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https://www.readbyqxmd.com/read/28332875/the-biologic-basis-of-transgender-identity-2d-4d-finger-length-ratios-implicate-a-role-for-prenatal-androgen-activity
#1
Matthew Leinung, Christina Wu
Objective The biologic basis for gender identity is unknown. Research has shown that the ratio of the length of the second and fourth digits (2D:4D) in mammals is influenced by gender in utero, but data on 2D:4D ratios in transgender individuals are scarce and contradictory. We sought an association with 2D:4D ratio and gender identity in our transgender clinic population in Albany, NY. Methods We prospectively recruited 118 transgender subjects undergoing hormonal therapy (50 female to male (FTM) and 68 male to female (MTF) for finger length measurement...
March 23, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28323803/patient-response-to-an-integrated-orthotic-and-rehabilitation-initiative-for-traumatic-injuries-the-prioriti-mtf-study
#2
Joseph R Hsu, Johnny G Owens, Jennifer DeSanto, John R Fergason, Kevin M Kuhn, Benjamin K Potter, Daniel J Stinner, Robert G Sheu, Sandra L Waggoner, Jason M Wilken, Yanjie Huang, Daniel O Scharfstein, Ellen J MacKenzie
Although limb salvage is now possible for many high-energy open fractures and crush injuries to the distal tibia, ankle, hindfoot, and midfoot, orthotic options are limited. The Intrepid Dynamic Exoskeletal Orthosis (IDEO) is a custom, energy-storing carbon fiber orthosis developed for trauma patients undergoing limb salvage. The IDEO differs from other orthoses in that it allows patients with ankle weakness to have more normal ankle biomechanics and increased ankle power. This article describes the design of a study to evaluate the effectiveness of the IDEO when delivered together with a high-intensity, sports medicine-based approach to rehabilitation...
April 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28297454/evaluation-of-cassette-based-digital-radiography-detectors-using-standardized-image-quality-metrics-aapm-tg-150-draft-image-detector-tests
#3
Guang Li, Travis C Greene, Thomas K Nishino, Charles E Willis
The purpose of this study was to evaluate several of the standardized image quality metrics proposed by the American Association of Physics in Medicine (AAPM) Task Group 150. The task group suggested region-of-interest (ROI)-based techniques to measure nonuniformity, minimum signal-to-noise ratio (SNR), number of anomalous pixels, and modulation transfer function (MTF). This study evaluated the effects of ROI size and layout on the image metrics by using four different ROI sets, assessed result uncertainty by repeating measurements, and compared results with two commercially available quality control tools, namely the Carestream DIRECTVIEW Total Quality Tool (TQT) and the GE Healthcare Quality Assurance Process (QAP)...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297344/improvement-in-ct-image-resolution-due-to-the-use-of-focal-spot-deflection-and-increased-sampling
#4
Nicholas Rubert, Timothy Szczykutowicz, Frank Ranallo
When patient anatomy is positioned away from a CT scanner's isocenter, scans of limited diagnostic value may result. Yet in some cases, positioning of patient anatomy far from isocenter is unavoidable. This study examines the effect of position and reconstruction algorithm on image resolution achieved by a CT scanner operating in a high resolution (HR) scan mode which incorporates focal spot deflection and acquires an increased number of projections per rotation. Images of a metal bead contained in a phantom were acquired on a GE CT750 HD scanner with multiple reconstruction algorithms, in the normal and HR scan mode, and at two positions, scanner isocenter and 15 cm directly above isocenter...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297337/one-year-analysis-of-elekta-cbct-image-quality-using-nps-and-mtf
#5
Satomi Nakahara, Masayuki Tachibana, Yoichi Watanabe
The image quality (IQ) of imaging systems must be sufficiently high for image-guided radiation therapy (IGRT). Hence, users should implement a quality assurance program to maintain IQ. In our routine IQ tests of the kV cone-beam CT system (Elekta XVI), image noise was quantified by noise standard deviation (NSD), which was the standard deviation of CT numbers measured in a small area in an image of an IQ test phantom (Catphan), and the high spatial resolution (HSR) was evaluated by the number of line-pairs (LPN) visually recognizable in the image...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297318/a-qualitative-and-quantitative-analysis-of-radiation-dose-and-image-quality-of-computed-tomography-images-using-adaptive-statistical-iterative-reconstruction
