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Demineralized bone matrix

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https://www.readbyqxmd.com/read/28321651/effects-of-strontium-ranelate-treatment-on-osteoblasts-cultivated-onto-scaffolds-of-trabeculae-bovine-bone
#1
Gerluza Aparecida Borges Silva, Bruno Machado Bertassoli, Cristiane Aparecida Sousa, Juliano Douglas Albergaria, Rayan Silva de Paula, Erika Cristina Jorge
Blocks of Bovine bone have shown promising results as implantable scaffolds to promote bone regeneration. Strontium ranelate (SrR) is both an antiresorptive and an anabolic drug that has been indicated for oral administration to treat osteoporosis. Few studies, however, have investigated the local effects of SrR and its use in association with biomaterials thus far. In this work, we investigated SrR effects in cultures of primary osteoblasts (PO, from Wistar rats calvaria) and immortalized osteoblasts (IO, from MC3T3-E1 cell line) cultivated as a monolayer or in association with scaffolds of bovine bone in mineralized (MBB) and demineralized (DBB) forms...
March 20, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28264244/demineralized-bone-matrix-dbm-as-a-bone-void-filler-in-lumbar-interbody-fusion-a-prospective-pilot-study-of-simultaneous-dbm-and-autologous-bone-grafts
#2
Bum-Joon Kim, Se-Hoon Kim, Haebin Lee, Seung-Hwan Lee, Won-Hyung Kim, Sung-Won Jin
OBJECTIVE: Solid bone fusion is an essential process in spinal stabilization surgery. Recently, as several minimally invasive spinal surgeries have developed, a need of artificial bone substitutes such as demineralized bone matrix (DBM), has arisen. We investigated the in vivo bone growth rate of DBM as a bone void filler compared to a local autologous bone grafts. METHODS: From April 2014 to August 2015, 20 patients with a one or two-level spinal stenosis were included...
March 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28264242/polyetheretherketone-cage-with-demineralized-bone-matrix-can-replace-iliac-crest-autografts-for-anterior-cervical-discectomy-and-fusion-in-subaxial-cervical-spine-injuries
#3
Soo-Han Kim, Jung-Kil Lee, Jae-Won Jang, Hyun-Woong Park, Hyuk Hur
OBJECTIVE: This study aimed to compare the clinical and radiologic outcomes of patients with subaxial cervical injury who underwent anterior cervical discectomy and fusion (ACDF) with autologous iliac bone graft or polyetheretherketone (PEEK) cages using demineralized bone matrix (DBM). METHODS: From January 2005 to December 2010, 70 patients who underwent one-level ACDF with plate fixation for post-traumatic subaxial cervical spinal injury in a single institution were retrospectively investigated...
March 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28253279/demineralized-bone-matrix-used-for-direct-pulp-capping-in-rats
#4
Qian Liu, Yanhong Ma, Junlan Wang, Xuefang Zhu, Yanjing Yang, Yufeng Mei
OBJECTIVES: To evaluate the wound healing process following direct pulp capping with demineralized bone matrix (DBM) and calcium hydroxide (Ca(OH)2). METHODS: Fifty 8-weeks-old SPF Wistar male rats were divided into two groups: one was the DBM treated group, and the other was the Ca(OH)2 treated group. Pulpotomy was performed on the maxillary first molar of one side of each rat, and the another side was left as the blank control. Rats were sacrificed after each observation period (1, 3, 7, 14 and 28 days) and specimen slices were made...
2017: PloS One
https://www.readbyqxmd.com/read/28240608/evaluation-of-extraction-site-dimensions-and-density-using-computed-tomography-treated-with-different-graft-materials-a-preliminary-study
#5
Filiz Hyusein Cavdar, Huseyin Gencay Keceli, Hasan Hatipoglu, Burak Demiralp, Feriha Caglayan
PURPOSE: The preliminary human study was designed to evaluate extraction site changes using CT after socket preservation (SP) with different materials. MATERIALS AND METHODS: Fifty-two sockets from 17 Turkish individuals (8 women and 9 men; mean age 44.70 ± 9.99 years) localized at the maxillary anterior area were treated with demineralized bone matrix + collagen membrane (CM) (N = 14), hydroxyapatite bone substitute (HBS) + CM (N = 14), CM (N = 13), or left empty (N = 11)...
