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Igor I Slukvin, Gene I Uenishi
Human pluripotent stem cells (hPSCs) have been suggested as a potential source for the de novo production of blood cells for transfusion, immunotherapies and transplantation. However, even with advanced hematopoietic differentiation methods, the primitive and myeloid-restricted waves of hematopoiesis dominate in hPSC differentiation cultures while cell-surface markers to distinguish these waves of hematopoiesis from lympho-myeloid hematopoiesis remain unknown. In the embryo, hematopoietic stem cells (HSCs) arise from hemogenic endothelium (HE) lining arteries, but not veins...
November 27, 2018: Experimental Hematology
Ling Zhu, Jingbo Wang, Huimin Shi, Xiaofeng Tao
BACKGROUND: Differential diagnosis of the mucosa-associated lymphoid tissue lymphoma (MALToma) and tumor-like benign lymphoepithelial lesion (BLEL) in the parotid gland is difficult. PURPOSE: To distinguish MALToma and BLEL with multimodality MRI including hydrogenproton magnetic resonance spectroscopy (1 H-MRS), diffusion-weighted imaging (DWI-MR), and dynamic contrast-enhanced (DCE-MR), and evaluate each sequence. STUDY TYPE: Retrospective...
November 26, 2018: Journal of Magnetic Resonance Imaging: JMRI
Wondimu Gudu
BACKGROUND: Pelvic tuberculosis is a rare form of extrapulmonary tuberculosis. It commonly involves the fallopian tubes and the uterus from a lympho-hematogeneous spread. The presentation of pelvic tuberculosis as an isolated ovarian abscess is extremely rare and is reported only twice. CASE PRESENTATION: a 25 yrs. old para III mother in the post partum period undergone laparotomy for suspected tuboovarian abscess/ovarian tumor after presenting with abdominal pain, pelvic mass and fever...
November 22, 2018: Journal of Ovarian Research
Mona Mlika, Besma Hamdi, Adel Marghli, Faouzi El Mezni
INTRODUCTION: Lympho-epithelioma like carcinoma is a rare lung tumour that acounts for less than 1% of non small cell lung carcinomas. It is defined as a special entity among the 2015 World Health Organization. AIM: Our aim was to describe a completely illustrated new case of lymhpo-epithelioma like carcinoma. We describe a new case diagnosed in our Department of Pathology. CASE PRESENTATION: The authors describe a case of a 22-year-old woman without a particular past medical history who presented non specific respiratory symptoms...
July 2018: La Tunisie Médicale
Basim Rassam Ghadhban
Background: Advanced breast cancer is a common disease among female in the world. There is a correlation between cancer and hyper coagulation. In a cancer state, there is an increase in the level of cross-linked fibrin degradation product (d-dimer)which indicates systemic activation of fibrinolysis and hemostasis. So, there is a relation between increase d-dimer value and advanced breast disease. Objective: To confirm the relation between increase d-dimer levels and advanced breast carcinoma in female patients...
December 2018: Annals of Medicine and Surgery
Virginie Lemiale, Sandrine Valade, Laure Calvet, Eric Mariotte
Hemophagocytic syndrome remains a rare but life-threatening complication and is associated with intensive care unit (ICU) admission. The pathophysiology is based on a defect of cytotoxicity in T cells that results in a state of hyperinflammation in the presence of a trigger. As a consequence, patients may develop multiorgan failure. The diagnosis of hemophagocytic syndrome (HS) remains difficult and relies on persistant high-grade fevers in the absence of infection and on constellation of laboratory parameters...
November 1, 2018: Journal of Intensive Care Medicine
Patrice Mathevet, Teresa Alvarez, Fernanda Herrera, Anita Wolfer
Endometrial carcinoma is one of the most frequent women cancer. Its incidence is increasing due to the aging of the population and changes in life. Fortunately, these cancers are usually detected at an early stage due to post-menopausal bleeding. The prognostic factors are quite well determined : loco-regional and distant tumoral extension according to the FIGO classification, grade and histological type and the presence of lympho-vascular space invasions. These cancers, however, are usually of good prognosis because of an early diagnosis, and their treatment is based on surgery, preferably minimally invasive approach, whose extension is adapted to the prognostic factors from the pre-therapeutic assessment...
October 24, 2018: Revue Médicale Suisse
Jean-Marc Classe, Cecile Loaec, P Gimbergues, S Alran, C Tunon de Lara, P F Dupre, Roman Rouzier, C Faure, N Paillocher, M P Chauvet, G Houvenaeghel, M Gutowski, P De Blay, J L Verhaeghe, E Barranger, C Lefebvre, C Ngo, G Ferron, C Palpacuer, L Campion
PURPOSE: GANEA2 study was designed to assess accuracy and safety of sentinel lymph node (SLN) after neo-adjuvant chemotherapy (NAC) in breast cancer patients. METHODS: Early breast cancer patients treated with NAC were included. Before NAC, patients with cytologically proven node involvement were allocated into the pN1 group, other patient were allocated into the cN0 group. After NAC, pN1 group patients underwent SLN and axillary lymph node dissection (ALND); cN0 group patients underwent SLN and ALND only in case of mapping failure or SLN involvement...
