Feifei Song, Mingcong Wei, Jingwen Wang, Yang Liu, Mingxiong Guo, Xiaolu Li, Jun Luo, Junying Zhou, Min Wang, Deyin Guo, Lang Chen, Guihong Sun
Hepatocellular carcinoma (HCC) is a common cancer with poor prognosis. Hepatitis B (HBV) is one of the leading causes of HCC, but the precise mechanisms by which this infection promotes cancer development are not fully understood. Recently, miR-340-5p, a microRNA (miRNA) that has been identified as a cancer suppressor gene, was found to inhibit the migration and invasion of liver cancer cells. However, the effect of miR-340-5p on cell proliferation and apoptosis in HBV-associated HCC remains unknown. In our study, we demonstrate that miR-340-5p plays an important role during HBV infection and hepatocellular carcinoma development...
March 19, 2019: Cancer Science