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https://www.readbyqxmd.com/read/30335643/efficacy-of-a-surfactant-based-wound-dressing-in-the-prevention-of-biofilms
#1
Anne-Marie Salisbury, Steven L Percival
OBJECTIVE: To assess the biofilm prevention action of two wound dressings, a concentrated surfactant gel preserved with antimicrobials and a concentrated surfactant gel with 1% silver sulfadiazine. METHODS: The microorganisms Staphylococcus aureus, methicillin-resistant S aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Enterococcus faecalis were used. Several biofilm models were used whereby the surfaces of each model were coated with either the concentrated surfactant gel preserved with antimicrobials or the concentrated surfactant gel with SSD before biofilm growth...
November 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/30335505/long-term-mortality-is-increased-in-patients-with-undetected-prediabetes-and-type-2-diabetes-hospitalized-for-worsening-heart-failure-and-reduced-ejection-fraction
#2
Andrija Pavlović, Marija Polovina, Arsen Ristić, Jelena P Seferović, Ivana Veljić, Dejan Simeunović, Ivan Milinković, Gordana Krljanac, Milika Ašanin, Irena Oštrić-Pavlović, Petar M Seferović
Background We assessed the prevalence of newly diagnosed prediabetes and type-2 diabetes mellitus (T2DM), and their impact on long-term mortality in patients hospitalized for worsening heart failure with reduced ejection fraction (HFrEF). Methods We included patients hospitalized with HFrEF and New York Heart Association (NYHA) functional class II-III. Baseline two-hour oral glucose tolerance test was used to classify patients as normoglycaemic or having newly diagnosed prediabetes or T2DM. Outcomes included post-discharge all-cause and cardiovascular mortality during the median follow-up of 2...
October 18, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/30334584/a-predictive-model-for-fall-risk-in-hospitalized-adults-a-case-control-study
#3
Isis Marques Severo, Ricardo Kuchenbecker, Débora Feijó Villas Boas Vieira, Luciana Ramos Correa Pinto, Michele Elisa Weschenfelder Hervé, Amália de Fátima Lucena, Miriam de Abreu Almeida
AIM: To develop and validate a predictive model for falls in hospitalized adult clinical and surgical patients, assessing intrinsic (i.e. patient-related) and extrinsic factors (i.e. care process-related). BACKGROUND: To identify factors predictive of falls and enable appropriate management of fall risk it is necessary to understand patient and environmental factors, along with care delivery processes. DESIGN: A matched case-control study...
October 18, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/30332515/adaptive-method-for-multicriteria-optimization-of-intensity-modulated-proton-therapy
#4
Hisham Kamal-Sayed, J Ma, H Tseung, A Abdel-Rehim, M G Herman, C J Beltran
PURPOSE: Provide an adaptive multicriteria optimization (MCO) method for intensity modulated proton therapy (IMPT) utilizing GPU technology. Previously described limitations of MCO such as Pareto approximation and limitation on the number of objectives were addressed. METHODS: The treatment planning process for IMPT must account for multiple objectives, which requires extensive treatment planning resources. Often a large number of objectives (>10) are required...
October 17, 2018: Medical Physics
https://www.readbyqxmd.com/read/30332320/a-novel-vertebrate-system-for-the-examination-and-direct-comparison-of-the-relative-biological-effectiveness-for-different-radiation-qualities-and-sources
#5
E R Szabó, Z Reisz, R Polanek, T Tőkés, Sz Czifrus, Cs Pesznyák, B Biró, A Fenyvesi, B Király, J Molnár, Sz Brunner, B Daroczi, Z Varga, K Hideghéty
PURPOSE: The recent rapid increase of hadron therapy applications requires the development of high performance, reliable in vivo models for preclinical research on the biological effects of high linear energy transfer (LET) particle radiation. AIM: The aim of this paper was to test the relative biological effectiveness (RBE) of the zebrafish embryo system at two neutron facilities. MATERIAL AND METHODS: Series of viable zebrafish embryos at 24-hour post-fertilization (hpf) were exposed to single fraction, whole-body, photon and neutron (reactor fission neutrons (<En = 1 MeV>) and (p (18 MeV)+Be, <En> = 3...
