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https://www.readbyqxmd.com/read/30335246/characterization-of-potential-drug-drug-interactions-in-patients-hospitalized-in-the-intensive-care-unit-of-a-tertiary-hospital-in-bogot%C3%A3
#1
Marcela Hernández, Gabriel Tribiño, Carlos Bustamante
Introduction: Drug-drug interactions occur more frequently in intensive care units than in other services. However, in Colombia, there are few studies on this problem in critically ill patients. Objectives: To characterize potential drug-drug interactions generated from prescriptions during hospitalization in an intensive care unit and to determine factors associated with their onset. Materials and methods: A retrospective cohort was assembled with patients hospitalized in an intensive care unit for a seven-month period...
September 1, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/30335218/coffee-ring-inspired-approach-toward-oriented-self-assembly-of-biomimetic-murray-mofs-as-sweat-biosensor
#2
Zhengyun Wang, Ting Liu, Yang Yu, Muhammad Asif, Ning Xu, Fei Xiao, Hongfang Liu
The emergence of metal-organic frameworks (MOFs) has sparked intensive attention and opened up the possibility of "crystal engineering." However, low conductivity, slow diffusion of guest molecules, as well as powder forms always hinder the development of MOF application, especially for biosensors and bioelectronics. Herein, a coffee ring-inspired strategy toward oriented self-assembly of a biomimetic MOF film following Murray's law is proposed, which can effectively reduce the transfer resistance...
October 18, 2018: Small
https://www.readbyqxmd.com/read/30335167/homodimerization-regulates-an-endothelial-specific-signature-of-the-sox18-transcription-factor
#3
Mehdi Moustaqil, Frank Fontaine, Jeroen Overman, Alex McCann, Timothy L Bailey, Paulina Rudolffi Soto, Akshay Bhumkar, Nichole Giles, Dominic J B Hunter, Yann Gambin, Mathias Francois, Emma Sierecki
During embryogenesis, vascular development relies on a handful of transcription factors that instruct cell fate in a distinct sub-population of the endothelium (1). The SOXF proteins that comprise SOX7, 17 and 18, are molecular switches modulating arterio-venous and lymphatic endothelial differentiation (2,3). Here, we show that, in the SOX-F family, only SOX18 has the ability to switch between a monomeric and a dimeric form. We characterized the SOX18 dimer in binding assays in vitro, and using a split-GFP reporter assay in a zebrafish model system in vivo...
October 18, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/30335160/multiple-rna-rna-tertiary-interactions-are-dispensable-for-formation-of-a-functional-u2-u6-rna-catalytic-core-in-the-spliceosome
#4
Penghui Bao, Kum-Loong Boon, Cindy L Will, Klaus Hartmuth, Reinhard Lührmann
The active 3D conformation of the spliceosome's catalytic U2/U6 RNA core is stabilised by a network of secondary and tertiary RNA interactions, but also depends on spliceosomal proteins for its formation. To determine the contribution towards splicing of specific RNA secondary and tertiary interactions in the U2/U6 RNA core, we introduced mutations in critical U6 nucleotides and tested their effect on splicing using a yeast in vitro U6 depletion/complementation system. Elimination of selected RNA tertiary interactions involving the U6 catalytic triad, or deletions of the bases of U6-U80 or U6-A59, had moderate to no effect on splicing, showing that the affected secondary and tertiary interactions are not required for splicing catalysis...
October 18, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/30335145/genome-sequence-of-the-wheat-stem-sawfly-cephus-cinctus-representing-an-early-branching-lineage-of-the-hymenoptera-illuminates-evolution-of-hymenopteran-chemoreceptors
#5
Hugh M Robertson, Robert M Waterhouse, Kimberly K O Walden, Livio Ruzzante, Maarten J M F Reijnders, Brad S Coates, Fabrice Legeai, Joanna C Gress, Sezgi Biyiklioglu, David K Weaver, Kevin W Wanner, Hikmet Budak
The wheat stem sawfly, Cephus cinctus, is a major pest of wheat and key ecological player in the grasslands of western North America. It also represents the distinctive Cephoidea superfamily of sawflies (Symphyta) that appeared early during the hymenopteran radiation, but after three early-branching eusymphytan superfamilies that form the base of the order Hymenoptera. We present a high-quality draft genome assembly of 162 Mbp in 1,976 scaffolds with a scaffold N50 of 622 kbp. Automated gene annotation identified 11,210 protein-coding gene models and 1,307 non-coding RNA models...
