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https://www.readbyqxmd.com/read/30317604/physiological-and-structural-changes-of-the-lung-tissue-in-male-albino-rat-exposed-to-immobilization-stress
#1
Entesar Ali Saber, Mohammed Mustafa Abd El Aleem, Neven Makram Aziz, Randa Ahmed Ibrahim
In case of a life-threatening, stressful event, the body prepares for an emergency. Indeed, the lung is unique in which alveolar cells are constantly exposed to physical and chemical stresses. This study aimed to study the impact of immobilization stress on the blood-air barrier and how it initiate and maintain an inflammatory response, plus determining the resolution of lung inflammation and repair. There was a significant increase in the plasma levels of stress markers "corticosterone and catecholamines" with a decrease in surfactant protein A (a lung-injury marker)...
October 14, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30317587/differentiation-of-microfluidic-encapsulated-trabecular-meshwork-mesenchymal-stem-cells-into-insulin-producing-cells-and-their-impact-on-diabetic-rats
#2
Ghasem Barati, Samad Nadri, Ramin Hajian, Ali Rahmani, Hossein Mostafavi, Yousef Mortazavi, Amir Hossein Taromchi
Tissue and stem cell encapsulation andtransplantation were considered as promising tools in the treatment of patients with diabetes mellitus. The aim of this study was to evaluate the effect of microfluidic encapsulation on the differentiation of trabecular meshwork mesenchymal stem cells (TM-MSC), into insulin-producing cells (IPCs) both in vitro and in vivo. The presence of differentiated cells in microfibers (three dimensional [3D]) and tissue culture plates (TCPS; two dimensional [2D]) culture was evaluated by detecting mRNA and protein expression of pancreatic islet-specific markers as well as measuring insulin release of cells in response to glucose challenges...
October 14, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30317466/elevated-c-reactive-protein-and-white-blood-cell-count-at-admission-predict-functional-outcome-after-non-aneurysmal-subarachnoid-hemorrhage
#3
Patrick Schuss, Alexis Hadjiathanasiou, Simon Brandecker, Ági Güresir, Hartmut Vatter, Erdem Güresir
INTRODUCTION: Patients with non-aneurysmal subarachnoid hemorrhage (SAH) are considered to have an overall benign course of disease compared to patients suffering from aneurysmal SAH. Nevertheless, a small but significant number of such patients might only achieve unfavorable outcome. Therefore, the purpose of the present study was to determine if routine laboratory markers of acute phase response are associated with unfavorable outcome in patients with non-aneurysmal SAH. METHODS: From 2006 to 2017, 154 patients suffering from non-aneurysmal SAH were admitted to our institution...
October 13, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/30317383/cardiovascular-resistance-to-thrombosis-in-13-lined-ground-squirrels
#4
Alison Bonis, Leah Anderson, Gaëlle Talhouarne, Emily Schueller, Jenna Unke, Catherine Krus, Jordan Stokka, Anna Koepke, Brittany Lehrer, Anthony Schuh, Jeremiah J Andersen, Scott Cooper
13-lined ground squirrels (Ictidomys tridecemlineatus) enter hibernation as a survival strategy during extreme environmental conditions. Typical ground squirrel hibernation is characterized by prolonged periods of torpor with significantly reduced heart rate, blood pressure, and blood flow, interrupted every few weeks by brief interbout arousals (IBA) during which blood flow fluctuates dramatically. These physiological conditions should increase the risk of stasis-induced blood clots and myocardial ischemia...
October 13, 2018: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/30317347/determination-of-reference-intervals-of-thyroid-markers-during-pregnancy-in-urban-area-of-district-rawalpindi-pakistan
#5
Mehwish Gilani, Naveed Asif, Ammad Akram, Mehreen Gilani, Aamir Ijaz, Saima Shakil Malik
OBJECTIVE: To determine the reference values for thyroid stimulating hormone, free tetra-iodothyronine and total tri-iodothyronine for healthy pregnant women. METHODS: This cross sectional study was conducted at the Armed Forces Institute of Pathology, Rawalpindi, Pakistan, from January 2016 to June 2017. Pregnant women with normal, single intrauterine, uncomplicated pregnancy were recruited from the local population. Blood sample was taken to analyse thyroid stimulating hormone, free tetra-iodothyronine and total tri-iodothyronine using chemiluminescence immunoassay...
