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Toxic nodular goiter

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https://www.readbyqxmd.com/read/30048169/unknown-and-already-known-thyroid-abnormalities-in-primary-hyperparathyroidism
#1
Adele Latina, Elena Castellano, Flora Cesario, Alberto Boriano, Roberto Attanasio, Giorgio Borretta
OBJECTIVE: Primary hyperparathyroidism (PHPT) and thyroid diseases are highly prevalent in the general population, but the putative link between the 2 conditions remains unclear. METHODS: A monocentric consecutive series of 434 patients with PHPT was retrospectively evaluated by lab and ultrasonography to look for thyroid abnormalities. Patients were classified in 3 groups: without thyroid abnormalities (group 1, n = 171), with thyroid diseases not previously known (group 2a, n = 69), and thyroid diseases previously known (group 2b, n = 194)...
July 2018: Endocrine Practice
https://www.readbyqxmd.com/read/30039748/patients-with-benign-thyroid-diseases-experience-an-impaired-sex-life
#2
Nadia Sawicka-Gutaj, Marek Ruchala, Ulla Feldt-Rasmussen, Ase Krogh Rasmussen, Laszlo Hegedus, Steen Joop Bonnema, Mogens Groenvold, Jakob Bue Bjorner, Torquil Watt
BACKGROUND: This study aimed to describe the frequency of self-reported thyroid-related impaired sex life in patients with thyroid diseases, to examine its clinical correlates and relationship with overall quality of life (QOL), and to investigate the effect of treatment. PATIENTS AND METHODS: Two separate patient samples with benign thyroid diseases were investigated: a cross-sectional sample (759 women and 118 men) treated at two Danish university hospital outpatient clinics, in 2007-2008, and a longitudinal sample (358 women and 74 men) undergoing treatment at the abovementioned centers, during 2008-2012, evaluated before and 6 months after therapy...
July 24, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29968224/therapeutic-plasmapheresis-in-thyrotoxic-patients
#3
Ilgin Yildirim Simsir, Murat Ozdemir, Soner Duman, Mehmet Erdogan, Ayhan Donmez, Ahmet Gokhan Ozgen
PURPOSE: For the treatment of thyrotoxicosis, alternative treatment modalities may be necessary if anti-thyroid drugs cannot be used due to side effects, inefficiencies, or there is a need to start a rapid action such as thyroid storm. By using therapeutic plasma exchange (TPE), it is possible to effectively and rapidly remove the increased thyroid hormones. We evaluated our results and experience on a rapid, effective, and reliable alternative treatment modality in thyrotoxic patients...
July 2, 2018: Endocrine
https://www.readbyqxmd.com/read/29872340/incidental-thyroid-carcinoma-in-surgery-treated-hyperthyroid-patients-with-graves-disease-a-systematic-review-and-meta-analysis-of-cohort-studies
#4
Qingyi Jia, Xiaodan Li, Ying Liu, Ling Li, Joey Sw Kwong, Kaiyun Ren, Yong Jiang, Xin Sun, Haoming Tian, Sheyu Li
Background: The association between Graves' disease (GD) and thyroid carcinoma remains controversial. This study aimed to investigate incidental thyroid carcinoma (ITC) in surgery-treated hyperthyroid patients with and without GD. Materials and methods: We searched PubMed and EMBASE for cohort studies investigating ITC in surgery-treated hyperthyroid patients without prediagnosed thyroid carcinoma in accordance with the Meta-Analysis of Observational Studies in Epidemiology guidelines...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29688762/the-trends-of-hyperthyroidism-treatment-in-taiwan-a-nationwide-population-based-study
#5
Edy Kornelius, Yi-Sun Yang, Chien-Ning Huang, Yu-Hsun Wang, Shih-Chang Lo, Yung-Rung Lai, Jeng-Yuan Chiou
OBJECTIVE: Few studies on hyperthyroidism treatment have been reported in the past 3 decades. We used a nationwide population-based database to evaluate the current practices and management of hyperthyroidism in Taiwan. METHODS: This retrospective study included a random selection of 1 million people in Taiwan between 2004 and 2010. We identified patients with hyperthyroidism who received antithyroid drugs (ATD), radioactive iodine (RAI), or surgery. We calculated the proportions and treatment trends of those 3 treatment options annually...
