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blood marker

Menglin Bai, Benkui Zou, Zhendan Wang, Pang Li, Huansheng Wang, Yang Ou, Kai Cui, Jiasheng Bian, Sheng Li, Xiaobin Xu
BACKGROUND/AIMS: Detection of circulating tumor cells (CTCs) in cancer patients has diagnostic and prognostic importance. However, the clinical implications of CTC detection in patients with renal cell carcinoma (RCC) are still unclear. In this study, we investigated the clinical significance of CTCs using two detection systems, the CellSearch system (CSS) and isolation by size of epithelial tumor cells (ISET), among RCC patients. METHODS: We recruited 36 RCC patients and 22 healthy volunteers as controls...
August 18, 2018: International Urology and Nephrology
Takashi Anayama, Masahiko Higashiyama, Hiroshi Yamamoto, Shinya Kikuchi, Atsuko Ikeda, Jiro Okami, Toshiteru Tokunaga, Kentaro Hirohashi, Ryohei Miyazaki, Kazumasa Orihashi
The AminoIndexTM Cancer Screening (AICS) system, a plasma-free amino acid (PFAA)-based multivariate discrimination index, is a blood screening test for lung cancer based on the comparison of PFAA concentrations between patients with lung cancer and healthy controls. Pre- and post-operative AICS values were compared among 72 patients who underwent curative resection for lung cancer. Post-operative changes in PFAA concentrations were also evaluated. AICS values were classified as rank A (0.0-4.9), B (5.0-7.9), or C (8...
August 17, 2018: Scientific Reports
Gene L Bowman, Loïc Dayon, Richard Kirkland, Jérôme Wojcik, Gwendoline Peyratout, India C Severin, Hugues Henry, Aikaterini Oikonomidi, Eugenia Migliavacca, Michael Bacher, Julius Popp
INTRODUCTION: Blood-brain barrier (BBB) breakdown is observed in older versus younger adults and in late-onset Alzheimer's disease versus age-matched controls, but its causes and consequences in aging are unclear. We tested the hypothesis that BBB breakdown is associated with cognitive decline and inflammation in nondemented elders. METHODS: Cerebrospinal fluid and serum inflammatory markers were measured using sandwich immunoassays in 120 subjects. Least Absolute Shrinkage and Selection Operator-logistic regression selected cerebrospinal fluid and serum signatures that best classified BBB impairment defined by the cerebrospinal fluid albumin index ≥9...
August 8, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
Chin-An Yang, Sandra Bauer, Yu-Chen Ho, Franziska Sotzny, Jan-Gowth Chang, Carmen Scheibenbogen
BACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic debilitating disease with huge social-economic impact. It has been suggested that immune dysregulation, nitrooxidative stress, and metabolic impairment might contribute to disease pathogenesis. However, the etiology of ME/CFS remains largely unclear, and diagnostic/prognostic disease markers are lacking. Several long noncoding RNAs (lncRNA, > 200 bp) have been reported to play roles in immunological diseases or in stress responses...
August 17, 2018: Journal of Translational Medicine
Zhaoyi Chen, Victoria Y Bird, Rupam Ruchi, Mark S Segal, Jiang Bian, Saeed R Khan, Marie-Carmelle Elie, Mattia Prosperi
BACKGROUND: Kidney stone (KS) disease has high, increasing prevalence in the United States and poses a massive economic burden. Diagnostics algorithms of KS only use a few variables with a limited sensitivity and specificity. In this study, we tested a big data approach to infer and validate a 'multi-domain' personalized diagnostic acute care algorithm for KS (DACA-KS), merging demographic, vital signs, clinical, and laboratory information. METHODS: We utilized a large, single-center database of patients admitted to acute care units in a large tertiary care hospital...
August 17, 2018: BMC Medical Informatics and Decision Making
Ima Dovinová, Eva Hrabárová, Eugene Jansen, Miroslava Kvandová, Miroslava Majzúnová, Andrea Berenyiová, Miroslav Barančík
Inhibition of nitric oxide (NO) production can influence blood pressure regulation and increase hypertension. Asymmetric dimethylarginine, ADMA, an analogue of L-arginine, can inhibit NO synthesis, impair endothelial function, and is a risk marker of cardiovascular diseases. Homocysteine (Hcy) level affects oxidative stress production of reactive oxygen species (ROS) in hypertension and also influences changes in signaling and cell damage. The present study was focused on experimental effects of exogenous NOS inhibitors and their effect on ADMA, an endogenous NOS inhibitor, homocysteine and ROS production measured as reactive oxidative metabolites (ROM)...
July 24, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Titi Liu, Zemin Xiang, Fei Chen, Dan Yin, Yewei Huang, Jing Xu, Lihong Hu, Huanhuan Xu, Xuanjun Wang, Jun Sheng
Drinking tea exhibits beneficial effects on bone health and may protect against osteoporosis, particularly in postmenopausal women. Theabrownin (TB) is the main component responsible for the biological activities of Pu-erh tea, but whether it possesses anti-osteoporotic potential remains unknown. Here we investigated the in vitro and in vivo anti-osteoporotic effects of TB in the RAW 264.7 cell line and ovariectomized (OVX) rats, respectively. Our in vitro studies showed that TB significantly suppressed RANKL-induced osteoclastogenesis and the expression of related marker proteins, including NFATc1, TRAP, c-Fos, and cathepsin K...
