keyword
Keywords Primary AND Hyperaldosteronism...

Primary AND Hyperaldosteronism AND adrenal AND adenoma

https://read.qxmd.com/read/38526863/conn%C3%A2-s-syndrome-after-kidney-transplantation
#1
JOURNAL ARTICLE
Michaela Javorkova, Andrea Bystricanova, Martina Cirbusova, Marcela Cvoligova, Martin Chrastina, Juraj Maris, Janka Otavkova, Zuzana Zilinska
Conn's syndrome, defined as unilateral aldosterone-producing adenoma, accounts for 35-40% of cases of primary hyperaldosteronism. Primary hyperaldosteronism typically occurs in younger patients with poorly controlled arterial hypertension due to extracellular fluid retention, in whom at least a triple combination of antihypertensives, including a diuretic, is needed to maintain normotension. The clinical picture of arterial hypertension may be complemented by symptoms associated with hypokalaemia, such as weakness, fatigue, palpitations, convulsions, polydipsia, or polyuria...
2024: Bratislavské Lekárske Listy
https://read.qxmd.com/read/38322542/-comparison-of-different-doses-of-acth-used-in-acth-stimulation-test-to-determine-the%C3%A2-subtypes%C3%A2-of%C3%A2-primary-aldosteronism
#2
JOURNAL ARTICLE
Ping Qiu, Li Zang, Li Zhang, Zhaohui Lyu, Yiming Mu, Qinghua Guo
OBJECTIVE: To compare the diagnostic value of adrenocorticotropic hormone (ACTH) stimulation test (AST) with different doses of ACTH combined with midnight administration of 1 mg dexamethasone for the determination of the subtypes of primary hyperaldosteronism (PA). METHODS: This is a prospective observational study. Patients diagnosed with PA in the Department of Endocrinology, the First Medical Center of of Chinese PLA General Hospital from January 1, 2020 to September 30, 2022 underwent AST with different doses of ACTH...
January 20, 2024: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://read.qxmd.com/read/38318706/unilateral-primary-aldosteronism-long-term-disease-recurrence-after-adrenalectomy
#3
JOURNAL ARTICLE
Martina Tetti, Denise Brüdgam, Jacopo Burrello, Aaron M Udager, Anna Riester, Thomas Knösel, Felix Beuschlein, William E Rainey, Martin Reincke, Tracy Ann Williams
BACKGROUND: Primary aldosteronism (PA) is frequently caused by a unilateral aldosterone-producing adenoma with a PA-driver mutation. Unilateral adrenalectomy has a high probability of short-term biochemical remission, but long-term postsurgical outcomes are relatively undefined. Our objective was to investigate the incidence of long-term recurrence of PA in individuals with postsurgical short-term biochemical remission. METHODS: Adrenalectomized patients for unilateral PA were included from a single referral center...
February 6, 2024: Hypertension
https://read.qxmd.com/read/38255973/what-we-know-about-and-what-is-new-in-primary-aldosteronism
#4
REVIEW
Natalia Ekman, Ashley B Grossman, Dorota Dworakowska
Primary aldosteronism (PA), a significant and curable cause of secondary hypertension, is seen in 5-10% of hypertensive patients, with its prevalence contingent upon the severity of the hypertension. The principal aetiologies of PA include bilateral idiopathic hypertrophy (BIH) and aldosterone-producing adenomas (APAs), while the less frequent causes include unilateral hyperplasia, familial hyperaldosteronism (FH) types I-IV, aldosterone-producing carcinoma, and ectopic aldosterone synthesis. This condition, characterised by excessive aldosterone secretion, leads to augmented sodium and water reabsorption alongside potassium loss, culminating in distinct clinical hallmarks: elevated aldosterone levels, suppressed renin levels, and hypertension...
January 11, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38234344/a-case-of-primary-aldosteronism-with-rhabdomyolysis-in-which-the-first-symptoms-were-thyrotoxicosis-and-peripheral-paralysis-and-literature-review
#5
Yunuo Zhang, Wenjuan Ni, Wei Wang
BACKGROUND: Primary aldosteronism (PA) is one of the main causes of secondary endocrine hypertension, especially refractory hypertension. Increased autonomous secretion leads to increased blood pressure and proinflammatory effects on different organ systems, including the cardiovascular system. However, because of its diverse clinical manifestations or the combination of other conditions, it sometimes causes problems for correct diagnosis. Therefore, we report and review the characteristics of some atypical and uncommon special case cases related to proaldosterone to provide clinical ideas for correct diagnosis and decision-making of proaldosterone...