#6
Fahad Ahmed Hussain, Noor Mail, Abdulrahman M Shamy, Suliman Alghamdi, Abdelhamid Saoudi
Image quality is a key issue in radiology, particularly in a clinical setting where it is important to achieve accurate diagnoses while minimizing radiation dose. Some computed tomography (CT) manufacturers have introduced algorithms that claim significant dose reduction. In this study, we assessed CT image quality produced by two reconstruction algorithms provided with GE Healthcare's Discovery 690 Elite positron emission tomography (PET) CT scanner. Image quality was measured for images obtained at various doses with both conventional filtered back-projection (FBP) and adaptive statistical iterative reconstruction (ASIR) algorithms...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28296647/intra-and-inter-rater-reliability-of-lower-leg-waterplethysmography-bioelectrical-impedance-and-muscle-twitch-force-for-the-use-in-standing-work-evaluation
#7
Rudolf Wall, Oliwia Lips, Robert Seibt, Monika Rieger, Benjamin Steinhilber
OBJECTIVES: Prolonged standing is associated with multiple risk factors for musculoskeletal and venous disorders. Basic understanding of prolonged standing physiology is lacking. We therefore plan to investigate the influence of multiple hours standing on lower limb oedema measured by waterplethysmography (WP) and bioelectrical impedance (BI) and lower leg musle fatigue using muscle twitch force (MTF). In order to interpret our results, test-retest and inter-rater reliability of these measurement methods was evaluated first...
March 15, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28291449/the-afghan-theater-a-review-of-military-medical-doctrine-from-2008-to-2014
#8
Ian Lane, Zsolt Stockinger, Samual Sauer, Mark Ervin, Michael Wirt, Stephen Bree, Kirby Gross, Jeffrey Bailey, Brig Timothy Hodgetts, Elizabeth Mann-Salinas
This article forms part of a series that will explore the effect that Role 2 (R2) medical treatment facilities (MTFs) had on casualty care during the military campaign in Afghanistan and how we should interpret this to inform the capabilities in, and training for future R2 MTFs. Key aspects of doctrine which influence the effectiveness of R2 MTFs include timelines to care, patient movement capabilities, and MTF capabilities. The focus of this analysis was to review allied doctrine from the United States, United Kingdom, and the North Atlantic Treaty Organization to identify similarities and differences regarding employment of R2 related medical assets in the Afghan Theater, specifically for trauma care...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28287171/fluorogenic-peptide-substrate-for-quantification-of-bacterial-enzyme-activities
#9
Ismail H Al-Abdullah, Karine Bagramyan, Shiela Bilbao, Meirigeng Qi, Markus Kalkum
A novel peptide substrate (A G G P L G P P G P G G) was developed for quantifying the activities of bacterial enzymes using a highly sensitive Fluorescence Resonance Energy Transfer (FRET) based assay. The peptide substrate was cleaved by collagenase class I, II, Liberase MTF C/T, collagenase NB1, and thermolysin/neutral protease, which was significantly enhanced in the presence of CaCl2. However, the activities of these enzymes were significantly decreased in the presence of ZnSO4 or ZnCl2. Collagenase I, II, Liberase MTF C/T, thermolysin/neutral protease share similar cleavage sites, L(↓)G and P(↓)G...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28268202/adverse-effects-of-parental-zinc-deficiency-on-metal-homeostasis-and-embryonic-development-in-a-zebrafish-model
#10
Laura M Beaver, Yasmeen M Nkrumah-Elie, Lisa Truong, Carrie L Barton, Andrea L Knecht, Greg D Gonnerman, Carmen P Wong, Robert L Tanguay, Emily Ho
The high prevalence of zinc deficiency is a global public health concern, and suboptimal maternal zinc consumption has been associated with adverse effects ranging from impaired glucose tolerance to low birthweights. The mechanisms that contribute to altered development and poor health in zinc deficient offspring are not completely understood. To address this gap, we utilized the Danio rerio model and investigated the impact of dietary zinc deficiency on adults and their developing progeny. Zinc deficient adult fish were significantly smaller in size, and had decreases in learning and fitness...
