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Demineralized bone matrix

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https://www.readbyqxmd.com/read/29784034/comparison-of-three-imaging-modalities-used-to-evaluate-bone-healing-after-tibial-tuberosity-advancement-in-cranial-cruciate-ligament-deficient-dogs-and-comparison-of-the-effect-of-a-gelatinous-matrix-and-a-demineralized-bone-matrix-mix-on-bone-healing-a-pilot
#1
Marije Risselada, Matthew D Winter, Daniel D Lewis, Emily Griffith, Antonio Pozzi
BACKGROUND: Bone healing and assessment of the state of bone bridging is an important part of clinical orthopedics, whether for fracture healing or for follow up of osteotomy procedures. Tibial tuberosity advancement (TTA) is designed to restore stability in cruciate deficient stifle joints by advancing the tuberosity while creating an osteotomy gap. The current study aims to: 1) compare three different imaging modalities to assess bone healing: ultrasound, radiographs and computed tomography (CT) and, to 2) compare the effect of a gelatinous matrix (GM) versus a demineralized bone matrix mix (DBM mix) on bone healing and bridging of this osteotomy gap in 10 otherwise healthy client-owned dogs with cranial cruciate ligament insufficiency...
May 22, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29768538/demineralized-bone-matrix-and-calcium-phosphate-cement-in-bone-regeneration-in-rats
#2
Luiz Carlos Ferreira da Silva, Gabriela Granja Porto, Emanuel Sávio de Souza Andrade, José Rodrigues Laureano Filho
PURPOSE: To compare bone regeneration in critical-sized defects in rat calvarium using demineralized bone matrix and calcium phosphate cement. METHODS: Thirty Wistar rats were divided into 3 groups of 10 animals each. Two defects of 5-mm were made in the parietal bones of each animal. Group I had calcium phosphate cement placed in the experimental defect, Group II had filled with demineralized bone matrix and Group III had with the combination of the matrix and cement in equal parts...
April 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29745814/trip-1-in-the-extracellular-matrix-promotes-nucleation-of-calcium-phosphate-polymorphs
#3
Amsaveni Ramachandran, Kun He, Chun-Chieh Huang, Reza Shahbazian-Yassar, Tolou Shokuhfar, Anne George
In search for bone and dentin extracellular matrix (ECM) proteins, transforming growth factor beta receptor II interacting protein 1 (TRIP-1) was identified as a novel protein synthesized by osteoblasts and odontoblasts and exported to the ECM. TRIP-1 is a WD-40 (WD is Tryptophan-Aspartic acid dipeptide) protein that has been well recognized for its physiological role in the endoplasmic reticulum (ER). In the ER, TRIP-1 functions as an essential subunit of eukaryotic elongation initiation factor 3 and is involved in the protein translational machinery...
December 2018: Connective Tissue Research
https://www.readbyqxmd.com/read/29685704/assessment-of-reamer-irrigator-aspirator-system-ria-filtrate-for-its-osteoinductive-potential-in-a-validated-animal-model
#4
Alex R Wessel, Brett D Crist, James P Stannard, Gregory J Della Rocca, Aaron M Stoker, Chantelle C Bozynski, Cristi R Cook, Keiichi Kuroki, Carin E Ahner, James L Cook
PURPOSE: Previous studies indicate that Reamer Irrigator Aspirator (RIA) filtrate contains proteins that have the potential to stimulate bone healing. This study aimed to determine the osteoinductive capabilities of RIA filtrate in a validated in vivo model. METHODS: With Institutional Review Board approval, RIA filtrates from 9 patients were collected. The filtrate was processed to remove cells and inorganic particles. A portion of each sample was set aside for protein analysis while the remainder was lyophilized and prepared for implantation...
