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Demineralized bone matrix

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https://www.readbyqxmd.com/read/28429412/bone-extracellular-matrix-hydrogel-enhances-osteogenic-differentiation-of-c2c12-myoblasts-and-mouse-primary-calvarial-cells
#1
Noura Alom, Heather Peto, Glen R Kirkham, Kevin M Shakesheff, Lisa J White
Hydrogel scaffolds derived from the extracellular matrix (ECM) of mammalian tissues have been successfully used to promote tissue repair in vitro and in vivo. The objective of this study was to evaluate the osteogenic potential of ECM hydrogels prepared from demineralized and decellularized bovine bone in the presence and absence of osteogenic medium. Culture of C2C12 and mouse primary calvarial cells (mPCs) on decellularized bone ECM (bECM) and demineralized bone matrix (DBM) gels resulted in increased expression of osteogenic gene markers, including a 3...
April 21, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28421389/preparation-and-biocompatibility-of-demineralized-bone-matrix-sodium-alginate-putty
#2
Yumin Zhang, Jianru Wang, Yanmiao Ma, Xiaojun Niu, Jianchun Liu, Lan Gao, Xiaoyan Zhai, Kaibo Chu, Bo Han, Liwang Yang, Jue Wang
Demineralized bone matrix (DBM) powder is widely used for bone regeneration due to its osteoinductivity and osteoconductivity. However, difficulties with handling, tendency to migrate from graft sites and lack of stability after surgery sometimes limit the clinical utility of this material. In this work, the possibility of using sodium alginate (ALG) carrier to deliver DBM powder was assessed. DBM-ALG putty with the DBM:ALG weight ratio of 5:5, 6:4, 7:3, 8:2 were prepared, respectively. The properties of the formed composite, including discrete degree, washout property, pH, equilibrium swelling as well as cytotoxicity in vivo, were adopted to ascertain the optimal ratio of DBM and ALG...
April 18, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28416462/clinical-assessment-of-115-cases-of-hindfoot-fusion-with-two-different-types-of-graft-allograft-dbm-bone-marrow-aspirate-versus-autograft-dbm
#3
Mathias Tricot, Paul-André Deleu, Christine Detrembleur, Thibaut Leemrijse
INTRODUCTION: Nonunion is a common complication (15%) of hindfoot and ankle arthrodesis. Autograft can improve the fusion rate because of its osteoconductive, osteoinductive and osteogenic properties. However, autograft harvesting is a source of morbidity. One alternative is to combine allograft with demineralized bone matrix (DBM) and iliac bone marrow aspirate (BMA). This combination graft has similar biological properties to healthy bone. When used alone, allograft has osteoconductive and sometimes structural properties...
April 14, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28412469/earliest-phases-of-chondrogenesis-are-dependent-upon-angiogenesis-during-ectopic-bone-formation-in-mice
#4
Beth Bragdon, Stephanie Lam, Sherif Aly, Alexandra Femia, Abigail Clark, Amira Hussein, Elise F Morgan, Louis C Gerstenfeld
Endochondral ossification is the process where cartilage forms prior to ossification and in which new bone forms during both fracture healing and ectopic bone formation. Transitioning to ossification is a highly coordinated process between hypertrophic chondrocytes, vascular endothelial cells, osteoblasts and osteoclasts. A critical biological process that is central to the interactions of these various cell types is angiogenesis. Although it is well established that angiogenesis is crucial for fracture repair, less is known pertaining to the role of angiogenesis in ectopic bone formation...
April 12, 2017: Bone
https://www.readbyqxmd.com/read/28409291/laser-sintered-porous-ti-6al-4v-implants-stimulate-vertical-bone-growth
#5
Alice Cheng, David J Cohen, Adrian Kahn, Ryan M Clohessy, Kaan Sahingur, Joseph B Newton, Sharon L Hyzy, Barbara D Boyan, Zvi Schwartz
The objective of this study was to examine the ability of 3D implants with trabecular-bone-inspired porosity and micro-/nano-rough surfaces to enhance vertical bone ingrowth. Porous Ti-6Al-4V constructs were fabricated via laser-sintering and processed to obtain micro-/nano-rough surfaces. Male and female human osteoblasts were seeded on constructs to analyze cell morphology and response. Implants were then placed on rat calvaria for 10 weeks to assess vertical bone ingrowth, mechanical stability and osseointegration...