October 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/30317189/mesenteric-panniculitis-diagnostic-precision
#6
Domingos Sousa, Ana Verónica Varela, Margarida Viana Coelho, Catarina Jorge
A previously healthy 74-year-old woman was admitted with vespertine fever, tremors, shivers and loss of appetite within the previous month. Blood tests revealed an elevated C reactive protein serum level. Serologies for infection were negative. Blood cultures grew no organisms. Colonoscopy revealed normal findings. CT showed typical findings of mesenteric panniculitis with infiltration of mesenteric fat that was circumscribed by hyperattenuating capsule and contained enlarged homogenous lymph nodes. The histopathological analysis from mesenterium revealed non-specific signs of chronic inflammation...
October 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/30317142/the-potential-value-of-surrogate-performance-markers-at-caesarean-section-for-the-assessment-of-surgical-competence
#7
Helen Sheehan, Thomas Gray, Tom Farrell
OBJECTIVES: We hypothsised that surrogate markers of competence (procedure time and estimated surgical blood loss) could be of value when assessing competence for trainees learning to undertake lower segment caesarean section (LSCS). The study aim was to investigate differences in surrogate markers of surgical competence at LSCS between different training grades of primary surgeon and for different grades of surgical assistant; to assess the potential value of using these surrogate markers in overall assessments of surgical competence...
October 5, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/30316949/establishment-of-tusmi005-a-an-induced-pluripotent-stem-cell-ipsc-line-from-a-32-year-old-chinese-han-patient-with-bipolar-disorder-bd
#8
Ying Wang, Qiang Fen, Hongxiang Yu, Haixia Qiu, Xiquan Ma, Ying Lei, Jian Zhao
A 32-year old Bipolar Disorder (BD) male patient donated his Peripheral blood mononuclear cells (PBMC). The non-integrating episomal vector system used to reprogram PBMCs with the human OKSM transcription factors. The pluripotency of transgene-free iPSCs was confirmed by immunocytochemistry for pluripotency markers and by the ability of the iPSCs to differentiate spontaneously into 3 germ layers in vitro. In addition, the iPSC line displayed a normal karyotype. Our model might offer a good platform to further study the pathological mechanisms, to identify early biomarkers, and also for drug testing studies in BD...
October 6, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/30316598/aluminosilicate-clay-improves-production-responses-and-reduces-inflammation-during-an-aflatoxin-challenge-in-lactating-holstein-cows
#9
R T Pate, D M Paulus Compart, F C Cardoso
Mitigation strategies are vital in minimizing the health and economic risks associated with dairy cattle exposure to aflatoxin (AF). The objective of this study was to determine the effects of a commercially available aluminosilicate clay in a lactation diet on production responses, blood chemistry, and liver inflammatory markers of multiparous lactating Holstein cows during an AF challenge. Sixteen multiparous lactating Holstein cows [body weight (mean ± SD) = 758 ± 76 kg; days in milk = 157 ± 43 d] were assigned to 1 of 4 treatments in a replicated 4 × 4 Latin square design with 21-d periods: no adsorbent and no AF challenge (CON), no adsorbent and an AF challenge (POS), 113 g of aluminosilicate clay top-dressed on the total mixed ration (adsorbent; FloMatrix, PMI Nutritional Additives, Arden Hills, MN) with an AF challenge (F4), or 227 g of adsorbent with an AF challenge (F8)...
October 10, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/30316321/increased-mitochondrial-dna-copy-number-in-maternal-peripheral-blood-is-associated-with-low-birth-weight-in-lombok-indonesia
#10
L Priliani, C A Febinia, B Kamal, A H Shankar, S G Malik
Fetal development depends on maternal metabolic energy from mitochondria. We investigated the association of maternal mitochondrial function, represented by mitochondrial DNA copy number (mtDNA-CN) of venous blood, with child birth weight (BW) from 528 randomly selected mothers enrolled in the Supplementation with Multiple Micronutrients Intervention Trial (ISRCTN 34151616). Real-time quantitative PCR of archived blood specimens and regression analysis adjusting for other primary determinants of BW showed that loge mtDNA-CN was inversely associated with BW (β = -204...
