keyword
Keywords Primary AND Hyperaldosteronism...

Primary AND Hyperaldosteronism AND adrenal AND adenoma

https://read.qxmd.com/read/37007341/anesthetic-implications-in-managing-a-case-of-primary-hyperaldosteronism-a-case-report
#21
Renjith Ravi, Mahesh Prabhu, Baby Thampuru Vamadevan
Primary hyperaldosteronism (also called Conn's syndrome) is a rare condition of the adrenal glands characterized by excessive secretion of the hormone aldosterone, which regulates the balance of water and electrolytes in the body, and maintains blood volume and pressure. Hyperaldosteronism causes sodium and water retention, hypokalemia, hypertension, and muscle weakness. Common cause of primary hyperaldosteronism is an adrenal adenoma or bilateral adrenal hyperplasia. A 36-year-old female presented with hypertension, hypokalemia and muscle cramps, and on further evaluation by computed tomography (CT) scan was found to have a right adrenal adenoma...
February 2023: Curēus
https://read.qxmd.com/read/36921907/18-oxocortisol-a-journey
#22
JOURNAL ARTICLE
Celso E Gomez-Sanchez, Elise P Gomez-Sanchez
The search for mineralocorticoids to explain some cases of low renin hypertension with suppressed aldosterone levels led to the isolation of the abundant steroid 18-hydroxycortisol in human urine. 18-Hydroxycortisol proved to be inactive, but because of its similarity to precursors for the synthesis of aldosterone, bullfrog adrenals were incubated with cortisol, resulting in the discovery of 18-oxocortisol which is structurally similar to aldosterone, but with a 17α-hydroxy group like cortisol. 18-Oxocortisol is a weak mineralocorticoid...
March 13, 2023: Journal of Steroid Biochemistry and Molecular Biology
https://read.qxmd.com/read/36871261/-the-genetic-background-of-primary-aldosteronism
#23
JOURNAL ARTICLE
Bálint Vékony, Péter Igaz
One of the most frequent causes of secondary hypertension is primary aldosteronism. The disease is caused by the autonomous aldosterone production of the adrenal cortex leading to elevated aldosterone levels causing hypertension and often hypokalemia, and if untreated, could lead to a plethora of pathophysiological issues. The diagnosis and treatment of primary aldosteronism is of paramount significance, since depending on its subtype, surgical or pharmaceutical intervention can lead to the full recovery of the patient...
March 5, 2023: Orvosi Hetilap
https://read.qxmd.com/read/36832140/an-ancillary-method-for-adrenal-venous-sampling-in-cases-in-which-right-adrenal-vein-sampling-is-difficult
#24
JOURNAL ARTICLE
Akira Yamamoto, Takeshi Fukunaga, Mitsuru Takeuchi, Hiroki Nakamura, Akihiko Kanki, Atsushi Higaki, Tsutomu Tamada
Catheterization of the right adrenal vein (rt.AdV) to obtain blood samples can often be difficult. The aim of the present study was to investigate whether blood sampling from the inferior vena cava (IVC) at its juncture with the rt.AdV can be an ancillary to sampling of blood directly from the rt.AdV. This study included 44 patients diagnosed with primary aldosteronism (PA) in whom AVS with adrenocorticotropic hormone (ACTH) was performed, resulting in a diagnosis of idiopathic hyperaldosteronism (IHA) ( n = 24), and patients diagnosed with unilateral aldosterone-producing adenoma (APA) ( n = 20; rt...
February 9, 2023: Diagnostics
https://read.qxmd.com/read/36810868/a-hyperaldosteronism-subtypes-predictive-model-using-ensemble-learning
#25
JOURNAL ARTICLE
Shigehiro Karashima, Masaki Kawakami, Hidetaka Nambo, Mitsuhiro Kometani, Isao Kurihara, Takamasa Ichijo, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Kenji Oki, Yoshihiro Ogawa, Ryuji Okamoto, Kouichi Tamura, Nobuya Inagaki, Takanobu Yoshimoto, Hiroki Kobayashi, Miki Kakutani, Megumi Fujita, Shoichiro Izawa, Tetsuya Suwa, Kohei Kamemura, Masanobu Yamada, Akiyo Tanabe, Mitsuhide Naruse, Takashi Yoneda
This study aimed to develop a machine-learning algorithm to diagnose aldosterone-producing adenoma (APA) for predicting APA probabilities. A retrospective cross-sectional analysis of the Japan Rare/Intractable Adrenal Diseases Study dataset was performed using the nationwide PA registry in Japan comprised of 41 centers. Patients treated between January 2006 and December 2019 were included. Forty-six features at screening and 13 features at confirmatory test were used for model development to calculate APA probability...
