keyword
MENU ▼
Read by QxMD icon Read
search

Anti NMO neuritis

keyword
https://www.readbyqxmd.com/read/30487360/-elderly-onset-case-of-neuromyelitis-optica-that-developed-at-the-age-of-90
#1
Mai Kikumoto, Megumi Nonaka, Jun Takeshita, Tomohiko Ohshita, Hiroshi Yamashita
We report a case of neuromyelitis optica (NMO) that was diagnosed at the age of 90. After initially developing visual loss in the right eye, a patient was diagnosed with optic neuritis. Although treatment with methylprednisolone therapy provided relief, 3 months later she developed optic neuritis on the other side. Visual activity recovered after further administration of methylprednisolone. At the age of 91, she presented with muscle weakness of her left extremities. A cervical MRI revealed myelitis with a longitudinally extensive spinal cord lesion from the second to fifth cervical vertebrae...
November 29, 2018: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/30448469/hiv-infection-associated-neuromyelitis-optica-spectrum-disorder-clinical-features-imaging-findings-management-and-outcomes
#2
Thomas Mathew, Amrutha Avati, Delon D'Souza, Manjusha Therambil, Anita Angela Baptist, Asha Shaji, Raghunandan Nadig, Smitha Mary Rockey, Gareth Parry
INTRODUCTION: HIV Infection associated NMOSD (HIV-NMOSD) is a recently recognized entity. Management of patients with HIV-NMOSD is a challenge. Here we report our own experience of HIV-NMOSD along with a complete review of all the cases of HIV-NMOSD reported in literature. OBJECTIVE: Describe the clinical features, radiological findings, treatment patterns and outcomes in patients with HIV-NMOSD. METHODS: The details of all cases of HIV- NMOSD were searched from our NMOSD registry...
November 13, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/30368225/comparing-myelin-oligodendrocyte-glycoprotein-antibody-mog-ab-and-non-mog-ab-associated-optic-neuritis-clinical-course-and-treatment-outcome
#3
Masoud Etemadifar, Maedeh Abbasi, Mehri Salari, Fatemeh Etemadifar, Hossein Tavakoli
BACKGROUND: Recent studies have suggested that anti-MOG antibodies and optic neuritis are associated and anti-MOG antibody positive patients have had better recoveries. The purpose of this study was to compare the clinical course and treatment outcome of MOG-Ab associated and non-MOG-Ab associated ON. METHODS: Patients diagnosed with optic neuritis were referred for brain and cervical MRI. Blood samples were also taken to measure MOG antibody and NMO antibody levels...
October 19, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/30122840/therapeutic-efficacy-of-plasma-exchange-in-neuromyelitis-optica
#4
Rajesh Kumar, Birinder Singh Paul, Gagandeep Singh, Amarjit Kaur
Background: Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that selectively affects the optic nerves and spinal cord and generally follows a relapsing course. Therapeutic plasma exchange (TPE) appears to be effective in patients with central nervous system inflammatory demyelinating disease who do not respond to first-line corticosteroid treatment. Objective: We represent a retrospective review of the use of TPE in the treatment of an acute attack of NMO in five patients who failed to respond to initial immunomodulatory treatment...
April 2018: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/29676196/contiguous-and-symmetrical-disease-expansion-and-massive-necrosis-of-the-cerebral-white-matter-in-a-patient-with-neuromyelitis-optica
#5
Chiho Ishida, Tokuhei Ikeda, Kiyonobu Komai, Kazuya Takahashi, Moeko Noguchi-Shinohara, Masahito Yamada
The present report discusses the case of a woman with neuromyelitis optica (NMO) who exhibited bilateral optic neuritis, longitudinally extensive myelitis, serum anti-aquaporin-4 antibodies, and a unique pattern of white matter involvement. The disease duration was 26 years, and the patient died at the age of 65 years. Sequential magnetic resonance images obtained during the last 6 years of life revealed leukoencephalopathy-like lesions extending symmetrically and contiguously from the periventricular regions, which had begun to transform into multiple cavities with semi-annular partitions...
