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Hiroki Yoshioka, Tsunemasa Nonogaki, Shiori Fukaya, Yoshimi Ichimaru, Akito Nagatsu, Masae Yoshikawa, Hirohisa Fujii, Makoto Nakao
BACKGROUND: The current study aimed to investigate the hepatoprotective effects of Sasa veitchii extract (SE) on carbon tetrachloride (CCl4 )-induced liver fibrosis in mice. METHODS: Male C57BL/6J mice were intraperitoneally injected with CCl4 dissolved in olive oil (1 g/kg) twice per week for 8 weeks. SE (0.1 mL) was administered orally once per day throughout the study, and body weight was measured weekly. Seventy-two hours after the final CCl4 injection, mice were euthanized and plasma samples were collected...
October 15, 2018: Environmental Health and Preventive Medicine
Safa Ali Ahmed Amar, Recep Eryilmaz, Halit Demir, Serdar Aykan, Canan Demir
In this study, the antioxidant enzyme activities such as (SOD, GSH, and CAT) and malondialdehyde (MDA) level which is the end product of lipid peroxidation, were determined from the serum samples taken from patients diagnosed with prostate cancer Van Yuzuncu Yıl University Medical Faculty of Educational Research and Training Hospital and İstanbul Bagcilar Education Research Hospital. The SOD, GSH, and CAT activity of patient groups was found significantly lower than the healthy control group in patients with prostate cancer (p < ...
October 15, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
Maria Elena González-Fraguela, Lisette Blanco-Lezcano, Caridad Ivette Fernandez-Verdecia, Teresa Serrano Sanchez, Maria de Los A Robinson Agramonte, Lidia Leonor Cardellá Rosales
The purpose of the present study is to access the linkage between dysregulation of glutamatergic neurotransmission, oxidative metabolism, and serine signaling in age-related cognitive decline. In this work, we evaluated the effect of natural aging in rats on the cognitive abilities for hippocampal-dependent tasks. Oxidative metabolism indicators are glutathione (GSH), malondialdehyde (MDA) concentrations, and cytosolic phospholipase A₂ (PLA₂) activity. In addition, neurotransmitter amino acid ( L -Glutamic acid, γ-aminobutyric acid (GABA), DL -Serine and DL -Aspartic acid) concentrations were studied in brain areas such as the frontal cortex (FC) and hippocampus (HPC)...
October 13, 2018: Behavioral Sciences
Can Zhao, Jing Jiang, Yong-Liang Wang, Yong-Quan Wu
Ischemic heart disease is widely considered as a major health threat, which causes a high number of deaths every year worldwide. Much evidence has shown that oxidative stress (OS) is implicated in the pathogenesis of ischemia-reperfusion injury (IRI). This study aims to evaluate the effect of miR-590-3p on the OS of IRI mice through the nuclear factor kappa-B (NF-κB) signaling pathway by targeting receptor-interacting protein kinase 1 (RIPK1). IRI mouse models were established for extracting myocardial tissues and isolating myocardial cells...
October 15, 2018: Journal of Cellular Biochemistry
En-Hui Yi, Feng Xu, Peng Li, Jian-Qiang Guo
Oxidative damage is believed to contribute to the pathogenesis of diabetic retinopathy (DR). The current study aimed to detect the effects of transactive response DNA binding protein of 43 (TDP-43) on cell damage induced by hydrogen peroxide (H2 O2 ) in retinal ganglion cells (RGCs) and to investigate the molecular mechanisms involved in this process. We observed that TDP-43 was highly expressed in RGC-5 cells induced by H2 O2 , and that repression of TDP-43 obviously ameliorated H2 O2 -induced RGC-5 cell injury...
October 15, 2018: Journal of Cellular Biochemistry
Yanqing Wu, Yiyang Li, Ting Jiang, Yuan Yuan, Rui Li, Zeping Xu, Xingfeng Zhong, Gaili Jia, Yanlong Liu, Ling Xie, Ke Xu, Hongyu Zhang, Xiaokun Li, Jian Xiao
Diabetic nephropathy (DN) is one of general and common complication of diabetes, which severely affects the physical and mental health of diabetic patients. Fibroblast growth factor 1 (FGF1), an effective control agent of blood glucose, plays an effective treatment role on diabetes-induced renal injury. But the specific molecule mechanism underlying it is still unclear. Since induction of cellular stress is the main and common mechanism of diabetes-induced complication, we hypothesized that reduction of cellular stress is also the molecular mechanism of FGF1 treatment for DN...
