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Dermal melanogenesis

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https://www.readbyqxmd.com/read/30102992/effects-on-skin-of-stichopus-japonicus-viscera-extracts-detected-with-saponin-including-holothurin-a-down-regulation-of-melanin-synthesis-and-up-regulation-of-neocollagenesis-mediated-by-erk-signaling-pathway
#1
Tae-Rin Kwon, Chang Taek Oh, Dong-Ho Bak, Jong Hwan Kim, Joon Seok, Jong Hoon Lee, Su Hwan Lim, Kwang Ho Yoo, Beom Joon Kim, Heesu Kim
ETHNOPHARMACOLOGICAL RELEVANCE: Stichopus japonicus (sea cucumber), edible traditional food in Asia, and its extracts are renowned for their wound healing, pain relieving, and cosmetic effects in traditional medicine. Holothurins, toxins isolated from sea cucumber, are thought to be active components for their beneficial effects. However, researchers have yet to outline specific mechanisms thereof. AIM OF THE STUDY: The present study was designed to evaluate the anti-melanogenic and anti-wrinkle properties of S...
August 10, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29983614/applications-of-panax-ginseng-leaves-mediated-gold-nanoparticles-in-cosmetics-relation-to-antioxidant-moisture-retention-and-whitening-effect-on-b16bl6-cells
#2
Zuly Elizabeth Jiménez-Pérez, Priyanka Singh, Yeon-Ju Kim, Ramya Mathiyalagan, Dong-Hyun Kim, Myoung Hee Lee, Deok Chun Yang
Background: Bioactive compounds in plant extracts are able to reduce metal ions to nanoparticles through the process of green synthesis. Panax ginseng is an oriental medicinal herb and an adaptogen which has been historically used to cure various diseases. In addition, the P. ginseng leaves-mediated gold nanoparticles are the value-added novel materials. Its potential as a cosmetic ingredient is still unexplored. The aim of this study was to evaluate the antioxidant, moisture retention and whitening properties of gold nanoparticles ( Pg AuNPs) in cosmetic applications...
July 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29797450/prediction-of-skin-anti-aging-clinical-benefits-of-an-association-of-ingredients-from-marine-and-maritime-origins-ex-vivo-evaluation-using-a-label-free-quantitative-proteomic-and-customized-data-processing-approach
#3
Sebastien Hameury, Laurent Borderie, Jean-Marc Monneuse, Gilbert Skorski, Dominique Pradines
BACKGROUND: The application of ingredients from marine and maritime origins is increasingly common in skin care products, driven by consumer expectations for natural ingredients. However, these ingredients are typically studied for a few isolated in vitro activities. OBJECTIVES: The purpose of this study was to carry out a comprehensive evaluation of the activity on the skin of an association of ingredients from marine and maritime origins using label-free quantitative proteomic analysis, in order to predict the clinical benefits if used in a skin care product...
May 23, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29510193/ccn1-cyr61-stimulates-melanogenesis-through-integrin-%C3%AE-6%C3%AE-1-p38-mapk-and-erk1-2-signaling-pathways-in-human-epidermal-melanocytes
#4
Zhongyi Xu, Li Chen, Min Jiang, Qianqian Wang, Chengfeng Zhang, Leihong Flora Xiang
Fibroblast-derived melanogenic paracrine mediators are known to play a role in melanogenesis. To investigate the effect of CCN1 (also called CYR61 or cysteine-rich 61) on melanogenesis, normal human epidermal melanocytes were treated with recombinant CCN1 protein. Our findings show that CCN1 activates melanogenesis through promoting melanosome maturation and up-regulation of MITF, TRP-1, and tyrosinase via the integrin α6β1, p38 MAPK, and ERK signaling pathways. Furthermore, we found that UVB irradiation stimulates the secretion of CCN1 from normal human dermal fibroblasts, and CCN1 knockdown in fibroblasts attenuates melanogenesis in melanocyte-fibroblast co-culture system...
