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Ommaya

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https://www.readbyqxmd.com/read/29850985/the-use-of-ommaya-reservoirs-to-deliver-central-nervous-system-directed-chemotherapy-in-childhood-acute-lymphoblastic-leukaemia
#1
Ruairi Wilson, Caroline Osborne, Christina Halsey
Prophylactic eradication of central nervous system (CNS) leukaemia is the current standard of care in treating childhood acute lymphoblastic leukaemia (ALL). This is conventionally achieved through regular lumbar punctures with intrathecal injections of methotrexate into the cerebrospinal fluid (CSF). Ommaya reservoirs are subcutaneous implantable devices that provide a secure route of drug delivery into the CSF via an intraventricular catheter. They are an important alternative in cases where intrathecal injection via lumbar puncture is difficult...
August 2018: Paediatric Drugs
https://www.readbyqxmd.com/read/29572169/surgical-management-of-adverse-radiation-effects-after-gamma-knife-radiosurgery-for-cerebral-arteriovenous-malformations-a-population-based-cohort-study
#2
Pietro Meneghelli, Alberto Pasqualin, Piergiuseppe Zampieri, Michele Longhi, Roberto Foroni, Antonio Sini, Nicola Tommasi, Antonio Nicolato
OBJECTIVE: The goal of this study is to report our experience in the surgical treatment of cerebral arteriovenous malformations (cAVMs) related permanent symptomatic adverse radiation effects (PSAREs), to clarify an appropriate surgical management and to identify the risk factors related to their development. METHODS: We evaluated 549 patients treated with Gamma Knife radiosurgery (GKRS) for cAVMs with a follow-up of at least 8 years. Univariate and multivariate analyses were used to test different risk factors related to the development of PSARE...
June 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29492136/adult-supratentorial-extraventricular-anaplastic-ependymoma-therapeutic-approach-and-clinical-review
#3
José Pedro Lavrador, Edson Oliveira, Joaquim Cruz Teixeira, José Pedro Lopes, José Pimentel, Manuel Herculano Carvalho
We report a 69-year-old patient with left paresthesia and hemiparesis. Magnetic resonance imaging revealed a right frontoparietal cystic tumor. A subtotal surgical resection was performed, and an Ommaya reservoir was left in place. The pathological diagnosis was supratentorial extraventricular anaplastic ependymoma. Radiation therapy was administered, and Ommaya reservoir drainages were performed. Four months after, her clinical status deteriorated after a reservoir drainage and image revealed an acute hemorrhage...
January 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29387478/retrospective-review-of-metastatic-melanoma-patients-with-leptomeningeal-disease-treated-with-intrathecal-interleukin-2
#4
Isabella C Glitza, Michelle Rohlfs, Nandita Guha-Thakurta, Roland L Bassett, Chantale Bernatchez, Adi Diab, Scott E Woodman, Cassian Yee, Rodabe N Amaria, Sapna P Patel, Hussein Tawbi, Michael Wong, Wen-Jen Hwu, Patrick Hwu, Amy Heimberger, Ian E McCutcheon, Nicholas Papadopoulos, Michael A Davies
Objectives: Metastatic melanoma patients with leptomeningeal disease (LMD) have an extremely poor prognosis, with a median survival measured in weeks, and few treatment options. Outcomes of a retrospective cohort of patients with LMD that were treated with intrathecal interleukin-2 (IT IL-2) were reviewed to assess the long-term efficacy of this therapy. Methods: The records of metastatic melanoma patients with LMD who were treated with IT IL-2 from 2006 to 2014 in a Compassionate Investigational New Drug study were reviewed...
