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Active surveillance kidney cancer

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https://www.readbyqxmd.com/read/30093473/synchronous-colon-cancer-with-pulmonary-metastasis-and-follicular-variant-of-papillary-thyroid-cancer-metastasising-to-kidney
#1
Arun Kadamkulam Syriac, Murtaza Mirza, Ashley Rose Malekunnel, Alberto Locante, Palak Desai
Thyroid malignancies are one of the fastest growing cancers in the world, with the majority being papillary thyroid cancer. Follicular variant of papillary thyroid cancer accounts for about 10%-20% of papillary thyroid carcinomas. The usual sites for metastases of these tumours are lungs and bones with renal metastases being extremely rare. We describe a case of a 64-year-old woman who presented with abdominal pain. On subsequent imaging, she was found to have a colonic mass with metastatic lesions in the lungs and tumour involving left kidney...
August 9, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/30022406/renal-tumor-biopsy-indicators-technique-safety-accuracy-results-and-impact-on-treatment-decision-management
#2
Jaime O Herrera-Caceres, Antonio Finelli, Michael A S Jewett
CONTEXT: Renal tumor biopsy (RTB), as distinct from the more common renal biopsy for medical renal disease, is an option for patients with renal masses. It is mainly used for small renal masses (SRM) but it may also be indicated for larger masses and even in the presence of metastatic disease. Its main indication in SRM is to avoid intervention for benign kidney tumors but increasingly enables more personalized treatment for kidney cancer patients. OBJECTIVE: The objective of this paper is to provide a comprehensive review of the most recent literature available for RTB including the indications, the technique and also the possible complications...
July 18, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/30017400/the-probability-of-aggressive-versus-indolent-histology-based-on-renal-tumor-size-implications-for-surveillance-and-treatment
#3
Bimal Bhindi, R Houston Thompson, Christine M Lohse, Ross J Mason, Igor Frank, Brian A Costello, Aaron M Potretzke, Robert P Hartman, Theodora A Potretzke, Stephen A Boorjian, John C Cheville, Bradley C Leibovich
BACKGROUND: While the probability of malignant versus benign histology based on renal tumor size has been described, this alone does not sufficiently inform decision-making in the modern era since indolent malignant tumors can be managed with active surveillance. OBJECTIVE: To characterize the probability of aggressive versus indolent histology based on radiographic tumor size. DESIGN, SETTING, AND PARTICIPANTS: We evaluated patients who underwent radical or partial nephrectomy at Mayo Clinic for a pT1-2, pNx/0, M0 solid renal tumor between 1990 and 2010...
July 12, 2018: European Urology
https://www.readbyqxmd.com/read/29776621/relationship-between-sleep-duration-and-self-reported-health-related-quality-of-life-among-us-adults-with-or-without-major-chronic-diseases-2014
#4
Yong Liu, Anne G Wheaton, Janet B Croft, Fang Xu, Timothy J Cunningham, Kurt J Greenlund
OBJECTIVES: To assess the association between sleep duration and health-related quality of life (HRQOL) among adults with or without chronic conditions. METHODS: Using the 2014 Behavioral Risk Factor Surveillance System, we analyzed self-reported data from adult respondents aged ≥18 years with (n=277,757, unhealthy group) and without (n=172,052. healthy group) reported history of any of nine chronic conditions (coronary heart disease, stroke, cancer, chronic obstructive pulmonary disease, diabetes, asthma, arthritis, depression, chronic kidney disease)...
June 2018: Sleep Health
https://www.readbyqxmd.com/read/29625756/active-surveillance-for-localized-renal-masses-tumor-growth-delayed-intervention-rates-and-5-yr-clinical-outcomes
#5
Andrew G McIntosh, Benjamin T Ristau, Karen Ruth, Rachel Jennings, Eric Ross, Marc C Smaldone, David Y T Chen, Rosalia Viterbo, Richard E Greenberg, Alexander Kutikov, Robert G Uzzo
BACKGROUND: Active surveillance (AS) has gained acceptance as a management strategy for localized renal masses. OBJECTIVE: To review our large single-center experience with AS. DESIGN, SETTING, AND PARTICIPANTS: From 2000 to 2016, we identified 457 patients with 544 lesions managed with AS from our prospectively maintained kidney cancer database. A subset analysis was performed for patients with ≥5-yr follow-up without delayed intervention (DI)...