October 17, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/30329224/pharmacokinetics-of-a-lobeglitazone-metformin-fixed-dose-combination-tablet-ckd-395-0-5-1000-mg-versus-concomitant-administration-of-single-agents-and-the-effect-of-food-on-the-metabolism-of-ckd-395-in-healthy-male-subjects
#6
Sun-Young Kim, Ji-Young Jeon, Shin Jung Park, Min-Gul Kim
This study aimed to compare the pharmacokinetic profile of combined CKD-395 0.5/1000 mg treatment with that of the coadministration of lobeglitazone sulfate 0.5 mg and metformin hydrochloride (HCl) extended-release (XR) 1000 mg and assess the effect of food on the pharmacokinetics of CKD-395 0.5/1000 mg. Two clinical trials were conducted as part of an open-label, single-dose, randomized, 2-period, 2-sequence crossover study. In study 1, a total of 26 subjects received either CKD-395 0.5/1000 mg as a test drug or coadministration of lobeglitazone sulfate 0...
October 17, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/30329199/efficacy-and-safety-of-a-triple-active-sore-throat-lozenge-in-the-treatment-of-patients-with-acute-pharyngitis-results-of-a-multi-centre-randomised-placebo-controlled-double-blind-parallel-group-trial-doripha
#7
Jürgen Palm, Katharina Fuchs, Holger Stammer, Anne Schumacher-Stimpfl, Jens Milde
OBJECTIVE: The aim of this multi-centre, randomised, double-blind, placebo-controlled trial was to compare the efficacy and safety of the fixed combination of 0.5 mg tyrothricin, 1.0 mg benzalkonium chloride, and 1.5 mg benzocaine (study drug marketed as Dorithricin® ) in repeat dosing for 3 days to match placebo lozenges in the treatment of acute pharyngitis in adults. METHODS: Patients (pts, aged ≥18 years) with acute pharyngitis, ie, non-streptococcal sore throat and moderate-to-severe pain (intensity NRS ≥ 7; VAS ≥ 50) were assigned to study drug (n = 160) or matching placebo (n = 161)...
October 17, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/30328894/long-term-bonding-efficacy-of-adhesives-containing-benzodioxioles-as-alternative-co-initiators
#8
Giana da Silveira Lima, Andressa Goicochea Moreira, Carine Tais Welter Meereis, Ginia Brito Lima, Fernanda Barbosa Leal, Rafael Ratto de Moraes, Fabrício A Ogliari, Cesar Liberato Petzhold, Evandro Piva
This study evaluated the three-year lifespan of the bond to dentin of experimental self-etch adhesives containing benzodioxole derivatives - 1,3-benzodioxole (BDO) and piperonyl alcohol (PA) - as co-initiator alternative to amines. Adhesive resins were formulated using Bis-GMA, TEGDMA, HEMA, camphorquinone and different co-initiators: BDO, PA or ethyl 4-dimethylamino benzoate (EDAB - amine). An experimental self-etch primer was used to complete the two-step, self-etch adhesive system. Clearfil SE Bond (CSE) was used as commercial reference...
October 11, 2018: Brazilian Oral Research
https://www.readbyqxmd.com/read/30328764/natural-language-processing-to-assess-end-of-life-quality-indicators-in-cancer-patients-receiving-palliative-surgery
#9
Charlotta Lindvall, Elizabeth J Lilley, Sophia N Zupanc, Isabel Chien, Brooks V Udelsman, Anne Walling, Zara Cooper, James A Tulsky
BACKGROUND: Palliative surgical procedures are frequently performed to reduce symptoms in patients with advanced cancer, but quality is difficult to measure. OBJECTIVE: To determine whether natural language processing (NLP) of the electronic health record (EHR) can be used to (1) identify a population of cancer patients receiving palliative gastrostomy and (2) assess documentation of end-of-life process measures in the EHR. DESIGN/SETTING: Retrospective cohort study of 302 adult cancer patients who received a gastrostomy tube at a single tertiary medical center...
October 17, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/30328405/a-standardized-low-cost-peer-role-playing-training-intervention-improves-medical-student-competency-in-communicating-bad-news-to-patients-in-botswana
#10
Katherine D Westmoreland, Francis M Banda, Andrew P Steenhoff, Elizabeth D Lowenthal, Erik Isaksson, Bernhard A Fassl
OBJECTIVE: The purpose of this study was to demonstrate effectiveness of an educational training workshop using role-playing to teach medical students in Botswana to deliver bad news. METHOD: A 3-hour small group workshop for University of Botswana medical students rotating at the Princess Marina Hospital in Gaborone was developed. The curriculum included an overview of communication basics and introduction of the validated (SPIKES) protocol for breaking bad news...