August 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29503529/therapeutic-potential-of-bimatoprost-for-the-treatment-of-eyebrow-hypotrichosis
#5
REVIEW
Nongsak Chanasumon, Tueboon Sriphojanart, Poonkiat Suchonwanit
Eyebrows serve as a key feature of the face and have many roles, including cosmetic appearance and social communication. Eyebrow hypotrichosis, which refers to reduction or absence of the eyebrow hair, could be a major problem that leads to negative functional, psychological, and social consequences. Bimatoprost is an ophthalmic prostamide analog that is approved by the United States Food and Drug Administration for the treatment of eyelash hypotrichosis. Its proposed mechanism is stimulation of the prostaglandin receptor in dermal papilla and melanocyte, thus leading to a prolonged anagen phase and increased melanogenesis...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29045012/photodynamic-therapy-inhibits-melanogenesis-through-paracrine-effects-by-keratinocytes-and-fibroblasts
#6
Sue Kyung Kim, Seung-Jae Oh, Se-Yeon Park, Woo-Jung Kim, You-Sun Kim, You Chan Kim
Photodynamic therapy (PDT) is a treatment option for skin cancer and premalignant skin diseases and exhibits rejuvenation effects, including reducing fine wrinkles and whitening, on aged skin. In this study, we investigated the mechanism underlying the whitening effects of PDT on melanocytes (MCs) in vitro and in vivo. Exposure of MCs to PDT in vitro reduced their melanin content and tyrosinase activity without, however, affecting cell survival. Interestingly, melanogenesis was also inhibited by exposing MCs to conditioned media of PDT-treated keratinocytes or dermal fibroblasts...
March 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28774590/human-adipose-mesenchymal-cells-inhibit-melanocyte-differentiation-and-the-pigmentation-of-human-skin-via-increased-expression-of-tgf-%C3%AE-1
#7
Agnes S Klar, Thomas Biedermann, Katarzyna Michalak, Teresa Michalczyk, Claudia Meuli-Simmen, Arnaud Scherberich, Martin Meuli, Ernst Reichmann
There is accumulating evidence that interactions between epidermal melanocytes and stromal cells play an important role in the regulation of skin pigmentation. In this study we established a pigmented dermo-epidermal skin model, melDESS, of human origin to investigate the effects of distinct stromal cells on melanogenesis. melDESS is a complex, clinically relevant skin equivalent composed of an epidermis containing both melanocytes and keratinocytes. Its dermal compartment consists either of adipose tissue-derived stromal cells, dermal fibroblasts (Fbs), or a mixture of both cell types...
December 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28436290/topography-of-protein-kinase-c-%C3%AE-ii-in-benign-and-malignant-melanocytic-lesions
#8
Konstanin Krasagakis, Eleftheria Tsentelierou, Gregory Chlouverakis, Efstathios N Stathopoulos
BACKGROUND: Protein kinase C βII promotes melanogenesis and affects proliferation of melanocytic cells but is frequently absent or decreased in melanoma cells in vitro. OBJECTIVE: To investigate PKC-βII expression and spatial distribution within a lesion in various benign and malignant melanocytic proliferations. METHODS: Expression of PKC-βII was semiquantitatively assessed in the various existing compartments (intraepidermal [not nested], junctional [nested], and dermal) of benign (n = 43) and malignant (n = 28) melanocytic lesions by immunohistochemistry...
September 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28303328/effects-of-palmitoyl-kvk-l-ascorbic-acid-on-skin-wrinkles-and-pigmentation
#9
Hyeong Mi Kim, Hyo Sun An, Jung-Soo Bae, Jung Yun Kim, Chi Ho Choi, Ju Yeon Kim, Joo Hyuck Lim, Joon-Hun Choi, Hyunnam Song, Sung Ho Moon, Young Jun Park, Shin-Jae Chang, Sun Young Choi
Wrinkle formation and abnormal pigmentation are major clinical alterations associated with skin aging. As the aim of our study was to investigate the effects of palmitoyl-KVK-L-ascorbic acid on skin aging, the anti-wrinkle and depigmentation effects of palmitoyl-KVK-L-ascorbic acid were evaluated by measuring collagen expression in dermal fibroblast cells and inhibition of melanogenesis in B16F1 cells, respectively. The anti-aging effect of palmitoyl-KVK-L-ascorbic acid cream was also evaluated against a placebo cream in a clinical trial...
July 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27416970/role-of-fibroblast-derived-factors-in-the-pathogenesis-of-melasma
#10
COMPARATIVE STUDY
J W Byun, I S Park, G S Choi, J Shin
BACKGROUND: The hyperactive melanocytes present in melasma skin are confined to the epidermis, but epidermal ablation to treat melasma pigmentation may lead to disease recurrence and aggravation. Melanocyte function is regulated by interactions between melanocytes and neighbouring cells such as keratinocytes and fibroblasts. Because melasma skin usually shows dermal changes after exposure to sunlight, we hypothesized that sun-damaged fibroblasts might play a crucial role in the pathogenesis of melasma...
