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Neuropathy, peripheral neuropathy, pain management in neuropathy, pain management

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https://www.readbyqxmd.com/read/30090684/clinical-decision-making-and-differential-diagnosis-in-a-cyclist-with-upper-quarter-pain-numbness-and-weakness-a-case-report
#1
Matthew S Briggs, Katherine K Rethman, Matthew T Lopez
Background and Purpose: Differentiating between cervical nerve root and peripheral nerve injuries can be challenging. A phenomenon known as double crush syndrome may increase the susceptibility to injury and symptoms at other locations along the course of the nerve. The purpose of this case report is to describe the physical therapy differential diagnosis and management of a cyclist with upper extremity pain, weakness, and paresthesia. Case Description: The subject was referred to physical therapy with a diagnosis of cervical disc disease...
April 2018: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/30030157/the-potential-of-transdermal-nitric-oxide-treatment-for-diabetic-peripheral-neuropathy-and-diabetic-foot-ulcers
#2
REVIEW
David M Walton, Stephen D Minton, Alonzo D Cook
The Center for Disease Control (CDC) estimates that 29 million Americans have diabetes, and 70% of diabetic patients develop diabetic peripheral neuropathy [1,2]. Up to 27% of the direct medical cost of diabetes may be attributed to DPN [3]. A 2013 article from the American Diabetes Association reported a $176 billion direct medical cost of diabetes in 2012 [4]. DPN patients often suffer from shooting and burning pain in their distal limbs and a severe loss of sensation. Diabetic foot ulcers, infections, and amputations may follow...
July 17, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/30028916/the-gradient-perfusion-model-part-2-substantiation-of-the-gpm-with-clinical-cases
#3
Michael B Strauss, Lientra Q Lu, Stuart S Miller
Introduction: In Part 1 of this three-part series, we provided an explanation as to why and at what sites decompression sickness (DCS) occurs, using the Gradient-Perfusion Model (GPM). In this part, we provide information to substantiate the concept and present clinical cases that were initially labeled as "unexplained DCS," but later disordering events were identified to explain the clinical presentations. Materials and Methods: Among 500 cases of DCS we have managed for over 50 years, a cohort of these patients was initially diagnosed as unexplained DCS...
May 2018: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29996117/blocking-mammalian-target-of-rapamycin-mtor-alleviates-neuropathic-pain-induced-by-chemotherapeutic-bortezomib
#4
Zongsheng Duan, Jing Li, Xiaochuan Pang, Hushan Wang, Zhenbo Su
BACKGROUND/AIMS: Bortezomib (BTZ) is largely used as a chemotherapeutic agent for the treatment of cancer. However, one of the significant limiting complications of BTZ is painful peripheral neuropathy during BTZ therapy. Drugs preventing and/or treating the painful symptoms induced by BTZ are lacking since the underlying mechanisms leading to neuropathic pain remain largely unclear. The purposes of this study were to examine 1) the effects of blocking mammalian target of rapamycin (mTOR) on mechanical pain and cold hypersensitivity evoked by BTZ and 2) the underlying mechanisms responsible for the role of mTOR in regulating BTZ-induced neuropathic pain...
July 11, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29976627/angiotensin-ii-triggers-peripheral-macrophage-to-sensory-neuron-redox-crosstalk-to-elicit-pain
#5
Andrew J Shepherd, Bryan A Copits, Aaron D Mickle, Páll Karlsson, Suraj Kadunganattil, Simon Haroutounian, Satya M Tadinada, Annette D de Kloet, Manouela V Valtcheva, Lisa A McIlvried, Tayler D Sheahan, Sanjay Jain, Pradipta R Ray, Yuriy M Usachev, Gregory Dussor, Eric G Krause, Theodore J Price, Robert W Gereau, Durga P Mohapatra
Injury, inflammation and nerve damage initiate a wide variety of cellular and molecular processes that culminate in hyperexcitation of sensory nerves, which underlies chronic inflammatory and neuropathic pain. Using behavioral readouts of pain hypersensitivity induced by Angiotensin II (Ang II) injection into mouse hindpaws, our study shows that activation of the type 2 Ang II receptor (AT2R) and the cell damage-sensing ion channel TRPA1 are required for peripheral mechanical pain sensitization induced by Ang II in male and female mice...
