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Periodontal disease interventions

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https://www.readbyqxmd.com/read/30094895/periodontal-diseases-and-adverse-pregnancy-outcomes
#1
Shihoko Komine-Aizawa, Sohichi Aizawa, Satoshi Hayakawa
From last decade of the 20th century, numerous epidemiological studies and intervention trials have attempted to prove the relationships between maternal periodontal diseases and adverse pregnancy outcomes (APO). Periodontal diseases are considered a risk factor for APO, including preterm birth, fetal growth restriction, low birthweight, pre-eclampsia and gestational diabetes. However, the efficacy of periodontal treatment during pregnancy is controversial. Two pathogenic mechanisms might explain the potential effect of periodontal diseases on pregnancy outcomes...
August 9, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/30077530/mitochondrial-oxidative-stress-endothelial-function-and-metabolic-control-in-patients-with-type-ii-diabetes-and-periodontitis-a-randomised-controlled-clinical-trial
#2
Stefano Masi, Marco Orlandi, Mohamed Parkar, Devina Bhowruth, Isabel Kingston, Caitriona O'Rourke, Agostino Virdis, Aroon Hingorani, Steven J Hurel, Nikolaos Donos, Francesco D'Aiuto, John Deanfield
BACKGROUND: Periodontitis (PD) and type 2 diabetes (T2D) are characterized by increased mitochondrial oxidative stress production (mtROS), which has been associated with a greater risk of cardiovascular diseases (CVD). Intensive PD treatment (IPT) can significantly improve endothelial function and metabolic control, although the mechanisms remain unclear. We explored whether, in patients with PD and T2D, changes of mtROS are associated with improvement of endothelial function and metabolic control after IPT...
August 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30077375/an-umbrella-review-exploring-the-effect-of-periodontal-treatment-in-pregnant-women-on-the-frequency-of-adverse-obstetric-outcomes
#3
Leidy Johana Rangel-Rincón, Annie M Vivares-Builes, Javier Enrique Botero, Andrés A Agudelo-Suárez
OBJECTIVE: In the recent years, efforts have been made to reduce epidemiologic indicators of periodontal disease in pregnant women. This umbrella review aims to analyze the systematic reviews/meta-analyses investigating the effect of periodontal therapy in pregnant women on the frequency of obstetric complications (low birth weight, preterm delivery, and preeclampsia) and to identify the gaps in the scientific literature. METHODS: A systematic review of systematic reviews with and without meta-analysis of intervention studies was conducted...
September 2018: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/30074866/effects-of-starch-on-oral-health-systematic-review-to-inform-who-guideline
#4
K Halvorsrud, J Lewney, D Craig, P J Moynihan
A systematic review was conducted to update evidence on the effect of total dietary starch and of replacing rapidly digestible starches (RDSs) with slowly digestible starches (SDSs) on oral health outcomes to inform updating of World Health Organization guidance on carbohydrate intake. Data sources included MEDLINE, Embase, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, LILACS, and Wanfang. Eligible studies were comparative and reported any intervention with a different starch content of diets or foods and data on oral health outcomes relating to dental caries, periodontal disease, or oral cancer...
August 3, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/30063147/is-there-an-association-between-various-aspects-of-oral-health-in-southern-italy-children-an-epidemiological-study-assessing-dental-decays-periodontal-status-malocclusions-and-temporomandibular-joint-function
#5
S Paduano, R Rongo, R Bucci, D Aiello, G Carvelli, A Ingenito, T Cantile, G F Ferrazzano
AIM: To describe the current oral health status of primary school children in Southern Italy, to investigate if there is an association between malocclusions and temporomandibular disorders (TMDs), and to investigate if there is an association between dental caries and periodontal disease. MATERIALS AND METHODS: Study design: Transversal epidemiological study. We examined 1086 children, considering them of the same socioeconomic status (medium). The Decayed, Missing, Filled (DMF) index and the Community Periodontal Index (CPI) were used to assess decay and periodontal status...