August 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27403230/biofunctional-activities-of-equisetum-ramosissimum-extract-protective-effects-against-oxidation-melanoma-and-melanogenesis
#11
Pin-Hui Li, Yu-Pin Chiu, Chieh-Chih Shih, Zhi-Hong Wen, Laura Kaodichi Ibeto, Shu-Hung Huang, Chien Chih Chiu, Dik-Lung Ma, Chung-Hang Leung, Yaw-Nan Chang, Hui-Min David Wang
Equisetum ramosissimum, a genus of Equisetaceae, is a medicinal plant that can be separated into ethyl acetate (EA), dichloromethane (DM), n-hexane (Hex), methanol (MeOH), and water extracts. EA extract was known to have potent antioxidative properties, reducing power, DPPH scavenging activity, and metal ion chelating activity. This study compared these five extracts in terms of their inhibiting effects on three human malignant melanomas: A375, A375.S2, and A2058. MTT assay presented the notion that both EA and DM extracts inhibited melanoma growth but did not affect the viabilities of normal dermal keratinocytes (HaCaT) or fibroblasts...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27289338/platelet-derived-growth-factor-regulates-the-proliferation-and-differentiation-of-human-melanocytes-in-a-differentiation-stage-specific-manner
#12
Tomohisa Hirobe, Tatako Shibata, Rumiko Fujiwara, Kiyoshi Sato
BACKGROUND: Although many kinds of keratinocyte-derived factors are known to regulate the proliferation and differentiation of human melanocytes, it is not well defined whether dermis-derived factors work in a similar way. OBJECTIVE: The aim of this study is to clarify whether dermal factors are involved in regulating the proliferation and differentiation of human melanocytes. METHODS: Human epidermal melanoblasts were cultured serially in a serum-free growth medium...
September 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27242917/-z-5-2-4-dihydroxybenzylidene-thiazolidine-2-4-dione-prevents-uvb-induced-melanogenesis-and-wrinkle-formation-through-suppressing-oxidative-stress-in-hrm-2-hairless-mice
#13
Bonggi Lee, Kyoung Mi Moon, Seong Jin Kim, So Hee Kim, Dae Hyun Kim, Hye Jin An, Ji Won Jeong, Ye Ra Kim, Sujin Son, Min Jo Kim, Ki Wung Chung, Eun Kyeong Lee, Pusoon Chun, Young Mi Ha, Min-Sun Kim, Sang Hyun Mo, Hyung Ryong Moon, Hae Young Chung
Background. Uncontrolled melanogenesis and wrinkle formation are an indication of photoaging. Our previous studies demonstrated that (Z)-5-(2,4-dihydroxybenzylidene)thiazolidine-2,4-dione (MHY498) inhibited tyrosinase activity and melanogenesis in vitro. Objective. To examine in vivo effects of MHY498 as an antiaging compound on UVB-induced melanogenesis and wrinkle formation, we topically applied MHY498 on dorsal skin of HRM-2 hairless mice. Methods. Using histological analysis, we evaluated effects of MHY498 on melanogenesis and wrinkle formation after UVB exposure...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27226145/anti-photoageing-and-anti-melanogenesis-activities-of-chrysin
#14
Li Zhu, Yue Lu, Wan-Guo Yu, Xin Zhao, Yan-Hua Lu
CONTEXT: Melanin plays an important role in preventing skin photoageing by blocking ultraviolet B (UVB). However, East Asian women prefer light and fair skin, therefore they want to keep their skin from photoageing and at the same time reduce the melanin in their skin. Chrysin is a kind of natural flavonoid with luxurious biological activities, which has a very promising effect on achieving this goal. OBJECTIVE: To elucidate the effects and mechanisms of chrysin on photoageing and melanogenesis...
November 2016: Pharmaceutical Biology
https://www.readbyqxmd.com/read/26894771/protein-expression-analysis-of-melanocyte-differentiation-antigen-trp-2
#15
Francesca Avogadri, Sacha Gnjatic, Jodie Tassello, Denise Frosina, Nicole Hanson, Megan Laudenbach, Erika Ritter, Taha Merghoub, Klaus J Busam, Achim A Jungbluth
Melanocyte differentiation antigens, such as gp100, tyrosinase, and Melan-A and their corresponding antibodies HMB45, T311, and A103, are major diagnostic tools in surgical pathology. Little is known about tyrosinase-related protein 2 (TRP-2, or dopachrome tautomerase/DCT) another melanocyte differentiation antigen, which is an enzymatic component of melanogenesis. We identified a commercial reagent to TRP-2, monoclonal antibody (mAb) C-9 and undertook a comprehensive analysis to assess its specificity and usefulness for surgical pathology...
