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Demineralized bone matrix

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https://www.readbyqxmd.com/read/28687387/hybrid-hydrogels-with-high-strength-and-biocompatibility-for-bone-regeneration
#1
Yongjiang Zheng, Keqing Huang, Xinru You, Bingxue Huang, Jun Wu, Zhipeng Gu
The development of hydrogels for bone regeneration has highlighted the challenge that load-bearing hydrogels need to be biocompatible while achieving high strength. Several approaches have been reported to improve the toughness of hydrogels, but achieving high toughness and biocompatibility simultaneously remains a challenge. Here we report a polyacrylic acid/alginate/demineralized bone matrix (PAA/Alg/DBM) hybrid double network hydrogel, which was synthesized by a two-step sequential polymerization with embedded DBM, possessing both high strength and biocompatibility...
July 4, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28684346/antibiotic-loaded-bone-graft-for-reduction-of-surgical-site-infection-in-spinal-fusion
#2
Stefanie M Shiels, Vivek P Raut, Patrick B Patterson, Brian R Barnes, Joseph C Wenke
BACKGROUND CONTEXT: Infections remain a leading complication associated with spinal arthrodesis, regardless of the use of prophylactic antibiotics and improved surgical techniques, with incidence of infection as high as 8.2%. Infection prolongs antibiotic usage, increases hospital time, and inevitably inflates overall treatment costs. Local antibiotics, such as vancomycin, have been used in combination with fusion materials over the past decade to decrease infection risk. An ideal graft material would serve a dual role: encourage vertebral fusion while reducing incidence of infection...
July 3, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28683667/early-immunomodulatory-effects-of-implanted-human-perivascular-stromal-cells-during-bone-formation
#3
Carolyn A Meyers, Jiajia Xu, Lei Zhang, Greg Asatrian, Catherine Ding, Noah Yan, Kristen Broderick, Justin Sacks, Raghav Goyal, Xinli Zhang, Kang Ting, Bruno Péault, Chia Soo, Aaron W James
Human perivascular stem/stromal cells (PSC) are a multipotent mesodermal progenitor cell population defined by their perivascular residence. PSC are most commonly derived from subcutaneous adipose tissue, and recent studies have demonstrated the high potential for clinical translation of this fluorescence activated cell sorting (FACS) derived cell population for bone tissue engineering. Specifically, purified PSC induce greater bone formation than unpurified stroma taken from the same patient sample. Here, we examined the differences in early innate immune response to human PSC or unpurified stroma (stromal vascular fraction, SVF) during the in vivo process of bone formation...
July 6, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28667922/combination-of-hydroxyapatite-platelet-rich-fibrin-and-amnion-membrane-as-a-novel-therapeutic-option-in-regenerative-periapical-endodontic-surgery-case-series
#4
Uday Kiran Uppada, Butchibabu Kalakonda, Pradeep Koppolu, Narendra Varma, Kiran Palakurthy, Venkatesh Manchikanti, Shilpa Prasad, Shereen Samar, Lingam Amara Swapna
INTRODUCTION: Periapical surgery is the last resort in the arsenal of an endodontist to effectively deal with periapical lesions that result from necrosis of the pulp. Bone grafts, growth factors and membranes form an array of regenerative materials that influence the healing outcome of periapical surgery. PRESENTATION OF CASE: The main purpose of the two cases reported here was to assess the potential benefits of a combination of bone graft, platelet-rich fibrin (PRF) and amnion membrane in terms of reduced post-operative discomfort, radiographic evidence of accelerated periapical bone healing and present a novel therapeutic option in the management of large periapical lesions...
June 15, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28622184/does-age-influence-the-efficacy-of-demineralized-bone-matrix-enriched-with-concentrated-bone-marrow-aspirate-in-lumbar-fusions
#5
Remi M Ajiboye, Mark A Eckardt, Jason T Hamamoto, Akshay Sharma, Adam Z Khan, Jeffrey C Wang
STUDY DESIGN: Retrospective study. OBJECTIVE: Evaluate the effect of age on the efficacy of allograft/demineralized bone matrix (DBM) enriched with concentrated bone marrow aspirate (BMA) in posterolateral lumbar fusions (PLFs). SUMMARY OF BACKGROUND DATA: Cell-based therapies such as concentrated BMA have been developed as a potential alternative to iliac crest bone graft (ICBG). BMA contains mesenchymal stem cells (MSCs) and growth factors that can confer osteogenic and osteoinductive potential to osteoconductive scaffolds such as DBM/allograft...
