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Upper tract urothelial

Yu I Osmanov, Zh A Gaibov, E A Kogan, S G Radenska-Lopovok, Kh Z Tursunov
Urothelial carcinoma is one of the most frequently diagnosed malignant tumors of the bladder and upper urinary tract, which ranks seventh in the pattern of cancer. Urothelial carcinoma of the renal pelvis is less common; but has a more aggressive clinical course and a worse prognosis than that of the bladder. This is due to the clinical and morphological features of this form of cancer, which, unlike bladder cancer, have not been studied enough. OBJECTIVE: To comparatively analyze the morphological and immunophenotypic parameters of urothelial carcinomas of the renal pelvis and bladder...
2018: Arkhiv Patologii
Jian-Ri Li, Kun-Yuan Chiu, Yen-Chuan Ou, Shian-Shiang Wang, Chuan-Su Chen, Cheng-Kuang Yang, Hao-Chung Ho, Chen-Li Cheng, Chi-Rei Yang, Cheng-Che Chen, Shu-Chi Wang, Chia-Yen Lin, Sheng-Chun Hung, Chiann-Yi Hsu, Chun-Jung Chen
Fibroblast growth factors (FGF) 19, 21, and 23 have been reported as functional factors in human metabolic diseases and malignancies. We performed a prospective survey to compare circulating FGF levels in urothelial carcinoma (UC) patients and normal controls. Between 2016 and 2017, 39 patients with UC of the urinary bladder or upper urinary tract who received surgical intervention were included. All the serum samples were obtained before surgeries. The control group included 28 healthy volunteers. Analysis of the circulating FGF19, 21, and 23 levels among all 67 subjects, as well as a subgroup analysis of the 39 UC patients were performed...
October 17, 2018: BioFactors
Fan Dong, Tianyuan Xu, Xianjin Wang, Yifan Shen, Xiaohua Zhang, Shanwen Chen, Shan Zhong, Minguang Zhang, Qiang Ding
OBJECTIVES: To evaluate the survival benefits that lymph node dissection (LND) brought to clinically node-negative upper tract urothelial carcinoma (UTUC) patients. METHODS: Non-metastatic node-negative UTUC patients were identified from the Surveillance, Epidemiology and End Results database. N0 patients were naturally divided as cN0-pNx group (clinically diagnosed as N0 without LND performed) and cNx-pN0 group (pathologically diagnosed as node-negative no matter what clinical node status they have)...
October 17, 2018: International Journal of Clinical Oncology
Takehiko Nakasato, Aya Hiramatsu, Yuki Matsui, Tsutomu Unoki, Hideaki Shimoyama, Kazuhiko Oshinomi, Jun Morita, Yoshiko Maeda, Michio Naoe, Kohzo Fuji, Hiroshi Ogura, Mayumi Homma, Toshiko Yamochi, Masafumi Takimoto, Yoshio Ogawa
BACKGROUND: Upper urinary tract neuroendocrine carcinoma (UUT-NEC) is extremely rare and has a poor prognosis. Although a few cases of successful treatment have been reported, no treatment has shown established efficacy. PATIENTS AND METHODS: We analyzed 70 UUT-NEC patients, including 68 with small cell neuroendocrine carcinoma (SCNEC) and large cell neuroendocrine carcinoma (LCNEC) reported between 1985 and 2017 and 2 treated at our hospital. RESULTS: Median patient age was 66 years, 58...
October 9, 2018: Cancer Treatment and Research Communications
Sung Han Kim, Mi Kyung Song, Jung Kwon Kim, Bumsik Hong, Seok Ho Kang, Ja Hyeon Ku, Byong Chang Jeong, Ho Kyung Seo
Purpose: To compare oncologic outcomes between open nephroureterectomy (ONU) and laparoscopic nephroureterectomy (LNU) in patients with upper tract urothelial carcinoma. Materials and Methods: The medical records of consecutive ONU and LNU cases from five tertiary institutions were retrospectively analyzed between 2000 and 2012. The propensity-score matching methodology was used to compare the two surgical approaches in terms of age, body mass index, American Society of Anesthesiologists score, tumor location, grade, pathologic T and N stages, the presence of lymphovascular invasion, and follow-up duration...