April 13, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28385228/comparative-study-on-the-healing-potential-of-chitosan-polymethylmethacrylate-and-demineralized-bone-matrix-in-radial-bone-defects-of-rat
#6
Soodeh Alidadi, Ahmad Oryan, Amin Bigham-Sadegh, Ali Moshiri
This study aimed to compare the effectiveness of xenogeneic demineralized bone matrix (DBM), chitosan (CS), and polymethylmethacrylate (PMMA) on the regeneration of the critical-sized radial bone defects in rats after eight weeks. Fifty bilateral radial bone defects were randomly divided into five groups including untreated defects and those treated with autograft, CS scaffold, PMMA, and DBM. The defects were evaluated by diagnostic imaging, histopathology, histomorphometry, scanning electron microscopy, and biomechanical testing...
June 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28369014/a-comparative-analysis-of-rhbmp-2-dbm-vs-icbg-for-secondary-alveolar-bone-grafts-in-patients-with-cleft-lip-and-palate-review-of-501-cases
#7
Jeffrey A Hammoudeh, Artur Fahradyan, Daniel D Gould, Fan Liang, Thomas Imahiyerobo, Leo Urbinelli, JoAnna T Nguyen, William Magee, Stephen Yen, Mark M Urata
BACKGROUND: Alveolar cleft reconstruction using iliac crest bone graft(ICBG) is considered standard of care for children with complete cleft lip and palate at the time of mixed dentition. Harvesting bone may result in donor site morbidity, additional operating time and length of hospitalization. Recombinant human bone morphogenetic protein(rhBMP)-2 with a demineralized bone matrix(DBM) was used as an alternative bone source for alveolar cleft reconstruction. We investigate the outcomes of rhBMP-2/DBM versus ICBG for alveolar cleft reconstruction by reviewing postoperative surgical complications and cleft closure...
March 31, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28358761/histomorphometric-comparison-of-bone-regeneration-in-critical-sized-bone-defects-using-demineralized-bone-matrix-platelet-rich-fibrin-and-hyaluronic-acid-as-bone-substitutes
#8
Alper Sindel, Ömür Dereci, Havva Serap Toru, Sinan Tozoğlu
AIM: To compare bone regeneration in the critical-sized bone defects grafted with demineralized bone matrix, platelet-rich fibrin, and hyaluronic acid in rats. MATERIALS AND METHODS: Forty Wistar Albino rats allocated into 4 experimental groups: platelet-rich fibrin (PRF) group, noncross-linked hyaluronic acid gel (HA) group, demineralized bone matrix in putty form (DBM) group, and control group. A critical-sized defect of 8 mm was formed involving the sagittal suture for each rat under anesthetic induction...
March 29, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28351338/dbm-as-a-carrier-for-bmp-2-burst-release-combined-with-long-term-binding-and-osteoinductive-activity-evaluated-in-vitro-and-in-vivo
#9
Elisabeth Huber, Anne-Marie Pobloth, Nicole Bormann, Nicolai Kolarczik, Katharina Schmidt-Bleek, Hanna Schell, Philipp Schwabe, Georg Duda, Britt Wildemann
To allow bone defect regeneration, autologous bone grafting still represents the gold standard. However, autograft harvesting has limitations including an additional surgery, donor site morbidity and limited availability. Demineralized bone matrix (DBM) would represent an alternative, yet lacks sufficient osteoinductive properties. Combining DBM with a potent agent such as bone morphogenetic protein-2 (BMP-2) might be a feasible alternative approach, optimizing an established grafting material with strong osteoinductive properties...
March 29, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28350271/human-tooth-derived-biomaterial-as-a-graft-substitute-for-hard-tissue-regeneration
#10
Girdhari Rijal, Hong-In Shin
AIM: The present study was conducted to evaluate the efficacy of human dentine grafts for new bone augmentation. MATERIALS & METHODS: Dentine grafts (demineralized dentine matrix [DDM]) and mineralized dentine matrix [MDM]) were prepared and implanted in rats. Tetracycline was administered twice. Paraffin and resin sections were prepared from the harvested grafts and stained respectively with hemotoxylin and eosin (in addition to tartrate acid phosphatase for osteoclasts) and Villanueva...
