Khalid Odamizil Alzamely, Farnaz Hajizadeh, Morteza Heydari, Mohamad Javad Ghaderi Sede, Sima Hydarzadeh Asl, Makwan Peydaveisi, Ali Masjedi, Sepideh Izadi, Afshin Nikkhoo, Fatemeh Atyabi, Afshin Namdar, Behzad Baradaran, Mozhdeh Sojoodi, Farhad Jadidi-Niaragh
Abnormal expression of several macromolecules within tumor milieu helps the development of neoplasia and immune suppression in various cancers. ZEB-1 and CD73 are important factors in tumor progression, which their overexpression in tumor site enhances several cancer hallmarks, including proliferation, angiogenesis, metastasis, migration, and invasion. In this study, we decided to inhibit the expression of these factors in the tumor site by using RGD-conjugated chitosan lactate (RGD-CL) nanoparticles (NPs) encapsulating CD73/ZEB-1 siRNA molecules, in vitro and in vivo...
October 18, 2020: Colloids and Surfaces. B, Biointerfaces