September 2018: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/30059656/removal-of-pre-existing-periodontal-inflammatory-condition-before-tooth-extraction-ameliorates-medication-related-osteonecrosis-of-the-jaw-mronj-like-lesion-in-mice
#6
Terresa Kim, Sol Kim, Minju Song, Cindy Lee, Hideo Yagita, Drake W Williams, Eric C Sung, Christine Hong, Ki-Hyuk Shin, Mo K Kang, No-Hee Park, Reuben H Kim
Medication-related osteonecrosis of the jaw (MRONJ) is a rare but detrimental intraoral lesion that predominantly occurs in patients with long-term use of anti-resorptive agents such as bisphosphonate and denosumab, a human anti-RANKL monoclonal antibody (Ab). Surgical intervention such as tooth extraction is a known risk factor for MRONJ, which is often performed to eliminate pre-exiting pathological inflammatory condition such as periodontal diseases. Nonetheless, it remains unknown whether pre-existing periodontal disease condition exacerbates, or removal of such condition ameliorates, MRONJ development following tooth extraction...
July 27, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/30058641/supracrestal-non-surgical-therapy-in-periodontal-diseases
#7
Khushboo Goel
Periodontal diseases are the complex disease with a dynamic relationship between biofilm and the host immunoinflammatory response. The goal of periodontal therapy is to preserve the natural dentition and increase their longevity by creation of a favorable environment around the teeth. The mainstay to achieve this is by the non-surgical periodontal therapy, followed by surgical and other recent treatment modalities. However, there seems no sure indication to choose amongst them that are clinically significant and offer long term predictability...
January 2018: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/30049446/low-intensity-pulsed-ultrasound-promotes-alveolar-bone-regeneration-in-a-periodontal-injury-model
#8
Yunji Wang, Ye Qiu, Jie Li, Chunliang Zhao, Jinlin Song
Periodontitis is a common oral disease characterized by progressive destruction of periodontal tissue and loss of teeth. However, regeneration of periodontal tissue is a time-consuming process. Low-intensity pulsed ultrasound (LIPUS) is a widely used non-invasive intervention for enhancing bone healing in fractures and non-unions. With the hypothesis that LIPUS may accelerate periodontal regeneration, the effects of LIPUS on periodontal tissue regeneration were investigated both in vitro and in vivo. LIPUS (90 mw/cm2 , 20 min/d, 1...
November 2018: Ultrasonics
https://www.readbyqxmd.com/read/30011036/impact-of-smoking-cessation-on-periodontitis-a-systematic-review-and-meta-analysis-of-prospective-longitudinal-observational-and-interventional-studies
#9
Fábio R M Leite, Gustavo G Nascimento, Stina Baake, Lisa D Pedersen, Flemming Scheutz, Rodrigo López
Aims: This systematic review aimed to estimate the effect of tobacco smoking cessation on the risk for periodontitis compared to the risk among never-smokers and to evaluate the effect of tobacco smoking cessation on the clinical outcomes of non-surgical periodontal treatment. Methods: Electronic searches were performed in PubMed, Scopus and Embase. Search strategy included MeSH and free terms: periodontitis, periodontal diseases, smoking, tobacco use, tobacco, tobacco products, cigarette, pipe and cigar...
July 13, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/30009515/keratinocyte-specific-ablation-of-protease-activated-receptor-2-prevents-gingival-inflammation-and-bone-loss-in-a-mouse-model-of-periodontal-disease
#10
Nidhish Francis, Babatunde A Ayodele, Neil M O'Brien-Simpson, Walter Birchmeier, Robert N Pike, Charles N Pagel, Eleanor J Mackie
Chronic periodontitis is characterised by gingival inflammation and alveolar bone loss. A major aetiological agent is Porphyromonas gingivalis, which secretes proteases that activate protease-activated receptor 2 (PAR2 ). PAR2 expressed on oral keratinocytes is activated by proteases released by P. gingivalis, inducing secretion of interleukin 6 (IL-6), and global knockout of PAR2 prevents bone loss and inflammation in a periodontal disease model in mice. To test the hypothesis that PAR2 expressed on gingival keratinocytes is required for periodontal disease pathology, keratinocyte-specific PAR2 -null mice were generated using K14-Cre targeted deletion of the PAR2 gene (F2rl1)...