April 2017: Implant Dentistry
https://www.readbyqxmd.com/read/28214897/mir-125b-regulates-the-osteogenic-differentiation-of-human-mesenchymal-stem-cells-by-targeting-bmpr1b
#6
Huaqing Wang, Zhao Xie, Tianyong Hou, Zhiqiang Li, Ke Huang, Jicheng Gong, Wei Zhou, Kanglai Tang, Jianzhong Xu, Shiwu Dong
BACKGROUND/AIMS: Osteogenic differentiation of mesenchymal stem cells (MSCs) plays a crucial role in bone regeneration and bone reparation. This complex process is regulated precisely and firmly by specific factors. Recent studies have demonstrated that miR-125b regulates osteogenic differentiation, but little is known about the molecular mechanisms of this regulation. Furthermore, how miR-125b regulates the osteogenic differentiation of MSCs still needs elucidation. METHODS: In the present study, human bone marrow-derived mesenchymal stem cells (hBMSCs) were isolated and induced to osteoblasts with miR-125b inhibition or overexpression...
January 31, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28207623/feasibility-of-percutaneous-posterolateral-spinal-fusion-with-recombinant-bone-morphogenetic-protein-2-rhbmp-2-a-comparison-with-standard-methods-using-an-animal-model-study
#7
Chris Yin Wei Chan, Mun Keong Kwan, Lim Beng Saw, Hussin Paisal
BACKGROUND CONTEXT: The clinical application of recombinant bone morphogenetic protein in spinal surgery has been shown to be safe and effective. However, its use in minimally invasive spine surgery has been limited to anterior interbody fusion procedures. To date, no study has evaluated the feasibility of percutaneous posterolateral fusion in the spine utilizing recombinant bone morphogenetic protein-2 (rhBMP-2). PURPOSE: To evaluate the feasibility of percutaneous posterolateral fusion in the spine utilizing rhBMP-2...
March 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28193541/a-nano-scaled-and-multi-layered-recombinant-fibronectin-cadherin-chimera-composite-selectively-concentrates-osteogenesis-related-cells-and-factors-to-aid-bone-repair
#8
Junchao Xing, Tieniu Mei, Keyu Luo, Zhiqiang Li, Aijun Yang, Zhilin Li, Zhao Xie, Zehua Zhang, Shiwu Dong, Tianyong Hou, Jianzhong Xu, Fei Luo
Easily accessible and effective bone grafts are in urgent need in clinic. The selective cell retention (SCR) strategy, by which osteogenesis-related cells and factors are enriched from bone marrow into bio-scaffolds, holds great promise. However, the retention efficacy is limited by the relatively low densities of osteogenesis-related cells and factors in marrow; in addition, a lack of satisfactory surface modifiers for scaffolds further exacerbates the dilemma. To address this issue, a multi-layered construct consisting of a recombinant fibronectin/cadherin chimera was established via a layer-by-layer self-assembly technique (LBL-rFN/CDH) and used to modify demineralised bone matrix (DBM) scaffolds...
February 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28188395/marshall-r-urist-and-the-discovery-of-bone-morphogenetic-proteins
#9
Lovorka Grgurevic, Marko Pecina, Slobodan Vukicevic
Over the last 40 years International Orthopaedics has published a series of articles on bone morphogenetic proteins (BMPs) covering topics from basic research to clinical applications. This includes also work submitted from the Laboratory for Mineralized Tissues of the School of Medicine University of Zagreb. Accordingly, we felt obliged to give a short summary of Dr. Urist's life and work as our gratitude to his discovery that demineralized bone matrix (DBM) activity induces bone when implanted ectopically into the muscle or under the skin due to bone inducing proteins, named BMPs...
February 11, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28174633/long-term-follow-up-of-autogenous-tooth-bone-graft-blocks-with-dental-implants
#10
Young-Kyun Kim, Kang-Mi Pang, Pil-Young Yun, Dae-Ho Leem, In-Woong Um
Demineralized dentin matrix block (ABTB: Autogenous Tooth Bone Graft Block) is 3-D scaffold with same components and geometry with alveolar bone. ABTB is well incorporated and remodelled into cortico-cancellous bone with dental implant. The shape and volume were maintained with little marginal bone loss after average 44 months of follow-up.