October 20, 2018: Breast Cancer Research and Treatment
Gilda Varricchi, Antonio Pecoraro, Ludovica Crescenzi, Giancarlo Marone, Antonio Travaglino, Francesco Paolo D'Armiento, Arturo Genovese, Giuseppe Spadaro
BACKGROUND: Common variable immunodeficiency (CVID) encompasses a heterogeneous group of primary antibody deficiency disorders characterized by recurrent infections, autoimmunity and malignancies. Gastrointestinal manifestations are frequently associated with CVID. OBJECTIVE: In this cross-sectional study, we evaluated gastric and duodenal involvement in a cohort of adult patients with CVID. METHODS: Upper gastrointestinal endoscopy was performed in 58 patients (26 males, mean age 47...
October 10, 2018: Current Pharmaceutical Biotechnology
Mohammed Fawzy El-Kamel, Mohamed Khaled Selim, Mamdouh Morsy Abdel Gawad
Rosai-Dorfman disease or sinus histiocytosis with massive lymphadenopathy is a benign lympho-histiocytic proliferative disorder initially described with bilateral painless lymphadenopathy (90 %), fever, leukocytosis, elevated ESR, anemia, and polyclonal hypergammaglobulinemia (90 %). Extranodal forms occur in 43% of cases, the skin being the most common site. Around 10% of patients have skin lesions and in 3%, the disease is limited exclusively to the skin. Here, we report a male patient who presented with pure cutaneous lesions which mimic eruptive xanthoma clinically...
October 17, 2018: Indian Journal of Dermatology, Venereology and Leprology
Konrad Whittaker, Konstanze Guggenberger, Nils Venhoff, Soroush Doostkam, Hans-Eckart Schaefer, Brita Fritsch
BACKGROUND: Crohn's disease (CD) is associated with a variety of extra-intestinal manifestations. Most commonly these involve the eye, skin, joints, coagulation system and liver. Cerebral manifestations of CD have been reported to a far lesser extent. The extensive detrimental impact of neurological symptoms on a patient's quality of life makes an early diagnosis and treatment particularly important. In previous case-reports, diagnosis of cerebral manifestations in CD often relied upon magnetic resonance imaging (MRI) and computed tomography (CT) alone...
October 3, 2018: BMC Neurology
Luis Carlos Pena Cortes, Rhiannon M LeVeque, Julie A Funk, Terence L Marsh, Martha H Mulks
Tonsils, lympho-epithelial tissues located at the junction of the oropharynx and nasopharynx, play a key role in surveillance, colonization, and persistence of inhaled and ingested pathogens. In pigs, the tonsils are a reservoir for numerous bacteria and viruses, including host-specific pathogens and potential zoonotic pathogens as well as commensal organisms. However, there are no in depth studies of the development of the tonsillar microbiome in pigs, or any mammal, over time. The goal of this study was to follow the development of the tonsil microbiome in healthy pigs from birth to market weight...
2018: Frontiers in Veterinary Science
Tomohiko Murakami, Satoshi Otsubo, Ryo Namitome, Masaki Shiota, Junichi Inokuchi, Ario Takeuchi, Eiji Kashiwagi, Katsunori Tatsugami, Masatoshi Eto
The present study investigated clinical factors affecting perioperative outcomes in robot-assisted radical prostatectomy (RARP). The study included 625 Japanese cases treated with RARP between 2009 and 2017. The association between clinical factors (age, overweight status, prostate volume, clinical T-stage, nerve sparing, lympho-node dissection, and the number of experienced cases) and perioperative outcomes (operation time, estimated blood loss, catheterization duration, and perioperative complication) were analyzed...
November 2018: Molecular and Clinical Oncology
Hirotaka Niwa, Rie Ozawa, Yasunori Kurahashi, Tsutomu Kumamoto, Yasutaka Nakanishi, Koichi Okumura, Ikuo Matsuda, Yoshinori Ishida, Seiichi Hirota, Hisashi Shinohara
Endoscopic submucosal dissection (ESD) for early gastric cancer does not always lead to complete cancer resection. The aim of this study was to determine indicators for cancer residue (CR) status in cases of non-curative ESD. We analyzed 47 cases of non-curative ESD followed by salvage surgery and collected data regarding the rates of CR, which included both local CR and lymph node metastasis (LNM). To elucidate the risk factors for CR status, we compared the CR positive and the CR negative groups among surgical specimens according to the following variables obtained from ESD findings: tumor location, tumor size, depth of invasion, lympho-vascular invasion, histological margin, and histological diagnosis...