October 12, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Hiroaki Suzuki, Kosuke Takemura, Kazumasa Sakamoto, Madoka Kataoka, Masaya Ito, Yasukazu Nakanishi, Ken-Ichi Tobisu, Fumitaka Koga
A 78-year-old man who had a horseshoe kidney (HSK) visited us because of gross hematuria and suspicious urine cytology. CT and MRI revealed a right renal pelvic tumor of 28 mm in diameter. He underwent gasless single-port retroperitoneoscopic nephroureterectomy with division of the isthmus via the right pararectal small incision using the RoboSurgeon system. Pathological diagnosis was invasive urothelial carcinoma, grade 3, pT3, pN0, LVI0, RM0. He was discharged from hospital on the 6th postoperative day without any perioperative complication...
2018: Case Reports in Urology
M Rouprêt, E Xylinas, P Colin, N Houédé, E Compérat, F Audenet, S Larré, A Masson-Lecomte, G Pignot, S Brunelle, M Roumiguié, Y Neuzillet, A Méjean
INTRODUCTION: To propose an update of the French guidelines from the national committee ccAFU on upper tract urothelial carcinomas (UTUC). METHODS: A systematic Medline search was performed between 2016 and 2018, with regards to the diagnosis, the options of treatment and the follow-up of UTUC, to evaluate the different studies with levels of evidence. RESULTS: The diagnosis of this rare disease is based on CT-scan acquisition during excretion and ureteroscopy with histological biopsies...
October 11, 2018: Progrès en Urologie
Bum Sik Tae, Ja Hyeon Ku, Cheol Kwak, Hyeon Hoe Kim, Chang Wook Jeong
OBJECTIVES: To compare renal function after radical nephrectomy for renal cell carcinoma (RCC) and for upper tract urothelial carcinoma (UTUC). METHOD: Data from 1,236 patients with RCC or UTUC treated surgically from 2000 to 2013 were enrolled. The estimated glomerular filtration rate (eGFR) was calculated preoperatively and postoperatively at 12, 24, 36, 48, and 60 months. A multivariate logistic regression was used to determine independent factors for a decrease in eGFR to < 60 mL/min/1...
October 12, 2018: Urologia Internationalis
Brendan M Browne, Kristian D Stensland, Chintan K Patel, Travis Sullivan, Eric J Burks, David Canes, Jay D Raman, Joshua Warrick, Kimberly M Reiger-Christ
OBJECTIVE: To evaluate microRNA biomarkers for upper tract urothelial carcinoma (UTUC) to improve risk stratification. METHODS: MicroRNA was isolated from 157 radical nephroureterectomy (RNU) specimens from two institutions. The relative expression of miRNA was examined for high grade versus low grade tumors as well as muscle invasive versus non-muscle invasive tumors. Recurrence free survival (RFS) and overall survival (OS) were also stratified using relative expression of specific miRNA...
October 10, 2018: Urology
Sebastiano Nazzani, Felix Preisser, Elio Mazzone, Zhe Tian, Francesco A Mistretta, Shahrokh F Shariat, Denis Soulières, Fred Saad, Emanuele Montanari, Stefano Luzzago, Alberto Briganti, Luca Carmignani, Pierre I Karakiewicz
OBJECTIVES: To analyze the potential survival benefit of perioperative chemotherapy (CHT) in patients treated with nephroureterectomy (NU) for non-metastatic locally advanced upper tract urothelial carcinoma. METHODS: Within the Surveillance, Epidemiology, and End Results database (2004-2014), we identified 1286 patients with T3 or T4, N 0-3 M0 UTUC. Kaplan-Meier plots, as well as multivariable Cox regression models (MCRMs) relying on inverse probability after treatment weighting (IPTW) and landmark analyses, were used to test the effect of CHT vs no CHT on overall mortality (OM) in the overall population (n =1286), as well as after stratification according to lymph node invasion (LNI)...