April 17, 2018: Injury
https://www.readbyqxmd.com/read/29682530/efficacy-of-rhbmp-2-loaded-pcl-%C3%AE-tcp-bdecm-scaffold-fabricated-by-3d-printing-technology-on-bone-regeneration
#5
Eun-Bin Bae, Keun-Ho Park, Jin-Hyung Shim, Ho-Yun Chung, Jae-Won Choi, Jin-Ju Lee, Chang-Hwan Kim, Ho-Jun Jeon, Seong-Soo Kang, Jung-Bo Huh
This study was undertaken to evaluate the effect of 3D printed polycaprolactone (PCL)/ β -tricalcium phosphate ( β -TCP) scaffold containing bone demineralized and decellularized extracellular matrix (bdECM) and human recombinant bone morphogenetic protein-2 (rhBMP-2) on bone regeneration. Scaffolds were divided into PCL/ β -TCP, PCL/ β -TCP/bdECM, and PCL/ β -TCP/bdECM/BMP groups. In vitro release kinetics of rhBMP-2 were determined with respect to cell proliferation and osteogenic differentiation. These three reconstructive materials were implanted into 8 mm diameter calvarial bone defect in male Sprague-Dawley rats...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29677404/hybrid-scaffolds-of-mg-alloy-mesh-reinforced-polymer-extracellular-matrix-composite-for-critical-sized-calvarial-defect-reconstruction
#6
Yingqi Chen, Sang-Ho Ye, Hideyoshi Sato, Yang Zhu, Vesselin Shanov, Tarannum Tiasha, Antonio D'Amore, Samuel Luketich, Guojiang Wan, William R Wagner
The challenge of developing scaffolds to reconstruct critical-sized calvarial defects without the addition of high levels of exogenous growth factor remains relevant. Both osteogenic regenerative efficacy as well as suitable mechanical properties for the temporary scaffold system are of importance. In this study, a Mg alloy mesh reinforced polymer/demineralized bone matrix (DBM) hybrid scaffold was designed where the hybrid scaffold was fabricated by a concurrent electrospinning/electrospraying of poly(lactic-co-glycolic) (PLGA) polymer and DBM suspended in hyaluronic acid (HA)...
April 20, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29655532/evaluation-of-different-therapeutic-carnoy-s-formulations-on-hard-human-tissues-a-raman-microspectroscopy-microhardness-and-scanning-electron-microscopy-study
#7
Francisco Samuel Rodrigues Carvalho, Victor Pinheiro Feitosa, Paulo Goberlânio de Barros Silva, Eduardo Costa Studart Soares, Thyciana Rodrigues Ribeiro, Cristiane Sá Roriz Fonteles, Fábio Wildson Gurgel Costa
PURPOSE: To evaluate different therapeutic Carnoy's solution formulations on hard human tissues. MATERIALS AND METHODS: An in vitro study was performed with human teeth (n = 36) and bone fragments (n = 18), randomly divided into two experimental groups (Group I = Carnoy solution with chloroform; Group II = Carnoy solution without chloroform) and a control group (saline solution). The groups were subdivided into pre-conditioning, post-conditioning, and post-conditioning with saline washing...
February 21, 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29600260/current-concepts-in-scaffolding-for-bone-tissue-engineering
#8
REVIEW
Toktam Ghassemi, Azadeh Shahroodi, Mohammad H Ebrahimzadeh, Alireza Mousavian, Jebraeel Movaffagh, Ali Moradi
Bone disorders are of significant worry due to their increased prevalence in the median age. Scaffold-based bone tissue engineering holds great promise for the future of osseous defects therapies. Porous composite materials and functional coatings for metallic implants have been introduced in next generation of orthopedic medicine for tissue engineering. While osteoconductive materials such as hydroxyapatite and tricalcium phosphate ceramics as well as some biodegradable polymers are suggested, much interest has recently focused on the use of osteoinductive materials like demineralized bone matrix or bone derivatives...
March 2018: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29600207/treating-a-recalcitrant-non-union-of-the-radius-using-autogenous-bone-equine-bone-paste-equine-demineralized-bone-matrix-platelet-rich-plasma-and-bone-marrow-aspirate-a-case-report
#9
Ferdinando Da Rin De Lorenzo
Introduction: Non-unions at forearms are usually challenging and difficult to treat. If additionally, an infection is present, reconstructive surgery should be planned only after full debridement, antibiotic treatment, and confirmation, based on clinical observation and laboratory tests that the infection has subsided. Bone grafting may be required for reconstruction. The use of autogenous bone calls for a second surgical site with an increased risk of morbidity. Using bone substitutes may reduce the need for autogenous bone...
