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Visceral adiposity index

Anna Solini, Marta Seghieri, Eleonora Santini, Livia Giannini, Edoardo Biancalana, Stefano Taddei, Duccio Volterrani, Rosa Maria Bruno
OBJECTIVE: Bariatric surgery may ameliorate renal function through vascular mechanisms. This study tested surgery's ability to improve measured glomerular filtration rate (mGFR) and identified clinical, renal, and systemic vascular predictors of such improvement. METHODS: Twenty-five nondiabetic subjects with severe obesity were studied before and 1 year after Roux-en-Y gastric bypass, evaluating mGFR and renal plasma flow, basal renal resistive index (RI) and dynamic renal RI, renal visceral fat, and systemic vascular parameters, including flow-mediated dilation, aortic pulse wave velocity, and carotid intima media thickness and stiffness...
December 5, 2018: Obesity
Lediya T Cheru, Elli A Park, Charles F Saylor, Tricia H Burdo, Kathleen V Fitch, Sara Looby, Jeffrey Weiner, Jake A Robinson, Jane Hubbard, Martin Torriani, Janet Lo
Background: Intestinal fatty acid binding protein (I-FABP) has been shown to be a marker of intestinal damage among people living with HIV. We hypothesized that I-FABP would be increased in chronically HIV-infected patents more than elite controllers and would relate to specific nutrient intake and body composition. Methods: In an observational study, serum I-FABP was measured by enzyme-linked immunosorbent assay. Anthropometric measurements, dual-energy x-ray absorptiometry, and single-slice abdominal computed tomography were obtained to assess body composition, as well as visceral and subcutaneous adipose tissue areas (VAT and SAT)...
November 2018: Open Forum Infectious Diseases
Paola Simeone, Rossella Liani, Romina Tripaldi, Augusto Di Castelnuovo, Maria Teresa Guagnano, Armando Tartaro, Riccardo C Bonadonna, Virginia Federico, Francesco Cipollone, Agostino Consoli, Francesca Santilli
Thromboxane (TX)-dependent platelet activation and lipid peroxidation, as reflected in vivo by the urinary excretion of 11-dehydro-TXB₂ and 8-iso-prostaglandin (PG)F2α , play a key role in atherothrombosis in obesity and type 2 diabetes mellitus (T2DM) since the earlier stages. Thirty-five metformin-treated obese subjects with prediabetes or newly-diagnosed T2DM were randomized to the glucagon-like peptide receptor agonist (GLP-RA) liraglutide (1.8 mg/day) or lifestyle counseling until achieving a comparable weight loss (-7% of initial body weight), to assess whether changes in subcutaneous (SAT) and visceral (VAT) adipose tissue distribution (MRI), insulin sensitivity (Matsuda Index) and beta-cell performance (multiple sampling OGTT beta-index), with either intervention, might affect TX-dependent platelet activation, lipid peroxidation and inflammation...
December 2, 2018: Nutrients
Stella Maris Honoré, Maria Virginia Grande, Jorge Gomez Rojas, Sara Serafina Sánchez
Smallanthus sonchifolius (yacon), a native plant of South America, was observed to improve lipid profile in rodents and humans. This study aimed to investigate the antiobesity properties of yacon roots in a high-fat-diet (HFD) model and the underlying mechanisms. A total of 30 Wistar male rats were divided into five groups ( n =6): the standard chow diet (SD) group was fed a SD; the HFD group was fed a HFD; and the HFD Y340 and HFD Y680 groups were fed a HFD plus yacon flour (340 and 680 mg FOS/kg b. w./day, respectively)...
2018: Journal of Obesity
Xing Zhen Liu, Hui Hua Li, Shan Huang, Dong Bao Zhao
BACKGROUND: The association between several novel adiposity indices and hyperuricemia is inconclusive. Therefore, we aimed to investigate this association so as to provide theoretical support for the management of hyperuricemia in overweight/obese individuals. METHODS: A cross-sectional study was carried out among 174,698 adults. The values of body adiposity index (BAI), conicity index (CI), a body shape index (ABSI), body roundness index (BRI), visceral adiposity index (VAI), lipid accumulation product (LAP) index, and cardiometabolic index (CMI) were divided into four quartiles, and multivariate logistic analysis was used to analyze the association between them and hyperuricemia...