February 20, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28256903/mr-imaging-in-patients-with-male-to-female-sex-reassignment-surgery-postoperative-anatomy-and-complications
#11
Michele Bertolotto, Giovanni Liguori, Stefano Bucci, Mariano Iannelli, Francesca Vedovo, Nicola Pavan, Carlo Trombetta, Lorenzo E Derchi
OBJECTIVE: To investigate the role of MRI in the evaluation of both the new female anatomy and complications in male-to-female sex reassignment surgery (MtF-SRS). METHODS: 71 consecutive patients with MtF-SRS had 74 MRI [age range, 21-63 years; mean (±standard deviation) age, 36 ± 10 years; median age, 37 years]. In 47 patients, MRI was performed to rule out early post-operative complications after gender conversion (n = 40), vaginoplasty (n = 6) or remodelling of the labia majora (n = 1)...
April 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28253636/towards-measuring-the-speech-transmission-index-in-fluctuating-noise-accuracy-and-limitations
#12
Jelmer van Schoonhoven, Koenraad S Rhebergen, Wouter A Dreschler
In the field of room acoustics, the modulation transfer function (MTF) can be used to predict speech intelligibility in stationary noise and reverberation and can be expressed in one single value: the Speech Transmission Index (STI). One drawback of the classical STI measurement method is that it is not validated for fluctuating background noise. As opposed to the classical measurement method, the MTF due to reverberation can also be calculated using an impulse response measurement. This indirect method presents an opportunity for STI measurements in fluctuating noise, and a first prerequisite is a reliable impulse response measurement...
February 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28248652/simultaneous-deblurring-and-iterative-reconstruction-of-cbct-for-image-guided-brain-radiosurgery
#13
SayedMasoud Hashemi, William Y Song, Arjun Sahgal, Young Lee, Christopher Huynh, Vladimir Grouza, Håkan Nordström, Markus Eriksson, Antoine Dorenlot, Jean Marie Régis, James G Mainprize, Mark Ruschin
One of the limiting factors in cone-beam CT (CBCT) image quality is system blur, caused by detector response, x-ray source focal spot size, azimuthal blurring, and reconstruction algorithm. In this work, we develop a novel iterative reconstruction algorithm that improves spatial resolution by explicitly accounting for image unsharpness caused by different factors in the reconstruction formulation. While the model-based iterative reconstruction techniques use prior information about the detector response and x-ray source, our proposed technique uses a simple measurable blurring model...
April 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28241610/using-sub-resolution-features-for-self-compensation-of-the-modulation-transfer-function-in-remote-sensing
#14
Jin Li, Zilong Liu, Fengdeng Liu
Space smart optical orbiting payloads integrated with attitude and position (SSPIAP) are emerging as an essential tool that is extensively used in microsatellites. The on-orbit imaging link of SSPIAPs includes atmospheric disturbances, defocusing, and relative motion, and other noises, thereby resulting in low modulation transfer function (MTF) and poor image quality. The introduction of MTF compensations has pushed the limits of optical imaging, enabling high-resolution on-orbit dynamic imaging. However, the external targets for compensating MTF are limited by space and time because the availability and access to external targets are infrequently easy when a remote sensor is working on-orbit...
February 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28236645/an-effective-noise-reduction-method-for-multi-energy-ct-images-that-exploits-spatio-spectral-features
#15
Zhoubo Li, Shuai Leng, Lifeng Yu, Armando Manduca, Cynthia H McCollough
PURPOSE: To develop and evaluate an image-domain noise reduction method for multi-energy CT (MECT) data. METHODS: Multi-Energy Non-Local Means (MENLM) is a technique that uses the redundant information in MECT images to achieve noise reduction. In this method, spatio-spectral features are used to determine the similarity between pixels, making the similarity evaluation more robust to image noise. The performance of this MENLM filter was tested on images acquired on a whole-body research photon counting CT system...
