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Hongjie Yi, Shichong Yu, Yanan Zhang, Runping Li, Dazhi Zhang, Dazhi Zhang, Weigang Xu
BACKGROUND: Recent studies indicated that ketone ester R,S-1,3-butanediol acetoacetate diester (BD-AcAc2 ) may be effective in preventing central nervous system oxygen toxicity (CNS-OT) and concomitant acute lung injury, a serious medical problem to be faced when breathing hyperbaric oxygen (HBO). This study aimed to further investigate the protective effects of BD-AcAc2 against CNS-OT and concomitant acute lung injury (ALI) in mice. METHODS: Mice were treated with BD-AcAc2 in peanut oil vehicle (2...
December 24, 2018: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
Dante Condori-Merma, Oscar Moreno-Loaiza, Azael Paz-Aliaga, José Barrionuevo-Rodríguez
OBJECTIVES: To assess the effects of the administration of oxytocin during labor management on the levels of malondialdehyde (MDA), nitric oxide (NO), and S100B protein in newborns. MATERIALS AND METHODS: We selected 80 term pregnant women without obstetric and fetal pathology, forming two groups: pregnant women with normal delivery and pregnant women conducted with oxytocin. Blood was collected immediately after delivery from the umbilical cord vein to measure MDA, ON and from the artery for protein S100B...
July 2018: Revista Peruana de Medicina Experimental y Salud Pública
Fábio Gonçalves Coutinho, Edna Maria de Albuquerque Diniz, Ingrid Kandler, Marco Antônio Cianciarullo, Natália Rodrigues Dos Santos
BACKGROUND: To determine the concentration of the Lipid Peroxidation Marker: Malondialdehyde (MDA), and Antioxidant Markers: Superoxide Dismutase (SOD), Glutathione Peroxidase (GPX), Catalase (CAL) in umbilical cord blood and in unstimulated saliva in the first 24 and 48 hours of life in the PTNB of mothers with and without risk factors for early-onset neonatal sepsis. METHODS: Cross-sectional study with the signing of informed consent by the pregnant women and application of a standard questionnaire classifying the PTNB in Group 1 or 2...
October 2018: Revista da Associação Médica Brasileira
Xiaomei Yu, Wenbo He, Jing Xie, Bo He, Da Luo, Xiaoying Wang, Hong Jiang, Zhibing Lu
INTRODUCTION: Our recent study found that selective ablation of the distal part of the ligament of Marshall (LOMLSPV ) could suppress ventricular arrhythmias (VAs) during acute myocardial infarction (AMI). This study was to investigate the possible underlying mechanisms. METHODS: Dogs were randomly subjected into the sham operated group (SO, n=6), AMI group (AMI, n=8) and the group undergoing LOMLSPV ablation ahead of AMI (LOMD+AMI, n=8). Incidence of VAs, serum levels of malondialdehyde (MDA) and superoxide diamutas (SOD), expression of connexin (Cx43), Bcl-2, Bax, Caspase-3, tumor necrosis factor (TNF)-α, IL-6 and high mobility group box (HMGB)1 were compared...
December 5, 2018: Journal of Cardiovascular Electrophysiology
Yu Wang, Hongjing Zhao, Menghao Guo, Yizhi Shao, Juanjuan Liu, Guangshun Jiang, Mingwei Xing
The kidney is the most crucial site for the excretion of arsenic and its metabolites. In this study, Hy-line chickens exposed to different toxicologically relevant doses of arsenic (0, 7.5, 15 and 30 mg kg-1 diet) presented marked renal injury as evidenced by the increased leakage of blood urea nitrogen (up to 2.6 folds) and creatinine (up to 2.3 folds). Furthermore, increased content of renal arsenic (up to 30 folds) and malondialdehyde restrained anti-hydroxyl radical ability, and the activities of antioxidant enzymes (glutathione peroxidase, catalase) further corroborated extensive renal damage...
December 5, 2018: Metallomics: Integrated Biometal Science
Merhan Mamdouh Ragy, Sabreen Mahmoud Ahmed
Diabetes and cardiometabolic risk factors including hypertension and dyslipidemia are the major threats to human health in the 21st century. Apoptosis in pancreatic tissue is one of the major causes of diabetes type 1 progression. The aim of this study was to investigate the effects of C-peptide or l-arginine on some cardiometabolic risk factors, pancreatic morphology, function and apoptosis, and the mechanisms of their actions. Forty adult male albino rats were divided into four equal groups: 1-control nondiabetic, 2-diabetic (no treatment), 3-diabetic + C-peptide, and 4-diabetic +  l-arginine...
December 4, 2018: Journal of Cellular Physiology
Engin Kolukcu, Sahin Kilic, Bekir Suha Parlaktas, Fikret Erdemir, Velid Unsal, Dogan Atılgan, Nihat Uluocak
PURPOSE: This study aimed to demonstrate the effects of oxytocin on penile tissues in ischemia-reperfusion injury developed after priapism. METHODS: Forty Wistar Albino strain male rats were divided into four groups. The control group (n = 10) was not intervened. In Group 2, a rat model of priapism was constructed and maintained for 1 h. In Group 3, reperfusion was ensured for 30 min following priapism. Rats in Group 4 rats were given oxytocin 30 min before the induction of reperfusion following priapism...
