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Sameera Nallanthighal, Ramune Reliene
Owing to new and unique properties, engineered nanoparticles (NPs) likely pose different risks than their constituent chemicals and these risks need to be understood. In particular, it is important to assess genotoxicity, since genotoxicity is a precursor to carcinogenicity. Here we describe a battery of tests for the assessment of genotoxicity of NPs in vivo in mice. Mice can be exposed to NPs for various exposure durations and by any route of exposure, provided NPs are absorbed into the systemic blood circulation...
2019: Methods in Molecular Biology
Baolong Liu, Maoquan Zhang, Jingming Zhao, Mei Zheng, Hao Yang
Macrophages, whether M1 or M2 subtype, have been found to be implicated in the pathogenesis of osteoarthritis (OA). However, no study regarding the status of M1 and M2 macrophages has been reported in knee OA. To investigate the status of M1 and M2 macrophages in knee OA, synovial fluid as well as peripheral blood were collected from 80 patients with knee OA and 80 healthy controls. Reverse transcription-quantitative PCR was used to quantitatively detect the expression of CD11c as a marker for M1 macrophages and CD206 as a marker for M2 macrophages from synovial fluids...
December 2018: Experimental and Therapeutic Medicine
Caibo Sun, Yuning Sun, Endong Zhang
Small nucleolar RNA host gene 20 (SNHG20) has been reported to serve roles in several types of malignancies, while its role in nasopharyngeal carcinoma remains unknown. In the present study, tumor tissues and adjacent healthy tissues of patient with nasopharyngeal carcinoma, as well as blood samples from patients with nasopharyngeal carcinoma and heathy controls were collected, and expression levels of SNHG20 were detected by reverse transcription-quantitative polymerase chain reaction. Receiver operating characteristic curve and survival curve analyses were performed to evaluate the diagnostic and prognostic values of SNHG20 expression for nasopharyngeal carcinoma, respectively...
December 2018: Experimental and Therapeutic Medicine
Mehrnush Amiri Siavashani, Shahrzad Zadeh Modarres, Naghmeh Mirhosseini, Esmat Aghadavod, Saghar Salehpour, Zatollah Asemi
Purpose: This study was performed to determine the effects of chromium supplementation on the gene expression of insulin, lipid, and inflammatory markers in infertile women with polycystic ovary syndrome (PCOS) who were candidate for in vitro fertilization (IVF). Methods: Forty women, aged 18-40 years, who had been selected for IVF were recruited in this randomized double-blinded, placebo-controlled trial. They ( n = 20/group) were randomly assigned into intervention groups to take either 200 μg/day of chromium or placebo for 8 weeks...
2018: Frontiers in Endocrinology
Gorka Fernández-Eulate, Ainhoa Alberro, Maider Muñoz-Culla, Miren Zulaica, Mónica Zufiría, Myriam Barandiarán, Igone Etxeberria, José Javier Yanguas, Maria Mercedes Gallardo, Nora Soberón, Ana María Lacosta, Virginia Pérez-Grijalba, Jesús Canudas, Noelia Fandos, Pedro Pesini, Manuel Sarasa, Begoña Indakoetxea, Fermin Moreno, Itziar Vergara, David Otaegui, Maria Blasco, Adolfo López de Munain
Many factors may converge in healthy aging in the oldest old, but their association and predictive power on healthy or functionally impaired aging has yet to be demonstrated. By detecting healthy aging and in turn, poor aging, we could take action to prevent chronic diseases associated with age. We conducted a pilot study comparing results of a set of markers (peripheral blood mononuclear cell or PBMC telomere length, circulating Aβ peptides, anti-Aβ antibodies, and ApoE status) previously associated with poor aging or cognitive deterioration, and their combinations, in a cohort of "neurologically healthy" (both motor and cognitive) nonagenarians ( n = 20) and functionally impaired, institutionalized nonagenarians ( n = 38) recruited between 2014 and 2015...
