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Bipolar Disorders

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https://www.readbyqxmd.com/read/29334291/prevalence-and-risk-factors-of-hyperprolactinemia-among-patients-with-various-psychiatric-diagnoses-and-medications
#1
Fahad D Alosaimi, Ebtihaj O Fallata, Mohammed Abalhassan, Abdulhadi Alhabbad, Nasser Alzain, Bandar Alhaddad, Mohammed Z Alassiry
OBJECTIVES: Hyperprolactinemia is a common adverse event associated with psychotropic medications (mainly antipsychotics) used in the management of schizophrenia and bipolar disorders. The aim of this study was to estimate the prevalence of hyperprolactinemia in psychiatric patients and to evaluate its association with various psychiatric diagnoses and the use of various psychotropic medications. METHODS: A cross-sectional observational study was conducted between July 2012 and June 2014...
January 15, 2018: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/29333954/prevalence-diagnosis-and-treatment-rates-of-mood-disorders-among-opioid-users-under-criminal-justice-supervision
#2
Mary Mbaba, Shan-Estelle Brown, Alese Wooditch, Marissa Kiss, Amy Murphy, Suneeta Kumari, Faye Taxman, Frederick Altice, William B Lawson, Sandra A Springer
BACKGROUND: Individuals involved in the criminal justice system have disproportionately high rates of psychiatric disorders when compared to the general U.S. POPULATION: If left untreated, the likelihood of subsequent arrest increases and risk for adverse health consequences is great, particularly among opioid users. OBJECTIVES: To explore the prevalence, characteristics, and treatment of mood disorders among justice involved opioid-dependent populations...
January 15, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29332095/both-serum-brain-derived-neurotrophic-factor-and-interleukin-6-levels-are-not-associated-with-therapeutic-response-to-lamotrigine-augmentation-therapy-in-treatment-resistant-depressive-disorder
#3
Shoko Kagawa, Kazuo Mihara, Takeshi Suzuki, Goyo Nagai, Akifumi Nakamura, Kenji Nemoto, Tsuyoshi Kondo
BACKGROUND/AIMS: Serum levels of brain-derived neurotrophic factor (BDNF) and interleukin-6 (IL-6) were prospectively monitored in relation with therapeutic response to lamotrigine augmentation therapy in 46 (15 males and 31 females) inpatients with treatment-resistant depressive disorder during an 8-week treatment with lamotrigine using an open-study design. METHODS: The subjects were 46 depressed patients who had already shown insufficient response to at least 3 psychotropics including antidepressants, mood stabilizers, and atypical antipsychotics...
January 12, 2018: Neuropsychobiology
https://www.readbyqxmd.com/read/29331931/resting-state-fmri-signals-in-offspring-of-parents-with-bipolar-disorder-at-the-high-risk-and-ultra-high-risk-stages-and-their-relations-with-cognitive-function
#4
Kangguang Lin, Robin Shao, Rui Lu, Kun Chen, Weicong Lu, Ting Li, Jiehua Kong, Kwok-Fai So, Guiyun Xu
BACKGROUND: Bipolar disorder (BD) has been associated with dysfunctional resting-state brain functioning. However, it is still not known whether the aberrant functioning occurs and predict cognitive functioning before illness onset. AIMS: We examined the resting-state regional and network dysfunctioning, and their correlates with neurocognitive performance, in the high-risk (HR) and ultra-high-risk (UHR) stages of bipolar disorder. METHODS: Using amplitude of low-frequency fluctuations (ALFF), region homogeneity (ReHo) and hypothesis-driven region-of-interest (ROI)-based connectivity, we examined resting-state fMRI data of 8- to 25-year-old healthy offspring (HR, n = 28) and offspring with subthreshold syndromes (UHR, n = 22) of a BD parent, and age-matched healthy controls without any personal or family psychopathology (HC, n = 46)...