October 18, 2018: Genome Biology and Evolution
https://www.readbyqxmd.com/read/30335115/in-situ-synthesis-of-ultrafine-metal-clusters-triggered-by-dodecaborate-supramolecular-organic-frameworks
#6
Bin Qi, Xin Li, Liang Sun, Bo Chen, Hao Chen, Chenchen Wu, Haibo Zhang, Xiaohai Zhou
Supramolecular nano-assemblies with tunable morphology have attracted extensive attention in composite material manufacturing and many other fields. Herein, a new class of shape-controlled dodecaborate-based supramolecular organic frameworks (BOFs), decorated with diverse ultrafine noble metal clusters (Au, Pd, Pt, Ag), has been successfully fabricated via the tunable host-guest assembly of cucurbit[n = 5,6,7,8]uril and Cs2[closo-B12H12]. Due to the unique dodecaborate-cucurbit[n]uril chaotropic effect, a breakthrough has been made in modulating the supramolecular frameworks in the urchin-like, network-like or octahedron-like structures without tedious chemical modifications or additional additives...
October 18, 2018: Nanoscale
https://www.readbyqxmd.com/read/30335096/preparation-of-cross-linked-supramolecular-polymers-based-on-benzo-21-crown-7-secondary-ammonium-salt-host-guest-interactions
#7
Xing Li, Li Wang, Yan Deng, Zheng Luo, Qiao Zhang, Shengyi Dong, Chengyou Han
We found that TC7 not only self-assembles into one-dimensional supramolecular aggregates in chloroform, but also forms cross-linked supramolecular polymers via host-guest complexation between benzo-21-crown-7 and secondary ammonium salts. Compared with one-dimensional linear supramolecular polymers, soft and long viscous fibers were pulled out from a concentrated solution of cross-linked supramolecular polymers as a result of higher viscosity and lower diffusion coefficients.
October 18, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/30335094/cellular-internalization-of-polypeptide-based-nanoparticles-effects-of-size-shape-and-surface-morphology
#8
Jiaxiao Xue, Zhou Guan, Xingyu Zhu, Jiaping Lin, Chunhua Cai, Xiao Jin, Yongsheng Li, Zhaoyang Ye, Wenjie Zhang, Xinquan Jiang
Nanoparticles (NPs) can be taken up by cells; however, the effects of the structural characteristics of NPs on their cellular internalization have not been well explored. In this work, cellular internalization performances of various NPs including rods with helical surface (helical rods), spheres with stripe-pattern surface (striped spheres), and spheres with smooth surface (smooth spheres) were investigated by a combination of experiments and theoretical simulations. This study focuses on the effects of the size, shape, and surface morphology on their cellular internalization behaviors...
October 18, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/30334805/mec-misassembly-error-correction-in-contigs-based-on-distribution-of-paired-end-reads-and-statistics-of-gc-contents
#9
Binbin Wu, Min Li, Xingyu Liao, Junwei Luo, Fangxiang Wu, Yi Pan, Jianxin Wang
The de novo assembly tools aim at reconstructing genomes from next-generation sequencing (NGS) data. However, the assembly tools usually generate a large amount of contigs containing many misassemblies, which are caused by problems of repetitive regions, chimeric reads and sequencing errors. As they can improve the accuracy of assembly results, detecting and correcting the misassemblies in contigs are appealing, yet challenging. In this study, a novel method, called MEC, is proposed to identify and correct misassemblies in contigs...