October 8, 2018: World Journal of Urology
Ashwin Sunil Tamhankar, Saurabh Ramesh Patil, Puneet Ahluwalia, Gagan Gautam
While pelvic lymphadenectomy during radical cystectomy for bladder cancer is a well-established standard of care, the same does not hold true for upper tract urothelial carcinoma (UTUC). Indeed, a template-based lymphadenectomy is rarely, if ever, performed in conjunction with radical nephroureterectomy at most centres across the globe. While multiple studies have explored the staging and therapeutic role of lymphadenectomy in cases of UTUC, there remain large gaps in our understanding of the indications, extent and safety of this procedure as an adjunct to nephroureterectomy...
September 2018: Indian Journal of Surgical Oncology
Minsun Jung, Bohyun Kim, Kyung Chul Moon
AIMS: Immunohistochemical (IHC) staining for CK5/6, CD44, and CK20 has been significantly associated with the prognosis of urinary bladder urothelial carcinoma and probably reflects its molecular characteristics. Because of its rarity, the IHC-based subgroups and their prognostic effects on upper tract urothelial carcinoma (UTUC) are still unclear, especially in non-muscle-invasive papillary UTUC. METHODS AND RESULTS: IHC staining for CK5/6, CK20, and CD44 was analyzed in 211 patients with non-muscle-invasive papillary UTUC...
October 4, 2018: Histopathology
Takashige Abe, Tsunenori Kondo, Toru Harabayashi, Norikata Takada, Ryuji Matsumoto, Takahiro Osawa, Keita Minami, Satoshi Nagamori, Satoru Maruyama, Sachiyo Murai, Kazunari Tanabe, Nobuo Shinohara
Objective: To assess the number of lymph nodes removed as a surrogate marker of the extent of lymph node dissection, and compare survival outcomes between laparoscopic radical nephroureterectomy (LRNU) and open radical nephroureterectomy (ORNU) in patients undergoing standardized lymph node dissection. Methods: We retrospectively analyzed the data of 214 cTanyN0M0 patients undergoing radical NU with regional lymph node dissection according to the tumor location...
September 29, 2018: Japanese Journal of Clinical Oncology
Alexander Upfill-Brown, Andrew T Lenis, Izak Faiena, Amirali H Salmasi, David C Johnson, Aydin Pooli, Alexandra Drakaki, Kiran Gollapudi, Jeremy Blumberg, Allan J Pantuck, Karim Chamie
PURPOSE: While radical nephroureterectomy (RNU) is the gold standard treatment for upper tract urothelial carcinoma (UTUC), select patients may benefit from endoscopic treatment (ET). European Association of Urology guidelines recommend ET for patients with low-risk (LR) disease: unifocal, < 2 cm, low-grade lesions without local invasion. To inform the utility of ET, we compare the overall survival (OS) of patients receiving ET and RNU using current and previous guidelines of LR disease...
September 28, 2018: World Journal of Urology
Sebastiano Nazzani, Felix Preisser, Elio Mazzone, Zhe Tian, Francesco A Mistretta, Denis Soulières, Emanuele Montanari, Pietro Acquati, Alberto Briganti, Shahrokh F Shariat, Firas Abdollah, Luca Carmignani, Pierre I Karakiewicz
BACKGROUND: Few studies examined the rates of guideline implementation and the survival effect of bladder cuff excision (BCE) at nephroureterectomy (NU). OBJECTIVE: To assess the rates of guideline implementation regarding NU with BCE relative to NU without BCE in patients with upper tract urothelial carcinoma (UTUC) and to test the effect of BCE on cancer-specific (CSM) and other-cause mortality (OCM). DESIGN, SETTING, AND PARTICIPANTS: We relied on Surveillance, Epidemiology, and End Results database (2004-2014) for UTUC of the renal pelvis patients (T1-T3, N0, M0) treated with NU with or without BCE...