February 25, 2017: Medical Physics
https://www.readbyqxmd.com/read/28231555/edge-preserving-denoising-for-intra-operative-cone-beam-ct-in-endovascular-aneurysm-repair
#16
Yi Liu, Miguel Castro, Mathieu Lederlin, Huazhong Shu, Adrien Kaladji, Pascal Haigron
C-arm cone-beam computed tomography (CBCT) acquisition during endovascular aneurysm repair (EVAR) is an emergent technology with more and more applications. It offers real time imaging with a stationary patient and provides 3-D information to achieve guidance of intervention. However, there is growing concern on the overall radiation doses delivered to patients all along the endovascular management due to pre-, intra-, and post-operative X-ray imaging. Manufactures may have their low dose protocols to realize reduction of radiation dose, but CBCT with a low dose protocol has too many artifacts, particularly streak artifacts, and decreased contrast-to-noise ratio (CNR)...
January 30, 2017: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/28229527/melanotransferrin-new-homolog-genes-and-their-differential-expression-during-intestinal-regeneration-in-the-sea-cucumber-holothuria-glaberrima
#17
Josué Hernández-Pasos, Griselle Valentín-Tirado, José E García-Arrarás
Melanotransferrin (MTf) is a protein associated with oncogenetic, developmental, and immune processes which function remains unclear. The MTf gene has been reported in numerous vertebrate and invertebrate species, including echinoderms. We now report the finding of four different MTfs in the transcriptome of the sea cucumber Holothuria glaberrima. Sequence studies and phylogenetic analyses were done to ascertain the similarities among the putative proteins and their relationship with other transferrin family members...
February 23, 2017: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
https://www.readbyqxmd.com/read/28224311/prevalence-incidence-and-sex-ratio-of-transsexualism-in-the-autonomous-region-of-madrid-spain-according-to-healthcare-demand
#18
Antonio Becerra-Fernández, José Miguel Rodríguez-Molina, Nuria Asenjo-Araque, María Jesús Lucio-Pérez, Miguel Cuchí-Alfaro, Eduardo García-Camba, Gilberto Pérez-López, Miriam Menacho-Román, María Carmen Berrocal-Sertucha, Domingo Ly-Pen, María Victorina Aguilar-Vilas
In recent years, different studies have provided estimates of the prevalence of transsexualism with very diverse results. The purpose of this study was to ascertain the prevalence, incidence, and sex ratio of transsexualism in the autonomous region of Madrid (Spain). A total of 1234 patients who attended from 2007 to the end of 2015 in the only Gender Identity Unit (GIU) in Madrid were analyzed. Sixty-three patients were excluded for various reasons; thus, 1171 could be included: 803 male-to-female (MtF) and 368 female-to-male (FtM) transsexual patients...
February 21, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28218276/natural-and-laboratory-mutations-in-kuzbanian-are-associated-with-zinc-stress-phenotypes-in-drosophila-melanogaster
#19
Hung Le Manh, Lain Guio, Miriam Merenciano, Quirze Rovira, Maite G Barrón, Josefa González
Organisms must cope with altered environmental conditions such as high concentrations of heavy metals. Stress response to heavy metals is mediated by the metal-responsive transcription factor 1 (MTF-1), which is conserved from Drosophila to humans. MTF-1 binds to metal response elements (MREs) and changes the expression of target genes. kuzbanian (kuz), a metalloendopeptidase that activates the evolutionary conserved Notch signaling pathway, has been identified as an MTF-1 target gene. We have previously identified a putatively adaptive transposable element in the Drosophila melanogaster genome, named FBti0019170, inserted in a kuz intron...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28217493/outcome-and-preferences-in-male-to-female-subjects-with-gender-dysphoria-experience-from-eastern-india
#20
Anirban Majumder, Debmalya Sanyal
CONTEXT: Gender dysphoria (GD) is an increasingly recognized medical condition in India, and little scientific data on treatment outcomes are available. AIMS: Our objective is to study the therapeutic options including psychotherapy, hormone, and surgical treatments used for alleviating GD in male-to-female (MTF) transgender subjects in Eastern India. SUBJECTS AND METHODS: This is a retrospective study of treatment preferences and outcome in 55 MTF transgender subjects who were presented to the endocrine clinic...
January 2017: Indian Journal of Endocrinology and Metabolism
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