February 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28162888/the-effectiveness-of-demineralized-cortical-bone-matrix-in-a-chronic-rotator-cuff-tear-model
#11
Tanujan Thangarajah, Frederick Henshaw, Anita Sanghani-Kerai, Simon M Lambert, Gordon W Blunn, Catherine J Pendegrass
BACKGROUND: The purpose of this study was to assess the effect of demineralized bone matrix (DBM) on rotator cuff tendon-bone healing. The hypothesis was that compared with a commercially available dermal matrix scaffold, DBM would result in a higher bone mineral density and regenerate a morphologically superior enthesis in a rat model of chronic rotator cuff degeneration. METHODS: Eighteen female Wistar rats underwent unilateral detachment of the supraspinatus tendon...
February 2, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28150691/repair-of-bone-defects-with-prefabricated-vascularized-bone-grafts-and-double-labeled-bone-marrow-derived-mesenchymal-stem-cells-in-a-rat-model
#12
Xiao-Rui Jiang, Hui-Ying Yang, Xin-Xin Zhang, Guo-Dong Lin, Yong-Chun Meng, Pei-Xun Zhang, Shan Jiang, Chun-Lei Zhang, Fei Huang, Lin Xu
This study aims to investigate the repair of bone defects with prefabricated vascularized bone grafts and double-labeled bone marrow-derived mesenchymal stem cells (BMSCs) in a rat model. BMSCs were separated from rat bone marrow. LTR-CMVpro-RFP and LTR-CMVpro-GFP were transfected into the BMSCs for in vitro and in vivo tracking. BMSCs-RFP and BMSCs-GFP were induced into endothelial progenitor cells (EPCs) and osteoblasts (OBs). Rats were divided into five groups: Group A: in vitro prefabrication with EPCs-RFP + in vivo prefabrication with arteriovenous vascular bundle + secondary OBs-GFP implantation; Group B: in vitro prefabrication with EPCs-RFP + secondary OBs-GFP implantation; Group C: in vivo prefabrication with arteriovenous vascular bundle + secondary OBs-GFP implantation; Group D: implantation of EPCs-RFP + implantation of with arteriovenous vascular bundle + simultaneous OBs-GFP implantation; Group E: demineralized bone matrix (DBM) grafts (blank control)...
February 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28138909/colloidal-gels-with-extracellular-matrix-particles-and-growth-factors-for-bone-regeneration-in-critical-size-rat-calvarial-defects
#13
Jakob M Townsend, S Connor Dennis, Jonathan Whitlow, Yi Feng, Jinxi Wang, Brian Andrews, Randolph J Nudo, Michael S Detamore, Cory J Berkland
Colloidal gels encapsulating natural materials and exhibiting paste-like properties for placement are promising for filling complex geometries in craniofacial bone regeneration applications. Colloidal materials have demonstrated modest clinical outcomes as bone substitutes in orthopedic applications, but limited success in craniofacial applications. As such, development of a novel colloidal gel will fill a void in commercially available products for use in craniofacial reconstruction. One likely application for this technology is cranial reconstruction...
January 30, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28133536/approaches-for-building-bioactive-elements-into-synthetic-scaffolds-for-bone-tissue-engineering
#14
Venu Kesireddy, F Kurtis Kasper
Bone tissue engineering (BTE) is emerging as a possible solution for regeneration of bone in a number of applications. For effective utilization, BTE scaffolds often need modifications to impart biological cues that drive diverse cellular functions such as adhesion, migration, survival, proliferation, differentiation, and biomineralization. This review provides an outline of various approaches for building bioactive elements into synthetic scaffolds for BTE and classifies them broadly under two distinct schemes; namely, the top-down approach and the bottom-up approach...