2024: AME Case Reports
https://read.qxmd.com/read/38181643/imaging-concordance-with-vein-sampling-for-primary-aldosteronism-a-cohort-study-and-literature-review
#6
JOURNAL ARTICLE
Sara Cartwright, MaKayla Gordon, Jessica Shank, Abbey Fingeret
INTRODUCTION: Adrenal venous sampling (AVS) is used to distinguish unilateral from bilateral aldosterone hypersecretion as a cause of primary aldosteronism (PA). Unilateral disease is treated with adrenalectomy and bilateral hypersecretion managed medically. METHODS: We performed a single institution retrospective cohort study of adult patients undergoing adrenalectomy for PA from July 2013 to June 2022. Concordance of imaging findings with AVS was evaluated. Statistical analysis was performed with Mann-Whitney U and chi-squared Fisher's exact...
January 4, 2024: Journal of Surgical Research
https://read.qxmd.com/read/38127970/correlation-of-histopathologic-subtypes-of-primary-aldosteronism-with-clinical-phenotypes-and-postsurgical-outcomes
#7
JOURNAL ARTICLE
Chang Ho Ahn, You-Bin Lee, Jae Hyeon Kim, Young Lyun Oh, Jung Hee Kim, Kyeong Cheon Jung
CONTEXT: Clinical implications of unilateral primary aldosteronism (PA) histopathology remain to be determined in various ethnic populations. OBJECTIVE: We examined the histopathology of unilateral PA using CYP11B2 immunostaining in relation to clinical phenotypes and postsurgical outcomes. METHODS: Patients consecutively operated for unilateral PA from 2010 to 2020 at three tertiary hospitals in South Korea were retrospectively enrolled. Adrenals with solitary aldosterone-producing adenomas and/or dominant aldosterone-producing nodules were classified as the classical and the others as the nonclassical groups...
December 21, 2023: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38073240/-primary-aldosteronism-without-hypertension-a-case-report-and-review-of-the-literature
#8
JOURNAL ARTICLE
Yves Dimitrov, Julien Ott, Lisa Beguin, Brieuc Muller
We describe the case of a patient who presented with hyperaldosteronism without arterial hypertension. She had been referred for consultation for persistent severe hypokalaemia despite oral KCl supplementation. The absence of hypertension had been proven by repeated clinical measurements and by ABPM. Hyperaldosteronism had been demonstrated by hormonal assays and catheterization of the adrenal veins. Abdominal CT revealed a left adrenal adenoma. Finally, the anatomopathological examination of the surgical specimen confirmed the adenoma...
December 11, 2023: Néphrologie & Thérapeutique
https://read.qxmd.com/read/37820987/success-rate-of-adrenal-venous-sampling-and-its-determining-factors-experience-of-a-single-centre-in-malaysia
#9
JOURNAL ARTICLE
Khadhratun Nadiah Muhamad Pauzi, Rozman Zakaria, Leong Yuh Yang, Nik Farhan Nik Fuad, Nik Azuan Nik Ismail, Norlela Sukor
BACKGROUND: Primary hyperaldosteronism has been regarded as the commonest and potentially curable cause of secondary hypertension in up to 80% of cases if this condition is detected early. Laparoscopic adrenalectomy proved to be a promising curable method for primary hyperaldosteronism secondary to aldosterone producing adenoma (APA), while primary hyperaldosteronism secondary to bilateral adrenal hyperplasia (BAH) requires optimization of medical treatment. Adrenal venous sampling (AVS) has been recommended by the Endocrine Society's guideline in addressing the subtypes of primary hyperaldosteronism...
October 9, 2023: Annals of Vascular Surgery
https://read.qxmd.com/read/37793023/surgery-based-on-computed-tomography-images-might-be-feasible-for-primary-aldosteronism-patients-with-visible-unilateral-adenoma
#10
JOURNAL ARTICLE
Chen Fang, Jun Dai, Juping Zhao, Xin Huang, Wei He, Jianzhong Xu, Fukang Sun
Primary aldosteronism (PA) with unilateral adrenal disease can be cured or improved by adrenalectomy. Adrenal venous sampling (AVS) is recommended to identify patients for surgical management. However, surgeries based on computed tomography (CT) images are only advocated for PA patients aged <35 with visible unilateral adenoma. Herein, we aimed to compare CT-based and AVS-based surgery outcomes for PA patients with visible unilateral adenomas for different age groups. A total of 178 PA patients who underwent unilateral adrenalectomy between June 2018 and January 2021 were included in the study based on CT (n = 54) or AVS (n = 124)...
