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https://www.readbyqxmd.com/read/29164967/increased-serum-midkine-levels-in-autism-spectrum-disorder-patients
#1
Erman Esnafoglu, Selma Cırrık
BACKGROUND: Midkine (MK) is a heparin binding growth factor and is involved in neurogenesis, neural development and neuroprotection. Additionally MK may contribute to cancer development and pathogenesis of neurodegenerative disorders and schizophrenia. Considering these effects of midkine, this study researched whether MK is involved in Autism spectrum disorders (ASD) pathogenesis. METHODS: We evaluated serum MK levels of 38 patients with ASD and 32 healthy control group...
November 22, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29164825/autism-spectrum-disorder-and-birth-spacing-findings-from-the-study-to-explore-early-development-seed
#2
Laura A Schieve, Lin H Tian, Carolyn Drews-Botsch, Gayle C Windham, Craig Newschaffer, Julie L Daniels, Li-Ching Lee, Lisa A Croen, M Danielle Fallin
Previous studies of autism spectrum disorder (ASD) and birth spacing had limitations; few examined phenotypic case subtypes or explored underlying mechanisms for associations and none assessed whether other (non-ASD) developmental disabilities (DDs) were associated with birth spacing. We assessed associations between inter-pregnancy interval (IPI) and both ASD and other DDs using data from the Study to Explore Early Development, a multi-site case-control study with rigorous case-finding and case-classification methods and detailed data collection on maternal reproductive history...
November 22, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29164765/maternal-pre-pregnancy-obesity-and-child-neurodevelopmental-outcomes-a-meta-analysis
#3
REVIEW
C E Sanchez, C Barry, A Sabhlok, K Russell, A Majors, S H Kollins, B F Fuemmeler
This review examined evidence of the association between maternal pre-pregnancy overweight/obesity status and child neurodevelopmental outcomes. PubMed and PsycINFO databases were systematically searched for empirical studies published before April 2017 using keywords related to prenatal obesity and children's neurodevelopment. Of 1483 identified papers, 41 were included in the systematic review, and 32 articles representing 36 cohorts were included in the meta-analysis. Findings indicated that compared with children of normal weight mothers, children whose mothers were overweight or obese prior to pregnancy were at increased risk for compromised neurodevelopmental outcomes (overweight: OR = 1...
November 22, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29164445/changes-in-depressive-symptoms-among-adolescents-with-asd-completing-the-peers-%C3%A2-social-skills-intervention
#4
Hillary K Schiltz, Alana J McVey, Bridget K Dolan, Kirsten S Willar, Sheryl Pleiss, Jeffrey S Karst, Audrey M Carson, Christina Caiozzo, Elisabeth M Vogt, Brianna D Yund, Amy Vaughan Van Hecke
Depression is a common concern among people with autism spectrum disorder (ASD) and is often associated with social skills and relationship challenges. The present data, from a randomized controlled trial, examined the effect of PEERS(®) on self-reported depressive symptoms via the Children's Depression Inventory (CDI) among 49 adolescents with ASD. Findings revealed that many CDI subscale scores declined (p's < 0.05) and were related to direct social contact on the Quality of Socialization Questionnaire at posttest (p's < 0...
November 21, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29164444/a-randomized-controlled-trial-of-the-social-tools-and-rules-for-teens-start-program-an-immersive-socialization-intervention-for-adolescents-with-autism%C3%A2-spectrum%C3%A2-disorder
#5
Ty W Vernon, Amber R Miller, Jordan A Ko, Amy C Barrett, Elizabeth S McGarry
Adolescents with ASD face numerous personal and contextual barriers that impede the development of social motivation and core competencies, warranting the need for targeted intervention. A randomized controlled trial was conducted with 40 adolescents to evaluate the merits of a multi-component socialization intervention that places emphasis on experiential learning. This investigation evaluated the impact of the 20-week START program on the social functioning of adolescents with ASD. Significant Group × Time differences between START and waitlist control groups were found across multiple measures...
November 21, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29164443/child-autism-spectrum-disorder-traits-and-parenting-stress-the-utility-of-using-a-physiological-measure-of-parental-stress
#6
Reina S Factor, Deanna M Swain, Angela Scarpa
Caregivers of children with autism spectrum disorder (ASD) report greater stress due to unique parenting demands (e.g.; Estes et al. in Brain Dev 35(2):133-138, 2013). Stress is often studied through self-report and has not been extensively studied using physiological measures. This study compared parenting stress in mothers of children with and without ASD traits. Twenty-seven mother-child dyads participated in an interaction task while measuring mother's heart rate variability (HRV) and mothers self-reported stress levels...