October 2018: Placenta
https://www.readbyqxmd.com/read/30316223/cardiopathology-in-acute-african-swine-fever
#11
Anna B Semerjyan, Marina R Tatoyan, Naira Yu Karalyan,, Narek H Nersisyan,, Lina H Hakobyan,, Hranush H Arzumanyan,, Zaven A Karalyan
The present study describes the gross, histopathologic lesions of the heart arising in pigs infected with acute African Swine Fever (ASF) and their biochemical profile. Ten pigs were infected by intramuscular injection of ASF virus (Georgia 2007). Selected heart samples were submitted for histopathological examination and Hematoxylin-Basic Fuchsin-Picric Acid (HBFP) staining. Enzymatic abnormalities were evaluated by measurement of main cardiac markers, whose activity increased during the early stage of infection, with histopathological changes occurring later...
2018: Annals of Parasitology
https://www.readbyqxmd.com/read/30316204/meta-analysis-of-neutrophil-to-lymphocyte-and-platelet-to-lymphocyte-ratio-in-rheumatoid-arthritis
#12
REVIEW
Gian Luca Erre, Panagiotis Paliogiannis, Floriana Castagna, Arduino Aleksander Mangoni, Ciriaco Carru, Giuseppe Passiu, Angelo Zinellu
BACKGROUND: We conducted a meta-analysis to review the available evidence regarding the associations between peripheral blood neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) and the presence of rheumatoid arthritis (RA). METHODS: PubMed, Web of Science, and Scopus, from inception to January 2018, were searched for studies reporting on NLR and PLR in RA in comparison to healthy subjects. Standardized mean difference (SMD) was calculated with a confidence interval (CI) of 95%...
October 13, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/30316184/associations-of-cumulative-exposure-to-heavy-metal-mixtures-with-obesity-and-its-comorbidities-among-u-s-adults-in-nhanes-2003-2014
#13
Xin Wang, Bhramar Mukherjee, Sung Kyun Park
BACKGROUND: Some heavy metals (e.g., arsenic, cadmium, lead, mercury) have been associated with obesity and obesity comorbidities. The analytical approach for those associations has typically focused on individual metals. There is a growing interest in evaluating the health effects of cumulative exposure to metal mixtures. OBJECTIVES: We utilized our Environmental Risk Score (ERS), a summary measure to examine the risk of exposure to multi-pollutants in epidemiologic research, to evaluate the associations of cumulative exposure to a mixture of correlated heavy metals with obesity and its comorbidities including hypertension, and type-2 diabetes mellitus (T2DM) while accounting for high degree correlations and interactions among metal mixtures components...
October 10, 2018: Environment International
https://www.readbyqxmd.com/read/30316040/generation-of-an-induced-pluripotent-stem-cell-line-from-a-hypertrophic-cardiomyopathy-patient-with-a-pathogenic-myosin-binding-protein-c-mybpc3-p-arg502trp-mutation
#14
Mira Holliday, Samantha Barratt Ross, Seakcheng Lim, Christopher Semsarian
Hypertrophic cardiomyopathy is an inherited cardiomyopathy with a prevalence of up to 1 in 200, which can result in significant morbidity and mortality. An iPSC line was generated from peripheral blood mononuclear cells obtained from the whole blood of a 58-year-old male with hypertrophic cardiomyopathy who carries the heterozygous pathogenic myosin binding protein C mutation p.Arg502Trp. Induced pluripotent stem cells express pluripotency markers, demonstrate trilineage differentiation potential, and display a normal karyotype...
October 6, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/30315659/blood-brain-barrier-disruption-and-angiogenesis-in-a-rat-model-for-neurocysticercosis
#15
Rogger P Carmen-Orozco, Danitza G Dávila-Villacorta, Yudith Cauna, Edson G Bernal-Teran, Leandra Bitterfeld, Graham L Sutherland, Nancy Chile, Rensson H Céliz, María C Ferrufino-Schmidt, Cesar M Gavídia, Charles R Sterling, Héctor H García, Robert H Gilman, Manuela Renee Verástegui
Neurocysticercosis (NCC) is a helminth infection affecting the central nervous system caused by the larval stage (cysticercus) of Taenia solium. Since vascular alteration and blood-brain barrier (BBB) disruption contribute to NCC pathology, it is postulated that angiogenesis could contribute to the pathology of this disease. This study used a rat model for NCC and evaluated the expression of two angiogenic factors called vascular endothelial growth factor (VEGF-A) and fibroblast growth factor (FGF2). Also, two markers for BBB disruption, the endothelial barrier antigen and immunoglobulin G, were evaluated using immunohistochemical and immunofluorescence techniques...