June 15, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28617737/3d-cone-beam-computed-tomography-volumetric-outcomes-of-rhbmp-2-demineralized-bone-matrix-vs-iliac-crest-bone-graft-for-alveolar-cleft-reconstruction
#6
Fan Liang, Stephen Yen, Thomas Imahiyerobo, Luke Sanborn, Leia Yen, Daniel Yen, Sheila Nazarian, Breanna Jedrzejewski, Mark Urata, Jeffrey Hammoudeh
BACKGROUND: Recent studies indicate that recombinant human bone morphogenetic protein (rhBMP-2) in a demineralized bone matrix scaffold (MS) is a comparable alternative to iliac bone autograft in the setting of secondary alveolar cleft repair. Post-reconstruction occlusal radiographs demonstrate improved bone stock when rhBMP-2/MS is used, but lack the capacity to evaluate bone growth in three dimensions. This study uses cone beam computed tomography (CBCT) to provide the first clinical evaluation of volumetric and density comparisons between these two treatment modalities...
June 14, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28589410/computational-segmentation-of-collagen-fibers-in-bone-matrix-indicates-bone-quality-in-ovariectomized-rat-spine
#7
Diaa Eldin S Daghma, Deeksha Malhan, Paul Simon, Sabine Stötzel, Stefanie Kern, Fathi Hassan, Katrin Susanne Lips, Christian Heiss, Thaqif El Khassawna
Bone loss varies according to disease and age and these variations affect bone cells and extracellular matrix. Osteoporosis rat models are widely investigated to assess mechanical and structural properties of bone; however, bone matrix proteins and their discrepant regulation of diseased and aged bone are often overlooked. The current study considered the spine matrix properties of ovariectomized rats (OVX) against control rats (Sham) at 16 months of age. Diseased bone showed less compact structure with inhomogeneous distribution of type 1 collagen (Col1) and changes in osteocyte morphology...
June 6, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28584412/demineralized-dentin-matrix-scaffolds-for-alveolar-bone-engineering
#8
REVIEW
In-Woong Um, Young-Kyun Kim, Masaharu Mitsugi
From the point of view of implant dentistry, this review discusses the development and clinical use of demineralized dentin matrix (DDM) scaffolds, produced from the patient's own extracted teeth, to repair alveolar bone defects. The structure and the organic and inorganic components of DDM are presented to emphasize the similarities with autogenous bone. Studies of DDM properties, such as osteoinductive and osteoconductive functions as well as efficacy and safety, which are mandatory for its use as a bone graft substitute, are also presented...
April 2017: Journal of Indian Prosthodontic Society
https://www.readbyqxmd.com/read/28577782/orthobiologics-in-pediatric-sports-medicine
#9
REVIEW
Christopher C Bray, Clark M Walker, David D Spence
Orthobiologics are biological substances that allow injured muscles, tendons, ligaments, and bone to heal more quickly. They are found naturally in the body; at higher concentrations they can aid in the healing process. These substances include autograft bone, allograft bone, demineralized bone matrix, bone morphogenic proteins, growth factors, stem cells, plasma-rich protein, and ceramic grafts. Their use in sports medicine has exploded in efforts to increase graft incorporation, stimulate healing, and get athletes back to sport with problems including anterior cruciate ligament ruptures, tendon ruptures, cartilage injuries, and fractures...
July 2017: Orthopedic Clinics of North America
https://www.readbyqxmd.com/read/28548246/comparison-of-three-different-types-of-scaffolds-preseeded-with-human-bone-marrow-mononuclear-cells-on-the-bone-healing-in-a-femoral-critical-size-defect-model-of-the-athymic-rat
#10
Maren Janko, Julian Sahm, Alexander Schaible, Jan C Brune, Marlene Bellen, Katrin Schröder, Caroline Seebach, Ingo Marzi, Dirk Henrich
Large bone defects often pose major difficulties in orthopedic surgery. The application of long term cultured stem cells combined with a scaffold lead to a significant improvement of bone healing in recent experiments but is strongly restricted by EU-law. Bone marrow mononuclear cells (BMC), however, can be isolated and transplanted within few hours and have been proven effective in experimental models of bone healing. The effectivity of the BMC supported therapy might be influenced by the type of scaffold...