October 4, 2023: Journal of Clinical Hypertension
https://read.qxmd.com/read/37766569/pathology-and-gene-mutations-of-aldosterone-producing-lesions
#11
JOURNAL ARTICLE
Koshiro Nishimoto, Tadashi Ogishima, Yuki Sugiura, Makoto Suematsu, Kuniaki Mukai
The human adrenal cortex secretes aldosterone and cortisol as major corticosteroids. For their production, CYP11B2 and CYP11B1 catalyze the last steps in the syntheses of aldosterone and cortisol, respectively. In our previous study, CYP11B2 was the first successfully purified from rat adrenals and human clinical samples and then was proved to be aldosterone synthase. We demonstrated the immunohistochemistry for CYP11B2 of both rats and humans and applied it clinically to visualize the functional histology of aldosterone-producing adenoma (APA) causing primary aldosteronism (PA)...
September 26, 2023: Endocrine Journal
https://read.qxmd.com/read/37660370/differences-between-left-adrenal-vein-sampling-sites-revealed-with-segmental-sampling-in-primary-aldosteronism
#12
JOURNAL ARTICLE
Hiromitsu Tannai, Kohzoh Makita, Kazuki Nakai, Yuko Sato, Yuya Tsurutani, Jun Saito, Seishi Matsui, Tetsuo Nishikawa
OBJECTIVES: To clarify the differences between two left sampling sites (left adrenal central vein [LCV] and common trunk [CMT], conjunction with LCV and inferior phrenic vein) and their impact on adrenal venous sampling (AVS) in primary aldosteronism by analyzing the results of segmental AVS (sAVS). METHODS: We retrospectively analyzed a final cohort of 432 patients who underwent cosyntropin-stimulated sAVS from 2017 to 2020. Hormone levels in the LCV and the CMT were compared...
September 3, 2023: British Journal of Radiology
https://read.qxmd.com/read/37641755/rare-challenges-in-diagnosing-cushing-s-syndrome-and-primary-aldosteronism-a-case-report-of-a-female-with-a-negative-workup
#13
Asiya Jatoi, Yasser Haider-Badenhorst
Cushing's syndrome with concurrent primary aldosteronism (PA) is a rare presentation, and establishing an early diagnosis is imperative to preventing morbidity and long-term sequelae. The diagnosis is established by sequential lab work, showing an elevated cortisol and aldosterone level. Taking the above into consideration, it is evident that repeatedly negative results on all three tests can present an extremely challenging case. In this report, we discuss a female who presented with an adrenal incidentaloma and features suggestive of primary hyperaldosteronism as well as Cushing's syndrome but no elevations in serum, urine, or salivary cortisol...
July 2023: Curēus
https://read.qxmd.com/read/37485117/cardiovascular-remodeling-in-chronic-mineralocorticoid-excess
#14
Pradnya Brijmohan Bhattad, Mazen Roumia
Primary hyperaldosteronism typically leads to resistant hypertension, hypokalemia, and metabolic alkalosis. Excess aldosterone secretion by the adrenal glands may lead to heart failure with preserved ejection fraction. Potassium-sparing diuretics and aldosterone antagonists directed to lower excess aldosterone levels may help treat the associated heart failure and lead to control of blood pressure, resulting in improved outcomes. We report a case of a 55-year-old male with poorly controlled hypertension and newly symptomatic heart failure with preserved ejection fraction in the setting of excess aldosterone activity and an adrenal adenoma suggesting primary aldosteronism-induced diastolic heart failure...
June 2023: Curēus
https://read.qxmd.com/read/37477496/the-value-of-targeting-cxcr4-with-68ga-pentixafor-pet-ct-for-subtyping-primary-aldosteronism
#15
JOURNAL ARTICLE
Yanqing Zheng, Tingting Long, Ning Peng, Mengling Zhen, Qianwen Ye, Zhen Zhang, Yao He, Zhi Chen, Yu Gan, Min Luo, Chun Li, Zehao Liu, Min Guo, Min Wang, Xianghang Luo, Shuo Hu, Longfei Liu, Tiejian Jiang
PURPOSE: Primary aldosteronism (PA) is one of the leading causes of secondary hypertension, and its diagnostic subtyping consistently presents a clinical challenge. This study aimed to investigate the potential of 68Ga-Pentixafor PET/CT in PA classification and its applicability in guiding the development of clinical treatment plans by increasing the sample size. METHODS: We prospectively enrolled 120 patients with either PA or nonfunctional adenoma (NFA) for analysis...