October 13, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/30315273/targeted-next-generation-sequencing-of-endometrial-cancer-and-matched-circulating-tumor-dna-identification-of-plasma-based-tumor-associated-mutations-in-early-stage-patients
#16
Ana M Bolivar, Rajyalakshmi Luthra, Meenakshi Mehrotra, Wei Chen, Bedia A Barkoh, Peter Hu, Wei Zhang, Russell R Broaddus
There is currently no blood-based marker in routine use for endometrial cancer patients. Such a marker could potentially be used for early detection, but it could also help to track tumor recurrence following hysterectomy. This is important, as extra-vaginal recurrence of endometrial endometrioid adenocarcinoma is usually incurable. This proof-of-principle study was designed to determine if tumor-associated mutations could be detected in cell-free DNA from the peripheral blood of early and late stage endometrial endometrioid carcinoma patients...
October 12, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/30315187/cytopathological-study-of-the-circulating-tumor-cells-filtered-from-the-cancer-patients-blood-using-hydrogel-based-cell-block-formation
#17
Yoon-Tae Kang, Young Jun Kim, Tae Hee Lee, Young-Ho Cho, Hee Jin Chang, Hyun-Moo Lee
Circulating tumor cells have emerged as biomarkers for estimating the tumor burden and metastatic potential of cancer patients. However, to date, most of studies and applications of circulating tumor cells have been conducted and applied to epithelial cancers such as breast, colorectal, and prostate tumor. The only FDA-cleared method, CellSearch, makes use of antibody against epithelial surface protein expressed on CTCs, thus obstructing wide application for various cancers with non-epithelial and semi-epithelial characteristics including renal cell carcinoma...
October 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30315178/regional-adiposity-and-markers-of-inflammation-in-pre-school-age-children
#18
Kerri Z Delaney, Catherine A Vanstone, Hope A Weiler, Sylvia Santosa
In adults, upper body fat partially increases metabolic disease risk through increasing systemic inflammation. Our objective was to determine if this relationship exists in preschool-aged children. A subset of children (n = 71, 35 males), 3.7 ± 1.0 y, were studied from n = 515 children recruited from randomly selected daycares in Montréal, QC. According to WHO charts for 2-5 y, 49 children were healthy weight (HW) and 21 were overweight (OW). Adiposity was determined through dual-energy x-ray absorptiometry...
October 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30314997/abnormally-expressed-mir-23b-in-chinese-mongolian-at-high-cardiovascular-risk-may-contribute-to-monocyte-macrophage-inflammatory-reaction-in-atherosclerosis
#19
Li-Ping He, Xing-Sheng Zhao, Le-Ping He
Background The prevalence of coronary heart disease (CHD) appears to be high among Chinese Mongolians. MiR-23b has been proven to play a key role in atherosclerosis. The expression and role of miR-23b in the Mongolians at high cardiovascular risk were explored in this study. Methods 40 cases of blood samples from the Mongolians at high cardiovascular risk were enrolled in this study. The expression of miR-23b was quantified by qRT-PCR. To induce monocytes differentiation into macrophages HP-1 cells were cultured with phorbol 12-myristate 13-acetate (PMA)...
October 12, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/30314489/prevalence-of-plasmodium-falciparum-infection-among-pregnant-women-at-first-antenatal-visit-in-post-ebola-monrovia-liberia
#20
Guillermo Martínez-Pérez, Dawoh Peter Lansana, Senga Omeonga, Himanshu Gupta, Bondey Breeze-Barry, Raquel González, Azucena Bardají, Adelaida Sarukhan, James D K Goteh, Edith Tody, Pau Cisteró, Benard Benda, Juwe D Kercula, Fanta D Kibungu, Ana Meyer García-Sípido, Quique Bassat, Christine K Tarr-Attia, Alfredo Mayor
BACKGROUND: Disruption of malaria control strategies during the West African 2014-2016 Ebola epidemic led to an increase in malaria-attributable mortality. However, recent data on malaria infection in vulnerable groups, such as pregnant women, are lacking in this post-Ebola scenario. This cross-sectional study aimed to assess the prevalence of Plasmodium falciparum infection and of molecular markers of drug resistance among pregnant women attending antenatal care in Monrovia, capital of Liberia...
October 11, 2018: Malaria Journal
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