October 18, 2018: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/30334665/primary-nonanaplastic-peripheral-natural-killer-t-cell-lymphoma-in-pediatric-patients-an-unusual-distribution-pattern-of-subtypes
#10
Adam C Wilberger, Xiayuan Liang
Peripheral NK/T-cell lymphoma (PNKTCL) represents a group of uncommon diagnoses for children in Western countries, and studies have often necessitated multiple institutions to assemble enough cases. We retrospectively analyzed 11 cases of nonanaplastic PNKTCL in children over 19 years at our institution with comparison to several published large multi-institutional studies. Patients included 9 males and 2 females of white (5), Native American (3), and Hispanic (3) background with 6 cases of extranodal NK/T-cell lymphoma, nasal type (EN-NKTL, 54...
October 18, 2018: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/30334344/bringing-darkness-to-light-intrinsic-disorder-as-a-means-to-dig-into-the-dark-proteome
#11
EDITORIAL
Vladimir N Uversky
Articles assembled to this Special Issue use the perspective of protein intrinsic disorder to highlight different aspects of the dark proteome (i.e., a part of protein universe that includes proteins, which are not amenable to experimental structure determination by existing means and inaccessible to homology modeling) and some of its components. They illustrate that IDPs/IDPRs do not only serve as important constituents of the biological dark matter, but clearly act as the dark horse of the protein universe, being almost completely unknown or at least very little known in a recent past, but suddenly emerging to prominence...
October 18, 2018: Proteomics
https://www.readbyqxmd.com/read/30334325/dynamic-covalent-self-assembly-based-on-oxime-condensation
#12
Libo Shen, Ning Cao, Lu Tong, Xinjiang Zhang, Guangcheng Wu, Tianyu Jiao, Qi Yin, Yuanjiang Pan, Hao Li
Oxime, whose dynamic nature was reported to be switchable between ON/OFF by tuning the acidity, could be employed as a novel type of dynamic covalent approach that is amenable to use in water for self-assembly of purely organic molecules. In strong-acidic conditions, the dynamic nature of oxime is turned ON, allowing occurrence of error-checking and therefore a catenane and a macrocycle were successfully self-assembled in high yields. In neutral conditions, oxime becomes an irreversible bond, which helps to trap the self-assembled products...
October 18, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/30334293/novel-triindolo-truxene-derivatives-design-synthesis-and-fine-tuning-of-electronic-properties-and-molecular-assembly-through-molecular-engineering
#13
Jun-Bo Chen, Cen Zhou, Ru-Qiang Lu, Xin-Chang Wang, Hang Qu, Mithu Saha, Hao-Liang Liu, Hui Zhang, Xiao-Yu Cao
Triindolo-truxene, a C3-symmetric molecule with a large π-conjugated plane, has six methylene carbon atoms and three aromatic carbon atoms which can be facilely functionalized. Herein, we introduce butyl, carbonyl, cyano, and/or malononitrile groups into six methylene carbon atoms (6-, 14-, 22-, or 8-, 16-, 24-positions) and/or three aromatic carbon atoms (2-, 10-, and 18-positions) of triindolo-truxene to produce eight derivatives. Their photophysical and electrochemical properties, and molecular assembly can be effectively modulated by substituents and substitution patterns...
October 17, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/30334276/stethoscope-of-the-21st-century-dominant-discourses-of-ultrasound-in-medical-education
#14
Zac Feilchenfeld, Ayelet Kuper, Cynthia Whitehead
CONTEXT: In recent years, point-of-care ultrasound (POCUS) has become a widely used clinical tool in a number of clinical specialties. In response, POCUS has been incorporated into medical curricula across the learning continuum, bolstered by enthusiastic appraisals of the technology's benefits for learners, clinicians and patients. In this project, we have sought to identify and understand the effects of dominant discourses influencing the integration of POCUS into medical education...
October 18, 2018: Medical Education
https://www.readbyqxmd.com/read/30334054/a-coordination-polymer-derived-co-3-o-4-co-n-nmc-composite-material-as-a-zn-air-battery-cathode-electrocatalyst-and-microwave-absorber
#15
Yaqin Wang, Xinxin Xu, Luyao Liu, Jin Chen, Guimei Shi
Zn-air batteries, promising energy storage equipment with high energy density, light weight and a compact structure, are a perfect power source for electric vehicles. For a Zn-air battery, the activity of the air cathode electrocatalyst plays an important role in its performance. Here, employing a coordination polymer as a precursor, a composite material built from Co3O4 and Co-N active centres with nitrogen-doped mesoporous carbon as a matrix has been synthesized successfully. This composite material possesses outstanding activity and stability in the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) processes...