June 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29546048/changes-of-nicotinamide-phosphoribosyltransferase-expressions-in-thyroid-glands-of-patients-with-different-thyroid-pathologies
#6
Nadia Sawicka-Gutaj, Mirosław Andrusiewicz, Agata Czarnywojtek, Joanna Waligórska-Stachura, Maciej Biczysko, Jerzy Skrobisz, Jerzy Sowiński, Marek Ruchała
Purpose: Our aim was to analyze NAMPT expression in thyroid tissue derived from patients with Graves' disease with (GD) and without (GO) orbitopathy, patients with toxic nodular goiters (TNG) and thyroid cancers (TC), and healthy controls. Methods: 153 thyroid tissue samples of consecutive patients who underwent thyroidectomy were collected. Previous therapy with steroids was an exclusion criterion. We collected clinicopathological data of all subjects and we assessed NAMPT expression using qPCR...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29504626/red-cell-distribution-width-a-new-marker-for-exacerbation-of-heart-failure-in-patients-with-hypothyroidism-following-radioiodine-therapy
#7
Agata Czarnywojtek, Nadia Sawicka-Gutaj, Izabela Miechowicz, Magdalena Borowska, Kosma Woliński, Maria Teresa Płazińska, Ariadna Zybek-Kocik, Ewa Straburzyńska-Migaj, Małgorzata Zgorzalewicz-Stachowiak, Aleksandra Hernik, Ewelina Szczepanek-Parulska, Marek Ruchała
INTRODUCTION: Cardiovascular diseases constitute a major cause of health problems and death in developed countries across the world. The increased value of the index of distribution of red blood cells volume (RDW) may be a prognostic marker in patients diagnosed with chronic heart failure (CHF). Hypothyroid patients present higher RDW values if compared to healthy controls. Taking into consideration that RDW might be both affected by thyroid status and CHF, we decided to determine the effect of concomitant hypothyroidism following radioiodine therapy (RIT) and CHF on hematological parameters...
2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29409365/a-single-session-of-laser-ablation-for-toxic-thyroid-nodules-three-year-follow-up-results
#8
Giovanni Gambelunghe, Elisa Stefanetti, Renato Colella, Massimo Monacelli, Nicola Avenia, Pierpaolo De Feo
PURPOSE: To confirm the effectiveness of laser ablation on toxic nodules in a large population with three years of follow-up. MATERIAL AND METHODS: Between 2009 and 2014, we treated 82 patients with hyperthyroidism related to the presence of a toxic nodular goitre. Patients were pre-treated pharmacologically with methimazole prior to single session of laser ablation (LA) and then followed up every 3 months with FT4 and TSH blood tests as well as ultrasound examination of the nodules treated...
August 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29198022/hyperthyroid-patients-without-graves-orbitopathy-are-not-at-increased-risk-of-developing-glaucoma-a-nationwide-danish-register-based-case-control-study
#9
F Brandt, M Thvilum, L Hegedüs, T H Brix
PURPOSE: Graves' disease (GD) and toxic nodular goiter (TNG) are associated with various comorbidities. However, it is unclarified whether TNG and GD without orbitopathy are associated with glaucoma. METHODS: This was a case-control study using record-linkage data from nationwide Danish health registers. 28,461 patients with GD and 17,283 with TNG were included. Each case was age and sex matched with four non-hyperthyroid controls and followed over a mean period of 8 years...
January 2018: Endocrine
https://www.readbyqxmd.com/read/29159003/toxic-adenoma-in-a-patient-with-thyroid-hemiagenesis
#10
Emin Gurleyik, Sami Dogan, Fuat Cetin, Fatih Gursoy, Alper M Ipor
Thyroid hemiagenesis (TH) is a rare congenital anomaly that is usually asymptomatic. Functional disorders of the thyroid make the patient symptomatic. TH is usually and incidentally established during evaluation of patients with symptomatic thyroid pathology. We report the case of a patient of TH who became symptomatic with hyperactivity of the gland. The patient presented with signs and symptoms of thyrotoxicosis. Physical examination revealed asymmetric nodular goiter at the right lobe. Biochemical analysis established the diagnosis of hyperthyroidism...