July 16, 2018: Cellular Microbiology
https://www.readbyqxmd.com/read/29996883/novel-paradigm-to-improve-inflammatory-burden-in-end-stage-renal-disease-repair-study-protocol-for-a-randomized-controlled-trial
#11
Ruchir Trivedi, George Fares, Victoria Barany Nunez, Ryan Campbell, Megyn Clement, Joseph Burleson, Jonathan Himmelfarb, Effie Ioannidou
BACKGROUND: Given the importance of inflammation as a predictor of poor outcomes in End Stage Renal Disease (ESRD), reductions in inflammatory biomarkers have been proposed as a critical target in this population. This study targets chronic periodontitis, an oral inflammatory disease of microbial etiology causing persistent inflammation in ESRD. Unlike the previously reported episodic periodontal interventions, we propose to control periodontal inflammation with a continuous maintenance and oral health behavior modifications...
July 11, 2018: Trials
https://www.readbyqxmd.com/read/29984691/improving-the-quality-of-dentistry-iquad-a-cluster-factorial-randomised-controlled-trial-comparing-the-effectiveness-and-cost-benefit-of-oral-hygiene-advice-and-or-periodontal-instrumentation-with-routine-care-for-the-prevention-and-management-of-periodontal
#12
Craig R Ramsay, Jan E Clarkson, Anne Duncan, Thomas J Lamont, Peter A Heasman, Dwayne Boyers, Beatriz Goulão, Debbie Bonetti, Rebecca Bruce, Jill Gouick, Lynne Heasman, Laura A Lovelock-Hempleman, Lorna E Macpherson, Giles I McCracken, Alison M McDonald, Fiona McLaren-Neil, Fiona E Mitchell, John Dt Norrie, Marjon van der Pol, Kirsty Sim, James G Steele, Alex Sharp, Graeme Watt, Helen V Worthington, Linda Young
BACKGROUND: Periodontal disease is preventable but remains the most common oral disease worldwide, with major health and economic implications. Stakeholders lack reliable evidence of the relative clinical effectiveness and cost-effectiveness of different types of oral hygiene advice (OHA) and the optimal frequency of periodontal instrumentation (PI). OBJECTIVES: To test clinical effectiveness and assess the economic value of the following strategies: personalised OHA versus routine OHA, 12-monthly PI (scale and polish) compared with 6-monthly PI, and no PI compared with 6-monthly PI...
July 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29972914/-consensus-of-chinese-stomatological-experts-on-the-efficacy-of-toothpaste-and-functional-toothpaste
#13
(no author information available yet)
Toothpaste is an oral health care product that can be used to help cleansing teeth and improve oral hygiene. Currently use of toothpaste has been transferred from the conventional objective of oral hygiene to the new era of prevention and intervention of oral diseases. Therefore, functional toothpaste has been developed in a fast way. It is imperative to investigate toothpaste, because the wise use of specific functional toothpaste could prevent or reduce oral diseases such as dental caries and periodontal diseases, improve people ' s oral and general health and save social healthcare resources...
September 9, 2017: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/29972709/periodontal-treatment-limits-platelet-activation-in-patients-with-periodontitis-a-controlled-randomized-intervention-trial
#14
Markus Laky, Isabella Anscheringer, Lukas Wolschner, Stefan Heber, Hady Haririan, Waltraud C Schrottmaier, Julia B Kral-Pointner, Manuel Salzmann, Ivo Volf, Andreas Moritz, Alice Assinger
AIM: Periodontitis results in platelet activation and enhanced risk for cardiovascular disease. As it is currently unknown whether periodontal treatment reverses platelet hyper-reactivity, we aimed to investigate the role of periodontal treatment on platelet activation. MATERIALS AND METHODS: In a prospective controlled therapeutic trial, 52 patients were enrolled and randomly selected for periodontal treatment or monitored without treatment for 3 months. Patient blood was analysed by flow cytometry for platelet activation markers and by light transmission aggregometry for platelet aggregation in response to pro-thrombotic stimuli...
July 4, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29962757/effect-of-initial-periodontal-therapy-on-salivary-trefoil-factor-tff3-in-otherwise-healthy-patients-with-gingivitis-and-chronic-periodontitis
#15
Devika Meesala, Gautami S Penmetsa, C D Dwarakanath, Ravikanth Manyam
Background: The search for an ideal biomarker which can determine the current disease status that predicts the sites and individuals with increased susceptibility to periodontal disease has been going on since a long time. One such group of molecules which have been investigated recently are the trefoil factors, and the present study aims to determine the role of salivary trefoil factor 3 (TFF3) in periodontitis and gingivitis patients. Materials and Methods: A total of fifty participants, of which 25 were diagnosed with moderate-to-severe periodontitis and 25 with chronic gingivitis were included in the study...
