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Rebecca J Evans-Polce, Megan S Schuler, John E Schulenberg, Megan E Patrick
INTRODUCTION: Sensation seeking is associated with elevated risk for substance use among adolescents and young adults. However, whether these associations vary across age for young men and women is not well characterized. METHODS: Using data from the Monitoring the Future (MTF) panel study, we examine the age-varying associations of sensation seeking and three types of substance use behavior (binge drinking, cigarette use, and marijuana use) across ages 18 to 30 using time-varying effect modeling...
May 4, 2018: Addictive Behaviors
Michael Francis, Arthur Grider
The purpose of this study was to determine the correlation between the position or number of metal regulatory elements (MREs) near gene transcriptional or translational start sites, and the strength of metal response element-binding transcription factor 1 (MTF-1) regulation. A secondary analysis was performed in silico on published results measuring the effects of Zn and MTF-1 on transcriptional regulation of genes (n = 120) in the Caco-2 cell line. MRE sequence variations throughout the human genome were sorted using a position weight matrix...
May 16, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
F van Ommen, E Bennink, A Vlassenbroek, J W Dankbaar, A M R Schilham, M A Viergever, H W A M de Jong
PURPOSE: Spectral CT using a dual layer detector offers the possibility of retrospectively introducing spectral information to conventional CT images. In theory, the dual-layer technology should not come with a dose or image quality penalty for conventional images. In this study, we evaluate the influence of a dual-layer detector (IQon Spectral CT, Philips) on the image quality of conventional CT images, by comparing these images with those of a conventional but otherwise technically comparable single-layer CT scanner (Brilliance iCT, Philips), by means of phantom experiments...
May 10, 2018: Medical Physics
Patrizio Barca, Marco Giannelli, Maria Evelina Fantacci, Davide Caramella
Computed tomography (CT) is a useful and widely employed imaging technique, which represents the largest source of population exposure to ionizing radiation in industrialized countries. Adaptive Statistical Iterative Reconstruction (ASIR) is an iterative reconstruction algorithm with the potential to allow reduction of radiation exposure while preserving diagnostic information. The aim of this phantom study was to assess the performance of ASIR, in terms of a number of image quality indices, when different reconstruction blending levels are employed...
May 8, 2018: Australasian Physical & Engineering Sciences in Medicine
Olalla López-Fernández, Eva Pose-Juan, Remedios Yáñez, Raquel Rial-Otero, Jesús Simal-Gándara
Five photodegradation products of metrafenone (MTF) and six of mepanipyrim (MEP) were identified in synthetic grape juice at 25 °C and the structures of the main reaction products established. The degradation of MTF and MEP was modelled by using three different strategies involving monitoring (a) the disappearance of the parent compound, (b) the conversion of the parent compound into its main structurally related reaction products and (c) the degradation of the parent compound to all intermediates and degradation end-products...
June 2018: Food Research International
Jeewan S Titiyal, Manpreet Kaur, Cijin P Jose, Ruchita Falera, Ashutosh Kinkar, Lalit Ms Bageshwar
Purpose: To compare toric intraocular lens (IOL) alignment assisted by image-guided surgery or manual marking methods and its impact on visual quality. Patients and methods: This prospective comparative study enrolled 80 eyes with cataract and astigmatism ≥1.5 D to undergo phacoemulsification with toric IOL alignment by manual marking method using bubble marker (group I, n=40) or Callisto eye and Z align (group II, n=40). Postoperatively, accuracy of alignment and visual quality was assessed with a ray tracing aberrometer...
2018: Clinical Ophthalmology
Dylan B Jackson, Wanda E Leal
BACKGROUND: Energy drinks have become quite popular in recent years among adolescents, prompting a wealth of recent research examining the potential deleterious consequences of energy drink consumption among youth. The present study adds to this body of work by exploring perceptions of risk and disapproval of soft and hard drugs among adolescents and whether such attitudes are predicted by patterns of energy drink/shot consumption. METHODS: Data were derived from the seven most recent cohorts (2010-2016) of the Monitoring the Future (MTF) study, a nationally representative survey of U...
April 21, 2018: Drug and Alcohol Dependence
Antonio González-López
Bar pattern phantoms are used to determine the maximum number of line-pairs per mm that an imaging system can resolve. In some cases, a numerical determination of the modulation transfer function (MTF) can also be carried out. However, calculations can only be performed in a relatively small number of frequencies because of the small number of bar groups in the phantom. In this work, a new bar pattern phantom has been simulated. This phantom consists of 66 pairs of lines of different periods and these periods vary exponentially with spatial position, like in a chirp wave...