September 17, 2017: Curēus
https://www.readbyqxmd.com/read/29151324/thyroid-malignancy-risk-in-different-clinical-thyroid-diseases
#11
Ahmet Dirikoç, Sevgül Fakı, Hüsniye Başer, Didem Özdemir, Cevdet Aydın, Reyhan Ersoy, Mehmet Kılıç, Aydan Kılıçarslan, Bekir Çakır
Background/aim: To evaluate the malignancy risk of thyroid nodules in different clinical thyroid diseases. Materials and methods: Patients who underwent thyroidectomy between 2007 and 2014 were grouped as euthyroid, hypothyroid, and hyperthyroid. Further classification was made depending on the presence of solitary/multiple thyroid nodules. Results: Among 2870 patients, 1719 (59.9%) were euthyroid, 962 (33.5%) were hyperthyroid, and 189 (6.6%) were hypothyroid. Overall malignancy was detected in 980 (34.1%) patients...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28957603/the-cardiovascular-system-in-type-2-diabetes-mellitus-and-thyroid-disorders-in-the-absence-of-thyroid-gland-dysfunction
#12
M F Ballyizek, Ignat'eva Pa
The state of the cardiovascular system was studied in patients with type 2 diabetes mellitus and thyroid disorders in the absence of thyroid gland dysfunction. 76.9% of the 302 patients with DM2 had thyroid pathology; in 23,8% it was not previously diagnosed. We compared euthyroid patients with DM2 without thy'ropathies and with diffuse-nodular changes largely in the form of difuse- multinodular non-toxic goiter and autoinnnune thyroiditis (AIT). It was demonstrated that enhanced frequency of thyroid disorders is related to DM2 duration and vascular complications...
2016: Klinicheskaia Meditsina
https://www.readbyqxmd.com/read/28729915/the-concomitant-association-of-thyroid-disorders-and-myasthenia-gravis
#13
Yu-Pei Lin, Usman Iqbal, Phung-Anh Nguyen, Md Mohaimenul Islam, Suleman Atique, Wen-Shan Jian, Yu-Chuan Jack Li, Chen-Ling Huang, Chung-Huei Hsu
BACKGROUND: Some of the thyroid disorders (TD) and Myasthenia gravis (MG) are autoimmune related disease. The purpose of the study to evaluate the relationship of MG with all morphological and functional thyroid disorders. METHODS: We constructed a population-based cohort study during the period from January 2000-December 2002 by using reimbursement data from the Bureau National Health Insurance (NHI) system in Taiwan. Patients with TD and MG were identified by referring to the ICD-9-CM codes...
2017: Translational Neuroscience
https://www.readbyqxmd.com/read/28671443/subclinical-hyperthyroidism-when-to-consider-treatment
#14
REVIEW
Ines Donangelo, Se Young Suh
Subclinical hyperthyroidism is defined by a low or undetectable serum thyroid-stimulating hormone level, with normal free thyroxine and total or free triiodothyronine levels. It can be caused by increased endogenous production of thyroid hormone (e.g., in Graves disease, toxic nodular goiter, or transient thyroiditis), by administration of thyroid hormone to treat malignant thyroid disease, or by unintentional excessive replacement therapy. The prevalence of subclinical hyperthyroidism in the general population is about 1% to 2%; however, it may be higher in iodinedeficient areas...
June 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28572231/thyrotoxicosis-investigation-and-management
#15
REVIEW
Jackie Gilbert
Graves' disease (GD) and toxic nodular (TN) goitre account for most cases of thyrotoxicosis associated with hyperthyroidism. Hyperthyroidism is confirmed with measurement of a suppressed serum thyrotropin concentration (TSH) and elevated free thyroid hormones. The three therapeutic options are antithyroid drugs, radioactive iodine and surgery. Thionamides achieve long-term remission in 35% of cases. Many centres administer fixed doses of iodine-131; larger doses result in improved rates of cure at the cost of hypothyroidism...