2018: ESMO Open
https://www.readbyqxmd.com/read/29322340/the-use-of-a-smartphone-assisted-ventricle-catheter-guide-for-ommaya-reservoir-placement-experience-of-a-retrospective-bi-center-study
#5
Sergey Ozerov, U W Thomale, M Schulz, A Schaumann, A Samarin, E Kumirova
BACKGROUND: For intraventricular chemotherapy (IVC) as part of many oncological treatment protocols, Ommaya reservoir is enabling repeated access to the cerebro-spinal fluid (CSF). The correct placement of the catheter in the ventricle is essential for correct application of drugs, which is enabled by sophisticated techniques such as neuronavigation. OBJECTIVE: In a bi-center retrospective study, we reviewed our experience using a smartphone-assisted ventricle catheter guide as simple solution for correct Ommaya reservoir placement...
May 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29305723/image-guided-ommaya-reservoir-insertion-for-intraventricular-chemotherapy-a-retrospective-series
#6
Jonathan C Lau, Suzanne E Kosteniuk, David R Macdonald, Joseph F Megyesi
BACKGROUND: Ayub Ommaya proposed a surgical technique for subcutaneous reservoir and pump placement in 1963 to allow access to intraventricular cerebrospinal fluid (CSF). Currently, the most common indication for Ommaya reservoir insertion (ORI) in adults is for patients with hematologic or leptomeningeal disorders requiring repeated injection of chemotherapy into the CSF space. Historically, the intraventricular catheter has been inserted blindly based on anatomical landmarks. The purpose of this study was to examine short-term complication rates with ORI with image guidance (IG) and without image guidance (non-IG)...
March 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29189615/multimodal-treatment-of-rhinocerebral-mucormycosis-in-a-pediatric-patient-with-relapsed-pre-b-acute-lymphoblastic-leukemia
#7
Zephyr D Dworsky, John S Bradley, Matthew T Brigger, Alice L Pong, Dennis John Kuo
A 17-year-old girl developed invasive rhinocerebral mucormycosis during intensive re-induction chemotherapy for relapsed pre-B acute lymphoblastic leukemia. Due to the high case fatality rate for invasive mucormycosis in profoundly immunosuppressed patients, an aggressive treatment regimen was pursued. In addition to the standard of care treatments with intravenous amphotericin and aggressive surgical debridements, she received intraventricular amphotericin to the brain via an Ommaya reservoir, hyperbaric oxygen treatments, filgrastim, intravenous immunoglobulin and antifungal in vitro synergy testing to allow for more targeted antifungal therapy with the addition of micafungin...
June 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28944129/endoscopic-assisted-ommaya-reservoir-placement-technical-note
#8
Jessica Lane, Brad E Zacharia
Ommaya reservoir placement has been an option for patients requiring cerebrospinal fluid (CSF) access since the 1960s. It is preferred to repeat lumbar punctures, both in terms of patient comfort and the consistency of intrathecal drug concentration. Technological developments have advanced the placement technique, allowing for better accuracy and reduced complications. Freehand placement was first augmented with pneumoencephalograms and intraoperative computerized tomography (CT), then with optical-based navigation, and finally by utilizing electromagnetic neuronavigation...
July 19, 2017: Curēus
https://www.readbyqxmd.com/read/28842304/establishment-of-a-rhesus-monkey-model-of-chronic-temporal-lobe-epilepsy-using-repetitive-unilateral-intra-amygdala-kainic-acid-injections
#9
Yajie Chi, Bolin Wu, Jianwei Guan, Kuntai Xiao, Ziming Lu, Xiao Li, Yuting Xu, Shan Xue, Qiang Xu, Junhua Rao, Yanwu Guo
OBJECTIVE: Temporal lobe epilepsy (TLE) is a common type of acquired epilepsy refractory to medical treatment. As such, establishing animal models of this disease is critical to developing new and effective treatment modalities. Because of their small head size, rodents are not suitable for comprehensive electroencephalography (EEG) evaluation via scalp or subdural electrodes. Therefore, a larger primate model that closely recapitulates signs of TLE is needed; here we describe a rhesus monkey model resembling chronic TLE...