November 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29594993/-experimental-study-of-demineralized-dentin-matrix-on-osteoinduction-and-related-cells-identification
#10
Yang Shengyin, Chen Ping, Bao Jibo, Ding Yixin, Zou Jinyang, Xie Zhigang
OBJECTIVE: The aim of this study was to explore the theoretical framework of cells and the forms of osteogenesis in the mechanism by which demineralized dentin matrix (DDM) induces osteogenesis. METHODS: A total of 24 New Zealand rabbits were used in this study. A total of 4 erector spinae bags were created in each animal. A total of 3 erector spinae bags were implanted with DDM by random selection, whereas the remaining one erector spinae bag was not implanted with DDM...
February 1, 2018: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29590225/periodontal-regenerative-treatment-of-intrabony-defects-in-the-esthetic-zone-using-modified-vestibular-incision-subperiosteal-tunnel-access-m-vista
#11
Babak Najafi, Parisa Kheirieh, Alireza Torabi, Emil G Cappetta
Periodontal regenerative treatment of intrabony defects in the esthetic zone often poses a significant challenge to clinicians. Various materials and techniques have been proposed to achieve periodontal regeneration. This article presents modified vestibular incision subperiosteal tunnel access (M-VISTA) for treatment of intrabony defects in the esthetic zone. Two cases were treated using the proposed approach with enamel matrix derivatives and demineralized freeze-dried bone allograft to optimize the regenerative outcomes without affecting the soft tissue profile in the esthetic zone...
March 28, 2018: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29570520/stranger-things-a-whimsical-account-of-a-demineralized-bone-matrix-study-with-unexpected-results
#12
William S Pietrzak
No abstract text is available yet for this article.
March 22, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29551486/parathyroid-hormone-gene-activated-matrix-with-dfdba-collagen-composite-matrix-enhances-bone-regeneration-in-rat-calvarial-bone-defects
#13
Po-Hui Lee, Tu-Lai Yew, Yu-Lin Lai, Shyh-Yuan Lee, Hen-Li Chen
BACKGROUND: Gene-activated matrix (GAM) induces sustained local production of growth factors to promote tissue regeneration. GAM contains a plasmid DNA (pDNA) encoding target proteins that is physically entrapped within a biodegradable matrix carrier. GAM with a pDNA encoding the first 34 amino acids of parathyroid hormone (PTH 1-34) and a collagen matrix enhances bone regeneration in long bone defects. Demineralized freeze-dried bone allograft (DFDBA) is a widely used osteoinductive bone graft...
March 15, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29550606/the-local-cytokine-and-growth-factor-response-to-rhbmp-2-after-spinal-fusion
#14
John D Koerner, Dessislava Z Markova, Greg D Schroeder, Brian P Calio, Anuj Shah, Corbin W Brooks, Alexander R Vaccaro, D Greg Anderson, Chris K Kepler
BACKGROUND CONTEXT: The systemic response regarding cytokine expression after application of recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) in a rat spinal fusion model has recently been defined1 , but the local response has not. Defining the local cytokine and growth factor response at the fusion site will help explain the roles of these molecules in the fusion process, as well as that of rhBMP-2. Our hypothesis is that application of rhBMP-2 to the fusion site will alter the local levels of cytokines and growth factors throughout the fusion process, in a manner that is different than the systemic response given the tissue-specific effects of rhBMP-2...
March 14, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29515143/a-combined-method-for-dna-analysis-and-radiocarbon-dating-from-a-single-sample
#15
Petra Korlević, Sahra Talamo, Matthias Meyer
Current protocols for ancient DNA and radiocarbon analysis of ancient bones and teeth call for multiple destructive samplings of a given specimen, thereby increasing the extent of undesirable damage to precious archaeological material. Here we present a method that makes it possible to obtain both ancient DNA sequences and radiocarbon dates from the same sample material. This is achieved by releasing DNA from the bone matrix through incubation with either EDTA or phosphate buffer prior to complete demineralization and collagen extraction utilizing the acid-base-acid-gelatinization and ultrafiltration procedure established in most radiocarbon dating laboratories...