August 2018: European Urology
https://www.readbyqxmd.com/read/29427767/an-assessment-of-the-relationship-of-physical-activity-obesity-and-chronic-diseases-conditions-between-active-obese-and-sedentary-normal-weight-american-women-in-a-national-sample
#6
J R Pharr, C A Coughenour, T J Bungum
OBJECTIVE: Obesity and physical inactivity are associated with increased rates of chronic diseases and conditions. However, the 'fit but fat' theory posits that cardiopulmonary fitness (or physical activity) can mitigate risks to health associated with obesity. The purpose of this study was to compare chronic diseases and conditions of highly active/obese women with inactive/normal weight women. STUDY DESIGN: This was a cross-sectional study of the 2015 Behavioral Risk Factor Surveillance System data...
March 2018: Public Health
https://www.readbyqxmd.com/read/29249291/a-multigene-signature-based-on-cell-cycle-proliferation-improves-prediction-of-mortality-within-5-yr-of-radical-nephrectomy-for-renal-cell-carcinoma
#7
Todd M Morgan, Rohit Mehra, Placede Tiemeny, J Stuart Wolf, Shulin Wu, Zaina Sangale, Michael Brawer, Steven Stone, Chin-Lee Wu, Adam S Feldman
BACKGROUND: There is a critical need for improved prognostic discrimination in patients with renal cell carcinoma (RCC) given the increasing awareness that some patients may be managed with active surveillance, while others with higher-risk disease might benefit from adjuvant therapy following surgery. OBJECTIVE: To determine whether a multigene proliferation signature predicts long-term oncologic outcomes in surgically resected RCC. DESIGN, SETTING, AND PARTICIPANTS: The cell cycle proliferation (CCP) score was determined after radical nephrectomy for localized clear cell, papillary, or chromophobe RCC in 565 patients...
May 2018: European Urology
https://www.readbyqxmd.com/read/29141564/a-review-on-the-management-of-small-renal-masses-active-surveillance-versus-surgery
#8
Giancarlo Marra, Marco Oderda, Marco Allasia, Stefania Munegato, Steven Joniau, Paolo Gontero
Despite the rise of small renal tumour (SRMs) diagnosis and related surgeries, death rate of kidney cancer is increasing, suggesting a non-optimal management of SRMs. Active Surveillance (AS) for kidney cancer was introduced to face this paradox. However, incertitude remains on whether and when AS can replace surgery in selected patients. We performed a literature search, reviewed and discussed the evidence in favour of AS or surgery for SRMs. Histopathology and natural history of SRMs, including the percentage of benign tumours amongst SRMs, tumour growth rate, life expectancy of SRMs patients being generally older, and current results of AS series seem to support its use in selected groups...
November 13, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28991563/imaging-and-screening-of-kidney-cancer
#9
REVIEW
Alberto Diaz de Leon, Ivan Pedrosa
Renal cell carcinoma (RCC) exhibits a diverse and heterogeneous disease spectrum, but insight into its molecular biology has provided an improved understanding of potential risk factors, oncologic behavior, and imaging features. Computed tomography (CT) and MR imaging may allow the identification and preoperative subtyping of RCC and assessment of a response to various therapies. Active surveillance is a viable management option in some patients and has provided further insight into the natural history of RCC, including the favorable prognosis of cystic neoplasms...
November 2017: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/28966417/latent-class-survival-models-linked-by-principal-stratification-to-investigate-heterogenous-survival-subgroups-among-individuals-with-early-stage-kidney-cancer
#10
Brian L Egleston, Robert G Uzzo, Yu-Ning Wong
Rates of kidney cancer have been increasing, with small incidental tumors experiencing the fastest growth rates. Much of the increase could be due to increased use of CT scans, MRIs, and ultrasounds for unrelated conditions. Many tumors might never have been detected or become symptomatic in the past. This suggests that many patients might benefit from less aggressive therapy, such as active surveillance by which tumors are surgically removed only if they become sufficiently large. However, it has been difficult for clinicians to identify subgroups of patients for whom treatment might be especially beneficial or harmful...
