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Wen-Qi Dong, Hong-Jie Sun, Yu Zhang, Hong-Jun Lin, Jian-Rong Chen, Hua-Chang Hong
Low concentrations of arsenic (As) contamination in aquatic environment is a worldwide issue, which is of great concern. To evaluate the impact of low concentrations of As on zebrafish, we measured the growth, antioxidant enzymes including superoxide dismutase (SOD) and catalase (CAT), oxidative damage (malondialdehyde, MDA) and apoptosis-related genes (nrf2, p53 and c-jun) of adult zebrafish after exposing to different AsIII concentrations (0, 10, 50, 100 or 150 μg L-1 ) for 28 d. Results indicated that exposure to low AsIII concentrations decreased the zebrafish weight by 14%, increased the activities of SOD and CAT by 23-41% and 31-59%, decreased the contents of MDA by 29-54%, and modulated transcription of apoptosis related genes...
August 3, 2018: Chemosphere
Yu Wang, Shanshan Zhao, Xu Liu, Yumin Zheng, Lei Li, Su Meng
OBJECTIVE: Autism is a neurodevelopmental disorder which significantly impacts the quality of people's life. Oxytocin is a hormone impacting the social cognition and interpersonal trust. In this study, we aimed to explore the role of oxytocin in autism. METHODS: Autistic mice models were established by valproate. Animal behaviors were assessed by open field test, tail suspension test, marble burying test and three-chamber social interaction test. Oxidative stress was evaluated by the levels or activities of malondialdehyde, superoxide dismutase, glutathion peroxidase, reduced glutathione and reactive oxygen species...
August 7, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Yue Wang, Quan Liu, Yi Huan, Rongcui Li, Caina Li, Sujuan Sun, Nan Guo, Miaomiao Yang, Shuainan Liu, Zhufang Shen
Recently, SIRT5 was reported to be a predominant desuccinylase and demalonylase in mitochondria. Ablation of SIRT5 enhances the systemic succinylation and malonylation of mitochondrial proteins, including various metabolic enzymes; however, its function in pancreatic β cells has not yet been clarified. In this study, we evaluated the effects of SIRT5 overexpression on glucolipotoxicity-induced apoptosis in β cell lines. Full-length SIRT5, which preferentially targeted to mitochondria and partially to the nucleus and cytoplasm, was overexpressed in NIT-1 cells...
August 8, 2018: Experimental Cell Research
B Gurel-Gokmen, H Ipekci, S Oktay, B Alev, U V Ustundag, E Ak, D Akakın, G Sener, E Emekli-Alturfan, A Yarat, T Tunali-Akbay
BACKGROUND: Diabetes mellitus is an endocrine disorder which is characterized by the development of resistance to the cellular activity of insulin or inadequate insulin production. It leads to hyperglycemia, prolonged inflammation and oxidative stress. Oxidative stress is assumed to play an important role in the development of diabetic complications. Melatonin is the hormone that interacts with insulin in diabetes. Therefore, in this study the effects of melatonin treatment with or without insulin were examined in diabetic rat brain...
August 11, 2018: Diabetes/metabolism Research and Reviews
Cheng Chaohui, Huang Wei, Wen Hongfeng, Zhang Yueliang, Peng Xiaoqin, Zhou Pingli, Ai Zhibing
Atherosclerosis is a complex chronic inflammatory disease that is characterized by the formation of lipid-rich plaques on the inner walls of the arteries. Inactive rhomboid protein 2 (iRhom2) was recently determined as a necessary regulator for the shedding of tumor necrosis factor-alpha (TNF-α) in immune cells. In the present study, we aimed to explore the effects of iRhom2 on the inflammatory response and oxidative stress induced by low-density lipoprotein (ox-LDL) in RAW264.7 and THP-1-derived macrophages...
August 7, 2018: Biochemical and Biophysical Research Communications
Jariya Umka Welbat, Pornthip Chaisawang, Wanassanun Pannangrong, Peter Wigmore
5-fluorouracil or 5-FU (a chemotherapeutic medication) has been revealed to induce memory deficits in many cancer patients. Asiatic acid (AA) is a triterpenoid extract from Centella asiatica. This compound can ameliorate intracellular oxidative stress caused by chemotherapy drugs. Recent studies have shown that AA is capable of inhibiting neuronal generation and memory deficit produced by 5-FU chemotherapy. This study aimed to assess the molecular mechanisms of AA related to hippocampal neurogenesis and memory in rats receiving 5-FU...
August 9, 2018: Nutrients
Yan-Lun Ju, Xiao-Feng Yue, Xian-Fang Zhao, Hui Zhao, Yu-Lin Fang
Grapes are one of the most important fruits because of their economic and nutritional benefits, and grapevines are widely cultivated in arid and semi-arid areas. Therefore, it is critical to study the mechanism by which grapevines respond to water stress. In this research, micro-morphological and metabolomic analyses were conducted to evaluate the effects of water stress on stomatal morphology and volatile compounds extracted from the leaves of grapevine plants. There were two treatments: well-watered plants (watered daily) and drought-stressed plants (no irrigation)...