September 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28790212/-neuro-endoscopic-surgery-for-multi-lobular-chronic-subdural-hematoma
#10
Toshihito Ishikawa, Katsuhiro Endo, Yuji Endo, Naoki Sato, Mamoru Ohta
BACKGROUND: Chronic subdural hematoma(CSDH)generally occurs in the elderly, and is usually treated by burr-hole craniotomy with closed-system drainage. Treatment of recurrent CSDH is more challenging, especially when the hematoma is multi-lobular. A variety of approaches to the management of multi-lobular CSDH have been described, including evacuation through a wide craniotomy, placement of an Ommaya reservoir, subdural peritoneal shunting, and embolization of the middle meningeal artery...
August 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28752498/pseudoprogression-in-pediatric-low-grade-glioma-after-irradiation
#11
Derek S Tsang, Erin S Murphy, John T Lucas, Pagona Lagiou, Sahaja Acharya, Thomas E Merchant
This study aimed to assess the incidence and management of pseudoprogression after radiation therapy (RT) in patients with pediatric low-grade glioma (LGG). This retrospective review included patients aged 21 years or younger with intracranial LGG treated with curative-intent RT. Pseudoprogression was defined as an increase in tumor size by ≥10% in at least two dimensions between two and three consecutive MR imaging studies. Overall survival (OS) and event-free survival (EFS) were measured from the first day of RT...
November 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28665393/-radiotherapy-and-radiosurgery-in-treatment-of-craniopharyngiomas
#12
REVIEW
A N Savateev, Yu Yu Trunin, N A Mazerkina
Craniopharyngiomas are benign epithelial tumors having a dysembryogenetic origin, which are usually located in the sellar/parasellar and/or third ventricle regions. Gross total resection is the modern standard of treatment for these tumors because of a low recurrence rate. However, this surgery in some patients with craniopharyngioma often leads to the development or worsening of diencephalic disorders poorly responding to treatment. Perhaps, in these cases, subtotal or partial tumor resection or implantation of an Ommaya reservoir into the tumor cyst followed by stereotactic radiotherapy/radiosurgery may provide better functional outcomes and higher life quality in patients, with tumor growth control being reasonable (according to the published data, the mean 10-year disease-free survival is 66...
2017: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/28660168/spontaneous-intraventricular-rupture-of-a-craniopharyngioma-cyst-a-case-report
#13
Kunal Vakharia, Ioannis Dimitrios Siasios, Alexander B Dorsch, Jody Leonardo
Intraventricular rupture of craniopharyngioma cysts is an unusual event which is associated with a high risk of loculated or communicating hydrocephalus. A 75-year-old woman presented at the Emergency Department of our hospital with mental status deterioration due to chemical ventriculitis and acute hydrocephalus following the intraventricular rupture of a craniopharyngioma cyst. The patient was treated with stress-dose steroid therapy. In addition, she underwent placement of an external ventricular drain and endoscopy-assisted intra-cystic placement of an Ommaya reservoir for the aspiration of the cystic fluid...
April 2017: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/28594737/safe-treatment-of-a-patient-with-an-ommaya-reservoir-with-electroconvulsive-therapy
#14
LETTER
Mesut Toprak, Rachel B Katz, Robert Ostroff
No abstract text is available yet for this article.
December 2017: Journal of ECT
https://www.readbyqxmd.com/read/28593552/a-reformed-surgical-treatment-modality-for-children-with-giant-cystic-craniopharyngioma
#15
Wanchun Zhu, Xiang Li, Jintao He, Tao Sun, Chunde Li, Jian Gong
OBJECTIVE: Surgical removal plays an important role in treating children's craniopharyngioma. For a safe and minimally invasive craniotomy, a reformed surgical modality was proposed in this paper by combining the insertion of an Ommaya reservoir system (ORS) by stereotactic puncture, aspiration of cystic fluid in 2-day interval for consecutive 7-10 days, and the delayed tumor resection. PATIENTS AND METHODS: Eleven patients (aged from 5 to 9 years old) with giant cystic craniopharyngiomas who had undergone the reformed surgical modality during November 2014 and December 2015 were collected as group A...