2018: Frontiers in Aging Neuroscience
Kaneez Fatima Shad, Nazar Luqman, Ann M Simpson, Sara Lal
Atherosclerosis is the underlying cause of most myocardial infarction (MI) and ischaemic stroke episodes. An early sign of atherosclerosis is hypertrophy of the arterial wall. It is known that increased intima media thickness (IMT) is a non-invasive marker of arterial wall alteration, which can easily be assessed in the carotid arteries by high-resolution B-mode ultrasound. Similarly, the other key element of MI and ischaemic strokes is the N-methyl-D-aspartate (NMDA) receptor which is an ionotropic glutamate receptor that mediates the vast majority of excitatory neurotransmission in the brain...
2018: Biomarker Insights
Miguel Sampedro-Núñez, Ana Serrano-Somavilla, Magdalena Adrados, José M Cameselle-Teijeiro, Concepción Blanco-Carrera, José Manuel Cabezas-Agricola, Rebeca Martínez-Hernández, Elena Martín-Pérez, José Luis Muñoz de Nova, José Ángel Díaz, Rogelio García-Centeno, Javier Caneiro-Gómez, Ihab Abdulkader, Roberto González-Amaro, Mónica Marazuela
The immune checkpoint based therapy targeting the programmed death-1 (PD-1) receptor and its PD-L1 ligand has recently been approved for the therapy of different malignant conditions, but not yet for gastroenteropancreatic neuroendocrine tumors (GEP-NETs). In this context, we evaluated the expression of PD-1 and PD-L1 in GEP-NETs and its potential correlations with clinical outcomes. Expression of PD-1/PD-L1 was analyzed by immunohistochemistry in 116 GEP-NETs and 48 samples of peritumoral tissue. In addition, the expression of these molecules was assessed by flow cytometry in peripheral blood mononuclear cells (PBMC) from patients with GEP-NETs (n = 32) and healthy controls (n = 32) and in intratumoral mononuclear cells (TMCs) (n = 3)...
December 13, 2018: Scientific Reports
Johanna P van Geffen, Sanne L N Brouns, Joana Batista, Harriet McKinney, Carly Kempster, Magdolna Nagy, Suthesh Sivapalaratnam, Constance C F M J Baaten, Nikki Bourry, Mattia Frontini, Kerstin Jurk, Manuela Krause, Daniele Pillitteri, Frauke Swieringa, Remco Verdoold, Rachel Cavill, Marijke J E Kuijpers, Willem H Ouwehand, Kate Downes, Johan W M Heemskerk
In combination with microspotting, whole-blood microfluidics can provide high-throughput information on multiple platelet functions in thrombus formation. Based on assessment of the inter- and intra-subject variability in parameters of microspot-based thrombus formation, we aimed to determine the platelet factors contributing to this variation. Blood samples from 94 genotyped healthy subjects were analysed for conventional platelet phenotyping: i.e. haematological parameters, platelet glycoprotein expression levels and activation markers (24 parameters)...
December 13, 2018: Haematologica
Bo-Yi Yang, Iana Markevych, Joachim Heinrich, Gayan Bowatte, Michael S Bloom, Yuming Guo, Shyamali C Dharmage, Bin Jalaludin, Luke D Knibbs, Lidia Morawska, Zhengmin Min Qian, Duo-Hong Chen, Huimin Ma, Da Chen, Shao Lin, Mo Yang, Kang-Kang Liu, Xiao-Wen Zeng, Li-Wen Hu, Guang-Hui Dong
BACKGROUND: Residing in greener places may be protective against diabetes mellitus (DM) but evidence is scarce and comes mainly from developed countries. OBJECTIVES: To investigate associations of residential greenness with DM prevalence and glucose-homeostasis markers in Chinese adults and whether these associations were mediated by air pollution, physical activity, and body mass index. METHODS: In 2009, a total of 15,477 adults from the cross-sectional 33 Communities Chinese Health Study provided blood samples and completed a questionnaire...