November 21, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29164442/brief-report-checklist-for-autism-spectrum-disorder-most-discriminating-items-for-diagnosing-autism
#7
Susan D Mayes
The smallest subset of items from the 30-item Checklist for Autism Spectrum Disorder (CASD) that differentiated 607 referred children (3-17 years) with and without autism with 100% accuracy was identified. This 6-item subset (CASD-Short Form) was cross-validated on an independent sample of 397 referred children (1-18 years) with and without autism and on data from 1417 children in the CASD standardization sample and 1052 children in the CASD normative sample, resulting in 98.5, 97.6, and 99.8% diagnostic accuracy, respectively...
November 21, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29164441/structure-mapping-in-autism-spectrum-disorder-levels-of-information-processing-and-relations-to-executive-functions
#8
Orit E Hetzroni, Kiril Shalahevich
Analogical reasoning was investigated among children with autism spectrum disorders (ASD) without intellectual disabilities and typical development (TD). Children were asked to select one of two targets in two conditions: (1) with and without spatial structure similarity; (2) with and without a perceptual distractor. Results demonstrate that children with ASD were able to select targets based on structural similarity, but this ability decreased to chance level when presented with a perceptual distractor. Everyday executive functions were positively correlated with structural selections among children with ASD...
November 21, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29164440/parent-and-teacher-concordance-of-child-outcomes-for-youth-with-autism-spectrum-disorder
#9
Kelsey S Dickson, Jessica Suhrheinrich, Sarah R Rieth, Aubyn C Stahmer
Cross-informant ratings of are considered gold standard for child behavioral assessment. To date, little work has examined informant ratings of adaptive functioning for youth with autism spectrum disorder (ASD). In a large, diverse sample of youth with ASD, this study evaluated parent-teacher concordance of ratings of adaptive functioning and ASD-specific symptomatology across time. The impact of child clinical characteristics on concordance was also examined. Participants included 246 children, their caregivers and teachers...
November 21, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29164438/brief-report-mapping-systems-of-support-and-psychological-well-being-of-mothers-of-adolescents-with-autism-spectrum-disorders
#10
Jocelyn Kuhn, Katie Ford, Leann Smith Dawalt
Parents of children with autism spectrum disorders are generally known to experience elevated levels of stress and poorer psychological well-being. To provide treatments and resources that most effectively support parent mental health, it is critical to understand how parents' connections with various networks and systems impact their well-being. This study examined the relationship between the psychological well-being of mothers of adolescents with ASD (n = 20) and their systems of support from an ecological systems theoretical framework...
November 21, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29164437/school-discipline-hospitalization-and-police-contact-overlap-among-individuals-with-autism-spectrum-disorder
#11
Paul Turcotte, Lindsay L Shea, David Mandell
The objective was to examine the frequency, correlates, and overlap of school disciplinary actions, psychiatric hospitalizations, and police contact among children and adolescents with autism. Survey results from 2525 caregivers of individuals with autism in elementary through high school were examined. Logistic regression was used to examine predictors of each outcome. Youth with autism most frequently experienced school disciplinary action (15.0%), followed by police contact (7.9%) and hospitalization (7...
November 21, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29164436/priorities-for-advancing-research-on-youth-with-autism-spectrum-disorder-and-co-occurring-anxiety
#12
Roma A Vasa, Amy Keefer, Judy Reaven, Mikle South, Susan W White
Research on anxiety disorders in youth with autism spectrum disorder (ASD) has burgeoned in the past two decades. Yet, critical gaps exist with respect to measuring and treating anxiety in this population. This study used the nominal group technique to identify the most important research priorities on co-occurring anxiety in ASD. An international group of researchers and clinicians with experience in ASD and anxiety participated in the process. Topics ranked as most important focused on understanding how ASD symptoms affect treatment response, implementing treatments in real world settings, developing methods to disentangle overlapping symptoms between anxiety and ASD, and developing objective measures to assess anxiety...
November 21, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29164435/written-expression-in-individuals-with-autism-spectrum-disorder-a-meta-analysis
#13
Elizabeth Finnegan, Amy L Accardo
Although studies exist measuring the effectiveness of writing interventions for students with autism spectrum disorder (ASD), research assessing the writing skills for this group is sparse. The present study identified differences in the written expression of individuals with ASD compared to typically developing (TD) peers, using variables selected from 13 different studies. Using Pearson Product Moment-correlation the relationship between the quality of research studies and the magnitude of the effect sizes was examined...
