keyword
https://read.qxmd.com/read/38535455/marine-derived-anticancer-agents-targeting-apoptotic-pathways-exploring-the-depths-for-novel-cancer-therapies
#1
REVIEW
Doralyn S Dalisay, Chuckcris P Tenebro, Edna M Sabido, Angelica Faith L Suarez, Melissa June V Paderog, Rikka Reyes-Salarda, Jonel P Saludes
Extensive research has been conducted on the isolation and study of bioactive compounds derived from marine sources. Several natural products have demonstrated potential as inducers of apoptosis and are currently under investigation in clinical trials. These marine-derived compounds selectively interact with extrinsic and intrinsic apoptotic pathways using a variety of molecular mechanisms, resulting in cell shrinkage, chromatin condensation, cytoplasmic blebs, apoptotic bodies, and phagocytosis by adjacent parenchymal cells, neoplastic cells, or macrophages...
February 28, 2024: Marine Drugs
https://read.qxmd.com/read/38535442/natural-products-derived-from-marine-sponges-with-antitumor-potential-against-lung-cancer-a-systematic-review
#2
REVIEW
Alba Ortigosa-Palomo, Francisco QuiƱonero, Raul Ortiz, Francisco Sarabia, Jose Prados, ConsolaciĆ³n Melguizo
Non-small-cell lung cancer (NSCLC), the most commonly diagnosed cancer and the leading cause of cancer-related death worldwide, has been extensively investigated in the last decade in terms of developing new therapeutic options that increase patient survival. In this context, marine animals are a source of new, interesting bioactive molecules that have been applied to the treatment of different types of cancer. Many efforts have been made to search for new therapeutic strategies to improve the prognosis of lung cancer patients, including new bioactive compounds and cytotoxic drugs from marine sponges...
February 23, 2024: Marine Drugs
https://read.qxmd.com/read/38535034/lifestyle-medicine-for-the-prevention-and-treatment-of-pancreatitis-and-pancreatic-cancer
#3
REVIEW
Sruthi Kapliyil Subramanian, Bhaumik Brahmbhatt, Jennifer M Bailey-Lundberg, Nirav C Thosani, Pritesh Mutha
The incidence of pancreatitis and pancreatic cancer is on the upswing in the USA. These conditions often lead to higher healthcare costs due to the complex nature of diagnosis and the need for specialized medical interventions, surgical procedures, and prolonged medical management. The economic ramification encompasses direct healthcare expenses and indirect costs related to productivity losses, disability, and potential long-term care requirements. Increasing evidence underscores the importance of a healthy lifestyle in preventing and managing these conditions...
March 14, 2024: Diagnostics
https://read.qxmd.com/read/38534922/unlocking-the-potential-of-therapy-induced-cytokine-responses-illuminating-new-pathways-in-cancer-precision-medicine
#4
REVIEW
Dilip R Gunturu, Mohammed Hassan, Deepa Bedi, Pran Datta, Upender Manne, Temesgen Samuel
Precision cancer medicine primarily aims to identify individual patient genomic variations and exploit vulnerabilities in cancer cells to select suitable patients for specific drugs. These genomic features are commonly determined by gene sequencing prior to therapy, to identify individuals who would be most responsive. This precision approach in cancer therapeutics remains a powerful tool that benefits a smaller pool of patients, sparing others from unnecessary treatments. A limitation of this approach is that proteins, not genes, are the ultimate effectors of biological functions, and therefore the targets of therapeutics...
February 23, 2024: Current Oncology
https://read.qxmd.com/read/38534736/unraveling-the-multifaceted-role-of-the-mir-17-92-cluster-in-colorectal-cancer-from-mechanisms-to-biomarker-potential
#5
REVIEW
Hakeemah H Al-Nakhle
Colorectal cancer (CRC) is a complex disease driven by intricate mechanisms, making it challenging to understand and manage. The miR-17-92 cluster has gained significant attention in CRC research due to its diverse functions and crucial role in various aspects of the disease. This cluster, consisting of multiple individual miRNAs, influences critical processes like tumor initiation, angiogenesis, metastasis, and the epithelial-mesenchymal transition (EMT). Beyond its roles in tumorigenesis and progression, miR-17-92's dysregulation in CRC has substantial implications for diagnosis, prognosis, and treatment, including chemotherapy responsiveness...
