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Keciany Alves de Oliveira, Maria Diana Moreira Gomes, Renata Prado Vasconcelos, Ewerton Sousa de Abreu, Rodrigo Soares Fortunato, Adriano César Carneiro Loureiro, Andrelina Noronha Coelho-de-Souza, Raquel Sombra Basílio de Oliveira, Cleverson Diniz Teixeira de Freitas, Márcio Viana Ramos, Ariclecio Cunha de Oliveira
Phytomodulatory proteins from the latex of the medicinal plant Calotropis procera has been shown to be implicated in many pharmacological properties. However there is no current information about their activity on glucose metabolism, although the latex is used in folk medicine for treating diabetes. In this study the phytomodulatory proteins (LP) from C. procera latex were assessed on glycemic homeostasis. Control animals received a single intravenous dose (5 mg/kg) of LP or saline solution (CTL). Four hours after treatment, the animals were euthanized and their livers were excised for analysis by western blot and RT-PCR AMP-activated protein kinase (AMPK), phosphoenolpyruvate carboxykinase (PEPCK) and tumor necrosis factor alpha (TNF-α)...
January 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Yaira Hamama-Raz, Michal Mahat-Shamir, Lia Ring, Shani Pitcho-Prelorentzos, Menachem Ben-Ezra
The current study aimed to explore Israelis' state anxiety due to a Syrian-Israeli incident that occurred on February 10, 2018, when an Israeli F-16 fighter jet was shot down by Syrian air defense forces. In line with the "looming vulnerability" model which emphasizes the importance of the dynamic nature of psychologically threatening situations, the following psychological factors were suggested: associative memory of prior events, worries of future war, sense of safety, and death anxiety. We employed two cross-sectional points of time in our assessment: 36 hours and three months after the incident...
December 2018: Psychiatry Research
András Szentkirályi, Ambra Stefani, Heinz Hackner, Maria Czira, Inga K Teismann, Henry Völzke, Beate Stubbe, Sven Gläser, Ralf Ewert, Thomas Penzel, Ingo Fietze, Peter Young, Birgit Högl, Klaus Berger
Study Objectives: Periodic limb movements in sleep (PLMS) are frequent motor phenomena; however, population-based data are scarce. We assessed the prevalence of PLMS and factors associated with PLMS within two German population-based cohorts, the SHIP-TREND and BiDirect. Methods: Single-night polysomnography was performed on 1107 subjects recruited from the general population (mean age: 52.9 years, 54.1% men) in the SHIP-TREND and on 247 participants (mean age: 57...
December 14, 2018: Sleep
Songita A Choudhury, Feng Xie, Shelby Kutty, John Lof, Elizabeth Stolze, Thomas R Porter
BACKGROUND: Microbubbles (MB) can be compressed to nanometer-sized droplets and reactivated with diagnostic ultrasound; these reactivated MB possess unique imaging characteristics. OBJECTIVE: We hypothesized that droplets formed from compressing Definity MB may be used for infarct-enhancement imaging. METHODS: Fourteen rats underwent ligation of their left anterior descending (LAD) artery, and five pigs underwent 90 minute balloon occlusions of their mid LAD...
2018: PloS One
Sidika S Gul, Eren Gozke
<i>Background:</i> Platelets play an important role in the pathogenesis of vascular disease, and the size of the platelets can determine their reactivity. Large platelets secrete more prothrombotic factors and aggregate more quickly. In this study, we aimed to investigate mean platelet volume (MPV) levels, which are considered to be an indication of the increase in platelet function in previous studies, in cases of acute ischemic stroke (AIS) with nonvalvular atrial fibrillation (NVAF). <i>Methods:</i> At Fatih Sultan Mehmet Training and Research Hospital, 297 patients diagnosed with acute ischemic stroke were included in the study and two groups were assigned as patients with and without NVAF...
October 31, 2018: Clinical Laboratory
Aritza Brizuela-Velasco, David Chávarri-Prado
PURPOSE: To assess the difference in the evolution of implant stability values, determined by resonance frequency analysis (RFA), between two groups of implants subjected to two different loading protocols: immediate and delayed. MATERIALS AND METHODS: A retrospective clinical study was conducted, including a total of 93 implants placed in 38 patients. All implants corresponded to one of two models of the Klockner Implant System (Essential Cone and Vega) and were divided into two groups according to the loading protocol adopted: delayed loading in group A (>10 weeks) and immediate loading in group B (<48 hours)...