March 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/26671310/cadherin-11-involved-in-basement-membrane-damage-and-dermal-changes-in-melasma
#16
Nan-Hyung Kim, Soo-Hyun Choi, Tae Ryong Lee, Chang-Hoon Lee, Ai-Young Lee
Basement membrane (BM) disruption and dermal changes (elastosis, collagenolysis, vascular ectasia) have been reported in melasma. Although ultraviolet (UV) irradiation can induce these changes, UV is not always necessary for melasma development. Cadherin 11 (CDH11), which is upregulated in some melasma patients, has previously been shown to stimulate melanogenesis. Because CDH11 action requires cell-cell adhesion between fibroblasts and melanocytes, BM disruption in vivo should facilitate this. The aim of this study was to examine whether CDH11 overexpression leads to BM disruption and dermal changes, independent of UV irradiation...
June 15, 2016: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/26537230/artepillin-c-and-other-herbal-pak1-blockers-effects-on-hair-cell-proliferation-and-related-pak1-dependent-biological-function-in-cell-culture
#17
Binh Cao Quan Nguyen, Nozomi Taira, Hiroshi Maruta, Shinkichi Tawata
PAK1 (RAC/CDC42-activated kinase 1) is the major oncogenic kinase, and a number of herbal PAK1-blockers such as propolis and curcumin have been shown to be anti-oncogenic and anti-melanogenic as well as anti-alopecia (promoting hair growth). Previously, we found several distinct PAK1-inhibitors in Okinawa plants including Alpinia zerumbet (alpinia). Thus, here, we tested the effects of these herbal compounds and their derivatives on the growth of cancer or normal hair cells, and melanogenesis in cell culture of A549 lung cancer, hair follicle dermal papilla cell, and B16F10 melanoma...
January 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/26230865/recent-progress-in-melasma-pathogenesis
#18
REVIEW
Ai-Young Lee
Melasma is a common skin pigmentation condition. Given therapeutic difficulty as one of the biggest concerns, understanding of the etiology and pathogenesis of melasma becomes essential. UV irradiation, female sex hormones, and inflammatory processes are addressed as triggering factors with genetic predisposition. The mechanism of UV-induced melanogenesis has been extensively investigated as a model system to study melasma pathogenesis. Hitherto, treatment modalities for melasma are similar to other hyperpigmentation disorders...
November 2015: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/26099836/expression-and-tissue-distribution-of-hepatocyte-growth-factor-hgf-and-its-receptor-c-met-in-alpacas-vicugna-pacos-skins-associated-with-white-and-brown-coat-colors
#19
Xiuju Yu, Xiaoyan He, Junbing Jiang, Junping He, Ruiwen Fan, Haidong Wang, Jianjun Geng, Changsheng Dong
Hepatocyte growth factor (HGF)/c-Met signaling has been considered as a key pathway in both melanocyte development and melanogenesis. To understand better the expression patterns and tissue distribution characterization of HGF and its receptor c-Met in skin of white versus brown alpaca (Vicugna pacos), we detected the tissue distribution of HGF and c-Met using immunohistochemistry and analyzed the expression patterns by using Western blot and quantitative real time PCR (qPCR). Immunohistochemistry analysis demonstrated that HGF staining robustly increased in the dermal papilla and mesenchymal cells of white alpaca skin compared with that of brown...
September 2015: Acta Histochemica
https://www.readbyqxmd.com/read/26078014/ascorbyl-coumarates-as-multifunctional-cosmeceutical-agents-that-inhibit-melanogenesis-and-enhance-collagen-synthesis
#20
Jun Yup Kwak, Soojin Park, Jin Kyung Seok, Kwang-Hyeon Liu, Yong Chool Boo
L-Ascorbic acid (AA) and p-coumaric acid (p-CA) are naturally occurring antioxidants that are known to enhance collagen synthesis and inhibit melanin synthesis, respectively. The purpose of this study was to examine hybrid compounds between AA and p-CA as multifunctional cosmeceutical agents. Ascorbyl 3-p-coumarate (A-3-p-C), ascorbyl 2-p-coumarate (A-2-p-C), and their parent compounds were tested for their effects on cellular melanin synthesis and collagen synthesis. At 100 μM, A-3-p-C and A-2-p-C decreased melanin content of human dermal melanocytes stimulated by L-tyrosine, by 65 and 59%, respectively, compared to 11% inhibition of AA and 70% inhibition of p-CA...
September 2015: Archives of Dermatological Research
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