February 28, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534423/research-progress-of-nanomaterials-acting-on-nk-cells-in-tumor-immunotherapy-and-imaging
#6
REVIEW
Yachan Feng, Haojie Zhang, Jiangtao Shao, Chao Du, Xiaolei Zhou, Xueling Guo, Yingze Wang
The prognosis for cancer patients has declined dramatically in recent years due to the challenges in treating malignant tumors. Tumor immunotherapy, which includes immune target inhibition and chimeric antigen receptor cell treatment, is currently evolving quickly. Among them, natural killer (NK) cells are gradually becoming another preferred cell immunotherapy after T cell immunotherapy due to their unique killing effects in innate and adaptive immunity. NK cell therapy has shown encouraging outcomes in clinical studies; however, there are still some problems, including limited efficacy in solid tumors, inadequate NK cell penetration, and expensive treatment expenses...
February 27, 2024: Biology
https://read.qxmd.com/read/38533507/cellular-interactions-in-tumor-microenvironment-during-breast-cancer-progression-new-frontiers-and-implications-for-novel-therapeutics
#7
REVIEW
Tosin Akinsipe, Rania Mohamedelhassan, Ayuba Akinpelu, Satyanarayana R Pondugula, Panagiotis Mistriotis, L Adriana Avila, Amol Suryawanshi
The breast cancer tumor microenvironment (TME) is dynamic, with various immune and non-immune cells interacting to regulate tumor progression and anti-tumor immunity. It is now evident that the cells within the TME significantly contribute to breast cancer progression and resistance to various conventional and newly developed anti-tumor therapies. Both immune and non-immune cells in the TME play critical roles in tumor onset, uncontrolled proliferation, metastasis, immune evasion, and resistance to anti-tumor therapies...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38532510/care-management-and-use-of-ferrets-in-biomedical-research
#8
REVIEW
Ravindran Kumar Pramod, Pravin Kumar Atul, Mamta Pandey, S Anbazhagan, Suhas T Mhaske, R Barathidasan
The ferret (Mustela putorius furo) is a small domesticated species of the family Mustelidae within the order Carnivora. The present article reviews and discusses the current state of knowledge about housing, care, breeding, and biomedical uses of ferrets. The management and breeding procedures of ferrets resemble those used for other carnivores. Understanding its behavior helps in the use of environmental enrichment and social housing, which promote behaviors typical of the species. Ferrets have been used in research since the beginning of the twentieth century...
March 26, 2024: Laboratory Animal Research
https://read.qxmd.com/read/38531982/the-pleiotropic-functions-of-reactive-oxygen-species-in-cancer
#9
REVIEW
Katherine Wu, Ahmed Ezat El Zowalaty, Volkan I Sayin, Thales Papagiannakopoulos
Cellular redox homeostasis is an essential, dynamic process that ensures the balance between reducing and oxidizing reactions within cells and thus has implications across all areas of biology. Changes in levels of reactive oxygen species can disrupt redox homeostasis, leading to oxidative or reductive stress that contributes to the pathogenesis of many malignancies, including cancer. From transformation and tumor initiation to metastatic dissemination, increasing reactive oxygen species in cancer cells can paradoxically promote or suppress the tumorigenic process, depending on the extent of redox stress, its spatiotemporal characteristics and the tumor microenvironment...
March 2024: Nature Cancer
https://read.qxmd.com/read/38531576/efficacy-and-safety-of-natural-killer-cells-injection-combined-with-xelox-chemotherapy-in-postoperative-patients-with-stage-iii-colorectal-cancer-in-china-a-prospective-randomised-controlled-clinical-trial-study-protocol
#10
JOURNAL ARTICLE
Shan Geng, Xingrui Yu, Shaohong Yu
BACKGROUND: Colorectal cancer (CRC) is the second most frequently diagnosed cancer and the fifth leading cause of cancer-related death in China. However, resistance to multiple chemotherapeutics after surgery leads to failure of the main therapy to CRC. Natural killer (NK) cells are innate cytotoxic lymphocytes that exhibit strong cytotoxic activity against tumour cells. NK cell-based therapy, either alone or in combination with chemotherapy, has achieved favourable results and holds promise for addressing recurrence and metastasis in CRC patients after surgery...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38530545/glioblastoma-stem-cell-metabolism-and-immunity
#11
REVIEW
Joseph Hawly, Micaela G Murcar, Alejandro Schcolnik-Cabrera, Mark E Issa
Despite enormous efforts being invested in the development of novel therapies for brain malignancies, there remains a dire need for effective treatments, particularly for pediatric glioblastomas. Their poor prognosis has been attributed to the fact that conventional therapies target tumoral cells, but not glioblastoma stem cells (GSCs). GSCs are characterized by self-renewal, tumorigenicity, poor differentiation, and resistance to therapy. These characteristics represent the fundamental tools needed to recapitulate the tumor and result in a relapse...