August 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29526320/optic-neuritis-in-paediatric-patients-experience-over-27-years-and-a-management-protocol
#6
L Monge Galindo, A L Martínez de Morentín, V Pueyo Royo, J P García Iñiguez, S Sánchez Marco, J López-Pisón, J L Peña-Segura
INTRODUCTION AND OBJECTIVE: In this article, we present our experience on optic neuritis (ON) and provide a diagnostic/therapeutic protocol, intended to rule out other aetiologies (particularly infection), and a fact sheet for parents. MATERIAL AND METHODS: We conducted a descriptive, retrospective study of patients with ON over a 27-year period (1990-2017). A review of the available scientific evidence was performed in order to draft the protocol and fact sheet...
March 8, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/29507012/sle-presenting-as-demyelinative-autoimmune-visual-loss
#7
Ami Schattner, Shilo Voichanski, Livnat Uliel
A healthy 38-year-old woman developed sudden unilateral vision loss due to retrobulbar optic neuritis in the wake of varicella-zoster virus infection. She had no further central nervous system (CNS) lesions. Antinuclear antibodies (ANA) and anti-aquaporin 4 antibodies were found, consistent with neuromyelitis optica (NMO). Later, serial MRIs showed dynamic short-segment and long-segment myelitis lesions, ANA titre increased and additional autoantibodies were found including anti-dsDNA, anti-chromatin/nucleosome and antiphospholipid antibodies...
March 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29306405/chloride-imbalance-between-serum-and-csf-in-the-acute-phase-of-neuromyelitis-optica
#8
Tetsuya Akaishi, Toshiyuki Takahashi, Ichiro Nakashima
We collected serum-cerebrospinal fluid (CSF)-paired samples during the acute phase of clinical episodes in MS and NMO patients, together with paired samples from non-MS/NMO patients, to compare the quotients of proteins and electrolytes among them. In NMO, the quotient of chloride was significantly higher in the acute phase of optic neuritis and brain lesions, but it was significantly lower in the acute phase of myelitis. Such findings were not observed in MS or in non-MS/NMO cases. With the coexistence of serum anti-AQP4-Ab, chloride imbalance between serum and CSF could be associated with the clinical episodes in NMO...
February 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29025172/-anti-myelin-oligodendrocyte-glycoprotein-antibodies-in-paediatric-patients-with-optic-neuritis
#9
Helmut Tegetmeyer, Andreas Merkenschlager
Background Myelin oligodendrocyte glycoprotein (MOG) is located on the surface of oligodendrocytes and myelin in the central nervous system. MOG-IgG is associated with acute disseminated encephalomyelitis (ADEM), relapsing and bilateral optic neuritis (NNO), and transverse myelitis (TM) in both paediatric and adult patients. The combination of NNO and TM or other inflammatory brain lesions is a typical feature of neuromyelitis optica spectrum disorders (NMO-SD) which are associated with specific pathogenic autoantibodies against the water channel aquaporin-4 (AQP4-IgG)...
October 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28391784/neuromyelitis-optica-spectrum-disorders
#10
REVIEW
Tetsuya Akaishi, Ichiro Nakashima, Douglas Kazutoshi Sato, Toshiyuki Takahashi, Kazuo Fujihara
Neuromyelitis optica (NMO) is clinically characterized by severe optic neuritis and transverse myelitis, but recent studies with anti-aquaporin-4-antibody specific to NMO have revealed that the clinical spectrum is wider than previously thought. International consensus diagnostic criteria propose NMO spectrum disorders (NMOSD) as the term to define the entire spectrum including typical NMO, optic neuritis, acute myelitis, brain syndrome, and their combinations. NMOSD is now divided into anti-aquaporin-4-antibody-seropositive NMOSD and -seronegative NMOSD (or unknown serostatus)...
May 2017: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/27928328/spontaneous-recovery-of-neuromyelitis-optica-spectrum-disorder-during-pregnancy
#11
Ryutaro Akiba, Toshiyuki Oshitari, Hirotaka Yokouchi, Takayuki Baba, Shuichi Yamamoto
Neuromyelitis optica spectrum disorder (NMO-SD) is an autoimmune inflammatory disorder associated with the anti-aquaporin-4 (AQP4) antibody. Over 90% of NMO-SD patients have poor prognosis, and pregnancy is a disease-worsening factor. The authors report the findings in a case of NMO-SD that recovered spontaneously during pregnancy. A 28-years-old woman developed optic neuritis (ON) of the right eye in the 14th week of pregnancy. Her best-correlated visual acuity (BCVA) was 0.02 OD, the critical flicker frequency (CFF) was not measurable, and the mean deviation (MD) of the Humphrey perimetry 30-2 was -42 dB...