April 2018: Physica Medica: PM
Pierluigi Piersimoni, Bruce A Faddegon, José Ramos Méndez, Reinhard W Schulte, Lennart Volz, Joao Seco
PURPOSE: To evaluate the accuracy of relative stopping power reconstructed with simulated helium CT (HeCT) in comparison to proton CT (pCT). METHODS: A Monte Carlo (MC) study with the TOPAS tool was performed to compare the accuracy of relative stopping power (RSP) reconstruction and spatial resolution of low-fluence HeCT to pCT, both using 200 MeV/u particles. An ideal setup consisting of a flat beam source and a totally absorbing energy-range detector was implemented to estimate the theoretically best achievable RSP accuracy for the calibration and reconstruction methods currently used for pCT...
May 4, 2018: Medical Physics
Sandra Isabel Moreno Abril, Camila Dalmolin, Patrícia Gomes Costa, Adalto Bianchini
Copper (Cu) mining in Minas do Camaquã-Brazil, released significant amounts of metals into the João Dias creek, where Hyphessobrycon luetkenii inhabit. Because the involvement of Cu in biological processes its concentration and availability is regulated by molecules as the metal regulatory transcription factor (MTF-1), metallothionein (MT) and transporters (ATP7A and CTR1). These genes were whole sequenced and their expression (GE) evaluated in gills, liver and intestine. Were collected fish in non-contaminated and contaminated (Cu 3...
April 26, 2018: Environmental Toxicology and Pharmacology
Jean Nghiem, Julien Jaeck, Jerome Primot, Christophe Coudrain, Sophie Derelle, Edouard Huard, Marcel Caes, Sylvie Bernhardt, Riad Haidar, Philippe Christol, Isabelle Ribet-Mohamed
In operational electro-optical systems, infrared focal plane arrays (IR FPA) are integrated in cryocoolers which induce vibrations that may strongly affect their modulation transfer function (MTF). In this paper, we present the MTF measurement of an IR FPA sealed in its cryocooler. The method we use to measure the MTF decorrelates operational constraints and the technological limitations of the IR FPA. The bench is based on the diffraction properties of a continuously self imaging grating (CSIG). The 26 µm pixel size extracted from the MTF measurement is in good agreement with the expected value...
April 16, 2018: Optics Express
Yannick Andéol, Jessica Bonneau, Laurence M Gagné, Kevin Jacquet, Véronique Rivest, Marc-Étienne Huot, Carl Séguin
Metal-responsive transcription factor-1 (MTF-1) is a metal-regulatory transcription factor essential for induction of the genes encoding metallothioneins (MTs) in response to transition metal ions. Activation of MTF-1 is dependent on the interaction of zinc with the zinc fingers of the protein. In addition, phosphorylation is essential for MTF-1 transactivation. We previously showed that inhibition of phosphoinositide 3-kinase (PI3K) abrogated <i></i>Mt<i></i> expression and metal-induced MTF-1 activation in human hepatocellular carcinoma (HCC) HepG2 and mouse L cells, thus showing that the PI3K signaling pathway positively regulates MTF-1 activity and <i></i>Mt<i></i> gene expression...
April 30, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
C A Inderjeeth, W D Raymond, A M Briggs, E Geelhoed, D Oldham, D Mountain
Fracture liaison service linked to an emergency department database effectively identifies patients with OP, improves best practice care, reduces recurrent fractures, and improves quality of life (QoL). The next step is to establish cost-effectiveness. This should be seen as the standard model of care. INTRODUCTION: The Western Australian Osteoporosis Model of Care recommends implementation of a fracture liaison service (FLS) to manage patients with minimal trauma fractures (MTFs). This study evaluates the efficacy of a FLS linked to a tertiary hospital emergency department information system (EDIS) in reducing recurrent fractures...
