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JOURNAL ARTICLE
Claudia Guízar-Sánchez, Cristina Hernández-Díaz, Diana Guízar-Sánchez, Ana Victoria Meza-Sánchez, Alejandra Torres-Serrano, María Elena Camacho Cruz, Lucio Ventura-Ríos
BACKGROUND: In cerebral palsy (CP), spasticity is the dominant symptom and hip pain is one of the most common secondary conditions. Aetiology is not clear. Musculoskeletal ultrasound (MSUS) is a low-cost, non-invasive imaging technique that allows assessment of structural status, dynamic imaging, and quick contralateral comparison. OBJECTIVE: A retrospective case-matched-control study. To investigate associated factors with painful spastic hip and to compare ultrasound findings (focusing on muscle thickness) in children with CP vs...
June 22, 2023: BMC Musculoskeletal Disorders
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JOURNAL ARTICLE
Faliang Zhou, Zhao Yang, Zezhong Tang, Yang Zhang, Hongmei Wang, Guoyu Sun, Rui Zhang, Yi Jiang, Congle Zhou, Xinlin Hou, Lili Liu
AIM: To assess the etiologies and adverse outcomes of infantile acquired hydrocephalus and predict prognosis. METHODS: A total of 129 infants diagnosed with acquired hydrocephalus were recruited from 2008 to 2021. Adverse outcomes included death and significant neurodevelopmental impairment which was defined as Bayley Scales of Infant and Toddler Development III score < 70, cerebral palsy, visual or hearing impairment, and epilepsy. Chi-squared was used to evaluate the prognostic factors of adverse outcomes...
May 24, 2023: BMC Pediatrics
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JOURNAL ARTICLE
Hyun Iee Shin, Myung Woo Park, Woo Hyung Lee
An estimated 15 million infants are born each year prematurely. Although the survival rate of preterm infants has increased with advances in perinatal and neonatal care, many of them still suffer from various complications. Since improving neurodevelopmental outcomes of preterm births are a crucial topic of interest, accurate evaluations should be preceded for the detection of high-risk infants for cerebral palsy. General movements are spontaneous movements involving the whole body as the expression of neural activity and can be an excellent biomarker of neural dysfunction caused by brain impairment in preterm infants...
May 16, 2023: Clinical and experimental pediatrics
#24
JOURNAL ARTICLE
Charlotte Binder, Pauline Schmid, Harald Abele, Joachim Graf
Introduction Premature births have a significantly increased risk of developing cerebral palsy. This clinical picture involves great restrictions and impairments in the lives of the children and their families. Its prevention is therefore of great importance. One method of neuroprotection to reduce the rate of infantile cerebral palsy is the antenatal administration of magnesium sulfate to the mother. The aim of this paper is to present the current state of research of existing reviews and meta-analyses on the topic and to review the evidence for this intervention...
May 2023: Geburtshilfe und Frauenheilkunde
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JOURNAL ARTICLE
Asunción Ferri-Morales, Rocío Palomo Carrión, Sara Ando-LaFuente, Rubén Arroyo Fernández, Jose Ignacio Calvo Arenillas, Virgilia Antón-Antón, Elisabeth Bravo Esteban
INTRODUCTION: Children with infantile hemiplegia with low or very low bimanual functional performance have great impediments to spontaneously use their affected upper limb, which affects their performance of day-to-day activities and their quality of life. OBJECTIVE: The main objective of our study was to determine whether the order of application and the dose of modified Constraint Induced Movement Therapy within a combined (hybrid) protocol influences the results of bimanual functional performance of the affected upper limb and the quality of life of children with congenital hemiplegia (5-8 years old) with very low/low bimanual functional performance...
May 4, 2023: PM & R: the Journal of Injury, Function, and Rehabilitation
#26
JOURNAL ARTICLE
Juntaek Hong, Dong-Wook Rha
Technological advances in neonatology led to the improvement of the survival rate in preterm babies with very low birth weights. However, intraventricular hemorrhage (IVH) has been one of the major complications of prematurity. IVH is relevant to neurodevelopmental disorders, such as cerebral palsy, language and cognitive impairments, and neurosensory and psychiatric problems, especially when combined with brain parenchymal injuries. Additionally, severe IVH requiring shunt insertion is associated with a higher risk of adverse neurodevelopmental outcomes...
