Maxim De Schepper, Thijs Koorman, François Richard, Matthias Christgen, Anne Vincent-Salomon, Stuart J Schnitt, Paul J van Diest, Gitte Zels, Freya Mertens, Marion Maetens, Isabelle Vanden Bempt, Nadia Harbeck, Ulrike Nitz, Monika Gräser, Sherko Kümmel, Oleg Gluz, Birgit Weynand, Giuseppe Floris, Patrick Wb Derksen, Christine Desmedt
Invasive lobular carcinoma (ILC) is the second most frequent type of breast cancer (BC) and its peculiar morphology is mainly driven by inactivation of CDH1, the gene coding for E-cadherin cell adhesion protein. ILC-specific therapeutic and disease-monitoring approaches are gaining momentum in the clinic, increasing the importance of accurate ILC diagnosis. Several essential and desirable morphological diagnostic criteria are currently defined by the World Health Organization, the routine use of immunohistochemistry (IHC) for E-cadherin is not recommended...
April 17, 2024: Modern Pathology