March 28, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28321651/effects-of-strontium-ranelate-treatment-on-osteoblasts-cultivated-onto-scaffolds-of-trabeculae-bovine-bone
#11
Gerluza Aparecida Borges Silva, Bruno Machado Bertassoli, Cristiane Aparecida Sousa, Juliano Douglas Albergaria, Rayan Silva de Paula, Erika Cristina Jorge
Blocks of Bovine bone have shown promising results as implantable scaffolds to promote bone regeneration. Strontium ranelate (SrR) is both an antiresorptive and an anabolic drug that has been indicated for oral administration to treat osteoporosis. Few studies, however, have investigated the local effects of SrR and its use in association with biomaterials thus far. In this work, we investigated SrR effects in cultures of primary osteoblasts (PO, from Wistar rats calvaria) and immortalized osteoblasts (IO, from MC3T3-E1 cell line) cultivated as a monolayer or in association with scaffolds of bovine bone in mineralized (MBB) and demineralized (DBB) forms...
March 20, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28264244/demineralized-bone-matrix-dbm-as-a-bone-void-filler-in-lumbar-interbody-fusion-a-prospective-pilot-study-of-simultaneous-dbm-and-autologous-bone-grafts
#12
Bum-Joon Kim, Se-Hoon Kim, Haebin Lee, Seung-Hwan Lee, Won-Hyung Kim, Sung-Won Jin
OBJECTIVE: Solid bone fusion is an essential process in spinal stabilization surgery. Recently, as several minimally invasive spinal surgeries have developed, a need of artificial bone substitutes such as demineralized bone matrix (DBM), has arisen. We investigated the in vivo bone growth rate of DBM as a bone void filler compared to a local autologous bone grafts. METHODS: From April 2014 to August 2015, 20 patients with a one or two-level spinal stenosis were included...
March 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28264242/polyetheretherketone-cage-with-demineralized-bone-matrix-can-replace-iliac-crest-autografts-for-anterior-cervical-discectomy-and-fusion-in-subaxial-cervical-spine-injuries
#13
Soo-Han Kim, Jung-Kil Lee, Jae-Won Jang, Hyun-Woong Park, Hyuk Hur
OBJECTIVE: This study aimed to compare the clinical and radiologic outcomes of patients with subaxial cervical injury who underwent anterior cervical discectomy and fusion (ACDF) with autologous iliac bone graft or polyetheretherketone (PEEK) cages using demineralized bone matrix (DBM). METHODS: From January 2005 to December 2010, 70 patients who underwent one-level ACDF with plate fixation for post-traumatic subaxial cervical spinal injury in a single institution were retrospectively investigated...
March 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28253279/demineralized-bone-matrix-used-for-direct-pulp-capping-in-rats
#14
Qian Liu, Yanhong Ma, Junlan Wang, Xuefang Zhu, Yanjing Yang, Yufeng Mei
OBJECTIVES: To evaluate the wound healing process following direct pulp capping with demineralized bone matrix (DBM) and calcium hydroxide (Ca(OH)2). METHODS: Fifty 8-weeks-old SPF Wistar male rats were divided into two groups: one was the DBM treated group, and the other was the Ca(OH)2 treated group. Pulpotomy was performed on the maxillary first molar of one side of each rat, and the another side was left as the blank control. Rats were sacrificed after each observation period (1, 3, 7, 14 and 28 days) and specimen slices were made...
2017: PloS One
https://www.readbyqxmd.com/read/28240608/evaluation-of-extraction-site-dimensions-and-density-using-computed-tomography-treated-with-different-graft-materials-a-preliminary-study
#15
Filiz Hyusein Cavdar, Huseyin Gencay Keceli, Hasan Hatipoglu, Burak Demiralp, Feriha Caglayan
PURPOSE: The preliminary human study was designed to evaluate extraction site changes using CT after socket preservation (SP) with different materials. MATERIALS AND METHODS: Fifty-two sockets from 17 Turkish individuals (8 women and 9 men; mean age 44.70 ± 9.99 years) localized at the maxillary anterior area were treated with demineralized bone matrix + collagen membrane (CM) (N = 14), hydroxyapatite bone substitute (HBS) + CM (N = 14), CM (N = 13), or left empty (N = 11)...