December 13, 2018: Clinical Implant Dentistry and related Research
Nahreen Tynngård, Niklas Boknäs, Marie Trinks, Arta Dreimane, Gösta Berlin
BACKGROUND: Storage of platelet concentrates (PCs) results in storage lesions with possible detrimental effects on platelet recovery after transfusion, which might affect their ability to prevent or arrest bleeding. The aim of this study was to compare the quality of PCs stored for 1 to 3 or 5 to 7 days by assessing the corrected count increment (CCI) after transfusion. To isolate the effects of storage time, we studied serial transfusions of PCs obtained from one donor and one donation, and transfused to one single recipient after storage for 1 to 3 days and 5 to 7 days...
December 12, 2018: Transfusion
Jansen N Seheult, Vincent P Anto, Nadim Farhat, Michelle N Stram, Philip C Spinella, Louis Alarcon, Jason Sperry, Darrell J Triulzi, Mark H Yazer
BACKGROUND: A supervised machine learning algorithm was used to generate decision trees for the prediction of massive transfusion at a Level 1 trauma center. METHODS: Trauma patients who received at least one unit of RBCs and/or low-titer group O whole blood between January 1, 2015, and December 31, 2017, were included. Massive transfusion was defined as the transfusion of 10 or more units of RBCs and/or low-titer group O whole blood in the first 24 hours of admission...
December 12, 2018: Transfusion
Woineshet Asrat, Teferi Mekonnen, Melkamu Bedimo
Background: Ethiopia is a Sub Saharan African country with an estimated contraceptive prevalence rate of 36% and 22% unmet need for family planning service among married women. Client satisfaction influences the use of Family Planning and other reproductive health services. There is limited information on satisfaction with family planning service among Family planning users particularly in the northern part of Ethiopia. Hence, this study aimed to provide information on client satisfaction and its determinant among women in Public Health facilities of Northwestern Ethiopia...
2018: Contraception and Reproductive Medicine
Yuan-Pin Hsu, Chin-Wang Hsu, Chyi-Huey Bai, Sheng-Wei Cheng, Chiehfeng Chen
BACKGROUND: Fascia iliaca compartment block (FICB) provides an analgesic option for positioning before spinal anesthesia in patients suffering from a femur fracture. The evidence supporting FICB is still not well established. The aim of our study is to assess the efficacy and safety of FICB comparing with intravenous analgesic (IVA) on the quality for positioning before spinal anesthesia in participants with a femur fracture. METHODS: PubMed, Embase, and Scopus databases were interrogated from their inceptions to September 2017...
December 2018: Medicine (Baltimore)
Deepti Sharma, Suresh Jain
This study investigates the impact of increased levels of indoor air pollution (IAP) caused due to biomass burning in the rural households of Northern India. A comparative assessment of the impact of traditional cookstoves (TCS) and improved cookstoves (ICS) coupled with the characteristics of kitchen was conducted to estimate the PM (PM10 , PM2.5 , PM1 ), CO/CO2 concentrations in the micro-environments of kitchen and living area of the households. The study incorporated both extensive and intensive real-time indoor air quality (IAQ) monitoring during the two cooking sessions of the day...
December 10, 2018: Environment International
Ole Emil Andersen, Ole Baekgaard Nielsen, Kristian Overgaard
Muscle damaging eccentric exercise impairs muscle glucose uptake several hours to days after exercise. Little, however, is known about the acute effects of eccentric exercise on contraction- and insulin-induced glucose uptake. This study compares glucose uptake rates in the first hours following eccentric, concentric, and isometric contractions with and without insulin present. Isolated rat extensor digitorum longus muscles were exposed to either an eccentric, concentric, or isometric contraction protocol, and muscle contractions were induced by electric stimulation that were identical between contraction protocols...
December 13, 2018: Journal of Applied Physiology
Zhuxi Yu, Beiyuan Zhang, Ying Xu, Yingying Hao, Jian Tang, Wenkui Yu, Qin Gu
OBJECTIVE: To analyze the clinical characteristics of bloodstream infection in patients with immune function inhibition. METHODS: A retrospective analysis was conducted. 234 patients with bloodstream infection admitted to intensive care unit (ICU) of the Affiliated Drum Tower Hospital of Nanjing University Medical School from August 1st in 2015 to December 31st in 2017 were enrolled. According to the immune function on the day of bloodstream infection, they were divided into normal immune function group [human leukocyte antigen DR (HLA-DR) > 30%, n = 144] and immunosuppression group (HLA-DR ≤ 30%, n = 90)...