July 5, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29963257/probiotic-dsf-counteracts-chemotherapy-induced-neuropathic-pain
#6
Vanessa Castelli, Paola Palumbo, Michele d'Angelo, Nandha Kumar Moorthy, Andrea Antonosante, Mariano Catanesi, Francesca Lombardi, Dalila Iannotta, Benedetta Cinque, Elisabetta Benedetti, Rodolfo Ippoliti, Maria Grazia Cifone, Annamaria Cimini
Chemotherapy-induced peripheral neuropathy (CIPN) is a widespread and potentially disabling side effect of various anticancer drugs. In spite of the intensive research focused on obtaining therapies capable to treat or prevent CIPN, the medical demand remains very high. Microtubule-stabilizing agents, among which taxanes, are effective chemotherapeutic agents for the therapy of several oncologic diseases. The inflammatory process activated by chemotherapeutic agents has been interpreted as a potential trigger of the nociceptive process in CIPN...
June 15, 2018: Oncotarget
https://www.readbyqxmd.com/read/29929349/neuropathic-cancer-pain-prevalence-pathophysiology-and-management
#7
So Young Yoon, Jeeyoung Oh
Neuropathic cancer pain (NCP) is caused by nerve damage attributable to the cancer per se, and/or treatments including chemotherapy, radiotherapy, and surgery; the prevalence is reported to be as high as 40%. The etiologies of NCP include direct nerve invasion or nerve compression by the cancer, neural toxicity, chemotherapy, and radiotherapy. NCP is subdivided into plexopathy, radiculopathy, and peripheral neuropathies, among several other categories. The clinical characteristics of NCP differ from those of nociceptive pain in terms of both the hypersensitivity symptoms (burning, tingling, and an electrical sensation) and the hyposensitivity symptoms (numbness and muscle weakness)...
June 25, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29890676/the-role-of-genetic-polymorphisms-in-chronic-pain-patients
#8
REVIEW
Nebojsa Nick Knezevic, Tatiana Tverdohleb, Ivana Knezevic, Kenneth D Candido
It is estimated that the total annual financial cost for pain management in the U.S. exceeds 100 billion dollars. However, when indirect costs are included, such as functional disability and reduction in working hours, the cost can reach more than 300 billion dollars. In chronic pain patients, the role of pharmacogenetics is determined by genetic effects on various pain types, as well as the genetic effect on drug safety and efficacy. In this review article, we discuss genetic polymorphisms present in different types of chronic pain, such as fibromyalgia, low back pain, migraine, painful peripheral diabetic neuropathy and trigeminal neuralgia...
June 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29889605/integrative-therapies-during-and-after-breast-cancer-treatment-asco-endorsement-of-the-sio-clinical-practice-guideline
#9
Gary H Lyman, Heather Greenlee, Kari Bohlke, Ting Bao, Angela M DeMichele, Gary E Deng, Judith M Fouladbakhsh, Brigitte Gil, Dawn L Hershman, Sami Mansfield, Dawn M Mussallem, Karen M Mustian, Erin Price, Susan Rafte, Lorenzo Cohen
Purpose The Society for Integrative Oncology (SIO) produced an evidence-based guideline on use of integrative therapies during and after breast cancer treatment that was determined to be relevant to the American Society of Clinical Oncology (ASCO) membership. ASCO considered the guideline for endorsement. Methods The SIO guideline addressed the use of integrative therapies for the management of symptoms and adverse effects, such as anxiety and stress, mood disorders, fatigue, quality of life, chemotherapy-induced nausea and vomiting, lymphedema, chemotherapy-induced peripheral neuropathy, pain, and sleep disturbance...
June 11, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29866282/history-diagnosis-and-management-of-chronic-inflammatory-demyelinating-polyradiculoneuropathy
#10
REVIEW
P James B Dyck, Jennifer A Tracy
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is probably the best recognized progressive immune-mediated peripheral neuropathy. It is characterized by a symmetrical, motor-predominant peripheral neuropathy that produces both distal and proximal weakness. Large-fiber abnormalities (weakness and ataxia) predominate, whereas small-fiber abnormalities (autonomic and pain) are less common. The pathophysiology of CIDP is inflammatory demyelination that manifests as slowed conduction velocities, temporal dispersion, and conduction block on nerve conduction studies and as segmental demyelination, onion-bulb formation, and endoneurial inflammatory infiltrates on nerve biopsies...