January 8, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29331712/genetic-biomarkers-for-differential-diagnosis-of-major-depressive-disorder-and-bipolar-disorder-a-systematic-and-critical-review
#5
REVIEW
Itiana Castro Menezes, Cristiane von Werne Baes, Riccardo Lacchini, Mario Francisco Juruena
Depressive symptoms are present in the depressive mood state of bipolar disorder (BPD) and major depression disorder (MDD). Often, in clinical practice, BPD patients are misdiagnosed with MDD. Therefore, genetic biomarkers could contribute to the improvement of differential diagnosis between BPD and MDD. This systematic and critical review aimed to find in literature reliable genetic biomarkers that may show differences between BPD and MDD. This systematic review followed the PRISMA-P method. The terms used to search PubMed, Scopus, PsycINFO, and Web of Science were depress*, bipolar, diagnos*, genetic*, biomark*...
January 10, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29331701/the-use-of-triiodothyronine-t3-in-the-treatment-of-bipolar-depression-a-review-of-the-literature
#6
REVIEW
T Parmentier, P Sienaert
BACKGROUND: There is a paucity of treatment options for bipolar depression. The use of triiodothyronine (T3) has been suggested as adjunctive treatment. METHODS: A search on Medline, Limo and ScienceDirect was performed using the search terms bipolar disorder, bipolar depression, treatment resistant, treatment refractory, thyroid hormones, triiodothyronine, T3, acceleration and augmentation. RESULTS: We retrieved three open studies, one comparative study, two double blind and one retrospective chart review...
January 9, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29331696/does-early-response-predict-subsequent-remission-in-bipolar-depression-treated-with-repeated-sleep-deprivation-combined-with-light-therapy-and-lithium
#7
Masahiro Suzuki, Sara Dallaspezia, Clara Locatelli, Makoto Uchiyama, Cristina Colombo, Francesco Benedetti
BACKGROUND: The combination of three cycles of sleep deprivation (SD), light therapy (LT), and lithium has recently been proposed as a possible first-line treatment for bipolar depression. However, it is unclear whether early improvement predicts final response/remission in bipolar depression treated with this regimen. METHOD: We studied 220 consecutively admitted inpatients with a major depressive episode in the course of bipolar disorder. The relation between response to first SD and response/remission at the end of the treatment (day 6) was analyzed using logistic regression analysis...
January 2, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29331693/disease-management-apps-and-technical-assistance-systems-for-bipolar-disorder-investigating-the-patients%C3%A2-point-of-view
#8
Henning Daus, Natalia Kislicyn, Stephan Heuer, Matthias Backenstrass
BACKGROUND: Smartphone-based disease management has become increasingly interesting for research in the field of bipolar disorders. This article investigates the attitudes of persons affected by this disorder towards the appropriation of mobile apps or assistance systems for the management of their disease. METHODS: We conducted two separate studies. Study 1 was an online survey with 88 participants. In study 2 we consulted 15 participants during a semi-structured interview...
January 2, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29331692/memory-performance-predicts-response-to-psychotherapy-for-depression-in-bipolar-disorder-a-pilot-randomized-controlled-trial-with-exploratory-functional-magnetic-resonance-imaging
#9
Thilo Deckersbach, Amy T Peters, Conor Shea, Aishwarya Gosai, Jonathan P Stange, Andrew D Peckham, Kristen K Ellard, Michael W Otto, Scott L Rauch, Darin D Dougherty, Andrew A Nierenberg
OBJECTIVE: This pilot randomized controlled trial compared Cognitive Behavior Therapy (CBT) and Supportive Psychotherapy (SP) for the treatment of depression in bipolar I disorder. We also examined whether exploratory verbal memory, executive functioning, and neural correlates of verbal memory during functional magnetic resonance imaging (fMRI) predicted change in depression severity. METHODS: Thirty-two adults (ages 18-65) with DSM-IV bipolar I disorder meeting current criteria for a major depressive episode were randomized to 18 weeks of CBT or SP...