May 26, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28514897/biomaterials-and-bioactive-agents-in-spinal-fusion
#11
Rui M Duarte, Pedro Varanda, Rui L Reis, Ana Rita C Duarte, Jorge Correia-Pinto
Management of degenerative spine pathologies frequently leads to the need for spinal fusion (SF), where bone growth is induced toward stabilization of the interventioned spine. Autologous bone graft (ABG) remains the gold-standard inducer, whereas new bone graft substitutes attempt to achieve effective de novo bone formation and solid fusion. Limited fusion outcomes have driven motivation for more sophisticated and multidisciplinary solutions, involving new biomaterials and/or biologics, through innovative delivery platforms...
June 28, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28467589/a-comparison-of-the-effects-of-platelet-rich-plasma-and-demineralized-bone-matrix-on-critical-bone-defects-an-experimental-study-on-rats
#12
Egemen Turhan, Mustafa Kemal Akça, Ahmet Bayar, Murat Songür, Selçuk Keser, Mahmut Nedim Doral
BACKGROUND: Delayed union of fractured bone is one of the main problems of orthopedics and traumatology practice. It was hypothesized that the beneficial effects of allogeneic platelet-rich plasma (PRP) would be valuable in the treatment of segmental bone defects. This study is a comparison of the effects of demineralized bone matrix (DBM) and PRP in a segmental bone defect model. METHODS: Total of 48 Wistar albino rats were separated into 4 groups. Segmental bone defect was created at right radius diaphysis in all specimens using dorsal approach...
March 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28466494/comparison-of-allografts-and-xenografts-used-for-alveolar-ridge-preservation-a-clinical-and-histomorphometric-rct-in-humans
#13
Carlos Alberto Serrano Méndez, Niklaus Peter Lang, Martina Caneva, Gloria Ramírez Lemus, Gerardo Mora Solano, Daniele Botticelli
BACKGROUND: Several types of bone grafts are used in ridge preservation procedures. PURPOSE: To compare the healing of allografts and xenografts applied for alveolar ridge preservation. MATERIALS AND METHODS: Twenty volunteers in need of extraction of a single-rooted tooth prior to implant installation were randomized into two groups. One group received a deproteinized cancellous bovine bone xenograft embedded in a 10% collagen matrix and the other a demineralized freeze-dried cortical bone allograft...
May 2, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28429412/bone-extracellular-matrix-hydrogel-enhances-osteogenic-differentiation-of-c2c12-myoblasts-and-mouse-primary-calvarial-cells
#14
Noura Alom, Heather Peto, Glen R Kirkham, Kevin M Shakesheff, Lisa J White
Hydrogel scaffolds derived from the extracellular matrix (ECM) of mammalian tissues have been successfully used to promote tissue repair in vitro and in vivo. The objective of this study was to evaluate the osteogenic potential of ECM hydrogels prepared from demineralized and decellularized bovine bone in the presence and absence of osteogenic medium. Culture of C2C12 and mouse primary calvarial cells (mPCs) on decellularized bone ECM (bECM) and demineralized bone matrix (DBM) gels resulted in increased expression of osteogenic gene markers, including a 3...
April 21, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28421389/preparation-and-biocompatibility-of-demineralized-bone-matrix-sodium-alginate-putty
#15
Yumin Zhang, Jianru Wang, Yanmiao Ma, Xiaojun Niu, Jianchun Liu, Lan Gao, Xiaoyan Zhai, Kaibo Chu, Bo Han, Liwang Yang, Jue Wang
Demineralized bone matrix (DBM) powder is widely used for bone regeneration due to its osteoinductivity and osteoconductivity. However, difficulties with handling, tendency to migrate from graft sites and lack of stability after surgery sometimes limit the clinical utility of this material. In this work, the possibility of using sodium alginate (ALG) carrier to deliver DBM powder was assessed. DBM-ALG putty with the DBM:ALG weight ratio of 5:5, 6:4, 7:3, 8:2 were prepared, respectively. The properties of the formed composite, including discrete degree, washout property, pH, equilibrium swelling as well as cytotoxicity in vivo, were adopted to ascertain the optimal ratio of DBM and ALG...