June 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29864425/accumulation-of-sorbitol-in-the-sciatic-nerve-modulates-circadian-properties-of-diabetes-induced-neuropathic-pain-hypersensitivity-in-a-diabetic-mouse-model
#11
Takahiro Akamine, Naoki Kusunose, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo
The intensity of pain in diabetic neuropathy varies in a circadian time-dependent manner. It is well known that diabetes has two distinct types, which are differentiated based on the cause of the disease. Previous studies have yet to compare the circadian properties of the pain intensity of diabetic neuropathy between type I and type II diabetes. In this study, we demonstrated that the pain intensity of diabetic peripheral neuropathy in a db/db mouse model of type II diabetes showed a significant diurnal oscillation, but such time-dependent oscillation was not detected in a streptozotocin (STZ)-induced type I diabetic mouse model...
June 8, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29758357/pharmacopuncture-with-scolopendra-subspinipes-suppresses-mechanical-allodynia-in-oxaliplatin-induced-neuropathic-mice-and-potentiates-clonidine-induced-anti-allodynia-without-hypotension-or-motor-impairment
#12
Seo-Yeon Yoon, Jeong-Yun Lee, Dae-Hyun Roh, Seog Bae Oh
Chemotherapy-induced neuropathic pain is a common dose-limiting side effect of anticancer drugs but lacks an effective treatment strategy. Scolopendra subspinipes has been used in traditional medicine to treat chronic neuronal diseases. Moreover, pharmacopuncture with S subspinipes (SSP) produces potent analgesia in humans and experimental animals. In this study, we examined the effect of SSP into the ST36 acupoint on oxaliplatin-induced mechanical allodynia in mice. Acupoint treatment with SSP (0.5%/20 μL) significantly decreased mechanical allodynia produced by a single oxaliplatin injection (10mg/kg i...
May 11, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29729786/oncology-acupuncture-for-chronic-pain-in-cancer-survivors-a-reflection-on-the-american-society-of-clinical-oncology-chronic-pain-guideline
#13
REVIEW
Weidong Lu, David S Rosenthal
Chronic pain syndromes associated with cancer treatment are common but difficult to manage. The American Society of Clinical Oncology recently published a practice guideline to address the unmet needs of cancer survivors, Management of Chronic Pain in Survivors of Adult Cancers, which stresses the importance of implementing integrative therapies including acupuncture. This review focuses on randomized clinical trials of acupuncture for chronic pain in cancer survivors, including its use in chemotherapy-induced peripheral neuropathy, aromatase inhibitor-associated arthralgia, and post neck dissection pain, and provides future directions of oncology acupuncture research in cancer survivorship...
June 2018: Hematology/oncology Clinics of North America
https://www.readbyqxmd.com/read/29709457/diabetic-peripheral-neuropathy-epidemiology-diagnosis-and-pharmacotherapy
#14
REVIEW
Zohaib Iqbal, Shazli Azmi, Rahul Yadav, Maryam Ferdousi, Mohit Kumar, Daniel J Cuthbertson, Jonathan Lim, Rayaz A Malik, Uazman Alam
PURPOSE: Diabetic peripheral neuropathy (DPN) is the commonest cause of neuropathy worldwide, and its prevalence increases with the duration of diabetes. It affects approximately half of patients with diabetes. DPN is symmetric and predominantly sensory, starting distally and gradually spreading proximally in a glove-and-stocking distribution. It causes substantial morbidity and is associated with increased mortality. The unrelenting nature of pain in this condition can negatively affect a patient's sleep, mood, and functionality and result in a poor quality of life...
June 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29695418/role-of-complement-in-a-rat-model-of-paclitaxel-induced-peripheral-neuropathy
#15
Jijun Xu, Lingjun Zhang, Mian Xie, Yan Li, Ping Huang, Thomas L Saunders, David A Fox, Richard Rosenquist, Feng Lin
Chemotherapy-induced peripheral neuropathy (CIPN) is a painful and debilitating side effect of cancer chemotherapy with an unclear pathogenesis. Consequently, the available therapies for this neuropathic pain syndrome are inadequate, leading to a significantly reduced quality of life in many patients. Complement, a key component of the innate immune system, has been associated with neuroinflammation, a potentially important trigger of some types of neuropathic pain. However, the role of complement in CIPN remains unclear...