December 10, 2018: International Journal of Hygiene and Environmental Health
N J Geraghty, D Watson, R Sluyter
Allogeneic haematopoietic stem cell transplantation (HSCT) is a frequent curative therapy for numerous haematological malignancies. However, HSCT is limited by the occurrence of graft-versus-host disease (GVHD), with current therapies restricted to general immunosuppression. Activation of the P2X7 receptor by extracellular adenosine triphosphate (ATP) causes inflammation and tissue damage in GVHD. Short-term pharmacological blockade of P2X7 has been shown to reduce clinical disease and/or reduce inflammatory markers in allogeneic and humanized mouse models of GVHD...
December 4, 2018: Cellular Immunology
Ali Taravati, Fatemeh Tohidi
Preeclampsia is a hypertensive disorder in pregnant women, which can be the leading cause of maternal and neonatal death or premature birth. Although the cause of preeclampsia is still not clear, local or systemic oxidative stress may explain the pathological features associated with this complication. However, it is not clear whether oxidative stress is the cause or the result of preeclampsia. For this purpose, the present meta-analysis was intended to evaluate the oxidant and antioxidant status in women with preeclampsia...
December 2018: Taiwanese Journal of Obstetrics & Gynecology
Rim Frikha, Tarek Rebai, Ben Mahmoud Lobna, Fakher Frikha, Moez Mdhaffar, Imen Frikha, Moez Elloumi, Nouha Bouayed
CONTEXT: Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms, mainly the C677T, have been implicated as risk factors for several cancers as the acute lymphoblastic leukemia (ALL). In addition, a potential effect of such variant on the efficacy of methotrexate (MTX) has been reported. OBJECTIVE: In this study, we evaluated the impact of the C677T variant of MTHFR on MTX-related toxicity in ALL patients from Tunisia; to provide new insights for a personalized therapy based on the human genotype...
December 14, 2018: Journal of Oncology Pharmacy Practice
Catalina Marín-Echeverri, Christopher N Blesso, Maria Luz Fernández, Yeisson Galvis-Pérez, Gelmy Ciro-Gómez, Vitelbina Núñez-Rangel, Juan C Aristizábal, Jacqueline Barona-Acevedo
Metabolic syndrome (MetS) is associated with low-grade inflammation and high-density lipoprotein (HDL) dysfunction. Polyphenol-rich foods may improve these alterations. Agraz is a fruit rich in polyphenols (mainly anthocyanins); however, there is limited information about its effects on human health. We evaluated the effects of agraz consumption as compared to placebo on HDL function and inflammation in women with MetS. Forty volunteers (25⁻60 years) were included in this double-blind crossover study. Women consumed agraz or placebo over 4 weeks; separated by a 4-week washout period...
December 8, 2018: Antioxidants (Basel, Switzerland)
Shih-Wei Huang, Yi-Ju Hsu, Mon-Chien Lee, Hua-Shuai Li, Paul Chee Wei Yeo, Ai Lin Lim, Chi-Chang Huang
Essence of chicken is a popular Asian nutritional supplement that is often taken to improve metabolism and general health. Although used as a traditional remedy for combating fatigue and general health, there has been few studies investigating the ergogenic properties of chicken essence and its associated mechanism. We conducted a study to investigate the anti-fatigue and anti-oxidant properties of essence of chicken (EC) after exercise. Six weeks old male Institute of Cancer Research (ICR) mice were divided to four groups (10 mice/group) and were provided different doses of Essence of Chicken (EC): (1) Vehicle (water), (2) EC-0...
December 7, 2018: Nutrients
Yang Liu, ShiYu Jia, Xue Liang, MeiXue Dong, XiaoMin Xu, ChangQi Lu, YouDong Wei
BACKGROUND: The blood-brain barrier is impaired in patients with stroke. The release of protein markers such as Sirtuin1 (SIRTl) into circulation may be useful to assess the prognosis of patients with cerebrovascular disease. In this study, we investigated the predictive value of SIRT1 levels in acute ischemic stroke (AIS) patients. METHODS: In all, 101 AIS patients and 38 healthy controls were enrolled, and blood samples were collected within 72 hours of stroke onset...