June 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28471268/increased-cardiovascular-mortality-and-morbidity-in-patients-treated-for-toxic-nodular-goiter-compared-to-graves-disease-and-nontoxic-goiter
#16
Peter Giesecke, Mårten Rosenqvist, Viveka Frykman, Leif Friberg, Göran Wallin, Jonas Höijer, Stefan Lönn, Ove Törring
BACKGROUND: Previous research has suggested an increased risk of death and cardiovascular disease in patients treated for hyperthyroidism. However, studies on this subject are heterogeneous, often based on old data, or have not considered the impact that treatment for hyperthyroidism might have on cardiovascular risk. It is also unclear whether long-term prognosis differs between Graves' disease and toxic nodular goiter. The aim of this study was to use a very large cohort built on recent data to assess whether improvements in cardiovascular care might have changed the prognosis over time...
July 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28025831/new-daily-persistent-headache-caused-by-a-multinodular-goiter-and-headaches-associated-with-thyroid-disease
#17
Randolph W Evans, Josefine S Timm
A 33-year-old female is presented with the first case to our knowledge of new daily persistent headache (NDPH) with a large right benign non-toxic multinodular goiter causing carotid and vertebral compression with complete resolution of the headache immediately after thyroidectomy. Although this may be quite rare, hypothyroidism or hyperthyroidism causing NDPH, migraine, or an exacerbation of pre-existing migraine is not. Clinicians should consider routinely obtaining serum thyroid-stimulating hormone (TSH) and free T4 in patients with new onset frequent headaches or an exacerbation of prior primary headaches...
February 2017: Headache
https://www.readbyqxmd.com/read/27703446/a-novel-germline-mutation-of-keap1-r483h-associated-with-a-non-toxic-multinodular-goiter
#18
Eijun Nishihara, Akira Hishinuma, Takahiko Kogai, Nami Takada, Mitsuyoshi Hirokawa, Shuji Fukata, Mitsuru Ito, Tomonori Yabuta, Mitsushige Nishikawa, Hirotoshi Nakamura, Nobuyuki Amino, Akira Miyauchi
BACKGROUND: A germline mutation of KEAP1 gene was reported as a novel genetic abnormality associated with familial multinodular goiter. That report was limited, and the pathogenic features were not well established. PATIENT FINDINGS: We report a 47-year-old Japanese woman who presented with hyperthyroidism and a large multinodular goiter. The family history was notable for a paternal history of goiter. Graves' disease was diagnosed based on positive TRAb, but scintiscan imaging showed that the patient's radioiodine uptake was restricted in the non-nodular areas, indicating largely cold nodules...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27529890/graves-disease-induced-by-radioiodine-therapy-for-toxic-nodular-goiter-a-case-report
#19
Yakup Yürekli, Arzu Cengiz, Engin Güney
Graves' disease (GD) may be observed as an infrequent adverse effect after radioiodine therapy (RAIT) for toxic thyroid adenoma (TA) and toxic multi nodular goiter (MNG). We present a case of a 55-year-old male with a toxic nodule who was treated with RAI. After therapy, the patient's serum free triiodothyronine (fT3) and free thyroxine (fT4) levels gradually increased. Antithyroid peroxidase (TPOAb), antithyroglobulin (TgAb) and TSH-receptor antibodies (TRAb) were also positive. Thyroid scintigraphy revealed diffuse intense uptake after four months of RAIT...
October 5, 2015: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/27529884/effectiveness-of-radioiodine-treatment-for-toxic-nodular-goiter
#20
Hatice Şakı, Arzu Cengiz, Yakup Yürekli
OBJECTIVE: The aim of this retrospective study is to evaluate the treatment outcomes in patients with toxic nodular goiter (TNG) that received radioiodine treatment (RAIT) and to determine the influence of age, gender, nodule size, I-131 dose, underlying etiology and antithyroid drugs on the outcomes of RAIT. METHODS: Two hundred thirty three patients (mean 64±10 years old) with TNG that received RAIT were included in the study. Treatment success was analyzed according to demographic (age and gender) and clinical data (thyroid function tests before and after RAIT, thyroid sonography and scintigraphy, I-131 dose, antithyroid drugs)...
October 5, 2015: Molecular Imaging and Radionuclide Therapy
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