June 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29689688/swimming-exercise-induced-reversed-expression-of-mir-96-and-its-target-gene-nav1-3-in-diabetic-peripheral-neuropathy-in-rats
#16
Amir Mahmoudi Aghdam, Parviz Shahabi, Elham Karimi-Sales, Rafigheh Ghiasi, Saeed Sadigh-Eteghad, Javad Mahmoudi, Mohammad Reza Alipour
Diabetes is a common metabolic disease which leads to diabetic peripheral neuropathy. Recently, the role of microRNA-96 (miR-96) in alleviating neuropathic pain by inhibiting the expression of NaV1.3, an isoform of voltage-gated sodium channels, has been shown. Peripheral nerve injuries result in NaV1.3 elevation. Exercise has beneficial role in diabetes management and peripheral neuropathy. However, the effects of exercise on miR-96 and its target gene NaV1.3 in diabetic rats are unknown. Therefore, the present study investigated the effects of exercise training on the expression of miR-96 and NaV1...
April 30, 2018: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29686181/the-effectiveness-of-aerobic-exercise-in-improving-peripheral-nerve-functions-in-type-2-diabetes-mellitus-an-evidence-based-case-report
#17
Listya Tresnanti Mirtha, Viandini Permatahati
BACKGROUND: peripheral neuropathy is known as one of most common complication in diabetes mellitus type 2 patient. This complication is caused by uncontrolled condition of blood glucose level in long periode. Regular physical activity in moderate to high intensity is beneficial in management of diabetes mellitus. This report aimed to know the effectiveness of aerobic exercise in causing improved peripheral functions in type 2 diabetes mellitus. METHODS: literature searching using several related keywords in Medline®, Pubmed®, and Cochrane library, following inclusion and exclusion criteria...
January 2018: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29643634/tanezumab-therapy-targeting-nerve-growth-factor-in-pain-pathogenesis
#18
Mona K Patel, Alan D Kaye, Richard D Urman
In recent years, nerve growth factor (NGF) and the NGF receptor have become potential therapeutic targets in the treatment of acute and chronic pain states. NGF is a neurotrophin involved in regulating the function of sensory and sympathetic neurons during development. Numerous pain states have been linked to elevated levels of NGF and its role in increasing the perception of pain. Tanezumab, a recombinant humanized monoclonal antibody (IgG), was developed to target NGF, binding both circulating and local tissue NGF preventing interaction with the tropomyosin-related kinase-A and p75 receptors...
January 2018: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29589820/text-messaging-to-improve-disease-management-in-patients-with-painful-diabetic-peripheral-neuropathy
#19
Victoria Bauer, Nancy Goodman, Brittany Lapin, Camille Cooley, Ed Wang, Terri L Craig, Scott E Glosner, Mark S Juhn, Joseph C Cappelleri, Alesia B Sadosky, Christopher Masi
Purpose The purpose of the study was to determine the impact of educational text messages on diabetes self-management activities and outcomes in patients with painful diabetic peripheral neuropathy (pDPN). Methods Patients with pDPN identified from a large integrated health system who agreed to participate were randomized to 6 months of usual care (UC) or UC plus twice-daily diabetes self-management text messages (UC+TxtM). Outcomes included the Pain Numerical Rating Scale, Summary of Diabetes Self-Care Activities (SDSCA), questions on diabetes health beliefs, and glycated hemoglobin (A1C)...
June 2018: Diabetes Educator
https://www.readbyqxmd.com/read/29587559/involvement-of-pro-inflammation-signal-pathway-in-inhibitory-effects-of-rapamycin-on-oxaliplatin-induced-neuropathic-pain
#20
Zongsheng Duan, Zhenbo Su, Hushan Wang, Xiaochuan Pang
Background Oxaliplatin is a third-generation chemotherapeutic agent that is commonly used to treat metastatic digestive tumors; however, one of the main limiting complications of oxaliplatin is painful peripheral neuropathy. The purpose of this study was to examine the underlying mechanisms by which mammalian target of rapamycin (mTOR) and its signal are responsible for oxaliplatin-evoked neuropathic pain. Methods Neuropathic pain was induced by intraperitoneal injection of oxaliplatin in rats. ELISA and Western blot analysis were used to examine the levels of pro-inflammatory cytokines (including interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α) and the expression of mTOR signal pathway...
January 2018: Molecular Pain
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