October 18, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/30334046/sodium-carbonate-promoted-3-2-annulation-of-%C3%AE-halohydroxamates-and-isocyanates
#16
Shaofa Sun, Rongxing Chen, Gangqiang Wang, Jian Wang
A new [3 + 2] annulation of readily available α-halohydroxamates and isocyanates has been developed. This protocol allows a rapid assembly of various hydantoins in good to high yields as well as a broad substrate scope and good functional group tolerance.
October 18, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/30334025/early-transition-metal-catalyzed-c-h-alkylation-hydroaminoalkylation-for-c-sp-3-c-sp-3-bond-formation-in-the-synthesis-of-selectively-substituted-amines
#17
P M Edwards, L L Schafer
Hydroaminoalkylation is a 100% atom economic method for forming Csp3-Csp3 bonds through C-H activation α to an amine and subsequent reaction with an alkene. When catalyzed by early transition metals, this reaction allows for alternative disconnections for the synthesis of structurally complex amines. This method avoids the installation of protecting groups or directing groups and does not require added oxidants, or photoredox catalysts. In this feature article, we discuss the various selectively substituted amines that can be accessed by hydroaminoalkylation, with a special focus on the development of early transition metal catalysts for their rapid, step and atom efficient assembly...
October 18, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/30333992/shaping-nanoparticle-fingerprints-at-the-interface-of-cholesteric-droplets
#18
Lisa Tran, Hye-Na Kim, Ningwei Li, Shu Yang, Kathleen J Stebe, Randall D Kamien, Martin F Haase
The ordering of nanoparticles into predetermined configurations is of importance to the design of advanced technologies. Here, we balance the interfacial energy of nanoparticles against the elastic energy of cholesteric liquid crystals to dynamically shape nanoparticle assemblies at a fluid interface. By adjusting the concentration of surfactant that plays the dual role of tuning the degree of nanoparticle hydrophobicity and altering the molecular anchoring of liquid crystals, we pattern nanoparticles at the interface of cholesteric liquid crystal emulsions...
October 2018: Science Advances
https://www.readbyqxmd.com/read/30333991/quantum-interference-mediated-vertical-molecular-tunneling-transistors
#19
Chuancheng Jia, Marjan Famili, Marco Carlotti, Yuan Liu, Peiqi Wang, Iain M Grace, Ziying Feng, Yiliu Wang, Zipeng Zhao, Mengning Ding, Xiang Xu, Chen Wang, Sung-Joon Lee, Yu Huang, Ryan C Chiechi, Colin J Lambert, Xiangfeng Duan
Molecular transistors operating in the quantum tunneling regime represent potential electronic building blocks for future integrated circuits. However, due to their complex fabrication processes and poor stability, traditional molecular transistors can only operate stably at cryogenic temperatures. Here, through a combined experimental and theoretical investigation, we demonstrate a new design of vertical molecular tunneling transistors, with stable switching operations up to room temperature, formed from cross-plane graphene/self-assembled monolayer (SAM)/gold heterostructures...
October 2018: Science Advances
https://www.readbyqxmd.com/read/30333951/high-throughput-sequencing-analysis-of-euphorbia-fischeriana-steud-provides-insights-into-the-molecular-mechanism-of-pharmaceutical-ingredient-biosynthesis
#20
Ming Jiang, Hui Li
High-throughput sequencing is an effective approach to analyse the bioinformation on the molecular biological and whole genome levels, especially in non-model plants for which reference genome sequences are unavailable. In this study, high-throughput sequencing analysis of Euphorbia fischeriana Steud was conducted on the Illumina HiSeq 2000 platform. A total of 9,6481,893 raw reads were generated and assembled into 304,217 transcripts and 186,384 unigenes. Of the 186,384 unigenes, 77.45% were annotated in at least one database, and some pathways involved in the biosynthesis of the terpenoid backbone were closely linked to the main anticancer components...
October 2018: 3 Biotech
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