September 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28439390/nosocomial-pseudomonas-putida-meningitis-a-case-report-and-literature-review
#16
Fahmi Yousef Khan, Mohammed AbuKamar, Deshmukh Anand
We report a case of Pseudomonas putida meningitis in a 26-year-old Nepalese man who was admitted to Hamad General Hospital with epidermoid cyst for drainage. Ommaya reservoir was placed into the cyst for drainage and externalventricular drainage (EVD) was performed. After four days, the patient was transferred to the ward in stable condition. His weakness resolved partially and headache severity decreased. After three days, the patient developed fever and headache severity increased with deterioration of consciousness level...
March 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28413743/real-time-fluoroscopic-and-c-arm-computed-tomography-evaluation-of-ommaya-reservoir-integrity
#17
Adrienne M Moraff, Melanie Hayden Gephart, Larry M Shuer, Jeremy J Heit
We describe a case of a 24-year-old patient with relapsed acute myelogenous leukemia involving the central nervous system. After placement of an Ommaya reservoir for intrathecal chemotherapy administration, the patient developed progressive headache, nausea, and drowsiness and was found to have an enlarging subdural collection underlying the Ommaya. To exclude leakage of the Ommaya system into the subdural space, real-time fluoroscopic and C-arm computed tomographic evaluation of the Ommaya reservoir was performed after iodinated contrast injection into the reservoir...
March 15, 2017: Curēus
https://www.readbyqxmd.com/read/28381331/social-and-health-determinants-of-adolescents-wellbeing-in-jordan-implications-for-policy-and-practice
#18
Diana H Arabiat, Abeer Shaheen, Ommaya Nassar, Mohammad Saleh, Ayman Mansour
PURPOSE: This study examined the extent to which health related aspect, health outcome, behaviour outcomes and social connectedness may predict adolescents' wellbeing at the schools of Jordan. METHODS: Using a two-stage cluster sampling technique 1166 adolescents completed the Health Behaviour of School Children survey. RESULTS: Stepwise Regression Analysis showed that the adolescents' wellbeing was predicted by academic achievements, bullying behaviour, eating habits, psycho-somatization, parent support and ease of communication with parents...
March 2018: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28223673/-a-case-of-meningeal-carcinomatosis-and-small-cell-lung-carcinoma-effectively-treated-using-a-multidisciplinary-approach
#19
Kota Hikima, Mikie Nagayama, Takashi Sato, Takashi Inoue, Mutsumi Nagai
A 65-year-old man visited our hospital with dyspnea and cough. He was diagnosed with small cell lung carcinoma (cT4N2M1b, Stage IV). The disease partially responded to systemic chemotherapy. However, it was progressive and metastasized to the brain 3 months after 6 courses of chemotherapy. Therefore, whole brain irradiation was performed. Subsequently, weakness of the lower extremities and vesicorectal disturbances appeared. Meningeal carcinomatosis was diagnosed by enhanced magnetic resonance imaging and liquid examination...
February 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28178712/surgical-treatment-for-leptomeningeal-disease
#20
REVIEW
Andrey A Volkov, Andreas K Filis, Frank D Vrionis
BACKGROUND: Advancements in cancer treatment have led to more cases of leptomeningeal disease, which requires a multimodal approach. METHODS: Treatment modalities are reviewed from a neurosurgical standpoint, focusing on intrathecal chemotherapy and shunting devices. Potential complications and how to avoid them are discussed. RESULTS: The Ommaya reservoir and the chemoport are used for administering intrathecal chemotherapy. Use of ventriculo-lumbar perfusion can efficiently deliver chemotherapeutic agents and improve intracerebral pressure...
January 2017: Cancer Control: Journal of the Moffitt Cancer Center
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