November 14, 2016: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/28128364/periostin-upregulates-wnt-%C3%AE-catenin-signaling-to-promote-the-osteogenesis-of-ctla4-modified-human-bone-marrow-mesenchymal-stem-cells
#15
Fei Zhang, Keyu Luo, Zhigang Rong, Zhengdong Wang, Fei Luo, Zehua Zhang, Dong Sun, Shiwu Dong, Jianzhong Xu, Fei Dai
The enhanced osteogenesis of mesenchymal stem cells (MSCs) modified by expression of cytotoxic T lymphocyte-associated antigen 4 (CTLA4) has been shown in previous studies, but the mechanism remains unknown. Here we found that the bone repair effect of CTLA4-modified MSCs in demineralized bone matrix (DBM) in a rabbit radius defect model was significantly better than that observed for unmodified MSCs in DBM or DBM alone, and the periostin (POSTN) expression in CTLA4-modified MSCs was significantly higher than that in unmodified MSCs both in vivo and in vitro...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28126356/efficacy-comparison-of-accell-evo3%C3%A2-and-grafton%C3%A2-demineralized-bone-matrix-putties-against-autologous-bone-in-a-rat-posterolateral-spine-fusion-model
#16
Antonio T Brecevich, Paul D Kiely, B Victor Yoon, Joseph T Nguyen, Frank P Cammisa, Celeste Abjornson
BACKGROUND CONTEXT: Spinal fusion procedures are intended to stabilize the spinal column for a multitude of disorders including abnormal curvature, traumatic instability, degenerative instability, and damage from infections or tumors. As an aid in the bone healing response, bone graft materials are utilized to bridge joints for arthrodesis and promote unions in pseudoarthrosis. Currently, the gold standard for stabilizing fusion masses in spinal procedures involves utilizing the osteogenic, osteoinductive, and osteoconductive properties of autologous iliac crest cortico-cancellous bone...
January 23, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28097682/evaluation-of-perforated-demineralized-dentin-scaffold-on-bone-regeneration-in-critical-size-sheep-iliac-defects
#17
Md Arafat Kabir, Masaru Murata, Toshiyuki Akazawa, Kaoru Kusano, Katsuhisa Yamada, Manabu Ito
OBJECTIVES: Regenerating critical-size bone injury is a major problem that continues to inspire the design of new graft materials. Therefore, tissue engineering has become a novel approach for targeting bone regeneration applications. Human teeth are a rich source of stem cells, matrix, trace metal ions, and growth factors. A vital tooth-derived demineralized dentin matrix is acid-insoluble and composed of cross-linked collagen with growth factors. In this study, we recycled human non-functional tooth into a unique geometric dentin scaffold, entitled perforated root-demineralized dentin matrix (PR-DDM)...
January 17, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/28050319/the-hidden-x-suture-a-technical-note-on-a-novel-suture-technique-for-alveolar-ridge-preservation
#18
Jung-Chul Park, Ki-Tae Koo, Hyun-Chang Lim
PURPOSE: The present study investigated the impact of 2 different suture techniques, the conventional crossed mattress suture (X suture) and the novel hidden X suture, for alveolar ridge preservation (ARP) with an open healing approach. METHODS: This study was a prospective randomized controlled clinical trial. Fourteen patients requiring extraction of the maxillary or mandibular posterior teeth were enrolled and allocated into 2 groups. After extraction, demineralized bovine bone matrix mixed with 10% collagen (DBBM-C) was grafted and the socket was covered by porcine collagen membrane in a double-layer fashion...
December 2016: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/28005380/hyaluronic-acid-hydroxyapatite-colloidal-gels-combined-with-micronized-native-ecm-as-potential-bone-defect-fillers
#19
S Connor Dennis, Jonathan Whitlow, Michael S Detamore, Sarah L Kieweg, Cory J Berkland
One of the grand challenges in translational regenerative medicine is the surgical placement of biomaterials. For bone regeneration in particular, malleable and injectable colloidal gelsare frequently designed to exhibit self-assembling and shear-response behavior which facilitates biomaterial placement in tissue defects. The current study demonstrated that by combining native extracellular matrix (ECM) microparticles, i.e., demineralized bone matrix (DBM) and decellularized cartilage (DCC), with hyaluronic acid (HA) and hydroxyapatite (HAP) nanoparticles, a viscoelastic colloidal gel consisting exclusively of natural materials was achieved...
December 22, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28003828/volar-locking-plate-breakage-after-nonunion-of-a-distal-radius-osteotomy
#20
Sergi Barrera-Ochoa, Sergi Rodríguez-Alabau, Andrea Sallent, Francisco Soldado, Xavier Mir
We report a 38-year-old male with a nonunion followed by plate breakage after volar plating of a distal radius osteotomy. Volar locking plates have added a new approach to the treatment of distal radius malunions, due to a lower morbidity of the surgical approach and the strength of the final construction, allowing early mobilization and return to function. Conclusion. Plate breakage is an uncommon complication of volar locking plate fixation. To our knowledge, few cases have been described after a distal radius fracture and no case has been described after a distal radius corrective osteotomy...
2016: Case Reports in Medicine
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