November 29, 2018: Clinical Rheumatology
Musa Moh'd Waleed Al-Batsh, Abla Albsoul-Younes, Violet Kasabri, Maysa Suyagh, Sundos Alalawi, Nada Yasin
Background Pentraxin-3 (PXT-3) and cystatin-C (Cys-C) are robustly related with central obesity and insulin resistance in prediabetes/metabolic syndrome (preDM-MetS). Materials and methods This cross-sectional study aimed to compare and correlate PXT-3 and Cys-C plasma levels in 29 normoglycemic MetS patients, 30 newly diagnosed drug naive preDM-MetS cases vs. 29 normoglycemic lean controls. Results Unlike PXT-3; Cys-C level was significantly higher in normoglycemic MetS (but not preDM-MetS) vs. healthy controls...
November 29, 2018: Hormone Molecular Biology and Clinical Investigation
Godfred Agongo, Engelbert Adamwaba Nonterah, Cornelius Debpuur, Lucas Amenga-Etego, Stuart Ali, Abraham Oduro, Nigel J Crowther, Michèle Ramsay
Dyslipidaemia is a primary risk factor for cardiometabolic disease, causing over 17 million deaths globally in 2015. However, the burden of dyslipidaemia and factors associated with lipid levels remain unknown in many rural African populations. Therefore, this study evaluated the association of socio-demographic, anthropometric and behavioural factors with lipid levels in rural Ghana. The prevalence of hypercholesterolaemia, hypertriglyceridaemia and elevated LDL-C in the total population of 1839 (846 men and 993 women) was 4...
2018: PloS One
Mauara Scorsatto, Glorimar Rosa, Aline de Castro Pimentel, Ronir Raggio Luiz, Gláucia Maria Moraes de Oliveira
BACKGROUND: Obesity is recognized as a major risk factor for the development of several metabolic complications. However, some obese individuals have a favorable metabolic profile. OBJECTIVE: The aim of this study was to identify an easy parameter for recognizing metabolically healthy obese (MHO) women. METHODS: A total of 292 non-diabetic women with a body mass index (BMI) ≥ 30 kg/m2 were selected, and 239 composed the final cohort. We classified the participants according to their metabolic state determined by homeostasis model assessment (HOMA) into MHO or metabolically unhealthy obese (MUO)...
November 2018: Arquivos Brasileiros de Cardiologia
Naoko Kamo, Toshimi Kaido, Yuhei Hamaguchi, Shinya Okumura, Atsushi Kobayashi, Hisaya Shirai, Siyuan Yao, Shintaro Yagi, Shinji Uemoto
BACKGROUND & AIM: Sarcopenia is known to be a poor prognostic factor after liver transplantation (LT). However, the significance of obesity in combination with sarcopenia (sarcopenic obesity) remains unclear. This study examined the impact of sarcopenic obesity on outcomes after living donor LT (LDLT). METHODS: We retrospectively analyzed 277 adult patients who underwent LDLT at our center between January 2008 and June 2016. Body composition parameters including skeletal muscle mass index (SMI), intramuscular adipose tissue content (IMAC), visceral fat area (VFA), and visceral-to-subcutaneous adipose tissue area ratio (VSR) were evaluated by preoperative plain computed tomography imaging at the level of the third lumbar vertebra...