September 25, 2018: European Urology Focus
A A Painel Seguel, M J Martínez Pérez, T Ripollés González, D P Gómez, J Vizuete Del Río, G Martín Benítez
AIM: To describe the findings and behaviour of contrast-enhanced ultrasound in the study of upper tract urothelial tumours and to assess its usefulness for diagnosis. MATERIAL AND METHODS: We reviewed our hospital's database over a period of 45 months to identify patients diagnosed with upper tract urothelial carcinomas. We reviewed the findings on mode B-ultrasound, contrast-enhanced ultrasound (location and qualitative assessment of intensity and washout of enhancement), and made a comparison with other techniques (computed tomography or magnetic resonance), and with the surgical specimen...
September 25, 2018: Radiología
Seiji Asai, Tetsuya Fukumoto, Ryuta Watanabe, Kanae Koyama, Yuichiro Sawada, Terutaka Noda, Noriyoshi Miura, Yutaka Yanagihara, Yuki Miyauchi, Masao Miyagawa, Tadahiko Kikugawa, Takashi Saika
Objectives: To evaluate the value of a classification of hydronephrosis on 18F-flurodeoxyglucose (FDG)-PET/CT in predicting post-operative renal function and pathological outcomes among patients with upper urinary tract urothelial carcinoma. Methods: We retrospectively reviewed 71 patients treated with nephroureterectomy (NU) for upper urinary tract urothelial carcinoma after FDG-PET/CT between 2010 and 2016. Eight patients treated with ureteral stent or nephrostomy at the time of FDG-PET/CT were excluded...
September 25, 2018: Japanese Journal of Clinical Oncology
X Li, X N Sheng, Z H Chi, C L Cui, L Si, L L Mao, B X Tang, B Lian, X Wang, X Q Yan, S M Li, X Bai, L Zhou, Y Kong, J Dai, J Guo
Objective: To observe the impact of first-line chemotherapy on renal function in patients with unresectable/metastatic upper tract urothelial carcinoma(UTUC). Methods: A total of 222 (130 males and 92 females) unresectable/metastatic upper tract urothelial carcinoma patients were included in the study between January 2005 and May 2017, with age of 29 to 87 (62.4±10.1) years old. The serum creatinine level and estimated glomerular filtration rate (eGFR) were compared before and after first-line chemotherapy...
August 28, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Ryo Nakayama, Akiyoshi Katagiri, Takashi Ando, Takaki Mizusawa
Common iliac artery (CIA) thrombosis is a rare surgical complication which may cause serious leg damage and may occasionally be fatal. We experienced two cases of CIA thrombosis in nephroureterectomy with the pluck technique for upper tract urothelial carcinoma. Patients were treated using emergent femoro-femoral bypass, and one patient was treated with fasciotomy of the lower extremity for compartment syndrome. CIA thrombosis is considered a possible complication of nephroureterectomy, particularly with the pluck technique in open surgery...
September 15, 2018: BMJ Case Reports
L Campedel, T Seisen, O Cussenot, E Comperat, J Varinot, M Rouprêt, G Cancel-Tassin
Current literature supports the efficacy of anti-PD-1 and anti-PD-L1 immune checkpoint inhibitors for the treatment of urothelial carcinomas. While the prognostic value of PD-1 and PD-L1 levels has been comprehensively analyzed for urothelial carcinoma of the bladder, less is known for upper tract urothelial carcinoma. In addition, available data on the prognostic value of PD-1 and/or PD-L1 level in the tumor and/or peritumoral microenvironment are heterogeneous and even sometimes contradictory. In this article, we compared the methodologies of the various available studies in order to highlight the factors that can explain these discordant results...
September 12, 2018: Progrès en Urologie
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