March 26, 2024: Cancer Metastasis Reviews
https://read.qxmd.com/read/38529282/immune-pathogenesis-of-idiopathic-granulomatous-mastitis-from-etiology-toward-therapeutic-approaches
#12
REVIEW
Xiaoli Wang, Xiujing He, Junzhi Liu, Haiyan Zhang, Hangyu Wan, Jing Luo, Jiqiao Yang
Idiopathic granulomatous mastitis (IGM) is a noncancerous, chronic inflammatory disorder of breast with unknown causes, posing significant challenges to the quality of life due to its high refractoriness and local aggressiveness. The typical symptoms of this disease involve skin redness, a firm and tender breast mass and mastalgia; others may include swelling, fistula, abscess (often without fever), nipple retraction, and peau d'orange appearance. IGM often mimics breast abscesses or malignancies, particularly inflammatory breast cancer, and is characterized by absent standardized treatment options, inconsistent patient response and unknown mechanism...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38528141/mirvetuximab-soravtansine-has-activity-in-platinum-sensitive-epithelial-ovarian-cancer
#13
JOURNAL ARTICLE
Diana Romero
No abstract text is available yet for this article.
March 25, 2024: Nature Reviews. Clinical Oncology
https://read.qxmd.com/read/38528062/extend-the-benchmarking-indel-set-by-manual-review-using-the-individual-cell-line-sequencing-data-from-the-sequencing-quality-control-2-seqc2-project
#14
JOURNAL ARTICLE
Binsheng Gong, Dan Li, Yifan Zhang, Rebecca Kusko, Samir Lababidi, Zehui Cao, Mingyang Chen, Ning Chen, Qiaochu Chen, Qingwang Chen, Jiacheng Dai, Qiang Gan, Yuechen Gao, Mingkun Guo, Gunjan Hariani, Yujie He, Wanwan Hou, He Jiang, Garima Kushwaha, Jian-Liang Li, Jianying Li, Yulan Li, Liang-Chun Liu, Ruimei Liu, Shiming Liu, Edwin Meriaux, Mengqing Mo, Mathew Moore, Tyler J Moss, Quanne Niu, Ananddeep Patel, Luyao Ren, Nedda F Saremi, Erfei Shang, Jun Shang, Ping Song, Siqi Sun, Brent J Urban, Danke Wang, Shangzi Wang, Zhining Wen, Xiangyi Xiong, Jingcheng Yang, Lihui Yin, Chao Zhang, Ruolan Zhang, Ambica Bhandari, Wanshi Cai, Agda Karina Eterovic, Dalila B Megherbi, Tieliu Shi, Chen Suo, Ying Yu, Yuanting Zheng, Natalia Novoradovskaya, Renee L Sears, Leming Shi, Wendell Jones, Weida Tong, Joshua Xu
Accurate indel calling plays an important role in precision medicine. A benchmarking indel set is essential for thoroughly evaluating the indel calling performance of bioinformatics pipelines. A reference sample with a set of known-positive variants was developed in the FDA-led Sequencing Quality Control Phase 2 (SEQC2) project, but the known indels in the known-positive set were limited. This project sought to provide an enriched set of known indels that would be more translationally relevant by focusing on additional cancer related regions...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38527559/reassessing-the-role-of-phytochemicals-in-cancer-chemoprevention
#15
REVIEW
Gian Luigi Russo, Carmela Spagnuolo, Maria Russo
In this comprehensive review we tried to reassess the role of phytochemicals in cancer chemoprevention. The exploration of the "synergistic effect" concept, advocating combined chemopreventive agents, faces challenges like low bioavailability. The review incorporates personal, occasionally controversial, viewpoints on natural compounds' cancer preventive capabilities, delving into mechanisms. Prioritizing significant contributions within the vast research domain, we aim stimulating discussion to provide a comprehensive insight into the evolving role of phytochemicals in cancer prevention...