June 2018: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29926958/dental-plaque-induced-gingival-conditions
#16
Shinya Murakami, Brian L Mealey, Angelo Mariotti, Iain L C Chapple
OBJECTIVE: This review proposes revisions to the current classification system for gingival diseases and provides a rationale for how it differs from the 1999 classification system. IMPORTANCE: Gingival inflammation in response to bacterial plaque accumulation (microbial biofilms) is considered the key risk factor for the onset of periodontitis. Thus, control of gingival inflammation is essential for the primary prevention of periodontitis. FINDINGS: The clinical characteristics common to dental plaque-induced inflammatory gingival conditions include: a) clinical signs and symptoms of inflammation that are confined to the gingiva: b) reversibility of the inflammation by removing or disrupting the biofilm; c) the presence of a high bacterial plaque burden to initiate the inflammation; d) systemic modifying factors (e...
June 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29926950/the-etiology-of-hard-and-soft-tissue-deficiencies-at-dental-implants-a-narrative-review
#17
Christoph H F Hämmerle, Dennis Tarnow
OBJECTIVE: The objective of the present paper was to review factors and conditions that are associated with hard and soft-tissue deficiencies at implant sites. IMPORTANCE: Hard- and soft-tissue deficiencies at dental implants are common clinical findings. They can lead to complications and compromise implant survival and, hence, may require therapeutic interventions. It is, therefore, important to understand the etiology of hard and soft-tissue deficiencies. Based on this understanding, strategies should be developed to correct hard and soft-tissue deficiencies with the aim of improving clinical outcomes of implant therapy...
June 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29926503/dental-plaque-induced-gingival-conditions
#18
Shinya Murakami, Brian L Mealey, Angelo Mariotti, Iain L C Chapple
OBJECTIVE: This review proposes revisions to the current classification system for gingival diseases and provides a rationale for how it differs from the 1999 classification system. IMPORTANCE: Gingival inflammation in response to bacterial plaque accumulation (microbial biofilms) is considered the key risk factor for the onset of periodontitis. Thus, control of gingival inflammation is essential for the primary prevention of periodontitis. FINDINGS: The clinical characteristics common to dental plaque-induced inflammatory gingival conditions include: a) clinical signs and symptoms of inflammation that are confined to the gingiva: b) reversibility of the inflammation by removing or disrupting the biofilm; c) the presence of a high bacterial plaque burden to initiate the inflammation; d) systemic modifying factors (e...
June 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29926502/the-etiology-of-hard-and-soft-tissue-deficiencies-at-dental-implants-a-narrative-review
#19
Christoph H F Hämmerle, Dennis Tarnow
OBJECTIVE: The objective of the present paper was to review factors and conditions that are associated with hard and soft-tissue deficiencies at implant sites. IMPORTANCE: Hard- and soft-tissue deficiencies at dental implants are common clinical findings. They can lead to complications and compromise implant survival and, hence, may require therapeutic interventions. It is, therefore, important to understand the etiology of hard and soft-tissue deficiencies. Based on this understanding, strategies should be developed to correct hard and soft-tissue deficiencies with the aim of improving clinical outcomes of implant therapy...
June 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29923534/a-cohort-study-on-risk-factors-for-preterm-births-in-rural-gujarat
#20
Poonam Trivedi, Deepak Saxena, Tapasvi Puwar, Shital Savaliya, Parthasarathi Ganguly
Background: Prematurity is one of the leading causes of neonatal and under-five mortalities globally and also in India. It is an important determinant of short- and long-term morbidities in infants and children. Unfortunately, risk factors of majority of preterm births (PTBs) remain unexplained which calls for appropriate action. There is a dearth of community-based research on PTB and its risk factors, especially in high burden countries like India. Objectives: The objective of the study was to explore different risk factors for PTB...
April 2018: Indian Journal of Public Health
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