July 23, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Xuesong Xu, Menghao Wang, Jin-Zheng Li, Si-Dong Wei, Hao Wu, Xing Lai, Ding Cao, Zhi-Bing Ou, Jianping Gong
The aim of this study is to investigate the protective effect and the mechanism of tauroursodeoxycholic acid (TUDCA) against hepatic ischemia reperfusion (IR) injury. Male Balb/c mice were intraperitoneally injected with tauroursodeoxycholic acid (400 mg/kg) or saline solution, once per day for 3 days before surgery, and then the model of hepatic I/R injury was established. Blood and liver samples were collected from each group at 3, 6, and 24 h after surgery. Liver pathological changes, liver function, hepatocyte apoptosis and proinflammatory factors were detected...
July 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Britta Wilms, Rahel Keppler, Barbara Ernst, Sebastian M Schmid, Martin Thurnheer, Bernd Schultes
BACKGROUND: Even subjects with severe obesity show a wide range of metabolic health states, with some showing marked alterations in glucose and lipid metabolism whereas others do not. In severely obese women, we could recently show that the degree of cardiorespiratory fitness is, independently of body mass and age, associated with several markers of glucose and lipid metabolism. AIMS: In our retrospective study on a clinical data set, we questioned whether such an association also exists in severely obese men...
August 17, 2018: Experimental and Clinical Endocrinology & Diabetes
Emmanuelle Rochette, Etienne Merlin, Christophe Hourdé, Bertrand Evrard, Bruno Peraira, Stephane Echaubard, Pascale Duché
The aim of this study was to measure the impact, at 24 h post-exercise, of a single exercise bout on plasma inflammatory markers such as calprotectin, IL-6, sIL-6 R, sgp130 and the hypothalamic-pituitary-adrenal (HPA) axis in children with juvenile idiopathic arthritis (JIA).Twelve children with JIA attended the laboratory on three consecutive days (control day, exercise day and 24 h post-exercise), including a 20-min exercise bout on a cycle-ergometer at 70% of max. HR at 8:30 a.m. on day 2. Plasma concentrations of calprotectin, IL-6, sIL-6 R, sgp130, cortisol, ACTH and DHEA were measured on venous blood samples taken every day...
August 17, 2018: International Journal of Sports Medicine
Heba Ahmed Osman, Sanaa S Aly, Hasan S Mahmoud, Eman H Ahmed, Eman M Salah Eldin, Eman A Abdelrahim, Muhammad A El Masry, Rania A Herdan, Mohammed H Hassan
BACKGROUND AND AIMS: Gastroesophageal reflux disease (GERD) is a common prevalent disease. We aimed to assess the dynamic changes in the peripheral T lymphocytes and lymphocytes infiltrating the esophageal mucosa after treatment with proton-pump inhibitor (PPI) in patients with GERD. PATIENTS AND METHODS: A total of 200 patients who presented with upper GIT symptoms were included in this prospective study. All patients were subjected to full history taking, clinical examination, and complete blood count...
August 16, 2018: Journal of Clinical Gastroenterology
Ling-Bing Meng, Ze-Mou Yu, Peng Guo, Qing-Qing Wang, Ruo-Mei Qi, Meng-Jie Shan, Jian Lv, Tao Gong
INTRODUCTION: Cardiac-cerebral vascular diseases (CCVDs) are global health problems due to the characteristic of high mortality. It is found that atherosclerosis (AS), a main cause of CCVDs, is significantly relevant to the change of intimal and media thickness. Neutrophil count (NEU) and neutrophil-lymphocyte ratio (N/L) are recognized possible risk factors for atherosclerosis (AS). However, there are few studies on the separate relationship between carotid intimal thickness, media thickness and NEU, N/L...
August 3, 2018: Thrombosis Research
Jing Wang, Run-Zhen He, Ge-Ling Lu, Heng-Li Luo, Dan-Qi Lu, An-Xing Li
To effectively increase production and improve economic returns, the co-culture of Nile tilapia (Oreochromis niloticus) and marine shrimp has been adopted in many countries, including China. Although O. niloticus is an euryhaline fish that can tolerate elevated salinities and even full-strength seawater, fluctuations in salinity levels can undoubtedly induce stress and affect the immune response of this fish. Therefore, this study assessed the impact of salinity on vaccine efficacy in Nile tilapia, which used serum antibody level as a surrogate marker to detect vaccine efficacy...