April 27, 2018: Osteoporosis International
Hong-Ting Liu, Zhou Zhou, Wu-Qiang Luo, Wen-Jing He, Owhofasa Agbedia, Jiang-Xia Wang, Jian-Zhong Huang, Xin Gao, Min Kong, Min Li, Li Li
AIM: To compare the optical quality after implantation of implantable collamer lens (ICL) and wavefront-guided laser in situ keratomileusis (WG-LASIK). METHODS: The study included 40 eyes of 22 patients with myopia who accepted ICL implantation and 40 eyes of 20 patients with myopia who received WG-LASIK. Before surgery and three months after surgery, the objective scattering index (OSI), the values of modulation transfer function (MTF) cutoff frequency, Strehl ratio, and the Optical Quality Analysis System (OQAS) values (OVs) were accessed...
2018: International Journal of Ophthalmology
Yoshie Shinohara, Mikiya Nakatsuka
We focus on Japanese individuals with gender identity disorder (GID), especially male-to-female (MTF) GID, who have experienced difficulty in adapting to social life. We clarify what gender dysphoria is, and we examine methods of intervention. Semi-structured interviews were conducted with 11 individuals with MTF-GID from August 2015 to April 2017. We categorized the subjects'experiences regarding dysphoria into the 'Onset of gender dysphoria,' 'Experience of feeling gender dysphoria,' and 'Changes due to receiving medical care...
April 2018: Acta Medica Okayama
Qihui Lyu, Chunlin Yang, Hao Gao, Yi Xue, Daniel O'Connor, Tianye Niu, Ke Sheng
PURPOSE: Megavoltage CT (MVCT) images are noisier than kilovoltage CT (KVCT) due to low detector efficiency to high energy X-rays. Conventional denoising methods compromise edge resolution and low contrast object visibility. In this work, we incorporated Block-Matching 3D-transform shrinkage (BM3D) transformation into MVCT iterative reconstruction as non-local patch-wise regularization. METHODS: The iterative reconstruction was achieved by adding to the existing least square data fidelity objective a regularization term, formulated as the L1 norm of the BM3D transformed image...
April 16, 2018: Medical Physics
Maria-Gabriela Garcia, Thomas Läubli, Bernard J Martin
OBJECTIVE: The aim of this study was to evaluate the long-lasting motor, behavioral, physiological, and perceptual effects of prolonged standing work in three work-rest cycle conditions including passive or active rest breaks. BACKGROUND: Muscle fatigue has been evidenced after prolonged standing work through physiological and neuromotor measures. It has been postulated that muscle fatigue induced by prolonged work could be attenuated by appropriate scheduling of work and rest periods...
April 1, 2018: Human Factors
Guang-Hui Chen, Zhi Luo, Chuan-Chuan Wei, Dan-Dan Li, Ya-Xiong Pan
Excessive Zn in the aquatic environment can be toxic and causes dysfunction in Zn homeostasis for fish, which ultimately influences the function of various biological processes. Zn homeostasis is controlled by Zn transporters. This study cloned and characterized the full-length cDNA sequences of six Zn transport-relevant genes (ZnT1, ZnT5, ZnT7, ZIP4, ZIP5 and MTF-1) from yellow catfish Pelteobagrus fulvidraco. The six genes share similar domains to their corresponding members of mammals. Their mRNA amounts were widely existent across eight tissues (intestine, liver, brain, heart, gill, muscle, spleen and mesenteric fat), but relatively predominant in the liver and intestine...
April 4, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Samaresh Srivastava, Vaishali Vasavada, Viraj Vasavada, Shail Vasavada, Mamidipudi R Praveen, Rajendra Reddy, Abhay R Vasavada
PURPOSE: To compare the change in ocular higher-order wavefront aberrations (HOAs), visual acuity, and modulation transfer function (MTF) after lens extraction with intraocular lens (IOL) implantation in patients with subluxated lenses. SETTING: Iladevi Cataract & IOL Research Centre, Ahmedabad, India. DESIGN: Prospective case series. METHODS: Eyes with subluxated lenses having lens extraction with IOL implantation were included...
March 31, 2018: Journal of Cataract and Refractive Surgery
Dominique Morsomme, Joana Revis, Elisabeth Thomas
Transgender MtF people (trans women) consult otorhinolaryngologists and vocologists with the aim of feminizing their voice and being consistently perceived as women. Treatment of these trans women always begins with a vocal assessment that is relatively unspecific as it was originally constructed for individuals with dysphonia. OBJECTIVES: This study examines the subjective portion of the assessment and specifically the self-assessment questionnaire. There is no French-language questionnaire designed to identify the issues facing people who want voice feminization and quantify the impact of their voice disorder on their daily lives...
March 30, 2018: Journal of Voice: Official Journal of the Voice Foundation
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