February 21, 2023: Scientific Reports
https://read.qxmd.com/read/36787883/many-faces-of-adrenal-lesions-in-a-large-patient-cohort-what-has-changed-over-the-last-two-decades
#26
REVIEW
Basak Ozgen Saydam, Mustafa Baris, Suleyman Cem Adiyaman, Tevfik Demir, Mehmet Ali Kocdor, Omer Demir, Mustafa Secil, Serkan Yener
OBJECTIVE: To review the presentation characteristics, clinical and hormonal evaluations, and histopathological results of patients with adrenal lesions over a 21-year period and evaluate the changes across the two decades. METHODS: This single-center, retrospective study included 1003 patients with adrenal lesions who presented to our department between 2000 and 2021. Clinical, metabolic, hormonal, radiological, and pathological data of the patients were collected...
April 2023: Experimental and Clinical Endocrinology & Diabetes
https://read.qxmd.com/read/36551831/autonomous-aldosterone-secretion-in-patients-with-adrenal-incidentaloma
#27
JOURNAL ARTICLE
Piotr Kmieć, Ewa Zalewska, Katarzyna Kunicka, Ewa Świerblewska, Krzysztof Sworczak
In recent years, research has emphasized the significance of mild clinical and biochemical presentations of primary aldosteronism (PA) that do not meet current diagnostic criteria of the syndrome. In this study, we assessed the prevalence of autonomous aldosterone (Ald) secretion (AAS), defined as a positive (>1.2 ng/dL/mIU/L) Ald-to-renin ratio (ADRR) combined with unsuppressed Ald (>4 ng/dL), and its associations with blood pressure (BP), cardiac function, and common carotid artery (CCA) intima-media thickness (IMT) in patients with incidentally discovered adrenal adenomas (AI), who were either normo- or hypertensive but had no other cardiovascular disease...
November 30, 2022: Biomedicines
https://read.qxmd.com/read/36458545/tspan12-tetraspanin-12-is-a-novel-negative-regulator-of-aldosterone-production-in-adrenal-physiology-and-aldosterone-producing-adenomas
#28
JOURNAL ARTICLE
Siyuan Gong, Martina Tetti, Elisabeth Kemter, Mirko Peitzsch, Paolo Mulatero, Martin Bidlingmaier, Graeme Eisenhofer, Eckhard Wolf, Martin Reincke, Tracy Ann Williams
BACKGROUND: Aldosterone-producing adenomas (APAs) are a major cause of primary aldosteronism, a condition of low-renin hypertension, in which aldosterone overproduction is usually driven by a somatic activating mutation in an ion pump or channel. TSPAN12 is differentially expressed in different subgroups of APAs suggesting a role in APA pathophysiology. Our objective was to determine the function of TSPAN12 (tetraspanin 12) in adrenal physiology and pathophysiology. METHODS: APA specimens, pig adrenals under dietary sodium modulation, and a human adrenocortical cell line HAC15 were used for functional characterization of TSPAN12 in vivo and in vitro...
February 2023: Hypertension
https://read.qxmd.com/read/36451593/adrenal-nodules-for-the-non-specialist-what-to-look-out-for-and-when-to-refer
#29
REVIEW
Alex J Graveling, Prakash Abraham
Almost all medical specialities utilise cross-sectional imaging of the abdomen to evaluate many different medical conditions. This ever-increasing use of cross-sectional imaging has led to a dramatic increase in the detection rate of adrenal nodules. Following appropriate biochemical and radiological evaluation, the vast majority of these are shown to be benign adrenal adenomas. A small minority are diagnosed with a functional or malignant lesion that may result in significant morbidity and mortality requiring specialist management...
December 2022: Journal of the Royal College of Physicians of Edinburgh
https://read.qxmd.com/read/36415024/do-multiple-types-of-confirmatory-tests-improve-performance-in-predicting-subtypes-of-primary-aldosteronism
#30
RANDOMIZED CONTROLLED TRIAL
Hiroki Kaneko, Hironobu Umakoshi, Tazuru Fukumoto, Norio Wada, Takamasa Ichijo, Shohei Sakamoto, Tetsuhiro Watanabe, Yuki Ishihara, Tetsuya Tagami, Masatoshi Ogata, Norifusa Iwahashi, Maki Yokomoto-Umakoshi, Yayoi Matsuda, Ryuichi Sakamoto, Yoshihiro Ogawa
OBJECTIVE: The clinical practice guideline for primary aldosteronism (PA) places a high value on confirmatory tests to sparing patients with false-positive results in case detection from undergoing adrenal venous sampling (AVS). However, it is unclear whether multiple types of confirmatory tests are more useful than a single type. To evaluate whether the machine-learned combination of two confirmatory tests is more useful in predicting subtypes of PA than each test alone. DESIGN: A retrospective cross-sectional study in referral centres...