December 4, 2018: International Urology and Nephrology
Wenqi Gao, Wei Wang, Gang Liu, Jing Zhang, Jian Yang, Zhifang Deng
Allicin, one of the main biologically active compounds derived from garlic, was previously reported to possess multiple pharmacological activities. Whether allicin protected against chronic social defeat stress (CSDS) induced depressive-like behaviors remained unknown. Thus, our present study for the first time investigated the potential antidepressant effects and the mechanisms of allicin on the CSDS mice model. Thirty minutes before social defeat stress, allicin (2, 10, 50 mg/kg) was treated by intraperitoneal injection...
December 4, 2018: Metabolic Brain Disease
Xian-Sheng Ren, Wei Ding, Xiao-Yu Yang
OBJECTIVE: To study the neuroprotective effect of icariin on spinal cord injury in rats. METHODS: A total 108 SPF male 3-month-old SD rats were divided into experimental group, control group and sham operation group according to the random number table. There were 36 rats in each group. In the control group and the experimental group, the modified Allen's method was used to make the spinal cord injury model. In the sham operation group, only the lamina was cut without damaging the spinal cord...
November 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Wang Lin, Honghui Guo, Lingkai Wang, Dandan Zhang, Xueyang Wu, Li Li, Dapeng Li, Rong Tang
Hazardous contaminants, such as nitrite and microcystin-leucine arginine (MC-LR), are released into water bodies during cyanobacterial blooms and may adversely influence the normal physiological function of hydrobiontes. The combined effects of nitrite and MC-LR on the antioxidant defense and innate immunity were evaluated through an orthogonal experimental design (nitrite: 0, 29, 290 μM; MC-LR: 0, 3, 30 nM). Remarkable increases in malondialdehyde (MDA) levels have suggested that nitrite and/or MC-LR exposures induce oxidative stress in fish spleen, which were indirectly confirmed by significant downregulations of total antioxidant capacity (T-AOC), glutathione (GSH) contents, as well as transcriptional levels of antioxidant enzyme genes cat1, sod1 and gpx1a...
December 3, 2018: Toxins
Hong Liu, Yifang Wan, Yuxin Wang, Yue Zhao, Yue Zhang, Ao Zhang, Qiang Weng, Meiyu Xu
Fenitrothion (FNT), an organophosphate pesticide, exerts an immunotoxic effect on splenocytes. Dietary polyphenol compounds exert antioxidant, anticancer and antihypertensive effects. In this study, we investigated the effect of walnut polyphenol extract (WPE) on FNT-induced immunotoxicity in splenic lymphocytes in vitro. Treatment with WPE significantly increased the proliferation of FNT-exposed splenocytes, as evidenced by increases in the proportions of splenic T lymphocytes (CD3⁺ T cells) and T-cell subsets (CD8⁺ T cells), as well as the secretion of the T-cell-related cytokines interleukin (IL)-2, interferon-γ, IL-4 and granzyme B...
November 30, 2018: Nutrients
Junqiang Yan, Liang Qiao, Jiannan Wu, Hua Fan, Jiachun Sun, Yude Zhang
BACKGROUND/AIMS: Many clinical studies have demonstrated that statins, especially simvastatin, can decrease the incidence of Parkinson's disease (PD). However, the specific underlying mechanism remains unclear. This study aimed to investigate how simvastatin affects experimental parkinsonian models via the regulation of extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated activation of the anti-oxidant system. METHODS: l-Methyl-4-phenylpyridine ion (MPP+)-treated SH-SY5Y cells and substantia nigra neurons were used to investigate the neuroprotective effect of simvastatin...
December 4, 2018: Cellular Physiology and Biochemistry
Mahdieh Nazari-Robati, Mahboobe Akbari, Mohammad Khaksari, Moghaddameh Mirzaee
OBJECTIVE: Inflammation and oxidative stress are implicated in pathogenesis of spinal cord injury (SCI). Trehalose, a nonreducing disaccharide, exhibits anti-inflammatory and antioxidant effects. The present study investigated the therapeutic efficacy of trehalose in the SCI model. DESIGN AND SETTING: An experimental study was designed using 120 male Wistar rats which were randomly divided into three groups including SCI, SCI + phosphate buffer saline (vehicle) and SCI + trehalose...
December 4, 2018: Journal of Spinal Cord Medicine
Chunhua Liu, Renfu Wang, Yu Zhang
Acute alcohol intoxication is a central nervous system disease that accounts for a large number of hospital admissions. In the present study, we have explored the role of GINS complex subunit 2 (GINS2) in acute alcohol intoxication and alcohol-induced brain injury. We began by determining that GINS2 mRNA expression was significantly increased in the serum of patients with alcohol abuse. We then found that GINS2 is increased in mouse brains after alcohol consumption. To explore the role of GINS2 in alcohol-induced microglia function, we knocked down GINS2 in mouse microglia and then treated the cells with alcohol...