October 17, 2018: Palliative & Supportive Care
https://www.readbyqxmd.com/read/30328091/assessment-of-stool-frequency-and-colonic-transit-time-in-indian-children-with-functional-constipation-and-healthy-controls
#11
Upender Shava, Surender Kumar Yachha, Anshu Srivastava, Ujjal Poddar, Moinak Sen Sarma
INTRODUCTION: Indian adults have higher stool frequency and shorter colonic transit time compared to the Western population. Colonic transit time has not been studied well in Indian children. We aimed to compare colonic transit time in normal and constipated children. METHODS: In this prospective study, stool characteristics and colonic transit time by radio-opaque markers were studied in healthy children (group A, n = 39) and functional constipation patients (group B, n = 61)...
October 17, 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/30327949/quantitative-and-qualitative-assessment-of-sensory-changes-induced-by-local-anesthetics-block-of-two-different-trigeminal-nerve-branches
#12
Simple Futarmal Kothari, Michiharu Shimosaka, Takashi Iida, Osamu Komiyama, Koh Shibutani, Peter Svensson, Lene Baad-Hansen
OBJECTIVES: The aims were to use different techniques to assess the degree of sensory changes and magnitude of perceived size changes in the facial region induced by nerve blocks of two different trigeminal nerve branches in healthy participants. MATERIALS AND METHODS: This placebo-controlled study included 30 healthy volunteers. The participants underwent quantitative and qualitative sensory testing (QST and QualST) thrice: before, 10 min, and 2 h after mental (n = 15) and infraorbital (n = 15) nerve blocks and during control (saline) sessions...
October 16, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/30327878/family-caregivers-for-adult-cancer-patients-knowledge-and-self-efficacy-for-pain-management-in-a-resource-limited-setting
#13
Irene Betty Kizza, Jeanette Maritz
Adult cancer patients (ACPs) in resource-limited settings disproportionately suffer from inadequate pain control despite advancements in pain management. Family caregivers (FCGs) can support optimal pain control for ACPs in these settings if they are knowledgeable and confident about the needed care. However, the status of FCGs' knowledge and self-efficacy (SE) for pain management in developing countries is not well established. PURPOSE: To assess the FCGs' knowledge and SE levels for pain management among ACPs while at home in a resource-limited setting...
October 16, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/30327415/a-simple-clinical-assessment-is-superior-to-systematic-triage-in-prediction-of-mortality-in-the-emergency-department
#14
Anne Kristine Servais Iversen, Michael Kristensen, Rebecca Monett Østervig, Lars Køber, György Sölétormos, Jakob Lundager Forberg, Jesper Eugen-Olsen, Lars Simon Rasmussen, Morten Schou, Kasper Karmark Iversen
OBJECTIVE: To compare the Danish Emergency Process Triage (DEPT) with a quick clinical assessment (Eyeball triage) as predictors of short-term mortality in patients in the emergency department (ED). METHODS: The investigation was designed as a prospective cohort study conducted at North Zealand University Hospital. All patient visits to the ED from September 2013 to December 2013 except minor injuries were included. DEPT was performed by nurses. Eyeball triage was a quick non-systematic clinical assessment based on patient appearance performed by phlebotomists...
October 16, 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/30326747/effects-of-robot-morning-walk-%C3%A2-assisted-gait-training-for-patients-after-stroke-a-randomized-controlled-trial
#15
JaYoung Kim, Dae Yul Kim, Min Ho Chun, Seong Woo Kim, Ha Ra Jeon, Chang Ho Hwang, Jong Kyoung Choi, Suhwan Bae
OBJECTIVE: To investigate the effects of Morning Walk® -assisted gait training for patients with stroke. DESIGN: Prospective randomized controlled trial. SETTING: Three hospital rehabilitation departments (two tertiary and one secondary). PATIENTS: We enrolled 58 patients with hemiparesis following a first-time stroke within the preceding year and with Functional Ambulation Category scores ⩾2. INTERVENTION: The patients were randomly assigned to one of two treatment groups: 30 minutes of training with Morning Walk® , a lower limb rehabilitation robot, plus 1 hour of conventional physiotherapy (Morning Walk® group; n = 28); or 1...
