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Poor exercise tolerance without hypoxia

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https://www.readbyqxmd.com/read/26115689/gill-paracellular-permeability-and-the-osmorespiratory-compromise-during-exercise-in-the-hypoxia-tolerant-amazonian-oscar-astronotus-ocellatus
#1
Lisa M Robertson, Daiani Kochhann, Adalto Bianchini, Victoria Matey, Vera F Almeida-Val, Adalberto Luis Val, Chris M Wood
In the traditional osmorespiratory compromise, fish increase their effective gill permeability to O2 during exercise or hypoxia, and in consequence suffer unfavorable ionic and osmotic fluxes. However oscars, which live in the frequently hypoxic ion-poor waters of the Amazon, actually decrease ionic fluxes across the gills during acute hypoxia without changing gill paracellular permeability, and exhibit rapid paving over of the mitochondrial-rich cells (MRCs). But what happens during prolonged exercise? Gill paracellular permeability, ionic fluxes, and gill morphology were examined in juvenile oscars at rest and during aerobic swimming...
October 2015: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/22280813/dehydroepiandrosterone-dhea-improves-pulmonary-hypertension-in-chronic-obstructive-pulmonary-disease-copd-a-pilot-study
#2
Eric Dumas de La Roque, Jean-Pierre Savineau, Anne-Cécile Metivier, Marc-Alain Billes, Jean-Philippe Kraemer, Stéphane Doutreleau, Jacques Jougon, Roger Marthan, Nicholas Moore, Michael Fayon, Etienne-Émile Baulieu, Claire Dromer
OBJECTIVES: It was previously shown that dehydroepiandrosterone (DHEA) reverses chronic hypoxia-induced pulmonary hypertension (PH) in rats, but whether DHEA can improve the clinical and hemodynamic status of patients with PH associated to chronic obstructive pulmonary disease (PH-COPD) has not been studied whereas it is a very severe poorly treated disease. PATIENTS AND METHODS: Eight patients with PH-COPD were treated with DHEA (200mg daily orally) for 3 months...
February 2012: Annales D'endocrinologie
https://www.readbyqxmd.com/read/9622840/-high-altitude-stay-and-air-travel-in-coronary-heart-disease
#3
REVIEW
Y Allemann, H Saner, B Meier
Acute exposure to high altitude produces hypoxia-associated stimulation of the sympathetic nervous system. This response is further enhanced by physical activity and induces an increase in heart rate and blood pressure. Consequently, cardiac work, myocardial oxygen consumption, and coronary blood flow are also increased. During the first 4 days of acute exposure to moderate or high altitude, coronary patients are at greatest risk of untoward events. Gradual ascent, early limitation of activity to a lower level than tolerated at low altitude, pre-ascent physical conditioning and rigorous blood pressure control should all help to minimise the cardiac risk...
April 25, 1998: Schweizerische Medizinische Wochenschrift
https://www.readbyqxmd.com/read/7376861/the-role-of-nutritional-status-airway-obstruction-hypoxia-and-abnormalities-in-serum-lipid-composition-in-limiting-exercise-tolerance-in-children-with-cystic-fibrosis
#4
A L Coates, P Boyce, D Muller, M Mearns, S Godfrey
Previous work has shown that impaired exercise tolerance in children with cystic fibrosis (C.F.) is related to the severity of airway obstruction without elucidating the possible roles of hypoxia or malnutrition. It has been suggested that poor nutrition leads to abnormalities in serum fatty acids composition, which may lead to tissue hypoxia. We investigated the roles of hypoxia, pulmonary mechanics, nutritional status, and serum fatty acid composition in limiting exercise tolerance in C.F. In 20 children with C...
May 1980: Acta Paediatrica Scandinavica
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