August 1, 2018: Plant Physiology and Biochemistry: PPB
Aydan Caglayan, Doruk Cevdi Katlan, Zafer Selcuk Tuncer, Kunter Yuce, Hasan Berkan Sayal, Belma Kocer-Gumusel
OBJECTIVES: Uterine myomas (UM) are responsible for significant morbidity and have adverse effects on quality of life in women. Reactive oxygen species (ROS) and antioxidant enzymes (AOE), as well as sex steroids play important roles in the reproductive physiology processes. Thus, we aimed to investigate the role of oxidant-antioxidant status in UM by measuring the AOE activities and lipid peroxidation (LPO) levels. This is the first study assessing these parameters together in UM based on also menopausal status and evaluating possible correlations between AOE activities, LPO markers, tumor biomarkers, female reproductive system hormone levels, comprehensively...
August 1, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Yin Heng, Wu Mao, Ma Yong, Guo Yang, Qiuju Su, Jianwei Wang
This study was to investigate the effects of paeoniflorin (PA) on lipopolysaccharides (LPS)-induced nucleus pulposus cells. Our results demonstrated that PA significantly reduced lipopolysaccharides (LPS) induced inflammatory factors including interleukin-1β (IL-1β), tumor necrosis Factor-α (TNF-α) and interleukin-6 (IL-6) in nucleus pulposus cells. PA also decreased of malondialdehyde (MDA) and increased superoxide dismutase (SOD) induced by LPS. Moreover, the expression of the protein levels of Nrf-2/HO-1/HMGB1/NF-κB were increased after LPS challenge, which were significantly restored after PA...
August 7, 2018: Microbial Pathogenesis
Rui Li, Lixing Zhang, Liu Wang, Lin Chen, Ruirui Zhao, Jiping Sheng, Lin Shen
Chilling stress is the main constraint in tomato (Solanum lycopersicum) production, as this is a chilling-sensitive horticultural crop. The highly conserved C-repeat binding factors (CBFs) are cold-response system components found in many species. In this study, we generated slcbf1 mutants using the CRISPR/Cas9 system and investigated the role of SlCBF1 in tomato plant chilling tolerances. The slcbf1 mutants exhibited more severe chilling injury symptoms with higher electrolyte leakage and malondialdehyde levels than wild type (WT) plants...
August 10, 2018: Journal of Agricultural and Food Chemistry
Mojtaba Shakibaie, Hamid Forootanfar, Atefeh Ameri, Mahboubeh Adeli-Sardou, Mandana Jafari, Hamid Reza Rahimi
This study was purposed to examine the cytotoxicity and functions of biologically synthesised bismuth nanoparticles (Bi NPs) produced by Delftia sp. SFG on human colon adenocarcinoma cell line of HT-29. The structural properties of Bi NPs were investigated using transmission electron microscopy, energy dispersive X-ray, and X-ray diffraction techniques. The cytotoxic effects of Bi NPs were analysed using flow cytometry cell apoptosis while western blot analyses were applied to analyse the cleaved caspase-3 expression...
August 2018: IET Nanobiotechnology
Jun Wang, Xinying Hou, Xiaofeng Xue, Xuexia Zhu, Yafen Chen, Zhou Yang
Obscure puffer (Takifugu obscurus) is an anadromous fish widely distributed around the coastal and inland rivers in East Asia. T. obscurus often encounters fluctuations in temperature and salinity. This study aimed to investigate the effect of the interactions of temperature and salinity on survival and oxidative stress response of newly hatched T. obscurus larvae. A combination of three temperatures (19, 25, and 31 °C) and three salinities (0, 10, and 20 ppt) was applied for 96 h under laboratory conditions...
August 9, 2018: Fish Physiology and Biochemistry
Leila Simani, Fari Ryan, Shadab Hashemifard, Etrat Hooshmandi, Maryam Madahi, Zahra Sahraei, Omidvar Rezaei, Kamran Heydari, Mahtab Ramezani
Disruption of prooxidant-antioxidant balance may lead to oxidative stress which is known as a mechanism contributing to ischemic stroke. Coenzyme Q10 (CoQ10) is an endogenous antioxidant that could be effective in preventing oxidative stress. However, the contribution of serum levels of CoQ10 in clinical neurological outcomes following ischemic stroke has not been clearly established. This study aims at measuring serum concentration of CoQ10 along with major indicators of antioxidant and oxidant among patients within 24 h after onset of the stroke symptoms, and investigating their relation with the clinical status of patients...