July 21, 2023: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/37335717/case-series-primary-aldosteronism-diagnosed-despite-normal-screening-investigations-a-report-of-three-cases
#16
JOURNAL ARTICLE
Minyue Jia, Liya Lin, Hanxiao Yu, Boyun Yang, Xiaohong Xu, Xiaoxiao Song
RATIONALE: Since the introduction of the aldosterone-to-renin ratio (ARR) as a screening tool for primary aldosteronism (PA), there has been a marked increase in the reported prevalence of this condition among hypertensive, even normotensive, subjects. PATIENT CONCERNS: But ARR as a spot blood draw for estimating a patient's aldosterone secretory status is influenced by many factors. DIAGNOSES: Here, we describe a series of patients with biochemically confirmed PA, whose diagnosis was delayed by the initial ARR assessment with non-suppressed renin...
May 19, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37311830/ca-v-3-2-cacna1h-in-primary-aldosteronism
#17
JOURNAL ARTICLE
Hoang An Dinh, Gabriel Stölting, Ute I Scholl
Aldosterone is a steroid hormone produced in the zona glomerulosa (ZG) of the adrenal cortex. The most prominent function of aldosterone is the control of electrolyte homeostasis and blood pressure via the kidneys. The primary factors regulating aldosterone synthesis are the serum concentrations of angiotensin II and potassium. The T-type voltage-gated calcium channel CaV 3.2 (encoded by CACNA1H) is an important component of electrical as well as intracellular calcium oscillations, which govern aldosterone production in the ZG...
June 14, 2023: Handbook of Experimental Pharmacology
https://read.qxmd.com/read/37202237/strategies-for-subtyping-primary-aldosteronism
#18
REVIEW
Yun-Hsuan Yang, Yu-Ling Chang, Bo-Ching Lee, Ching-Chu Lu, Wei-Ting Wang, Ya-Hui Hu, Han-Wen Liu, Yung-Hsiang Lin, Chin-Chen Chang, Wan-Chen Wu, Fen-Yu Tseng, Yen-Hung Lin, Vin-Cent Wu, Chii-Min Hwu
Adrenal venous sampling (AVS) is a crucial method for the lateralization of primary aldosteronism (PA). It is advised to halt the use of the patient's antihypertensive medications and correct hypokalemia prior to undergoing AVS. Hospitals equipped to conduct AVS should establish their own diagnostic criteria based on current guidelines. If the patient's antihypertensive medications cannot be discontinued, AVS can be performed as long as the serum renin level is suppressed. The Task Force of Taiwan PA recommends using a combination of adrenocorticotropic hormone stimulation, quick cortisol assay, and C-arm cone-beam computed tomography to maximize the success of AVS and minimize errors by using the simultaneous sampling technique...
May 16, 2023: Journal of the Formosan Medical Association
https://read.qxmd.com/read/37125608/primary-aldosteronism-spatial-multiomics-mapping-of-genotype-dependent-heterogeneity-and-tumor-expansion-of-aldosterone-producing-adenomas
#19
JOURNAL ARTICLE
Siyuan Gong, Na Sun, Lucie S Meyer, Martina Tetti, Christina Koupourtidou, Stefan Krebs, Giacomo Masserdotti, Helmut Blum, William E Rainey, Martin Reincke, Axel Walch, Tracy Ann Williams
BACKGROUND: Primary aldosteronism is frequently caused by an adrenocortical aldosterone-producing adenoma (APA) carrying a somatic mutation that drives aldosterone overproduction. APAs with a mutation in KCNJ5 (APA- KCNJ5MUT ) are characterized by heterogeneous CYP11B2 (aldosterone synthase) expression, a particular cellular composition and larger tumor diameter than those with wild-type KCNJ5 (APA- KCNJ5WT ). We exploited these differences to decipher the roles of transcriptome and metabolome reprogramming in tumor pathogenesis...
July 2023: Hypertension
https://read.qxmd.com/read/37067841/-adrenalectomy-for-primary-hyperaldosteronism-retrospective-review-of-57-patients-in-chu-of-liege
#20
JOURNAL ARTICLE
Emilie Wilmont, Etienne Hamoir
Primary hyperaldosteronism is the most common cause of secondary hypertension. Diagnostic clarification is essential because surgery is the treatment of choice for patients with unilateral disease (aldosterone-producing adenoma and unilateral cortical hyperplasia). We report a series of 57 patients that had adrenalectomy for primary hyperaldosteronism between April 1994 to January 2022 by the endocrine surgery team of the University Hospital of Liege. Our aim is to evaluate the diagnostic performance of adrenal venous sampling in lateralizing aldosterone hypersecretion and to compare it with other imaging techniques...
April 2023: Revue Médicale de Liège
keyword
keyword
166139
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.