2017: Journal of the American Statistical Association
https://www.readbyqxmd.com/read/28723504/active-surveillance-for-small-renal-masses-when-less-is-more
#11
REVIEW
Benjamin T Ristau, Alexander Kutikov, Robert G Uzzo, Marc C Smaldone
CONTEXT: A marked increase in incidentally detected small renal masses (SRMs) has occurred over the past decade. Active surveillance (AS) has emerged as an initial management option for these patients. OBJECTIVE: (1) To determine selection criteria, assess appropriate imaging modalities and surveillance frequencies, and define triggers for delayed intervention (DI) for patients on AS. (2) To describe oncologic outcomes for patients on AS protocols. EVIDENCE ACQUISITION: The PubMed database was queried for English language articles using the keywords "surveillance" and "renal mass" or "renal cell carcinoma" or "kidney cancer...
December 15, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28678574/active-surveillance-of-nonfatty-renal-masses-in-patients-with-lymphangioleiomyomatosis-use-of-ct-features-and-patterns-of-growth-to-differentiate-angiomyolipoma-from-renal-cancer
#12
Nilo A Avila, Andrew J Dwyer, Joel Moss
OBJECTIVE: The objective of this study was to report our experience with active surveillance of nonfatty renal masses in a large cohort of patients with lymphangioleiomyomatosis (LAM), correlate their CT features and patterns of growth with histopathology results, and provide guidelines for management. SUBJECTS AND METHODS: Yearly CT examinations were performed of 367 women (age range, 21-75 years; mean age, 47 years). For the 31 patients with 37 nonfatty renal masses that were biopsied, excised, or followed for ≥ 5 years, CT enhancement characteristics and patterns of growth were compared with the histopathology results...
September 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28411917/comparative-effectiveness-of-surgical-treatments-for-small-renal-masses
#13
REVIEW
Shree Agrawal, Hillary Sedlacek, Simon P Kim
In the management of small renal masses (SRMs), treatment options include partial nephrectomy (PN), radical nephrectomy (RN), ablation, renal biopsy, and active surveillance. Large series retrospective and meta-analyses demonstrate PN may confer greater preservation of renal function, overall survival, and equivalent cancer control when compared with RN. As newer therapies emerge, we should critically evaluate the risks and benefits associated with the surgical management of SRMs among patients with competing comorbidities, complex tumors, and high-risk disease...
May 2017: Urologic Clinics of North America
https://www.readbyqxmd.com/read/28411909/current-trends-in-renal-surgery-and-observation-for-small-renal-masses
#14
REVIEW
Siri Drangsholt, William C Huang
There has been a rising incidence of small renal masses and concomitant downward stage migration. This has led to an evolution in the management of kidney cancer from radical nephrectomy to nephron-sparing treatment options including observation. The adoption of partial nephrectomy continues to increase but is still incomplete leading to significant disparities in the delivery of care throughout the country. Surgical excision remains the treatment of choice for small kidney cancers; however, ablative therapies and active surveillance are emerging as reasonable options for select patients...
May 2017: Urologic Clinics of North America
https://www.readbyqxmd.com/read/28365130/predictors-of-growth-kinetics-and-outcomes-in-small-renal-masses-srm-%C3%A2-4%C3%A2-cm-in-size-tayside-active-surveillance-cohort-tasc-study
#15
C Paterson, C Yew-Fung, C Sweeney, M Szewczyk-Bieda, S Lang, G Nabi
OBJECTIVE: To determine outcomes of small renal masses (≤4 cm) on active surveillance and explore factors which can influence their growth. PATIENTS AND METHODS: Two hundred twenty six patients between January 2007 and December 2014 were analysed using cross-linked methodology of healthcare data and independent review. Cancer specific and non-specific survival were the primary outcomes. Growth kinetics, factors influencing growth and need for interventions were secondary outcomes...