September 28, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Jennifer Mancio, Diana Azevedo, Mariana Fragao-Marques, Ines Falcao-Pires, Adelino Leite-Moreira, Nuno Lunet, Ricardo Fontes-Carvalho, Nuno Bettencourt
Many studies have explored the hypothesis that epicardial adipose tissue (EAT) accumulation adversely affects cardiac remodeling. We assessed, through a systematic review and meta-analysis, whether EAT is linked to left atrial (LA) and left ventricular (LV) structure and function, irrespective of global or abdominal visceral adiposity. We searched MEDLINE, Scopus, and Web of Science for studies evaluating the association of EAT volume quantified by computed tomography with cardiac morphology and function. We used DerSimonian and Laird random-effects models to summarize the adjusted-effect of 10 ml variation of EAT on LA size, LV mass, LV diastolic and systolic functions parameters, and presence of diastolic dysfunction...
November 6, 2018: American Journal of Cardiology
Ruth Schübel, Johanna Nattenmüller, Disorn Sookthai, Tobias Nonnenmacher, Mirja E Graf, Lena Riedl, Christopher L Schlett, Oyunbileg von Stackelberg, Theron Johnson, Diana Nabers, Romy Kirsten, Mario Kratz, Hans-Ulrich Kauczor, Cornelia M Ulrich, Rudolf Kaaks, Tilman Kühn
Background: Although preliminary evidence suggests that intermittent calorie restriction (ICR) exerts stronger effects on metabolic parameters, which may link obesity and major chronic diseases, compared with continuous calorie restriction (CCR), there is a lack of well-powered intervention studies. Objective: We conducted a randomized controlled trial to test whether ICR, operationalized as the "5:2 diet," has stronger effects on adipose tissue gene expression, anthropometric and body composition measures, and circulating metabolic biomarkers than CCR and a control regimen...
November 1, 2018: American Journal of Clinical Nutrition
Y Zhang, J P Wang, X L Wang, H Tian, T T Gao, L M Tang, F Tian, J W Wang, H J Zheng, L Zhang, X J Gao, G L Li, X Y Wang
Background: Malnutrition is a common and critical problem that influences outcome in cancer patients. Body composition reflects a patient's metabolic profile and physiologic reserves, which might be the true determinant of prognosis. In the present study, which aimed to identify valuable new prognostic indicators, we investigated the association between computed tomography-quantified body composition and short-term outcomes after gastrectomy for gastric cancer. Methods: Skeletal muscle index, mean muscle attenuation, and ratio of visceral-to-subcutaneous adipose tissue area (vsr) were calculated from preoperative computed tomography images...
October 2018: Current Oncology
Lucas Jurado-Fasoli, Francisco J Amaro-Gahete, Alejandro De-la-O, Manuel Dote-Montero, Ángel Gutiérrez, Manuel J Castillo
Background: Ageing is associated with sleep pattern changes and body composition changes, which are related to several diseases. Purpose: This study aimed to analyse the association between sleep quality and an extensive set of body composition parameters (waist-hip ratio, body mass index, bone mineral content, bone mineral density, lean mass, lean mass index, fat mass, fat mass percentage, fat mass index, visceral adipose tissue) and sleep quality in sedentary middle-aged adults. We also aimed to evaluate whether the possible associations accord between subjective and objective measurements of sleep quality...
November 19, 2018: Medicina
Gregory Xiang Wen Pek, Clara Lee Ying Ngoh, Boon Wee Teo, Anantharaman Vathsala, Benjamin Yen Seow Goh, Clement Hsiang Rong Yong, Lata Raman, Ho Yee Tiong
INTRODUCTION: Obesity may be a risk factor for kidney donors to develop reduced renal function. The Framingham heart study suggested that visceral adipose tissue (VAT) confers a more adverse metabolic profile compared with subcutaneous adipose tissue (SAT). Asians tend to have a higher VAT composition and it is unclear if their kidney function is affected differently. We hypothesized that Asian living kidney donors who have visceral obesity are at a higher risk of renal function deterioration 1 year after donation...