December 27, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29331691/design-limitations-to-bipolar-ii-treatment-efficacy-studies-a-challenge-and-a-revisionist-strategy
#10
REVIEW
Gordon B Parker, Gabriela Tavella
BACKGROUND: Trials examining medication efficacy for bipolar II disorder commonly employ a set of standardized interval measures to assess outcomes. The key issue is whether such interval measures pick up changes in the severity, duration and frequency of depressive, hypomanic and euthymic episodes. METHOD: We examine the application of measures most commonly used to monitor progress in nine studies involving participants with a bipolar II disorder and published in journals with a moderate to high impact factor...
January 5, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29331603/metabolic-risk-factors-in-schizophrenia-and-bipolar-disorder-the-effect-of-comedication-with-selective-serotonin-reuptake-inhibitors-and-antipsychotics
#11
K K Fjukstad, A Engum, S Lydersen, I Dieset, N Eiel Steen, O A Andreassen, O Spigset
BACKGROUND: The aim of this observational study was to investigate the relationship between metabolic factors and use of selective serotonin reuptake inhibitors (SSRIs) combined with olanzapine, quetiapine or risperidone. METHODS: Data from the Norwegian Thematically Organized Psychosis study, a cross-sectional study on 1301 patients with schizophrenia (n=868) or bipolar disorder (n=433), were analyzed. As exposure variables in the linear regression model were included the dose or serum concentration of SSRIs (n=280) and of olanzapine (n=398), quetiapine (n=234) or risperidone (n=128)...
April 17, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29331354/specificity-in-etiology-of-subtypes-of-bipolar-disorder-evidence-from-a-swedish-population-based-family-study
#12
Jie Song, Ralf Kuja-Halkola, Arvid Sjölander, Sarah E Bergen, Henrik Larsson, Mikael Landén, Paul Lichtenstein
BACKGROUND: Uncertainty remains whether bipolar I disorder (BDI) and bipolar II disorder (BDII) differ etiologically. We used a population-based family sample to examine the etiological boundaries between BDI and BDII by assessing their familial aggregation/coaggregation and by assessing the coaggregation between them and schizophrenia, depression, attention-deficit/hyperactivity disorder, eating disorders, autism spectrum disorder, substance use disorders, anxiety disorders, and personality disorders...
November 20, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29329741/sex-differences-of-hippocampal-structure-in-bipolar-disorder
#13
Jing Shi, Hua Guo, Fengmei Fan, Hongzhen Fan, Huimei An, Zhiren Wang, Shuping Tan, Fude Yang, Yunlong Tan
Although differential patterns in clinical characteristics have been consistently noted between male and female patients with bipolar disorder (BD), the effect of sex on the hippocampal structure remains unclear. To address this, the present study investigated the effects of BD and sex on the hippocampal structure, and the relationship between the hippocampal structure and cognitive performance. Morphometric and neurocognitive analyses were performed in 91 subjects (patients with BD: male/female = 33/19; normal controls: male/female = 22/17)...
December 1, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29329664/the-impact-of-mental-health-disorders-on-30-day-readmission-after-bariatric-surgery
#14
Megan Litz, Andrea Rigby, Ann M Rogers, Douglas L Leslie, Christopher S Hollenbeak
BACKGROUND: Mental health disorders are common among bariatric surgery patients. Mental health disorders, particularly depression, have been associated with poorer surgical outcomes, indicating the bariatric surgery patient population warrants special clinical attention. OBJECTIVE: Our study sought to examine the effect of diagnosed mental health disorders on 30-day readmission for those undergoing bariatric surgery in hospitals across Pennsylvania from 2011 to 2014...
December 8, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29329066/association-of-suicidal-risk-with-ratings-of-affective-temperaments
#15
Leonardo Tondo, Gustavo H Vázquez, Gabriele Sani, Marco Pinna, Ross J Baldessarini
BACKGROUND: Ratings of particular temperament-types with the TEMPS-A autoquestionnaire have been associated with suicidal risk, and combinations of such ratings may enhance the association. However, the predictive value of scores for individual temperaments and combinations remains to be quantified. METHOD: We evaluated associations of TEMPS-A ratings for anxious (anx), cyclothymic (cyc), dysthymic (dys), hyperthymic (hyp) and irritable (irr) temperaments, with a history of suicidal acts or reported suicidal ideation in 882 patients with bipolar (BD; n = 509), major depressive (MDD; n = 268) or anxiety (ANX; n = 105) disorders...