August 9, 2018: Journal of Molecular Neuroscience: MN
Ibrar Anjum, Syeda S Jaffery, Muniba Fayyaz, Abdullah Wajid, Armghan H Ans
Sugar-sweetened beverages containing caffeine are widely used among humans nowadays and can have negative consequences on the overall health. Our study aims to discuss the effects of these sugar-sweetened beverages (SSB) and how they can impact the health in different ways particularly on the brain. Some of the mechanisms by which soft drinks can exert adverse effects include an increase in glutathione-6-dehydrogenase level, increased levels of gamma-aminobutyric acid (GABA), glutamate and dopamine alteration in brain waves on electroencephalography (EEG) eventually leading to stroke and dementia...
June 7, 2018: Curēus
Li Wu, Meihong Ye, Jie Zhang
Lipopolysaccharide (LPS) induced keratitis is a progressive infectious ocular disease in which innate inflammatory responses often cause clinical tissue damage and vision loss. In this study, the potential protective effects of vincamine, a plant alkaloid used clinically as a peripheral vasodilator, against LPS induced inflammation and oxidative stress were investigated on human corneal epithelial cells (HCECs). HCECs were treated with LPS and vincamine at various concentrations. Cell viability, reactive oxygen species (ROS) levels, and the gene expression levels of interleukin-6 (IL-6), IL-8, IL-1β, TNF-α, transforming growth factor-β (TGF-β) in HCECs, were assessed...
2018: American Journal of Translational Research
Muhammad Shaban, Muhammad Mahmood Ahmed, Heng Sun, Abid Ullah, Longfu Zhu
BACKGROUND: Plant lipoxygenase (LOX) genes are members of the non-haeme iron-containing dioxygenase family that catalyze the oxidation of polyunsaturated fatty acids into functionally diverse oxylipins. The LOX family genes have been extensively studied under biotic and abiotic stresses, both in model and non-model plant species; however, information on their roles in cotton is still limited. RESULTS: A total of 64 putative LOX genes were identified in four cotton species (Gossypium (G...
August 9, 2018: BMC Genomics
Fusheng Zhao, Fang Lei, Xiang Yan, Senfeng Zhang, Wen Wang, Yu Zheng
BACKGROUND/AIMS: Cigarette smoke exposure (CSE) during pregnancy is a well-recognized health hazard that causes placental damage. Hydrogen sulfide (H2S) has been reported to protect multiple organs from injury. However, the protective effects of H2S have not been tested in the placenta. This study aimed to explore the potential of H2S in protecting placenta against oxidative injury induced by CSE during pregnancy and the possible underlying mechanisms. METHODS: Pregnant SD rats were randomly divided into 4 groups: NaCl, NaHS (a donor of H2S), CSE and CSE+NaHS...
August 9, 2018: Cellular Physiology and Biochemistry
Zhenzhen Huang, Kai He, Zhongxian Song, Guangming Zeng, Anwei Chen, Lei Yuan, Hui Li, Liang Hu, Zhi Guo, Guiqiu Chen
Antioxidative response of Phanerochaete chrysosporium induced by silver nanoparticles (AgNPs) and their toxicity mechanisms were comprehensively investigated in a complex system with 2,4-dichlorophenol (2,4-DCP) and Ag+ . Malondialdehyde content was elevated by 2,4-DCP, AgNPs, and/or Ag+ in concentration- and time-dependent manners within 24 h, indicating an increase in lipid peroxidation. However, beyond 48 h of exposure, lipid peroxidation was alleviated by upregulation of intracellular protein production and enhancement in the activities of superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD)...
August 2, 2018: Chemosphere
Fatma H Rizk, Naglaa I Sarhan, Nema A Soliman, Marwa A A Ibrahim, Marwa Abd-Elsalam, Sherief Abd-Elsalam
Lactoferrin (LF) was previously suggested to have a protective effect against liver fibrosis by preventing hepatic stellate cells (HSCs) activation. The effect of LF on heat shock protein 47 (HSP47) has not yet been studied so this study was designed to investigate LF effect on HSP47 as a potential target for management of liver fibrosis and comparing it with silymarin (SM) in a thioacetamide (TAA)-induced liver fibrosis model. Rats were divided into four groups; normal control, TAA (TAA-treated), LF (LF + TAA-treated), and SM (SM + TAA-treated)...
August 9, 2018: IUBMB Life
Seyed Mohammad Owji, Elahe Nikeghbal, Seyed Mostafa Shid Moosavi
NEW FINDINGS: What is central question of this study? Acute kidney injury (AKI) in patients is usually due to renal artery hypoperfusion or occasionally vein thrombosis, but murine model of ischemic AKI is mostly induced via pedicle-clamping. Hence, the traditional renal pedicle-clamping model was compared with models of occluding renal artery or vein alone in rats. What is main finding and its importance? During renal venous occlusion, transmission of high arterial pressure into renal capillaries likely caused rupture of their walls and occurrence of hemorrhagic congestion that led to higher kidney tissue damage and dysfunction than pedicle and artery clamping...
August 9, 2018: Experimental Physiology
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