August 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28105368/clinical-and-immunologic-correlates-of-response-to-pd-1-blockade-in-a-patient-with-metastatic-renal-medullary-carcinoma
#16
Kathryn E Beckermann, Pradeep C Jolly, Ju Y Kim, Jennifer Bordeaux, Igor Puzanov, W Kimryn Rathmell, Douglas B Johnson
BACKGROUND: Renal medullary carcinoma (RMC) is a rare kidney tumor that occurs in adolescent and young adults, typically in association with sickle cell trait. RMC exhibits rapid disease progression, frequent metastases at diagnosis, and dismal clinical outcomes. Currently available therapies, including cisplatin-based combination chemotherapy, multi-tyrosine kinase, and mTOR inhibitor strategies demonstrate either transient responses or minimal activity. Therefore, further molecular characterization and additional treatment strategies are urgently needed in this aggressive disease...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/27989290/sociodemographic-patterns-of-chronic-disease-how-the-mid-south-region-compares-to-the-rest-of-the-country
#17
COMPARATIVE STUDY
Gabriela R Oates, Bradford E Jackson, Edward E Partridge, Karan P Singh, Mona N Fouad, Sejong Bae
INTRODUCTION: States in the Mid-South region are among the least healthy in the nation. This descriptive study examines sociodemographic differences in the distribution of chronic diseases and health-related behaviors in the Mid-South versus the rest of the U.S., identifying subgroups at increased risk of chronic disease. METHODS: Data were obtained from the 2013 Behavioral Risk Factor Surveillance System; analyses were completed in January 2016. Twelve chronic health conditions were assessed: obesity, diabetes, high blood pressure, coronary heart disease, myocardial infarction, stroke, chronic kidney disease, cancer, arthritis, asthma, chronic obstructive pulmonary disease, and depression...
January 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/27323710/contemporary-issues-surrounding-small-renal-masses-evaluation-diagnostic-biopsy-nephron-sparing-and-novel-treatment-modalities
#18
REVIEW
Andrew R Leone, Gregory J Diorio, Philippe E Spiess, Scott M Gilbert
Incidental identification of small renal masses (SRMs) has become increasingly common with widespread adoption of cross-sectional imaging. To date, early detection of SRMs has not translated to a substantial improvement in cancer-specific survival. Guidelines on the management of SRMs are evolving to reflect recent developments in treatment. The major approaches to managing SRMs include active surveillance, partial/radical nephrectomy, and ablative therapies, such as radiofrequency ablation with cryoablation...
June 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27157369/management-of-renal-masses-and-localized-renal-cancer-systematic-review-and-meta-analysis
#19
REVIEW
Phillip M Pierorazio, Michael H Johnson, Hiten D Patel, Stephen M Sozio, Ritu Sharma, Emmanuel Iyoha, Eric B Bass, Mohamad E Allaf
PURPOSE: Several options exist for management of clinically localized renal masses suspicious for cancer, including active surveillance, thermal ablation and radical or partial nephrectomy. We summarize evidence on effectiveness and comparative effectiveness of these treatment approaches for patients with a renal mass suspicious for localized renal cell carcinoma. MATERIALS AND METHODS: We searched MEDLINE®, Embase® and the Cochrane Central Register of Controlled Trials from January 1, 1997 through May 1, 2015...
October 2016: Journal of Urology
https://www.readbyqxmd.com/read/27012073/-intermediate-term-follow-up-of-patients-undergoing-active-surveillance-for-small-renal-mass-indications-for-surgical-intervention
#20
Zaher Bahouth, Sarel Halachmi, Boaz Moskovitz, Ofer Nativ
INTRODUCTION: The increase in the use of imaging studies led to an increase in the diagnosis of small renal masses. However, most of the small renal masses are asymptomatic, grow slowly, and will not metastasize due to their relative benign biology. We still cannot differentiate malignant from benign masses using imaging studies, hence there is a dilemma between excision and follow-up. OBJECTIVE: To report our intermediate-term results of active surveillance in patients with small renal masses in our urology department at the Bnai-Zion Medical Center...
January 2016: Harefuah
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