January 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29329056/subjective-and-objective-sleep-discrepancy-in-symptomatic-bipolar-disorder-compared-to-healthy-controls
#16
Venkatesh Krishnamurthy, Dahlia Mukherjee, Aubrey Reider, Scott Seaman, Gagan Singh, Julio Fernandez-Mendoza, Erika Saunders
BACKGROUND: Bipolar disorder (BD) is associated with sleep misperception. The objective of this study was to investigate the correlation between subjective and objective measures of sleep in persons with symptomatic bipolar disorder (BDS) compared to healthy controls (HC). METHODS: We studied 24 BDS and 30 HC subjects similar in age, race and sex. Subjective sleep was measured with Pittsburgh Sleep Quality Index (PSQI) and objective sleep with 7-days of actigraphy...
January 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29329044/neurological-soft-signs-in-bipolar-and-unipolar-disorder-a-case-control-study
#17
Tareq Al Sagheer, Shafika Assaad, Georges Haddad, Dory Hachem, Chadia Haddad, Souheil Hallit
Neuropsychiatric disorders are associated with neurological soft signs (NSS), including motor, sensory, and inhibitory dysfunction. The present study aims at determining the prevalence of NSS and explore the association of sociodemographic characteristics with the occurrence of NSS in patients with bipolar disorder and unipolar depression compared to healthy controls. A case-control study included a sample of 50 bipolar and unipolar patients and 50 healthy controls. NSS subscales of the Neurological Evaluation Scale (NES) were administered to each participant...
January 4, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29329043/impact-of-synthetic-cannabinoid-use-on-hospital-stay-in-patients-with-bipolar-disorder-versus-schizophrenia-or-other-psychotic-disorders
#18
Huiqiong Deng, Satyajit Mohite, Robert Suchting, David A Nielsen, Olaoluwa O Okusaga
Synthetic cannabinoid products have become popular and have led to an increased number of patients presenting to emergency departments and psychiatric hospitals. The purpose of this study was to evaluate the impact of synthetic cannabinoid use at admission on length of stay and doses of antipsychotics at discharge in individuals with bipolar disorder, schizophrenia and other psychotic disorders. We retrospectively examined medical records of 324 inpatients admitted from January 2014 to July 2015. We found that synthetic cannabinoid use predicted length of stay and antipsychotic dose using structural equation modeling...
January 3, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29329041/thiol-disulphide-homeostasis-in-bipolar-disorder
#19
Gamze Erzin, Vahap Ozan Kotan, Canan Topçuoğlu, Güven Özkaya, Özcan Erel, Rabia Nazik Yüksel, Emre Ürer, Makbule Çiğdem Aydemir, Erol Göka
Bipolar disorder (BD) patients have increased oxidative stress, which can disturb thiol/disulphide homeostasis, causing disulphide formation. The aim of the study is to investigate dynamic thiol/disulphide (SH/SS) homeostasis in BD patients, which is a novel evaluation method of oxidative status. Ninety-four BD patients (50 in the manic episode and 44 in remission) and 44 healthy controls were included in the study. Blood serum native thiol (SH) and total thiol (ToSH) concentrations were measured in a paired test...
January 2, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29328948/psychopathology-and-episodic-future-thinking-a-systematic-review-and-meta-analysis-of-specificity-and-episodic-detail
#20
D J Hallford, D W Austin, K Takano, F Raes
Episodic future thinking (EFT) refers to the mental simulation of future events that might be personally-experienced; a crucial mental process in adaptation. Psychiatric disorders are associated with deficits in recalling episodic memory, however, no study has reviewed the empirical literature to assess for similar deficits in EFT. A systematic review comparing psychiatric groups with control groups on the specificity and episodic detail of EFT returned 19 eligible studies. An overall effect of g = -0.84 (95%CI = -1...
January 5, 2018: Behaviour Research and Therapy
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