March 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29496620/superior-calvarial-bone-regeneration-using-pentenoate-functionalized-hyaluronic-acid-hydrogels-with-devitalized-tendon-particles
#16
Jakob M Townsend, Brian T Andrews, Yi Feng, Jinxi Wang, Randolph J Nudo, Erik Van Kampen, Stevin H Gehrke, Cory J Berkland, Michael S Detamore
Traumatic brain injury (TBI) is a life-threatening condition defined by internal brain herniation. Severe TBI is commonly treated by a two-stage surgical intervention, where decompressive craniectomy is first conducted to remove a large portion of calvarial bone and allow unimpeded brain swelling. In the second surgery, spaced weeks to months after the first, cranioplasty is performed to restore the cranial bone. Hydrogels with paste-like precursor solutions for surgical placement may potentially revolutionize TBI treatment by permitting a single-stage surgical intervention, capable of being implanted with the initial surgery, remaining pliable during brain swelling, and tuned to regenerate calvarial bone after brain swelling has subsided...
April 15, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29479658/no-correlation-between-radiological-and-clinical-outcome-1-year-following-cervical-arthrodesis
#17
Ehab Shiban, Moritz Nies, Johann Kogler, Lorenz Kogler, Pedro Ribeiro da Cunha, Bernhard Meyer, Jens Lehmberg
AIM: To correlate clinical and radiological outcome following one- and two-level anterior cervical discectomy and fusion (ACDF) with stand-alone polyetheretherketone (PEEK) cages filled with demineralized bone matrix (DBM). METHODS: We performed a retrospective review of a consecutive patient cohort with degenerative disc disease that underwent ACDF with stand-alone PEEK cages filled with demineralized bone matrix (DBM) between 2010 and 2013 with a minimum follow-up of 12 months...
April 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29479561/using-biomimetic-polymers-in-place-of-noncollagenous-proteins-to-achieve-functional-remineralization-of-dentin-tissues
#18
Yung-Ching Chien, Jinhui Tao, Kuniko Saeki, Alexander F Chin, Jolene L Lau, Chun-Long Chen, Ronald N Zuckermann, Sally J Marshall, Grayson W Marshall, James J De Yoreo
In calcified tissues such as bones and teeth, mineralization is regulated by an extracellular matrix, which includes non-collagenous proteins (NCP). This natural process has been adapted or mimicked to restore tissues following physical damage or demineralization by using polyanionic acids in place of NCPs, but the remineralized tissues fail to fully recover their mechanical properties. Here we show that pre-treatment with certain amphiphilic peptoids, a class of peptide-like polymers consisting of N-substituted glycines that have defined monomer sequences, enhances ordering and mineralization of collagen and induces functional remineralization of dentin lesions in vitro ...
December 11, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29461365/alternatives-to-autologous-bone-graft-in-alveolar-cleft-reconstruction-the-state-of-alveolar-tissue-engineering
#19
Fan Liang, Hyuma Leland, Breanna Jedrzejewski, Allyn Auslander, Seija Maniskas, Jordan Swanson, Mark Urata, Jeffrey Hammoudeh, William Magee
Alveolar cleft reconstruction has historically relied on autologous iliac crest bone grafting (ICBG), but donor site morbidity, pain, and prolonged hospitalization have prompted the search for bone graft substitutes. The authors evaluated bone graft substitutes with the highest levels of evidence, and highlight the products that show promise in alveolar cleft repair and in maxillary augmentation. This comprehensive review guides the craniofacial surgeon toward safe and informed utilization of biomaterials in the alveolar cleft...
May 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29430398/revision-of-failed-rotator-cuff-reconstruction-with-a-large-humeral-head-cyst
#20
Bashar Reda, Catherine Coady, Ivan Wong
A revision rotator cuff repair is a technically challenging surgical procedure. This can be further complicated by the presence of poor quality of the cuff tissue, as well as a large greater tuberosity cyst, typically located at the rotator cuff footprint. This Technical Note discusses the surgical approach to deal with a revision rotator cuff tear with a large humeral head cyst. This described arthroscopic technique is performed in a single-stage procedure using a human dermal allograft (GraftJacket) for augmentation...
October 2017: Arthroscopy Techniques
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