November 21, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29163293/adaptation-and-validation-of-the-ados-2-polish-version
#14
Izabela Chojnicka, Ewa Pisula
Autism Diagnostic Observation Schedule (ADOS) is one of the most popular instruments used world-widely in the diagnosis of autism spectrum disorders (ASD). Unfortunately, there are only a few studies of the psychometric properties of non-English language versions of this instrument and none of the adaptation of its second edition (ADOS-2). The objective of this study was to verify the psychometric properties of the Polish version of the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2-PL). The authors recruited 401 participants: 193 with ASDs (ASD group) and 78 with non-spectrum disorders, plus 130 typically developing participants (control group)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29163099/a-computational-analysis-of-neural-mechanisms-underlying-the-maturation-of-multisensory-speech-integration-in-neurotypical-children-and-those-on-the-autism-spectrum
#15
Cristiano Cuppini, Mauro Ursino, Elisa Magosso, Lars A Ross, John J Foxe, Sophie Molholm
Failure to appropriately develop multisensory integration (MSI) of audiovisual speech may affect a child's ability to attain optimal communication. Studies have shown protracted development of MSI into late-childhood and identified deficits in MSI in children with an autism spectrum disorder (ASD). Currently, the neural basis of acquisition of this ability is not well understood. Here, we developed a computational model informed by neurophysiology to analyze possible mechanisms underlying MSI maturation, and its delayed development in ASD...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29162518/ripe-for-solution-delayed-development-of-multisensory-processing-in-autism-and-its-remediation
#16
REVIEW
Shlomit Beker, John J Foxe, Sophie Molholm
Difficulty integrating inputs from different sensory sources is commonly reported in individuals with Autism Spectrum Disorder (ASD). Accumulating evidence consistently points to altered patterns of behavioral reactions and neural activity when individuals with ASD observe or act upon information arriving through multiple sensory systems. For example, impairments in the integration of seen and heard speech appear to be particularly acute, with obvious implications for interpersonal communication. Here, we explore the literature on multisensory processing in autism with a focus on developmental trajectories...
November 18, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29162036/sorafenib-treatment-for-papillary-thyroid-carcinoma-with-diffuse-lung-metastases-in-a-child-with-autism-spectrum-disorder-a-case-report
#17
Yousuke Higuchi, Takayuki Motoki, Hisashi Ishida, Kiichiro Kanamitsu, Kana Washio, Takanori Oyama, Takuo Noda, Yasuko Tsurumaru, Ayumi Okada, Hirokazu Tsukahara, Akira Shimada
BACKGROUND: Pediatric papillary thyroid carcinoma frequently presents with lymph node involvement and distant metastases. Sorafenib, an oral multikinase inhibitor, has been used to treat radioactive iodine (RAI) therapy-refractory thyroid carcinoma in adults; however, pediatric experience is limited. Medical procedures and hospitalization for children with autism spectrum disorder may be challenging. CASE PRESENTATION: An 11-year-old boy with autism spectrum disorder and moderate intellectual impairment presented with dyspnea on exertion with thyroid carcinoma and diffuses lung metastases...
November 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29161772/microarray-analysis-of-gene-expression-in-the-cyclooxygenase-cox-knockout-mice-a-connection-to-autism-spectrum-disorder
#18
Ravneet Rai-Bhogal, Eizaaz Ahmad, Hongyan Li, Dorota A Crawford
The cellular and molecular events that take place during brain development play an important role in governing function of the mature brain. Lipid signalling molecules such as prostaglandin E2 (PGE2 ) play an important role in healthy brain development. Abnormalities along the COX/PGE2 signalling pathway due to genetic or environmental causes have been linked to Autism Spectrum Disorders (ASDs). This study aims to evaluate the effect of altered COX/PGE2 signalling on development and function of the prenatal brain using male mice lacking cyclooxygenase-1 and -2 (COX-1(-/-) and COX-2(-/-) ) as potential model systems of ASD...
November 21, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29161222/perspectives-of-mothers-of-transgender-and-gender-nonconforming-children-with-autism-spectrum-disorder
#19
Katherine A Kuvalanka, Derek J Mahan, Jenifer K McGuire, Tracey K Hoffman
This study represents findings from interviews at two time points with three mothers of transgender and gender-nonconforming (TGNC) children (ages eight to 12 years at T1) with autism spectrum disorder (ASD). Of interest was the mothers' experiences of raising a TGNC child with ASD, and whether/how the children's autism played a role in their understandings of their children's gender identities and expressions. The mothers' fear of a transphobic/cisnormative society and wondering about whether their children's ASD influenced or caused their children's gender variance were barriers to fully embracing their children's gender nonconformity...
November 21, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/29161137/pragmatic-competence-of-children-with-autism-spectrum-disorder-impact-of-theory-of-mind-verbal-working-memory-adhd-symptoms-and-structural-language
#20
Inmaculada Baixauli-Fortea, Ana Miranda Casas, Carmen Berenguer-Forner, Carla Colomer-Diago, Belén Roselló-Miranda
The primary aim of this study is to increase the existing knowledge about the pragmatic skills of children with autism spectrum disorders (ASD). Specifically, the study has two objectives. The first is to provide a profile of characteristics based on The Children's Communication Checklist (CCC-2) pragmatics scales (inappropriate initiation, stereotyped language, use of context, nonverbal communication, and general pragmatics) and narrative task indicators. To this end, children with ASD will be compared to children with typical development (TD), controlling the effects of sex and structural language (speech, syntax, semantics, coherence)...
November 21, 2017: Applied Neuropsychology. Child
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