November 19, 2018: World Journal of Urology
Joon Young Kim, Fida Bacha, Hala Tfayli, Sara F Michaliszyn, Shahwar Yousuf, Silva Arslanian
OBJECTIVE: Adipose tissue insulin resistance is one of the pathophysiological components of type 2 diabetes. Herein we investigated: 1 ) adipose insulin resistance index (Adipose-IR) (calculated as fasting insulin × free fatty acids [FFAs]) in youth across the spectrum of adiposity from normal weight to obese and the spectrum from normal glucose tolerance (NGT) to impaired glucose tolerance (IGT) to type 2 diabetes, 2 ) the relationship of Adipose-IR with physical and metabolic characteristics, and 3 ) the predictive power of Adipose-IR for determining dysglycemia in youth...
November 19, 2018: Diabetes Care
Carla de Oliveira, Joice Soares de Freitas, Isabel Cristina Macedo, Vanessa Leal Scarabelot, Roberta Ströher, Daniela Silva Santos, Andressa Souza, Felipe Fregni, Wolnei Caumo, Iraci L S Torres
Obesity is a multifactorial disease associated with metabolic dysfunction and the prevention and treatment of obesity are often unsatisfactory. Transcranial direct-current stimulation (tDCS) is a non-invasive brain stimulation technique that has proven promising in the treatment of eating disorders such as obesity. We investigate the effects of tDCS on locomotor and exploratory activities, anxiety-like and feeding behavior, and levels of brain-derived neurotrophic factor (BDNF), IL (interleukin)-10, IL-1β, and tumor necrosis factor-alpha (TNF-α) in the cerebral cortex of obese rats...
October 31, 2018: Neuropeptides
Unhee Lim, Kristine R Monroe, Steve Buchthal, Bo Fan, Iona Cheng, Bruce S Kristal, Johanna W Lampe, Meredith A Hullar, Adrian A Franke, Daniel O Stram, Lynne R Wilkens, John Shepherd, Thomas Ernst, Loïc Le Marchand
BACKGROUND & AIMS: We compared fat storage in the abdominal region among individuals from 5 different ethnic/racial groups to determine whether fat storage is associated with disparities observed in the metabolic syndrome and other obesity-associated diseases. METHODS: We collected data from 1794 participants in the Multiethnic Cohort Study (60-77 years old; of African, European (white), Japanese, Latino, or Native Hawaiian ancestry) with body mass index values of 17...
November 13, 2018: Gastroenterology
P H He, Y L Min, C M Zhou, X Y Tong, X Lin, Q Li, Y Zha
Objective: To evaluate the relationship between surrogate markers of visceral obesity[hypertriglyceridemic waist (HW) phenotype, visceral adiposity index (VAL), lipid accumulation product (LAP)]and atherosclerosis in hemodialysis patients. Methods: A multi-center cross-sectional study was carried out. A total of 961 maintenance hemodialysis (MHD) patients from 11 hemodialysis centers of Guizhou province between July 2016 and September 2017 were enrolled in the study. Anthropometric measures were performed in all subjects...
November 13, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Lei Zhao, Liyong Zhu, Zhihong Su, Weizheng Li, Pengzhou Li, Yong Liu, Shengping Liu, Shaihong Zhu
Background: Most Chinese patients with type 2 diabetes mellitus (T2DM) have mild obesity and central obesity. Central obesity is combined with insulin resistance. The aim of this study was to assess the effect of abdominal adipose tissue on insulin-sensitivity improvement after Roux-en-Y gastric bypass (RYGB) in Chinese diabetic patients with mild and central obesity. Methods: Seventeen T2DM patients with a mean body mass index of 30.3 kg/m2 were scheduled for laparoscopic RYGB...
November 2018: Gastroenterology Report
Daniel G Whitney, Harshvardhan Singh, Chuan Zhang, Freeman Miller, Christopher M Modlesky
BACKGROUND: Individuals with cerebral palsy (CP) are at increased risk for obesity and obesity-related complications. Studies of total body fat in those with CP are inconsistent and studies of abdominal fat are lacking in children with CP. The objective of this study was to determine if ambulatory children with spastic CP have greater central adiposity compared to typically developing children. METHODOLOGY: Eighteen ambulatory children with spastic CP (n = 5 girls; 8...
September 22, 2018: Journal of Clinical Densitometry
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