May 2023: Journal of Korean Neurosurgical Society
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JOURNAL ARTICLE
Characteristics and Challenges of Epilepsy in Children with Cerebral Palsy-A Population-Based Study.
Ana Dos Santos Rufino, Magnus Påhlman, Ingrid Olsson, Kate Himmelmann
The aim of this population-based study was to describe the prevalence and characteristics of epilepsy in children with cerebral palsy (CP), focusing on antiseizure medication (ASM) and seizure outcome. Findings were related to CP type, gross motor function and associated impairments. Data on all 140 children with CP born in 2003-2006 were taken from the CP register of Western Sweden. Medical records were reviewed at ages 9-12 and 13-16 years. In total 43% had a diagnosis of epilepsy. Epilepsy was more common in children with dyskinetic CP, who more often had a history of infantile spasms, continuous spike-and-wave during sleep and status epilepticus...
January 1, 2023: Journal of Clinical Medicine
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JOURNAL ARTICLE
Kuan-Ru Chen, Tsung Yu, Yueh-Ju Lien, Yen-Yin Chou, Pao-Lin Kuo
AIM: To assess the risk of a wide spectrum of neurodevelopmental disorders (NDDs) in offspring of mothers with type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), and gestational diabetes mellitus (GDM). METHOD: This retrospective cohort study included 877 233 singletons born between 2004 and 2008 in Taiwan. Children were followed up to 2015 for diagnoses of NDDs, including autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), developmental delay, intellectual disability, cerebral palsy, and epilepsy/infantile spasms using health insurance claims data...
December 21, 2022: Developmental Medicine and Child Neurology
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REVIEW
Nikki Milne, Lauren Longeri, Anokhi Patel, Jan Pool, Kenneth Olson, Annalie Basson, Anita R Gross
PURPOSE: To i) identify and map the available evidence regarding effectiveness and harms of spinal manipulation and mobilisation for infants, children and adolescents with a broad range of conditions; ii) identify and synthesise policies, regulations, position statements and practice guidelines informing their clinical use. DESIGN: Systematic scoping review, utilising four electronic databases (PubMed, Embase, CINHAL and Cochrane) and grey literature from root to 4th February 2021...
December 19, 2022: BMC Pediatrics
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REVIEW
Arne Jensen
Cerebral palsy, the most common disability in childhood, is a devastating non-progressive ailment of the infants' brain with lifelong sequelae, e.g., spastic paresis, chronic pain, inability to walk, intellectual disability, behavioral disorders, for which there is no cure at present. CP may develop after pediatric brain damage caused, e.g., by hypoxic-ischemia, periventricular leukomalacia, intracranial hemorrhage, hypoxic-ischemic encephalopathy, trauma, stroke, and infection. About 17 million people worldwide live with cerebral palsy as a result of pediatric brain damage...
July 26, 2023: Journal of Perinatal Medicine
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JOURNAL ARTICLE
Rocío Palomo-Carrión, Elena Pinero-Pinto, Helena Romay-Barrero, Isabel Escobio-Prieto, Carmen Lillo-Navarro, Rita-Pilar Romero-Galisteo
BACKGROUND: It is crucial to start an early intervention in unilateral cerebral palsy. Intensive therapies are focused on training based on activities. OBJECTIVE: The objective of the study was to study the changes in the bimanual functional performance (BFP) after early intensive therapies at home compared with standard care in children with unilateral cerebral palsy from 9 to 18 months of age. DESIGN: A single-blind comparative effectiveness study will be conducted...
2022: Therapeutic Advances in Chronic Disease
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JOURNAL ARTICLE
Viviana Lo Buono, Michele Torrisi, Simona Leonardi, Alessandra Pidalà, Francesco Corallo
RATIONALE: Spastic quadriplegia is most severe form of Infantile Cerebral Palsy. Patients are unable to use their legs, arms and body and show language disorder and profound intellectual disability. The treatment of patients diagnosed with spastic quadriplegia is complex and multidisciplinary. In this case report we described the positive effect of multisensory environment (MSEs) rehabilitation, and the strategies and technologies used to provide child who have to severe spastic quadriplegia and intellectual disability, palsy with playful and fun activities designed according to his abilities...