December 4, 2018: Artificial Cells, Nanomedicine, and Biotechnology
E Yuluğ, S Türedi, Ö Yıldırım, E Yenilmez, Y Aliyazıcıoğlu, S Demir, S Özer-Yaman, A Menteşe
Cisplatin (CP) is a chemotherapeutic agent used to treat various types of cancer; nephrotoxicity is the most common adverse effect of the drug. We investigated the protective effects of propolis against CP induced kidney injury. Thirty-six male rats were divided into six equal groups: untreated control group, 50 mg/kg/day propolis group, 100 mg/kg/day propolis group, single-dose 7 mg/kg CP group, 7 mg/kg CP + 50 mg/kg/day propolis and 7 mg/kg CP + 100 mg/kg propolis. Rats were sacrificed after 14 days and kidneys were removed for histopathological and biochemical analyses...
December 4, 2018: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
Abdelgawad A Fahmi, Mariam Abdur-Rahman, Asmaa F Aboul-Naser, Manal A Hamed, Howida I Abd-Alla, Mohamed I Nasr
CONTEXT: Stomach ulcers are the common gastrointestinal disorders worldwide. OBJECTIVE: This study aimed to investigate the therapeutic impact of Pulicaria crispa aerial part ethanol extract against gastric ulcer in rats. MATERIALS AND METHODS: Ulcer was induced by one oral dose of ethanol (0.5 ml/100g body weight) on 24 hours empty stomach, then the plant extract (500 mg/kg b.wt.) was orally administered daily for one week. Ranitidine (100mg/kg b...
December 4, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Parvin Mirmiran, Hoda Hadavi, Azadeh Mottaghi, Fereidoun Azizi
Background: Metabolic syndrome is a prevalent condition with dramatic rising trend worldwide. Single dietary factors, such as omega-3 fatty acids consumption protect body against oxidative damage by reinforcement of dietary total antioxidant capacity but the combination of all dietary components may be more effective when studied as integrated dietary patterns. This present study was designed to assess the association between different dietary patterns and oxidative stress in a population of Tehranian adults suffering from metabolic syndrome...
2018: Caspian Journal of Internal Medicine
Xian-Zhe Dong, Yu-Ning Wang, Xiao Tan, Ping Liu, Dai-Hong Guo, Can Yan
This study aims at investigating the radioprotective effect of ethanol extract from Ji-Xue-Teng (JXT, Spatholobus suberectus ) on radiation-induced hematopoietic alteration and oxidative stress in the liver. Mice were exposed to a single acute γ -radiation for the whole body at the dose of 6.0 Gy, then subjected to administration of amifostine (45 mg/kg) or JXT (40 g crude drug/kg) once a day for 28 consecutive days, respectively. Bone marrow cells and hemogram including white cells, red cells, platelet counts, and hemoglobin level were examined...
2018: Oxidative Medicine and Cellular Longevity
Mustafa S Atta, Ali H El-Far, Foad A Farrag, Mohamed M Abdel-Daim, Soad K Al Jaouni, Shaker A Mousa
Diabetic cardiomyopathy is a diabetic complication due to oxidative stress injuries. This study examined the protecting influence of thymoquinone (TQ) on diabetes-caused cardiac complications. The intracellular means by which TQ works against diabetes-caused cardiac myopathy in rats is not completely understood. In this study, Wistar male rats ( n = 60) were assigned into four groups: control, diabetic (diabetes induced by IP infusion of streptozotocin, 65 mg/kg), diabetic + TQ (diabetic rats given TQ (50 mg/kg) administered once per day by stomach gavage), and TQ (50 mg/kg) for 12 weeks...
2018: Oxidative Medicine and Cellular Longevity
Katarzyna Pawlak-Osińska, Henryk Kaźmierczak, Maria Marzec, Daria Kupczyk, Rafał Bilski, Emilia Mikołajewska, Dariusz Mikołajewski, Beata Augustyńska
Background: Tinnitus is defined as a phantom auditory perception, i.e., sound experience despite the lack of acoustic stimuli in the environment. The aim of this study was to assess the state of the natural antioxidant barrier of a body in patients complaining about the presence of tinnitus. Material and Methods: The study included a total of 51 patients aged from 20 to 62 years with diagnosed idiopathic tinnitus and 19 healthy subjects as a control group. All patients underwent the audiometric tone test, speech audiometry, distortion otoacoustic emission product testing, study of evoked auditory potentials of short latency, and biochemical analysis of venous blood concerning values of activity or concentration of glutathione, glutathione peroxidase, S-transferase, glutathione reductase superoxide dismutase, malondialdehyde, and ceruloplasmin as the selected parameters of oxidative stress...
2018: Oxidative Medicine and Cellular Longevity
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