Nicholas A Vitanza, Rebecca Ronsley, Michelle Choe, Casey Henson, Mandy Breedt, Adriel Barrios-Anderson, Amy Wein, Christopher Brown, Adam Beebe, Ada Kong, Danielle Kirkey, Brittany M Lee, Sarah E S Leary, Erin E Crotty, Corrine Hoeppner, Susan Holtzclaw, Ashley L Wilson, Joshua A Gustafson, Jessica B Foster, Jeffrey J Iliff, Hannah E Goldstein, Samuel R Browd, Amy Lee, Jeffrey G Ojemann, Navin Pinto, Juliane Gust, Rebecca A Gardner, Michael C Jensen, Jason S Hauptman, Julie R Park
Central nervous system (CNS) tumors are the most common solid malignancy in the pediatric population. Based on adoptive cellular therapy's clinical success against childhood leukemia and the preclinical efficacy against pediatric CNS tumors, chimeric antigen receptor (CAR) T cells offer hope of improving outcomes for recurrent tumors and universally fatal diseases such as diffuse intrinsic pontine glioma (DIPG). However, a major obstacle for tumors of the brain and spine is ineffective T cell chemotaxis to disease sites...
January 2, 2023: Neoplasia: An International Journal for Oncology Research