November 18, 2022: Medicine (Baltimore)
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JOURNAL ARTICLE
Mark D Peterson, Allecia M Wilson, Edward A Hurvitz
BACKGROUND: Adults with cerebral palsy (CP) represent a growing population whose healthcare needs are poorly understood. The purpose of this study was to examine trends in the underlying causes of death (UCOD) among adults with CP in the United States. METHODS: A national cohort was created from the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (WONDER) database from 1999 to 2019. The UCOD was determined using the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10 code G80x, Infantile CP) based on death certificate adjudication...
October 27, 2022: Journal of Clinical Medicine
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JOURNAL ARTICLE
Ken Saida, Reza Maroofian, Toru Sengoku, Tadahiro Mitani, Alistair T Pagnamenta, Dana Marafi, Maha S Zaki, Thomas J O'Brien, Ehsan Ghayoor Karimiani, Rauan Kaiyrzhanov, Marina Takizawa, Sachiko Ohori, Huey Yin Leong, Gulsen Akay, Hamid Galehdari, Mina Zamani, Ratna Romy, Christopher J Carroll, Mehran Beiraghi Toosi, Farah Ashrafzadeh, Shima Imannezhad, Hadis Malek, Najmeh Ahangari, Hoda Tomoum, Vykuntaraju K Gowda, Varunvenkat M Srinivasan, David Murphy, Natalia Dominik, Hasnaa M Elbendary, Karima Rafat, Sanem Yilmaz, Seda Kanmaz, Mine Serin, Deepa Krishnakumar, Alice Gardham, Anna Maw, Tekki Sreenivasa Rao, Sarah Alsubhi, Myriam Srour, Daniela Buhas, Tamison Jewett, Rachel E Goldberg, Hanan Shamseldin, Eirik Frengen, Doriana Misceo, Petter Strømme, José Ricardo Magliocco Ceroni, Chong Ae Kim, Gozde Yesil, Esma Sengenc, Serhat Guler, Mariam Hull, Mered Parnes, Dilek Aktas, Banu Anlar, Yavuz Bayram, Davut Pehlivan, Jennifer E Posey, Shahryar Alavi, Seyed Ali Madani Manshadi, Hamad Alzaidan, Mohammad Al-Owain, Lama Alabdi, Ferdous Abdulwahab, Futoshi Sekiguchi, Kohei Hamanaka, Atsushi Fujita, Yuri Uchiyama, Takeshi Mizuguchi, Satoko Miyatake, Noriko Miyake, Reem M Elshafie, Kamran Salayev, Ulviyya Guliyeva, Fowzan S Alkuraya, Joseph G Gleeson, Kristin G Monaghan, Katherine G Langley, Hui Yang, Mahsa Motavaf, Saeid Safari, Mozhgan Alipour, Kazuhiro Ogata, André E X Brown, James R Lupski, Henry Houlden, Naomichi Matsumoto
PURPOSE: Brain monoamine vesicular transport disease is an infantile-onset movement disorder that mimics cerebral palsy. In 2013, the homozygous SLC18A2 variant, p.Pro387Leu, was first reported as a cause of this rare disorder, and dopamine agonists were efficient for treating affected individuals from a single large family. To date, only 6 variants have been reported. In this study, we evaluated genotype-phenotype correlations in individuals with biallelic SLC18A2 variants. METHODS: A total of 42 affected individuals with homozygous SLC18A2 variant alleles were identified...
October 31, 2022: Genetics in Medicine: Official Journal of the American College of Medical Genetics
#35
JOURNAL ARTICLE
Jenna Nyman, Kirsi Mikkonen, Marjo Metsäranta, Sanna Toiviainen-Salo, Sampsa Vanhatalo, Leena Lauronen, Päivi Nevalainen
OBJECTIVE: This study evaluated the accuracy of neonatal amplitude-integrated electroencephalography (aEEG) brain monitoring for predicting development of postneonatal epilepsy after perinatal hypoxic ischemic encephalopathy (HIE). METHODS: We studied a population-based cohort of 85 consecutive neonates with moderate-to-severe HIE that had aEEG started <12 hours postnatally. We marked electrographic seizures and graded each hour of the aEEG background as inactive, burst-suppression, or continuous without or with sleep cycling...