April 2023: Clinical Endocrinology
https://read.qxmd.com/read/36229523/catheter-based-adrenal-ablation-an-alternative-therapy-for-patients-with-aldosterone-producing-adenoma
#31
JOURNAL ARTICLE
Fang Sun, Xiaoli Liu, Hexuan Zhang, Xunmei Zhou, Zhigang Zhao, Hongbo He, Zhencheng Yan, Yingsha Li, Qiang Li, Yaoming Li, Jun Jiang, Zhiming Zhu
Unilateral adrenalectomy is the standard treatment for patients with aldosterone-producing adenoma (APA), but it lacks an option for patients with APA who refuse or are not suitable for surgery. In this study, we studied whether catheter-based adrenal ablation for APA is comparable to adrenalectomy. A total of 2185 hypertensive patients were screened, and 112 patients with APA were recruited and counselled on the treatment options. Fifty-two patients opted for catheter-based adrenal ablation, and 60 opted for adrenalectomy...
October 14, 2022: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/36198431/remission-of-progressive-metastatic-castration-resistant-prostate-cancer-during-abiraterone-therapy-following-unilateral-adrenalectomy-for-a-functioning-adrenal-adenoma
#32
JOURNAL ARTICLE
Katelyn Nazaneen Seale, Matthew K Labriola, Xiaoyin Sara Jiang, Andrew Armstrong
Despite advances and introduction of new therapies in the last decade, metastatic castration-resistant prostate cancer (mCRPC) has a poor prognosis. The development of androgen axis-targeted therapies such as abiraterone acetate, enzalutamide and darolutamide can prolong survival in mCPRC; however, resistance remains a barrier to prolonged response, necessitating exploration into resistance mechanisms and locoregional therapies. Here, we describe a patient with mCRPC that was progressing on abiraterone acetate...
October 5, 2022: BMJ Case Reports
https://read.qxmd.com/read/36070092/functional-nodules-in-primary-aldosteronism-identification-of-cxcr4-expression-with-68-ga-pentixafor-pet-ct
#33
JOURNAL ARTICLE
Yinjie Gao, Jie Ding, Yunying Cui, Tianyi Li, Hao Sun, Dachun Zhao, Yushi Zhang, Li Huo, Anli Tong
OBJECTIVES: We analyzed the diagnostic efficiency of 68 Ga-pentixafor PET/CT for functional nodules in primary aldosteronism (PA). Furthermore, we compared the correlation of CXCR4 expression with aldosterone synthase (CYP11B2) expression and PET/CT uptake in these patients. METHODS: We prospectively assessed 50 patients diagnosed with PA and 10 patients with non-functional adrenal adenoma (NFA). All patients underwent 68 Ga-pentixafor PET/CT before adrenalectomy...
February 2023: European Radiology
https://read.qxmd.com/read/36027381/the-exploration-of-the-renine-angiotensin-system-in-nephrology-experience-of-the-nephrology-department-of-the-hedi-chaker-university-hospital-center-of-sfax
#34
JOURNAL ARTICLE
Aminetou El Atigh, Najla Dammak, Ikram Agrebi, Khanssa Chaabouni, Salma Toumi, Hanen Chaker, Soumeya Yaich, Khawla Kammoun, Fatma Ayedi, Mohamed Ben Hmida
OBJECTIVE: Plasma renin and aldosterone assays are useful in clinical practice for the aetiological assessment of arterial hypertension (hypertension) and / or a disturbance of the electrolyte balance. The objective of our work is to describe the main indications exploration of the renin aldosterone system, its results, its diagnostic and etiological impact. DESIGN AND METHOD: We conducted a retrospective study of 40 patients who received a renin / aldosterone dosage, collected in the Nephrology department at the Hédi Chaker CHU in Sfax for a period of 6 years from January 2014 until December 2020...
June 1, 2022: Journal of Hypertension
https://read.qxmd.com/read/36027148/cardiovascular-and-gluco-metabolic-complications-in-patients-with-primary-hyperaldosteronism
#35
JOURNAL ARTICLE
Ergita Nelaj, Julinda Koci, Irida Kecaj, Mihal Tase
OBJECTIVE: Primary hyperaldosteronism (PA) is an under-diagnosed cause of hypertension. The presentation is classically known to occur in a patient with hypertension and hypokalemia. However, in reality, most patients will present without hyperkalemia. PA is characterized by the development of cardiovascular, renal and metabolic complications, including left ventricular hypertrophy, myocardial infarction, atrial fibrillation and stroke, microalbuminuria, as well as metabolic syndrome...