February 2015: Neuro-ophthalmology
https://www.readbyqxmd.com/read/27928290/neuromyelitis-optica-spectrum-disorder-in-a-chinese-woman-with-ocular-myasthenia-gravis-first-reported-case-in-the-chinese-population
#12
Gordon S K Yau, Jacky W Y Lee, Theo T K Chan, Can Y F Yuen
Coexisting myasthenia gravis and neuromyelitis optica spectrum disorder was reported as a rare association, with only 26 reported cases in the literature. The authors report the case of a middle-aged Chinese woman with bilateral recurrent optic neuritis and seropositive ocular myasthenia gravis who was subsequently diagnosed with neuromyelitis optica spectrum. She was tested seropositive for the neuromyelitis optica immunoglobulin G (NMO-IgG) and had elevated antinuclear antibody titres, but workup for other autoimmune disorders were negative...
2014: Neuro-ophthalmology
https://www.readbyqxmd.com/read/27806869/serum-specam-1-and-svcam-1-levels-are-associated-with-conversion-to-multiple-sclerosis-in-patients-with-optic-neuritis
#13
Alicja Kalinowska-Łyszczarz, Sławomir Michalak, Mikołaj A Pawlak, Jacek Losy, Wojciech Kozubski
Platelet-Endothelial-Cell-Adhesion-Molecule-1 (PECAM-1) and Human-Vascular-CAM-1 (VCAM-1) are adhesion molecules involved in leukocyte-endothelial interaction. In our study serum levels of sPECAM-1 and sVCAM-1 were measured (ELISA) in twenty-nine patients during their first monosymptomatic optic neuritis (ON) episode. Anti-aquaporin-4-antibodies (AQP4-IgG) were detected with the cell-based assay. Patients were followed for seven years, during which 16/24 AQP4-IgG (-) patients developed MS and 2/5 AQP4-IgG (+) patients developed NMO...
November 15, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27645337/how-long-does-it-take-to-diagnose-patients-with-neuromyelitis-optica-nmo-using-the-2006-diagnostic-criteria
#14
Tanawat Tengsirikomol, Sasitorn Siritho, Naraporn Prayoonwiwat
BACKGROUND AND PURPOSE: A few reports studied the time use to diagnose patient with neuromyelitis optica (NMO). The Aim of the study is to evaluate the interval from disease onset to the time when patients fulfilled the NMO diagnostic criteria 2006 in Thai. METHOD: A retrospective study of the NMO patients visiting the MS clinic and related disorders at Siriraj hospital was reviewed. RESULTS: There were 42 definite NMO. All were female. The most common first presentations were optic neuritis (ON) (45...
September 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27538635/clinical-characteristics-of-disabling-attacks-at-onset-in-patients-with-neuromyelitis-optica-spectrum-disorder
#15
Jin Myoung Seok, Eun Bin Cho, Hye Lim Lee, Hye-Jin Cho, Ju-Hong Min, Kwang Ho Lee, Byoung Joon Kim
BACKGROUND: Individual attacks of neuromyelitis optica (NMO) are generally severe enough to cause disability even after the onset attack. We aimed to elucidate the clinical characteristics of disabling attacks at the onset of NMO. METHODS: We investigated the clinical characteristics at onset and at first relapse in patients with NMO or NMO spectrum disorder with seropositive for the anti-aquaporin-4 antibody. A disabling attack at onset (DAO) was defined as an onset attack in which, at best recovery (allowing up to one year), patients were unable to walk without assistance or were left functionally blind in at least one affected eye...