November 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Xin Chen, Wansheng Peng, Zhen Zhang, Qian Zhao, Yan Zhou, Li Chen, Jiahua Pan
OBJECTIVE: To evaluate the efficacy and safety of selective brain hypothermia (SBH) in the treatment of neonates with moderate or severe neonatal hypoxic-ischemic encephalopathy (HIE), and the effect of SBH treatment on serum levels of neuron-specific enolase (NSE) and central nervous specific protein S100. METHODS: A prospective randomized controlled trial was conducted. From January 2015 to June 2017, 42 children with moderate to severe HIE in the neonatal intensive care unit (NICU) of the First Affiliated Hospital of Bengbu Medical College were enrolled, and they were randomly divided into SBH treatment group and routine treatment group after obtaining the consent of the guardian of the children...
November 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Weina Guo, Chunmei Wang, Fangjie Huo, Hongqiang Li, Yanli Yan, Shumin Xu, Huihui Xu, Yusheng Li, Xiaoming Zhang, Jianwen Bai
OBJECTIVE: To evaluate the prognostic value of human antibacterial peptide LL-37 in elderly patients with sepsis. METHODS: Elderly sepsis patients over 65-year-old satisfied the diagnostic criteria for sepsis and septic shock admitted to intensive care unit of East Hospital of Tongji University from January 2016 to December 2017 were enrolled (elderly sepsis group). Aged community-acquired pneumonia (CAP) patients hospitalized during the same period were enrolled as a control group for pneumonia, and the aged health check-ups served as a healthy control group during the same period...
November 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Nicola Adams, Dawn A Skelton, Denise Howel, Cathy Bailey, Rosy Lampitt, Tony Fouweather, Joanne Gray, Dorothy Coe, Jennifer Wilkinson, Sheena Gawler, Lex D de Jong, Heather Waterman, Vincent Deary, Michael Clarke, Steve W Parry
BACKGROUND: Visually impaired older people (VIOP) have a higher risk of falling than their sighted peers, and are likely to avoid physical activity. The aim was to adapt the existing Falls Management Exercise (FaME) programme for VIOP, delivered in the community, and to investigate the feasibility of conducting a definitive randomised controlled trial (RCT) of this adapted intervention. METHODS: Two-centre randomised mixed methods pilot trial and economic evaluation of the adapted group-based FaME programme for VIOP versus usual care...
December 12, 2018: BMC Geriatrics
C R Chen, J W Zheng, B Meng, B Lu, X J Zhai
Objective: To investigate effects of two anesthesia methods on the first night sleep quality in middle-aged and elderly patients after surgery. Methods: This was a prospective study conducted from November 2017 to March 2018. Sixty patients, aged 50-70, undergoing elective surgery for unilateral lower extremity varicose vein at Ningbo No.2 Hospital, with American Society of Anesthesiologists (ASA) grade Ⅰ or Ⅱ, were enrolled and randomly allocated to two groups ( n =30), general anesthesia group and spinal anesthesia group...
December 11, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Eyal Eliakim, Ofer Doron, Yoav Meckel, Dan Nemet, Alon Eliakim
The aim of the present study was to assess prospectively the effect of pre-season fitness on injury rate during the competitive season among professional soccer players. Thirty-one players participated in the study during two consecutive competitive seasons (2015-16 and 2016-17; a squad of 22 players in each season). During the 6-week pre-season training period (8 training sessions and a friendly match every week, 14-18 training hours/week) there was a significant improvement in VO 2 max, a significant increase in ideal and total sprint time and no change in vertical jump, flexibility and repeated sprint-test performance decrement...
June 2018: Sports medicine international open
Rune D Bech, Ole Ovesen, Jens Lauritsen, Claus Emmeluth, Peter Lindholm, Søren Overgaard
Background and purpose: Local infiltration analgesia (LIA) supports early mobilization after hip and knee arthroplasty. Inspired by this, we studied the effectiveness of wound infiltration with the long acting local anesthetic ropivacaine in an effort to decrease the need for postoperative opioids after osteosynthesis of extracapsular hip fracture. Methods: Forty-nine patients undergoing osteosynthesis with a sliding hip screw were randomized into two groups in a double-blind study (ClinicalTrials...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
Yousef D Alqurashi, Takashi Nakamura, Valentin Goverdovsky, James Moss, Michael I Polkey, Danilo P Mandic, Mary J Morrell
Objectives: Detecting sleep latency during the Multiple Sleep Latency Test (MSLT) using electroencephalogram (scalp-EEG) is time-consuming. The aim of this study was to evaluate the efficacy of a novel in-ear sensor (in-ear EEG) to detect the sleep latency, compared to scalp-EEG, during MSLT in healthy adults, with and without sleep restriction. Methods: We recruited 25 healthy adults (28.5±5.3 years) who participated in two MSLTs with simultaneous recording of scalp and in-ear EEG...
2018: Nature and Science of Sleep
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