June 1, 2022: Journal of Hypertension
https://read.qxmd.com/read/36012306/clinical-translationality-of-kcnj5-mutation-in-aldosterone-producing-adenoma
#36
REVIEW
Takumi Kitamoto, Tetsuo Nishikawa
Hypertension due to primary aldosteronism poses a risk of severe cardiovascular complications compared to essential hypertension. The discovery of the KCNJ5 somatic mutation in aldosteroene producing adenoma (APA) in 2011 and the development of specific CYP11B2 antibodies in 2012 have greatly advanced our understanding of the pathophysiology of primary aldosteronism. In particular, the presence of CYP11B2-positive aldosterone-producing micronodules (APMs) in the adrenal glands of normotensive individuals and the presence of renin-independent aldosterone excess in normotensive subjects demonstrated the continuum of the pathogenesis of PA...
August 12, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36004349/primary-aldosteronism-pathophysiological-mechanisms-of-cell-death-and-proliferation
#37
REVIEW
Martina Tetti, Siyuan Gong, Franco Veglio, Martin Reincke, Tracy Ann Williams
Primary aldosteronism is the most common surgically curable form of hypertension. The sporadic forms of the disorder are usually caused by aldosterone overproduction from a unilateral adrenocortical aldosterone-producing adenoma or from bilateral adrenocortical hyperplasia. The main knowledge-advances in disease pathophysiology focus on pathogenic germline and somatic variants that drive the excess aldosterone production. Less clear are the molecular and cellular mechanisms that lead to an increased mass of the adrenal cortex...
2022: Frontiers in Endocrinology
https://read.qxmd.com/read/35841527/update-on-the-genetics-of-primary-aldosteronism-and-aldosterone-producing-adenomas
#38
REVIEW
Georgia Pitsava, Fabio R Faucz, Constantine A Stratakis, Fady Hannah-Shmouni
PURPOSE OF THE REVIEW: Primary aldosteronism (PA) is the leading cause of secondary hypertension, accounting for over 10% of patients with high blood pressure. It is characterized by autonomous production of aldosterone from the adrenal glands leading to low-renin levels. The two most common forms arise from bilateral adrenocortical hyperplasia (BAH) and aldosterone-producing adenoma (APA). We discuss recent discoveries in the genetics of PA. RECENT FINDINGS: Most APAs harbor variants in the KCNJ5, CACNA1D, ATP1A1, ATP2B3, and CTNNB1 genes...
September 2022: Current Cardiology Reports
https://read.qxmd.com/read/35813615/pathogenesis-of-primary-aldosteronism-impact-on-clinical-outcome
#39
REVIEW
Lucas S Santana, Augusto G Guimaraes, Madson Q Almeida
Primary aldosteronism (PA) is the most common form of secondary arterial hypertension, with a prevalence of approximately 20% in patients with resistant hypertension. In the last decade, somatic pathogenic variants in KCNJ5 , CACNA1D, ATP1A1 and ATP2B3 genes, which are involved in maintaining intracellular ionic homeostasis and cell membrane potential, were described in aldosterone-producing adenomas (aldosteronomas). All variants in these genes lead to the activation of calcium signaling, the major trigger for aldosterone production...
2022: Frontiers in Endocrinology
https://read.qxmd.com/read/35796577/characterization-of-aldosterone-producing-cell-cluster-apcc-at-single-cell-resolution
#40
JOURNAL ARTICLE
Norifusa Iwahashi, Hironobu Umakoshi, Tsugio Seki, Celso E Gomez-Sanchez, Kuniaki Mukai, Makoto Suematsu, Yuta Umezawa, Mototsugu Oya, Takeo Kosaka, Masahide Seki, Yutaka Suzuki, Yutaka Horiuchi, Yoshihiro Ogawa, Koshiro Nishimoto
CONTEXT: The adrenal cortex consists of zona glomerulosa (ZG), fasciculata (ZF), and reticularis. Aldosterone-producing cell clusters that strongly express aldosterone synthase (CYP11B2) are frequently found in adult adrenals and harbor somatic mutations that are also detected in aldosterone-producing adenomas (APAs). Primary aldosteronism is mainly caused by APAs or idiopathic hyperaldosteronism (IHA). We presume that APCCs are causing IHA and are precursors of APAs. However, the gene expression characteristics and especially the development of APCC are not well understood...
July 7, 2022: Journal of Clinical Endocrinology and Metabolism
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