 days; the rats were then subjected to the open-field test (to evaluate spontaneous locomotion), and the novel object recognition and step-down inhibitory avoidance tests (to evaluate cognition)...
August 9, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28802190/alcohol-use-and-bipolar-disorders-risk-factors-associated-with-their-co-occurrence-and-sequence-of-onsets
#12
Jean-Michel Azorin, Léa C Perret, Eric Fakra, Sébastien Tassy, Nicolas Simon, Marc Adida, Raoul Belzeaux
BACKGROUND: Little is known about the sequence of onsets in patients affected by comorbid alcohol use and bipolar disorder. This study examines the risk factors associated with their co-occurrence and order of onset. METHOD: The demographic, clinical, and temperament characteristics as well as the course of illness were analyzed within our sample of 1090 DSM-IV bipolar I manic patients. Our sample was categorized according to the presence of comorbid alcohol use disorder and the sequence of onsets of bipolar and alcohol use disorders i...
August 3, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28800800/behavioral-emergencies-special-considerations-in-the-pregnant-patient
#13
REVIEW
Awais Aftab, Asim A Shah
This article describes psychiatric emergencies in pregnant women. The perinatal period is a time of psychiatric vulnerability. Up to 1 in 6 pregnant women experience major depressive disorder, and 1 in 4 pregnant women with bipolar disorder experience mood exacerbation. We discuss the management of severe mental illness in pregnancy, risk to mother and child of untreated psychiatric illness in pregnancy, risk of relapse of psychiatric disorders in pregnancy with medication discontinuation, psychopharmacologic considerations of teratogenicity and other fetal adverse effects, acute agitation in the pregnant patient, suicidality in pregnancy, and emergency considerations related to substance use disorders...
September 2017: Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/28800514/the-relationship-between-executive-functions-and-fluid-intelligence-in-euthymic-bipolar-disorder-patients
#14
Belén Goitia, Facundo Manes, Teresa Torralva, Mariano Sigman, John Duncan, Marcelo Cetkovich, María Roca
Distinct cognitive deficits have been described in Bipolar disorder (BD), including executive impairments, commonly attributed to frontal dysfunction. However, recent attention has been paid to the heterogeneity of cognitive functioning in this population, suggesting that the executive deficits observed in BD might be due to a loss in fluid intelligence (g). Following our previous line of investigation in multiple neurological and psychiatric conditions we aimed at determining the role of g in frontal deficits in BD...
August 1, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28800513/serum-tnf-related-weak-inducer-of-apoptosis-tweak-and-tnf-related-apoptosis-inducing-ligand-trail-levels-of-patients-with-bipolar-disorder-in-manic-episode-in-remission-and-healthy-controls
#15
Merve Cingi Yirün, Onur Yirün, Kübranur Ünal, Rabia Nazik Yüksel, Neslihan Altunsoy, Elif Tatlidil Yaylaci, Makbule Çiğdem Aydemir, Erol Göka
TNF-related weak inducer of apoptosis (TWEAK) and TNF-related apoptosis-inducing ligand (TRAIL) are members of TNF superfamily, which has various roles in immunologic and inflammatory reactions in the organism. Pathophysiology in bipolar disorder is still under investigation and altered serum levels of cytokines are often encountered. Aim of this study is to detect serum TWEAK and TRAIL levels of patients with bipolar disorder and healthy controls. For this purpose, 55 patients with bipolar disorder -27 manic episode (ME), 28 remission (RE) and 29 healthy controls (HC) were included...
August 1, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28800512/metabotropic-glutamate-receptors-as-emerging-research-targets-in-bipolar-disorder
#16
REVIEW
Caren J Blacker, Charles P Lewis, Mark A Frye, Marin Veldic
Glutamatergic dysregulation is implicated in the neuropathology of bipolar disorder (BD). There is increasing interest in investigating the role of metabotropic glutamate receptors (mGluRs) in BD and as a target for treatment intervention. Bipolar mGluR studies (published January 1992-April 2016) were identified via PubMed, Embase, Web of Science, and Scopus. Full-text screening, data extraction, and quality appraisal were conducted in duplicate, with strict inclusion and exclusion criteria. The initial literature search for mGluRs in BD, including non-bipolar mood disorders and primary psychotic disorders, identified 1544 articles...
July 31, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28800423/relationship-of-executive-functioning-deficits-to-n-acetyl-aspartate-naa-and-gamma-aminobutyric-acid-gaba-in-youth-with-bipolar-disorder
#17
Rebekah S Huber, Douglas G Kondo, Xian-Feng Shi, Andrew P Prescot, Elaine Clark, Perry F Renshaw, Deborah A Yurgelun-Todd
BACKGROUND: Although cognitive deficits in bipolar disorder (BD) have been repeatedly observed, our understanding of these impairments at a mechanistic level remains limited. Few studies that investigated cognitive impairments in bipolar illness have examined the association with brain biochemistry. This pilot study utilized proton magnetic resonance spectroscopy ((1)H-MRS) to evaluate the relationship between neurocognitive performance and brain metabolites in youth with BD. METHODS: Thirty participants, twenty depressed BD participants and ten healthy comparison participants, ages 13-21, completed mood and executive function measures...
August 1, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28799261/serum-osmolarity-in-male-patients-with-bipolar-disorder-manic-episode
#18
Tevfik Kalelioglu, Nesrin Karamustafalioglu, Abdullah Genc, Murat Kocabiyik
Imbalance of water and electrolyte homeostasis has been suggested to be associated with the acute episodes of bipolar disorder. In this study we aimed to investigate, for the first time, the serum osmolarity in bipolar disorder manic episode. A total of 68 bipolar inpatients in manic episode and 60 age-gender matched healthy controls were included in the study. Serum osmolarity was calculated from Sodium (Na(+) ), glucose and blood urea nitrogen (BUN) according to formula of (2 × Na(+) ) + (BUN/2.8) + (Glucose/18)...
August 10, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28797920/prefrontal-activation-during-a-working-memory-task-differs-between-patients-with-unipolar-and-bipolar-depression-a-preliminary-exploratory-study
#19
Yue Zhu, Wenxiang Quan, Huali Wang, Yantao Ma, Jun Yan, Hua Zhang, Wentian Dong, Xin Yu
BACKGROUND: To identify bipolar disorder during the initial stages of a depressive episode has always been a great clinical challenge. Patterns of functional brain activity may underlie the differences in the neural mechanisms of bipolar depression (BD) and unipolar depression (UD). This study aimed to investigate the differences in neural activity between BD and UD patients during executive task. METHODS: We performed a 52-channel near-infrared spectroscopy (NIRS) scan in 39 patients with BD, 35 patients with UD, and 36 healthy controls (HCs)...
July 18, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28796557/revisiting-the-concept-of-severe-mental-illness-severity-indicators-and-healthcare-spending-in-psychotic-depressive-and-dissociative-disorders
#20
Ana Isabel Gonzalez Vazquez, Natalia Seijo Ameneiros, Juan Carlos Díaz Del Valle, Ester Lopez Fernandez, Miguel Angel Santed Germán
BACKGROUND: The concept of severe mental illness (SMI) has been related to bipolar or psychotic diagnosis, or to some cases of depressive disorders. Other mental health problems such as personality disorders or posttraumatic dissociative conditions, which can sometimes lead to relevant functional impairments, remain separate from the SMI construct. AIMS: This study aimed to evaluate the clinical severity as well as healthcare spending on dissociative disorders (DDs)...
August 10, 2017: Journal of Mental Health
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