2018: PloS One
Saeko Sugimoto, Shin Morizane, Hayato Nomura, Mina Kobashi, Satoru Sugihara, Keiji Iwatsuki
BACKGROUND: Lympho-epithelial Kazal-type inhibitor (LEKTI) tightly controls the activities of serine proteases such as kallikrein-related peptidase (KLK) 5 and KLK7 in the epidermis. LEKTI is known to be an essential molecule for the epidermal skin barrier, as demonstrated by SPINK5 nonsense mutation, which results in Netherton syndrome. Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns or damage-associated molecular patterns and produce inflammatory cytokines, chemokines, and antimicrobial peptides...
September 15, 2018: Journal of Dermatological Science
Giovanni Biondo, Giuseppe Pistone, Maria R Bongiorno
Targetoid hemosiderotic hemangioma represents an uncommon, distinctive, benign lympho-vascular lesion, with a variable clinical appearance, typically occurs in the lower limbs and trunk. Most patients are in their 20's or 30's. We describe three dermoscopic cases followed by the review of the literature. Dermoscopic images have been collected and have been evaluated for the presence of dermoscopic features. Concerning the review, we researched on pubmed and records were reviewed noting patient age of onset, sex, location, overall size, dermoscopic appearance...
October 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Marcos Isidoro-Ayza, Daniel A Grear, Aurélie Chambouvet
Severe Perkinsea infection (SPI) is an emerging disease of frogs responsible for mass mortalities of tadpoles across the United States. It is caused by protozoa belonging to the phylum Perkinsozoa that form a distinct group referred to as the Pathogenic Perkinsea Clade of frogs. In this work, we provide detailed description of gross and histologic lesions from 178 naturally infected tadpoles, including 10 species from 22 mortality events and 6 amphibian health monitoring studies from diverse geographic areas...
September 20, 2018: Veterinary Pathology
P Conte, A Frassoldati, G Bisagni, A A Brandes, M Donadio, O Garrone, F Piacentini, L Cavanna, F Giotta, M Aieta, V Gebbia, A Molino, A Musolino, A Ferro, R Maltoni, S Danese, C Zamagni, A Rimanti, K Cagossi, A Russo, P Pronzato, F Giovanardi, G Moretti, L Lombardo, A Schirone, A Beano, L Amaducci, E A Bajardi, R Vicini, S Balduzzi, R D'Amico, V Guarneri
Background: Chemotherapy plus 1-year trastuzumab is the standard adjuvant treatment for HER2-positive breast cancer. The efficacy of less extended trastuzumab exposure is under investigation. The Short-HER study was aimed to assess the non-inferiority of 9 weeks vs 1 year of adjuvant trastuzumab combined with chemotherapy. Patients and methods: HER2-positive breast cancer patients with node-positive or, if node negative, with at least one risk factor (pT > 2cm, G3, lympho-vascular invasion, Ki-67>20%, age ≤35 years, or hormone receptor negativity) were randomly assigned to receive sequential anthracycline-taxane combinations plus 1-year trastuzumab (arm A, long) or plus 9-weeks trastuzumab (arm B, short)...
September 13, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Ali Bohlok, Melody El Khoury, Berenice Tulelli, Laurine Verset, Anthony Zaarour, Pieter Demetter, Pierre Eisendrath, Issam El Nakadi
INTRODUCTION: Immunoglobulin G4 related disease is a recently recognized systemic fibro-inflammatory disorder affecting virtually every organ in the body, characterized by lympho-plasmacytic dense infiltrates rich in IgG4 positive plasmacytes along with storiform fibrosis, inconstantly associated with elevated serum IgG4 levels. Few cases of Immunoglobulin G4 related disease occurring solely in the stomach have been published. PRESENTATION OF CASE: We herein present a rare case of a 57 year old male patient presenting with an incidentally discovered asymptomatic pre-pyloric submucosal gastric lesion confused with a gastro-intestinal stromal tumor with failed endoscopic biopsy attempts due to tumor mobility...
2018: International Journal of Surgery Case Reports
Alberto Paderno, Michele Tomasoni, Davide Mattavelli, Simonetta Battocchio, Davide Lombardi, Piero Nicolai
OBJECTIVES: Primary cancer of the parotid gland (PG) is a rare disease characterized by a wide variety of histologies and subtypes. The aim of the study was to identify factors influencing survival and validate the prognostic scores (PS1 and PS2) by Vander Poorten et al. STUDY DESIGN: Retrospective cohort study. METHODS: All patients with previously untreated PG epithelial malignancies who underwent surgery with curative intent from 2002 to 2015 at a single center were retrospectively reviewed...
September 12, 2018: European Archives of Oto-rhino-laryngology
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