October 15, 2018: Journal of Cellular and Molecular Medicine
Jinrong Fu, Jinjing Zou, Cheng Chen, Hongying Li, Lei Wang, Yanli Zhou
Reactive oxygen species (ROS) impair neovascularization and perfusion recovery following limb ischemia in patients with peripheral arterial disease (PAD). Hydrogen molecules (H2) comprise an antioxidant gas that has been reported to neutralize cytotoxic ROS. The present study investigated whether H2 may serve as a novel therapeutic strategy for PAD. H2‑saturated water or dehydrogenized water was supplied to mice with experimental PAD. Laser Doppler perfusion imaging demonstrated that H2‑saturated water improved perfusion recovery, decreased the rate of necrosis, increased the capillary density in the gastrocnemius muscle and increased the artery density in the abductor muscle in the ischemic limbs, at 14 and 21 days post‑hindlimb ischemia...
October 10, 2018: Molecular Medicine Reports
Jingya Zeng, Ying Pan, Baohong Cui, Taiyu Zhai, Song Gao, Qianyu Zhao, Yihua Sun
Acute myocardial infarction (AMI) is a disease associated with inflammation. T lymphocytes are involved by secreting cytokines and inflammatory factors. In our previous study, it was found that the T lymphocytes exhibited certain functional changes, the onset of which was induced by modulating calcium‑sensing receptor (CaSR) in AMI. In the present study, western blotting was used to verified the expression of T lymphocyte CaSR and pathway proteins, including phosphorylated extracellular signal‑regulated kinase (P‑ERK)1/2 and phosphorylated c‑Jun N‑terminal kinase (P‑JNK), and used cytometric bead array to detect the secretion of interleukin (IL)‑4, IL‑6, IL‑10 and tumor necrosis factor (TNF)‑α in AMI onset, the results demonstrated that they were all increased...
October 10, 2018: International Journal of Molecular Medicine
Jianmei Gao, Yingshu Xu, Jianyong Zhang, Jingshan Shi, Qihai Gong
Lithocarpus polystachyus Rehd. (sweet tea; ST) leaves is a type of Chinese folkloric medicine from southern China. The purpose of the present study was to explore the neuroprotective effect of ST, and to explore its underlying mechanisms in hydrogen peroxide (H2O2)‑induced neuronal cell injury in cultured human neuroblastoma. H2O2 was used as oxidant inducer and human SH‑SY5Y neuroblastoma cells were treated with various concentrations of ST. Cell viability and cell death were detected using MTT and LDH assays, respectively...
October 5, 2018: International Journal of Molecular Medicine
Shiqin Peng, Ping Wei, Qun Lu, Rui Liu, Yue Ding, Jiuliang Zhang
The effects of propolis on blood glucose regulation and the alleviation of various complications caused by diabetes have been widely studied. The main source of propolis in the northern temperate zone is poplar buds. However, there is limited research on the antidiabetic activity of poplar buds. In order to evaluate the effect of poplar buds on type-2 diabetes, crude extract and 50% fraction of poplar buds were used to feed streptozotocin-induced type-2 diabetic mice. The results showed that 50% fraction could increase insulin sensitivity and reduce insulin resistance, as well as decrease the levels of fasting blood glucose, glycated hemoglobin, and glycosylated serum proteins in diabetic mice...
2018: Journal of Immunology Research
Pu Reum Seok, Jung Hoan Kim, Hye Ri Kwon, Jin Sun Heo, Jong Ryeol Choi, Jae-Ho Shin
An overdose of acetaminophen (AAP) causes hepatic and renal toxicity. This study examined the protective effects of Gastrodia elata Blume (GEB) on hepatic and renal injury induced by AAP. Rats were orally administered distilled water or GEB for 14 days and injected with AAP 1 h after the oral last administration; control rats were administered water without AAP injection. All rats were sacrificed 24 h after AAP injection. The GEB pretreatment group showed decreased necrosis and the expression of pro-inflammatory cytokines in the liver and kidney...
October 2018: Food Science and Biotechnology
Yun-Zhi Shi, Song Jin, Han Qin, Heng-Bo Jiang, Guo-Hua Song, Shu-Cun Qin
Dehydration is one of the intrauterine abnormalities that could lead to fetal growth retardation and to increase the risk of a variety of adult diseases later in life. This study were to determine the impact of hydrogen-rich water (HRW) supplementation on placental angiotensin II type 1 receptor and placental oxidative stress induced by water restriction. Pregnant Wistar rat were randomly assigned to one of the three groups ( n =12 per group). In control group, pure water and food were supplied ad libitum. Water restriction group and HRW group were respectively given pure water and HRW with free access to food, excepting only one hour was available for drinking from day 7 to day 17 of pregnancy...