November 2022: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
#36
JOURNAL ARTICLE
Jingya Yan, Kavitha Kothur, Emily A Innes, Velda X Han, Hannah F Jones, Shrujna Patel, Erica Tsang, Richard Webster, Sachin Gupta, Christopher Troedson, Manoj P Menezes, Jayne Antony, Simone Ardern-Holmes, Esther Tantsis, Shekeeb Mohammad, Louise Wienholt, Ananda S Pires, Benjamin Heng, Gilles J Guillemin, Anna Guller, Deepak Gill, Sushil Bandodkar, Russell C Dale
BACKGROUND: Epileptic (previously infantile) spasms is the most common epileptic encephalopathy occurring during infancy and is frequently associated with abnormal neurodevelopmental outcomes. Epileptic spasms have a diverse range of known (genetic, structural) and unknown aetiologies. High dose corticosteroid treatment for 4 weeks often induces remission of spasms, although the mechanism of action of corticosteroid is unclear. Animal models of epileptic spasms have shown decreased brain kynurenic acid, which is increased after treatment with the ketogenic diet...
October 2022: EBioMedicine
#37
J A Anido Guzmán, F J Robles Barragán, I Funcia de la Torre, F Alfonso Sanz, I A Becerra Cayetano, C de la Hoz Serrano
Effective management and control of peri- and postoperative pain in hip surgery is essential in order to minimize the use of opioids and their adverse effects. Effective regional analgesia for hip pain is made particularly challenging by the complex innervation of the hip joint. Standard regional techniques can be associated with complications, including incomplete anesthesia, hypotension, or lower limb weakness. We present the case of a 5-year-old girl with a history of infantile cerebral palsy who underwent bilateral varus derotation osteotomy and adductor tenotomy due to paralytic dislocation...
October 2022: Revista española de anestesiología y reanimación
#38
REVIEW
M Oliva-Sierra, M Ríos-León, V Abuín-Porras, P Martín-Casas
The aim of this review was to assess the effectiveness of mirror therapy (MT) and action observation therapy (AOT) on upper limb-related body structures, body functions, activity, and involvement in patients with infantile cerebral palsy (ICP). We carried out a systematic review of randomized controlled trials published over the past 10 years, in which MT or AOT was compared to other ICP-directed interventions. Nine studies met the inclusion criteria and we measured their methodological quality using the PEDro scale...
August 16, 2022: Anales del Sistema Sanitario de Navarra
#39
JOURNAL ARTICLE
Giuseppe Gullo, Marco Scaglione, Gaspare Cucinella, Antonino Perino, Vito Chiantera, Rosario D'Anna, Antonio Simone Laganà, Giovanni Buzzaccarini
Subfertility and infertility are common problems among couples of reproductive age, and they increasingly require the use of assisted reproductive techniques (ART). Understandably, doubts about the safety of such methods are increasing among future parents. The purpose of this review is to analyse the real impact of ART, such as in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI), on the health of the unborn baby; in particular, this work is focussed on the problems related to the neuro-psycho-motor area...
August 12, 2022: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
#40
JOURNAL ARTICLE
Joseph A Stern, Mohamed Elsingergy, Shyam Sunder B Venkatakrishna, Fikadu Worede, Jelena Curic, Savvas Andronikou
BACKGROUND: Ulegyria is an under-recognized and underreported potential sequela of hypoxic-ischemic injury (HII) in full-term neonates. Ulegyria is a unique form of parenchymal scarring that leads to a mushroom-shape of the affected gyri resulting from volume loss at the deep portions of the sulci during HII in this specific period in infantile neurodevelopment. Identifying ulegyria is important for ascribing cause and timing of HII on delayed magnetic resonance imaging (MRI) scans and because of its close association with pharmaco-resistant epilepsy...
July 27, 2022: Pediatric Radiology
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