August 14, 2018: Fish & Shellfish Immunology
Eliane Campos Alves, Jacqueline de Almeida Gonçalves Sachett, Vanderson Souza Sampaio, José Diego de Brito Sousa, Sâmella Silva de Oliveira, Elizandra Freitas do Nascimento, Alessandra Dos Santos Santos, Iran Mendonça da Silva, Ana Maria Moura da Silva, Fan Hui Wen, Mônica Colombini, Marcus Vinicius Guimarães de Lacerda, Wuelton Marcelo Monteiro, Luiz Carlos de Lima Ferreira
Acute Kidney Injury (AKI) is the main systemic complication and cause of death in viperid envenomation. Although there are hypotheses for the development of AKI, the mechanisms involved are still not established. The aim of this study was to evaluate the clinical-laboratorial-epidemiological factors associated with AKI in victims of Bothrops sp envenomation. This is an observational study carried out at the Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. AKI was defined according to the guidelines of the Acute Kidney Injury Network (AKIN)...
2018: PloS One
Susan A Safley, Norma S Kenyon, Dora M Berman, Graham F Barber, Melissa Willman, Stephanie Duncanson, Neal Iwakoshi, Robert Holdcraft, Lawrence Gazda, Peter Thompson, I Raul Badell, Athanassios Sambanis, Camillo Ricordi, Collin J Weber
BACKGROUND: Xenogeneic donors would provide an unlimited source of islets for the treatment of type 1 diabetes (T1D). The goal of this study was to assess the function of microencapsulated adult porcine islets (APIs) transplanted ip in streptozotocin (STZ)-diabetic non-human primates (NHPs) given targeted immunosuppression. METHODS: APIs were encapsulated in: (a) single barium-gelled alginate capsules or (b) double alginate capsules with an inner, islet-containing compartment and a durable, biocompatible outer alginate layer...
August 17, 2018: Xenotransplantation
Mazen M Jamil Al-Obaidi, Mohd Nasir Mohd Desa
This review aims to elucidate the different mechanisms of blood brain barrier (BBB) disruption that may occur due to invasion by different types of bacteria, as well as to show the bacteria-host interactions that assist the bacterial pathogen in invading the brain. For example, platelet-activating factor receptor (PAFR) is responsible for brain invasion during the adhesion of pneumococci to brain endothelial cells, which might lead to brain invasion. Additionally, the major adhesin of the pneumococcal pilus-1, RrgA is able to bind the BBB endothelial receptors: polymeric immunoglobulin receptor (pIgR) and platelet endothelial cell adhesion molecule (PECAM-1), thus leading to invasion of the brain...
August 16, 2018: Cellular and Molecular Neurobiology
Myat Su Bo, Whye Lian Cheah, Soe Lwin, Tin Moe Nwe, Than Than Win, Myint Aung
Background: Atherogenic index of plasma (AIP) was found to be one of the strongest markers in predicting the cardiovascular disease (CVD) risk. This study was to determine the AIP and its relationship with other CVD risk factors. Materials and Methods: This cross-sectional study was done among 349 staff of a public university in Sarawak. Data were collected using questionnaire, blood sampling, and anthropometric and blood pressure measurement. Data were analyzed using IBM SPSS version 20...
2018: Journal of Nutrition and Metabolism
Iryna Rusanova, María E Diaz-Casado, Marisol Fernández-Ortiz, Paula Aranda-Martínez, Ana Guerra-Librero, Francisco J García-García, Germaine Escames, Leocadio Mañas, Darío Acuña-Castroviejo
Although circulating microRNAs (miRNAs) can modulate gene expression and affect immune system response, little is known about their participation in age-associated frailty syndrome and sarcopenia. The aim of this study was to determine miRNAs as possible biomarkers of age and frailty and their correlation with oxidative and inflammatory state in human blood. Three inflammation-related miRNAs (miR-21, miR-146a, and miR-223) and one miRNA related with the control of melatonin synthesis (miR-483) were analyzed...
2018: Oxidative Medicine and Cellular Longevity
Marilena Greco, Claudio Palumbo, Fernando Sicuro, Giambattista Lobreglio
Background: Sepsis is currently defined as a life-threatening organ dysfunction caused by a deregulated host response to infection. There is increasing evidence that the endothelium plays a crucial and pathogenic role in sepsis. Profound alterations of the endothelium associated with sepsis include increased leucocytes adhesions, shift to a procoagulant state, vasodilatation, altered barrier function with more permeable capillaries and tissue edema. The vascular endothelial growth factor (VEGF) pathway is involved in the control of microvascular permeability and has been involved in the pathogenesis of conditions associated with endothelial barrier disruption such as sepsis...
September 2018: Journal of Clinical Medicine Research
Jianhong Wang, Zicheng Hu, Shu Yang, Chengchun Liu, Haimei Yang, Duozi Wang, Fuqiang Guo
Cerebral apoplexy is a disease caused by obstruction of the blood circulation in the brain. Evidence has indicated that inflammatory cytokines are implicated in ischaemic cerebral apoplexy and are regarded as a general cardiovascular risk factor, which may be a possible immediate trigger, a component of the response to tissue injury and a therapeutic target. The present study investigated changes of inflammatory cytokines and cells in patients with cerebral apoplexy at the intensive care unit (ICU). The plasma concentrations of inflammatory cytokines, including tumor necrosis factor (TNF)-α, interleukin (IL)-4, IL-6, IL-8, IL-10, IL-1β and IL-17A were evaluated using ELISA...
August 2018: Experimental and Therapeutic Medicine
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