July 2018: Medical Gas Research
Lifang Sun, Minjie Mao, Zhisheng Yan, Cuiyun Zuo, Xiaojie Zhang
Pulmonary fibrosis is a chronic and fatal disease of lung tissue with high incidence and mortality in the world. The exploration of effective treatment for pulmonary fibrosis remains an urgent challenge. In our study, Qingfei Xieding was investigated as a novel Chinese traditional patent medicine against pulmonary fibrosis. A pulmonary fibrosis mouse model was constructed by injecting with bleomycin sulfate. Following Qingfei Xieding administration, lung samples were collected to assess pulmonary phenotype changes by analyzing lung coefficient, wet/dry, and histopathologic section...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
Roberto Menicagli, O Marotta, Laura Menicagli
Background: Many studies indicate the difficulty on assessing the possible carcinogenic effects of hair dyes, for their high time of the latence. Objectives: Our objective is to determine their prognostic index, by monitoring the oxidative stress, produced exposed to hair dyes, in hairdressers, and in consumers, by measuring the concentration of salivary malondialdehyde. Materials and Methods: Saliva samples are provided by the hairdressers, working in private (NP) or shopping center (CC), by users of hair dyes, for at least 10 years, and by a control group...
May 2018: Indian Journal of Occupational and Environmental Medicine
Bineeta Kashyap, Nisha Goyal, G K Das, N P Singh, I R Kaur
TB as the cause of uveitis varies from 0.5 to 10.5%; low sensitivity of confirmatory laboratory investigations and inconsistency of diagnostic criteria leads to paucity of data. Diagnosis requires a high level of suspicion and is often presumptive based on indirect evidences. Interferon gamma, Interleukin-2 and Neopterin are key biomarkers in immuno-regulation of Mycobacterium tuberculosis infection. The relative shift from Interleukin-2 towards Interferon gamma (Interferon gamma/Interleukin-2) is more discriminatory for active tuberculosis...
October 2018: Indian Journal of Clinical Biochemistry: IJCB
Subhabrata Moitra, Jayashree Ghosh, Jannatul Firdous, Arghya Bandyopadhyay, Monojit Mondal, Jayanta Kumar Biswas, Subhashis Sahu, Soumya Bhattacharyya, Saibal Moitra
BACKGROUND: Despite the available clinico-epidemiological evidence of heavy metal-associated respiratory health hazards among metal arc-welders, experimental confirmation of such an association is lacking. METHODS: In this study, we recruited 15 metal arc-welders and 10 referent workers without direct exposure. We assessed respiratory health through a questionnaire and spirometry; estimated manganese, nickel and cadmium levels in blood, urine and induced sputum; performed differential counts of sputum leucocytes and measured plasma malondialdehyde (MDA)...
October 14, 2018: Toxicology and Industrial Health
B Tutun, H Elbe, N Vardi, H Parlakpinar, A Polat, M Gunaltili, M M Guclu, E N Yasar
Hyperglycemia increases reactive oxygen species (ROS) and the resulting oxidative stress contributes to the development of diabetic complications. Dexpanthenol (Dxp) is the biological active form of pantothenic acid. We investigated whether Dxp administration could decrease oxidative stress as a way to treat renal complications of diabetes mellitus (DM). Thirty-two male Wistar albino rats were divided into four groups: control, Dxp, DM and DM + Dxp. Experimental diabetes was induced by a single dose of streptozotocin (STZ)...
October 15, 2018: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
B Zhang, S S Li, L Li, R Han, Z H Zhang
Objective: To observe the effect of crotonaldehyde long-term exposure on kidney injury in male rats, and to explore the specific mechanism of toxic action. Methods: 32 specific pathogen free healthy adult male wistar rats were randomly divided into 4 groups with 8 rats in each group: high-, moderate-, low-dose groups and a control group. Rats were treated with 8.5, 4.5, 2.5 and 0.0 mg/kg body weight crotonaldehyde by gavage, once a day for consecutive 128 days. After the last treatment, they were sacrificed and separated bilateral kidney...
August 20, 2018: Chinese Journal of Industrial Hygiene and Occupational Diseases
Walaa Hassan Nazmy, Eman Abdelmonem Elbassuoni, Fatma Farrag Ali, Rehab Ahmed Rifaai
Diabetes mellitus (DM) is closely associated with male infertility and sexual dysfunction. Recent data indicate that the proinsulin C-peptide (CP) exerts important physiological effects and shows the characteristics of an endogenous peptide hormone. So, this study was done to investigate the effect of C-peptide with or without insulin treatment on testicular function and architecture in diabetic rats. Rats were divided into the following groups: control, diabetic, and diabetic groups treated with either CP alone or combined with insulin...
October 14, 2018: Journal of Cellular Physiology
Entesar Ali Saber, Mohammed Mustafa Abd El Aleem, Neven Makram Aziz, Randa Ahmed Ibrahim
In case of a life-threatening, stressful event, the body prepares for an emergency. Indeed, the lung is unique in which alveolar cells are constantly exposed to physical and chemical stresses. This study aimed to study the impact of immobilization stress on the blood-air barrier and how it initiate and maintain an inflammatory response, plus determining the resolution of lung inflammation and repair. There was a significant increase in the plasma levels of stress markers "corticosterone and catecholamines" with a decrease in surfactant protein A (a lung-injury marker)...
October 14, 2018: Journal of Cellular Physiology
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