December 2018: Medicine (Baltimore)
R Akbari Moghaddam Kakhki, Z Lu, A Thanabalan, H Leung, M Mohammadigheisar, E Kiarie
There is limited information on the effects of enteric pathogen on bone quality in rapidly growing broiler chicks. We examined tibia and femur attributes (length, diameter, relative weight of ash content [AC] to the BW, ash concentration [AP]) and serum bone-turnover markers including receptor activator of nuclear factor kappa-B ligand (RANKL) for resorption, alkaline phosphatase (ALP) for mineralization, and selected serum metabolites in 14-day-old broilers challenged with Eimeria. A total of 160 (80 males and 80 females) 1-day-old Ross × Ross 708 chicks were used...
December 13, 2018: Poultry Science
Karlijn F M Denissen, Sandra G Heil, Simone J P M Eussen, Jim P J Heeskens, Carel Thijs, Monique Mommers, Luc J M Smits, Martien C J M van Dongen, Pieter C Dagnelie
Background: The effect of vitamin B-12 from different animal foods on vitamin B-12 biomarker status has not previously been evaluated in pregnant women. Objective: We examined the association of vitamin B-12 intake from dairy, meat, fish (including shellfish), and eggs with circulating concentrations of vitamin B-12 biomarkers and with the presence of vitamin B-12 deficiency in 1266 pregnant women participating in the KOALA Birth Cohort Study. Methods: Blood samples were collected in weeks 34-36 of pregnancy, and vitamin B-12 intake from foods and supplements was estimated with a semiquantitative food-frequency questionnaire (FFQ)...
December 12, 2018: Journal of Nutrition
Kenta Yoshida, Koichi Uemura, Masahiro Inoue, Nobuhiko Mizuno, Takayuki Murakami, Futoshi Tsuchiya
A 68-year-old man with swelling of his left testis was referred to our hospital. There was no history of hematologic disease. The diameter of the testicular mass was 40 mm. We performed a left orchiectomy. Histopathologic examination revealed diffuse infiltration of immature neoplastic cells with a high nuclearcytoplasmic ratio. Immunohistochemical analysis revealed that cells were positive for myeloperoxidase, while T-cell and B-cell markers were negative. There was no evidence of leukemia cells in peripheral blood or in bone marrow...
November 2018: Hinyokika Kiyo. Acta Urologica Japonica
Abbas Al-Qamari, Ibukunoluwa Adeleke, Adam Kretzer, Charles W Hogue
PURPOSE OF REVIEW: Central pulse pressure (PP), a marker of vascular stiffness, is a novel indicator of risk for perioperative morbidity including ischemic stroke. Appreciation for the mechanism by which vascular stiffness leads to organ dysfunction along with understanding its clinical detection may lead to improved patient management. RECENT FINDINGS: Vascular stiffness is associated with increased mortality and neurologic, cardiac, and renal injury in nonsurgical and surgical patients...
December 12, 2018: Current Opinion in Anaesthesiology
Azadeh Rasooli, Elham Ghafari, Hamed Saedi, Saba Miri
Background/aim: Sepsis is an unregulated systemic response to microbial invasion that can lead to multiple organ failure. This study aims at investigating the relationships among myeloperoxidase (MPO) and CD177 in major organ systems including whole blood, liver, and lung tissues in septic rats. Materials and methods: Sepsis was induced by cecal ligation and puncture (CLP) in female Wistar rats. Whole blood, liver, and lung samples were obtained from rats of 3 groups (n = 10 for each group, n total = 30: control as a wild-type group, laparotomy group (LAP), and CLP)...
December 12, 2018: Turkish Journal of Medical Sciences
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