September 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27455255/comparative-analysis-for-the-presence-of-igg-anti-aquaporin-1-in-patients-with-nmo-spectrum-disorders
#16
COMPARATIVE STUDY
Ismael Sánchez Gomar, María Díaz Sánchez, Antonio José Uclés Sánchez, José Luis Casado Chocán, Nela Suárez-Luna, Reposo Ramírez-Lorca, Javier Villadiego, Juan José Toledo-Aral, Miriam Echevarría
Detection of IgG anti-Aquaporin-4 (AQP4) in serum of patients with Neuromyelitis optica syndrome disorders (NMOSD) has improved diagnosis of these processes and differentiation from Multiple sclerosis (MS). Recent findings also claim that a subgroup of patients with NMOSD, serum negative for IgG-anti-AQP4, present antibodies anti-AQP1 instead. Explore the presence of IgG-anti-AQP1 using a previously developed cell-based assay (CBA) highly sensitive to IgG-anti-AQP4. Serum of 205 patients diagnosed as NMOSD (8), multiple sclerosis (94), optic neuritis (39), idiopathic myelitis (29), other idiopathic demyelinating disorders of the central nervous system (9), other neurological diseases (18) and healthy controls (8), were used in a CBA over fixed HEK cells transfected with hAQP1-EGFP or hM23-AQP4-EGFP, treated with Triton X-100 and untreated...
July 23, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27349083/-anti-mog-neuromyelitis-optica-spectrum-disorders-treated-with-plasmapheresis
#17
Azusa Oshiro, Sadao Nakamura, Kunihito Tamashiro, Kazuo Fujihara
A 10-year-old boy developed bilateral optic neuritis and myelitis after a suspected viral infection and appendicitis. Magnetic resonance imaging (MRI) showed multiple lesions in both optic nerves, the optic chiasm, and the spinal cord. Several small lesions were also observed in the cerebellum and cerebral white matter. The serum tested negative for anti-aquaporin (AQP)-4 antibody and positive for anti-myelin oligodendrocyte glycoprotein (MOG) antibody. The diagnosis was neuromyelitis optica spectrum disorder (NMOSD)...
May 2016: No to Hattatsu. Brain and Development
https://www.readbyqxmd.com/read/27167974/common-and-rare-manifestations-of-neuromyelitis-optica-spectrum-disorder
#18
REVIEW
Dominique Rosales, Ilya Kister
The discovery of a highly specific biomarker of neuromyelitis optica (NMO)-the anti-aquaporin-4 (AQP4) antibody-has opened new paths to understanding disease pathogenesis and afforded a way to confirm the diagnosis in clinical practice. An important consequence of the discovery is the broadening of the spectrum of syndromes seen in the context of AQP4 autoimmunity. These syndromes have been subsumed under the rubric of NMO spectrum disorder (NMOSD). The current classification recognizes not only optic neuritis and myelitis as core syndromes of NMOSD but also cerebral, diencephalic, brainstem, and area postrema syndromes...
June 2016: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/27049558/lesion-length-of-optic-neuritis-impacts-visual-prognosis-in-neuromyelitis-optica
#19
Tetsuya Akaishi, Ichiro Nakashima, Takayuki Takeshita, Shunji Mugikura, Douglas Kazutoshi Sato, Toshiyuki Takahashi, Shuhei Nishiyama, Kazuhiro Kurosawa, Tatsuro Misu, Toru Nakazawa, Masashi Aoki, Kazuo Fujihara
OBJECTIVES: The visual acuity prognoses of patients with neuromyelitis optica (NMO) are worse than those with optic neuritis (ON) caused by other diseases. Predicting the prognoses of ON at the time of onset is important for selecting treatments for NMO patients. METHODS: Twenty-three consecutive anti-aquaporin-4 autoantibody-positive NMO patients who presented with ON and had contrast-enhanced optic MRIs in the acute phase of their first ON episode were examined...
April 15, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/26514655/hypothalamic-abnormality-in-patients-with-inflammatory-demyelinating-disorders
#20
Cong Gao, Linzhan Wu, Xiaohui Chen, Youming Long, Rong Zhong, Ning Yang, Yaotang Chen
BACKGROUND: Hypothalamic lesions in neuromyelitis optica (NMO) patients might be more specific for NMO than multiple sclerosis (MS). However, this is controversial. OBJECTIVE: To characterize clinical features of patients with inflammatory demyelinating disorders (IDDs) with visible hypothalamic lesions using magnetic resonance imaging (MRI). METHODS: Patients with IDDs (n = 429) were recruited retrospectively. RESULTS: Of 52 patients with hypothalamic images enrolled, 42 were positive for aquaporin-4 (AQP4) antibodies, including 28 patients with NMO, 6 with recurrent transverse myelitis, 3 with recurrent optic neuritis, and 5 with brainstem and brain syndrome...
November 2016: International Journal of Neuroscience
keyword
keyword
166099
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"