April 2017: Implant Dentistry
https://www.readbyqxmd.com/read/28214897/mir-125b-regulates-the-osteogenic-differentiation-of-human-mesenchymal-stem-cells-by-targeting-bmpr1b
#16
Huaqing Wang, Zhao Xie, Tianyong Hou, Zhiqiang Li, Ke Huang, Jicheng Gong, Wei Zhou, Kanglai Tang, Jianzhong Xu, Shiwu Dong
BACKGROUND/AIMS: Osteogenic differentiation of mesenchymal stem cells (MSCs) plays a crucial role in bone regeneration and bone reparation. This complex process is regulated precisely and firmly by specific factors. Recent studies have demonstrated that miR-125b regulates osteogenic differentiation, but little is known about the molecular mechanisms of this regulation. Furthermore, how miR-125b regulates the osteogenic differentiation of MSCs still needs elucidation. METHODS: In the present study, human bone marrow-derived mesenchymal stem cells (hBMSCs) were isolated and induced to osteoblasts with miR-125b inhibition or overexpression...
January 31, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28207623/feasibility-of-percutaneous-posterolateral-spinal-fusion-with-recombinant-bone-morphogenetic-protein-2-rhbmp-2-a-comparison-with-standard-methods-using-an-animal-model-study
#17
Chris Yin Wei Chan, Mun Keong Kwan, Lim Beng Saw, Hussin Paisal
BACKGROUND CONTEXT: The clinical application of recombinant bone morphogenetic protein in spinal surgery has been shown to be safe and effective. However, its use in minimally invasive spine surgery has been limited to anterior interbody fusion procedures. To date, no study has evaluated the feasibility of percutaneous posterolateral fusion in the spine utilizing recombinant bone morphogenetic protein-2 (rhBMP-2). PURPOSE: To evaluate the feasibility of percutaneous posterolateral fusion in the spine utilizing rhBMP-2...
March 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28193541/a-nano-scaled-and-multi-layered-recombinant-fibronectin-cadherin-chimera-composite-selectively-concentrates-osteogenesis-related-cells-and-factors-to-aid-bone-repair
#18
Junchao Xing, Tieniu Mei, Keyu Luo, Zhiqiang Li, Aijun Yang, Zhilin Li, Zhao Xie, Zehua Zhang, Shiwu Dong, Tianyong Hou, Jianzhong Xu, Fei Luo
Easily accessible and effective bone grafts are in urgent need in clinic. The selective cell retention (SCR) strategy, by which osteogenesis-related cells and factors are enriched from bone marrow into bio-scaffolds, holds great promise. However, the retention efficacy is limited by the relatively low densities of osteogenesis-related cells and factors in marrow; in addition, a lack of satisfactory surface modifiers for scaffolds further exacerbates the dilemma. To address this issue, a multi-layered construct consisting of a recombinant fibronectin/cadherin chimera was established via a layer-by-layer self-assembly technique (LBL-rFN/CDH) and used to modify demineralised bone matrix (DBM) scaffolds...
February 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28188395/marshall-r-urist-and-the-discovery-of-bone-morphogenetic-proteins
#19
Lovorka Grgurevic, Marko Pecina, Slobodan Vukicevic
Over the last 40 years International Orthopaedics has published a series of articles on bone morphogenetic proteins (BMPs) covering topics from basic research to clinical applications. This includes also work submitted from the Laboratory for Mineralized Tissues of the School of Medicine University of Zagreb. Accordingly, we felt obliged to give a short summary of Dr. Urist's life and work as our gratitude to his discovery that demineralized bone matrix (DBM) activity induces bone when implanted ectopically into the muscle or under the skin due to bone inducing proteins, named BMPs...
February 11, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28174633/long-term-follow-up-of-autogenous-tooth-bone-graft-blocks-with-dental-implants
#20
Young-Kyun Kim, Kang-Mi Pang, Pil-Young Yun, Dae-Ho Leem, In-Woong Um
Demineralized dentin matrix block (ABTB: Autogenous Tooth Bone Graft Block) is 3-D scaffold with same components and geometry with alveolar bone. ABTB is well incorporated and remodelled into cortico-cancellous bone with dental implant. The shape and volume were maintained with little marginal bone loss after average 44 months of follow-up.
February 2017: Clinical Case Reports
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