March 23, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38525971/therapeutic-implications-of-dietary-polyphenols-loaded-nanoemulsions-in-cancer-therapy
#16
REVIEW
Ritu Tomar, Sabya Sachi Das, Venkata Krishna Rao Balaga, Srusti Tambe, Jagannath Sahoo, Santosh Kumar Rath, Janne Ruokolainen, Kavindra Kumar Kesari
Cancer is one of the major causes of death worldwide, even the second foremost cause related to non-communicable diseases. Cancer cells typically possess several cellular and biological processes including, persistence, propagation, differentiation, cellular death, and expression of cellular-type specific functions. The molecular picture of carcinogenesis and progression is unwinding, and it appears to be a tangled combination of processes occurring within and between cancer cells and their surrounding tissue matrix...
March 25, 2024: ACS Applied Bio Materials
https://read.qxmd.com/read/38523646/insights-into-the-glioblastoma-tumor-microenvironment-current-and-emerging-therapeutic-approaches
#17
REVIEW
Dev Kumar Tripathy, Lakshmi Priya Panda, Suryanarayan Biswal, Kalpana Barhwal
Glioblastoma (GB) is an intrusive and recurrent primary brain tumor with low survivability. The heterogeneity of the tumor microenvironment plays a crucial role in the stemness and proliferation of GB. The tumor microenvironment induces tumor heterogeneity of cancer cells by facilitating clonal evolution and promoting multidrug resistance, leading to cancer cell progression and metastasis. It also plays an important role in angiogenesis to nourish the hypoxic tumor environment. There is a strong interaction of neoplastic cells with their surrounding microenvironment that comprise several immune and non-immune cellular components...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38523637/akr1c3-in-carcinomas-from-multifaceted-roles-to-therapeutic-strategies
#18
REVIEW
Mengnan Li, Limin Zhang, Jiahui Yu, Xiaoxiao Wang, Le Cheng, Zhaowu Ma, Xiaoguang Chen, Lingzhi Wang, Boon Cher Goh
Aldo-Keto Reductase Family 1 Member C3 (AKR1C3), also known as type 5 17β-hydroxysteroid dehydrogenase (17β-HSD5) or prostaglandin F (PGF) synthase, functions as a pivotal enzyme in androgen biosynthesis. It catalyzes the conversion of weak androgens, estrone (a weak estrogen), and PGD2 into potent androgens (testosterone and 5α-dihydrotestosterone), 17β-estradiol (a potent estrogen), and 11β-PGF2α, respectively. Elevated levels of AKR1C3 activate androgen receptor (AR) signaling pathway, contributing to tumor recurrence and imparting resistance to cancer therapies...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38523440/efficient-electrochemiluminescence-sensing-in-microfluidic-biosensors-a-review
#19
JOURNAL ARTICLE
Clementine Juliat Louw, Pim de Haan, Elisabeth Verpoorte, Priscilla Baker
Microfluidic devices are capable of handling 10-9 L to 10-18 L of fluids by incorporating tiny channels with dimensions of ten to hundreds of micrometers, and they can be fabricated using a wide range of materials including glass, silicon, polymers, paper, and cloth for tailored sensing applications. Microfluidic biosensors integrated with detection methods such as electrochemiluminescence (ECL) can be used for the diagnosis and prognosis of diseases. Coupled with ECL, these tandem devices are capable of sensing biomarkers at nanomolar to picomolar concentrations, reproducibly...
2024: Critical Reviews in Biomedical Engineering
https://read.qxmd.com/read/38523142/assessing-anatomical-variations-of-the-inferior-mesenteric-artery-via-three-dimensional-ct-angiography-and-laparoscopic-colorectal-surgery-a-retrospective-observational-study
#20
JOURNAL ARTICLE
Yuanyi Ding, Botian Zhao, Wenbo Niu, Xuhua Hu, Chenhui Li, Zining Liu, Bin Yu
To assess the anatomy of the inferior mesenteric artery (IMA) and its branches by reviewing laparoscopic left-sided colorectal cancer surgery videos and comparing them with preoperative three-dimensional computed tomography (3D-CT) angiography, to verify the accuracy of 3D-CT vascular reconstruction techniques. High-definition surgical videos and preoperative imaging data of 200 patients who underwent laparoscopic left-sided colorectal cancer surgery were analysed, and the alignment of the IMA and its branches in relation to the inferior mesenteric vein (IMV) was observed and summarized...
March 24, 2024: Scientific Reports
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