October 16, 2018: Clinical Rehabilitation
https://www.readbyqxmd.com/read/30325547/effects-of-storage-conditions-on-two-platelet-agonists-for-whole-blood-impedance-platelet-aggregometry-in-dogs
#16
Sarah B Shropshire, Christine S Olver
BACKGROUND: Whole blood impedance platelet aggregometry (Multiplate-) can be performed with different agonists to evaluate platelet function. Although the manufacturer recommends disposal of stored reagents after 1 month at -20°C or 24 hours at 4°C, reagent integrity after reconstitution under different storage conditions is unknown. If reagent integrity is stable for longer periods, assay costs could decrease dramatically. OBJECTIVES: This study aimed to determine the stability of reconstituted arachidonic acid (AA) and adenosine diphosphate (ADP) platelet agonists stored at -20°C and -80°C for up to 6 months...
October 16, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/30325529/follow-up-study-of-the-early-randomised-paracetamol-trial-to-preterm-infants-found-no-adverse-reactions-at-the-two-years-corrected-age
#17
S Juujärvi, H Kallankari, P Pätsi, M Leskinen, T Saarela, M Hallman, O Aikio
AIM: We examined the long-term outcomes and safety of early intravenous paracetamol for ductus arteriosus closure at a corrected age of two years. METHODS: This was a follow-up of the 2013-2014 randomised, double-blind Preterm Infant's Paracetamol Study at Oulu University Hospital, Finland, which recruited 48 very preterm infants within 24 hours of birth. They received intravenous paracetamol or a placebo for four days. In 2015-2017 we followed up 44 infants (92%) at two years of corrected age...
October 16, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/30325237/a-pilot-study-using-electronic-reminders-for-amblyopia-treatment
#18
Aldo Vagge, Kammi B Gunton, Bruce Schnall
Treatment compliance is the most important factor for predicting a successful outcome in amblyopia treatment. Electronic applications have been successfully employed in other medical conditions in an effort to improve compliance. AIM: To determine whether a smartphone medical adherence application (app) (RxmindMe® Prescription/Medicine Reminder and Pill Tracker) may be successfully incorporated into the treatment plan of patients 3-7 years of age who have not previously been treated for amblyopia...
October 16, 2018: Strabismus
https://www.readbyqxmd.com/read/30321906/very-early-versus-delayed-mobilisation-after-stroke
#19
REVIEW
Peter Langhorne, Janice M Collier, Patricia J Bate, Matthew Nt Thuy, Julie Bernhardt
BACKGROUND: Very early mobilisation (VEM) is performed in some stroke units and recommended in some acute stroke clinical guidelines. However, it is unclear whether very early mobilisation independently improves outcome after stroke. OBJECTIVES: To determine whether very early mobilisation (started as soon as possible, and no later than 48 hours after onset of symptoms) in people with acute stroke improves recovery (primarily the proportion of independent survivors) compared with usual care...
October 16, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30321655/olopatadine-mometasone-combination-nasal-spray-improves-seasonal-allergic-rhinitis-symptoms-in-an-environmental-exposure-chamber-study
#20
Piyush Patel, Anne Marie Salapatek, Sudeesh K Tantry
BACKGROUND: GSP301 nasal spray is a fixed-dose combination of the antihistamine olopatadine hydrochloride and the corticosteroid mometasone furoate intended for seasonal allergic rhinitis (SAR) treatment. OBJECTIVE: Efficacy and safety of GSP301 once-daily (QD) or twice-daily (BID) were evaluated in a ragweed pollen Environmental Exposure Chamber (EEC). METHODS: In this randomized, double-blind, double-dummy study, adults (18-65 years) with SAR were equally randomized to GSP301 BID (olopatadine 665μg/mometasone 25μg), GSP301 QD (olopatadine 665μg/mometasone 50μg), AzeFlu (FDA-approved azelastine 137μg/fluticasone 50μg BID), Olopatadine (FDA-approved formulation 665μg BID), or placebo (BID)...
October 12, 2018: Annals of Allergy, Asthma & Immunology
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