June 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28416462/clinical-assessment-of-115-cases-of-hindfoot-fusion-with-two-different-types-of-graft-allograft-dbm-bone-marrow-aspirate-versus-autograft-dbm
#16
M Tricot, P-A Deleu, C Detrembleur, T Leemrijse
INTRODUCTION: Nonunion is a common complication (15%) of hindfoot and ankle arthrodesis. Autograft can improve the fusion rate because of its osteoconductive, osteoinductive and osteogenic properties. However, autograft harvesting is a source of morbidity. One alternative is to combine allograft with demineralized bone matrix (DBM) and iliac bone marrow aspirate (BMA). This combination graft has similar biological properties to healthy bone. When used alone, allograft has osteoconductive and sometimes structural properties...
April 15, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28412469/earliest-phases-of-chondrogenesis-are-dependent-upon-angiogenesis-during-ectopic-bone-formation-in-mice
#17
Beth Bragdon, Stephanie Lam, Sherif Aly, Alexandra Femia, Abigail Clark, Amira Hussein, Elise F Morgan, Louis C Gerstenfeld
Endochondral ossification is the process where cartilage forms prior to ossification and in which new bone forms during both fracture healing and ectopic bone formation. Transitioning to ossification is a highly coordinated process between hypertrophic chondrocytes, vascular endothelial cells, osteoblasts and osteoclasts. A critical biological process that is central to the interactions of these various cell types is angiogenesis. Although it is well established that angiogenesis is crucial for fracture repair, less is known pertaining to the role of angiogenesis in ectopic bone formation...
August 2017: Bone
https://www.readbyqxmd.com/read/28409291/laser-sintered-porous-ti-6al-4v-implants-stimulate-vertical-bone-growth
#18
Alice Cheng, David J Cohen, Adrian Kahn, Ryan M Clohessy, Kaan Sahingur, Joseph B Newton, Sharon L Hyzy, Barbara D Boyan, Zvi Schwartz
The objective of this study was to examine the ability of 3D implants with trabecular-bone-inspired porosity and micro-/nano-rough surfaces to enhance vertical bone ingrowth. Porous Ti-6Al-4V constructs were fabricated via laser-sintering and processed to obtain micro-/nano-rough surfaces. Male and female human osteoblasts were seeded on constructs to analyze cell morphology and response. Implants were then placed on rat calvaria for 10 weeks to assess vertical bone ingrowth, mechanical stability and osseointegration...
April 13, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28385228/comparative-study-on-the-healing-potential-of-chitosan-polymethylmethacrylate-and-demineralized-bone-matrix-in-radial-bone-defects-of-rat
#19
Soodeh Alidadi, Ahmad Oryan, Amin Bigham-Sadegh, Ali Moshiri
This study aimed to compare the effectiveness of xenogeneic demineralized bone matrix (DBM), chitosan (CS), and polymethylmethacrylate (PMMA) on the regeneration of the critical-sized radial bone defects in rats after eight weeks. Fifty bilateral radial bone defects were randomly divided into five groups including untreated defects and those treated with autograft, CS scaffold, PMMA, and DBM. The defects were evaluated by diagnostic imaging, histopathology, histomorphometry, scanning electron microscopy, and biomechanical testing...
June 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28369014/a-comparative-analysis-of-rhbmp-2-dbm-vs-icbg-for-secondary-alveolar-bone-grafts-in-patients-with-cleft-lip-and-palate-review-of-501-cases
#20
Jeffrey A Hammoudeh, Artur Fahradyan, Daniel D Gould, Fan Liang, Thomas Imahiyerobo, Leo Urbinelli, JoAnna T Nguyen, William Magee, Stephen Yen, Mark M Urata
BACKGROUND: Alveolar cleft reconstruction using iliac crest bone graft(ICBG) is considered standard of care for children with complete cleft lip and palate at the time of mixed dentition. Harvesting bone may result in donor site morbidity, additional operating time and length of hospitalization. Recombinant human bone morphogenetic protein(rhBMP)-2 with a demineralized bone matrix(DBM) was used as an alternative bone source for alveolar cleft reconstruction. We investigate the outcomes of rhBMP-2/DBM versus ICBG for alveolar cleft reconstruction by reviewing postoperative surgical complications and cleft closure...
March 31, 2017: Plastic and Reconstructive Surgery
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