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Upper tract urothelial

Masafumi Otsuka, Tomohiko Kamasako, Toshihiro Uemura, Nobushige Takeshita, Tetsuo Shinozaki, Masayuki Kobayashi, Atsushi Komaru, Satoshi Fukasawa
OBJECTIVES: To elucidate the effects of the preoperative albumin : globulin ratio on the survival of patients with upper tract urothelial carcinoma after radical nephroureterectomy. METHODS: We retrospectively reviewed 124 consecutive patients with upper tract urothelial carcinoma who underwent radical nephroureterectomy at Chiba Cancer Center, Chiba, Japan between 2002 and 2015. The albumin : globulin ratio was defined: albumin / (total protein - albumin)...
August 13, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
Kyosuke Matsuzaki, Kazutoshi Fujita, Yujiro Hayashi, Makoto Matsushita, Satoshi Nojima, Kentaro Jingushi, Taigo Kato, Atsunari Kawashima, Takeshi Ujike, Akira Nagahara, Motohide Uemura, Ryoichi Imamura, Seiji Yamaguchi, Hiroaki Fushimi, Hiroshi Miyamoto, Eiichi Morii, Norio Nonomura
Signal transducer and activator of transcription 3 (STAT3) plays a prominent role in the growth and invasion of several types of solid tumors. In this study, to assess the expression status and prognostic significance of the STAT3 pathway in upper urinary tract urothelial carcinoma (UTUC), we immunohistochemically stained for STAT3 and STAT3 pathway proteins, sphingosine-1-phosphate receptor 1 (S1PR1) and interleukin-6 (IL-6), in a tissue microarray containing 99 UTUC specimens. There were no significant associations between STAT3, S1PR1, or IL-6 expression pattern and tumor grade or pT stage...
2018: PloS One
Yuki Kohada, Tetsutaro Hayashi, Keisuke Goto, Kohei Kobatake, Hamidreza Abdi, Yukiko Honda, Kazuhiro Sentani, Shogo Inoue, Jun Teishima, Kazuo Awai, Wataru Yasui, Akio Matsubara
Background: To improve the prediction of outcomes in patients who will undergo radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC), we examined the preoperative prognostic factors and established a risk classification model. Methods: A total of 148 patients who underwent RNU without history of neo-adjuvant chemotherapy between 1999 and 2016 in Hiroshima University Hospital were retrospectively reviewed. Associations between preoperative/clinicopathological factors and outcomes including cancer-specific survival (CSS) and recurrence-free survival (RFS) were assessed...
July 31, 2018: Japanese Journal of Clinical Oncology
Yu Miyama, Teppei Morikawa, Jimpei Miyakawa, Yuichi Koyama, Taketo Kawai, Haruki Kume, Masashi Fukayama
Programmed cell death ligand-1 (PD-L1) is a ligand for programmed cell death-1 (PD-1) that negatively regulates T-cell activation and plays a crucial role in suppressing anti-tumor host immunity. Although PD-L1 is a promising immunotherapy target in various cancers, including urothelial carcinoma (UC), the prognostic significance of PD-L1 in UC is unclear. As platelets help protect tumor cells from immune elimination in the circulatory system, we hypothesized that tumor PD-L1 and circulating platelets might synergistically promote tumor metastasis, and that the prognostic significance of PD-L1 might vary according to platelet count...
July 31, 2018: Cancer Medicine
Ashwin Sunil Tamhankar, Saurabh Ramesh Patil, Puneet Ahluwalia, Gagan Gautam
Introduction: Robot-assisted radical nephroureterectomy (RANU) with extended template lymphadenectomy (E-LND) is the leading treatment option for nonmetastatic upper tract urothelial carcinoma. Due to the rarity of this disease, there is a lack of consensus regarding the best approach and the extent of lymphadenectomy. We report our technique and its initial outcomes from the retrospective evaluation of a prospectively maintained database of 11 consecutive cases of RANU + E-LND. To the best of our knowledge, our series represents the first published experience of this procedure from India...
July 2018: Indian Journal of Urology: IJU: Journal of the Urological Society of India
Xin-Ke Zhang, Ping Yang, Zhi-Ling Zhang, Wan-Ming Hu, Yun Cao
PURPOSE: Urothelial carcinoma of the upper urinary tract (UUTUC) is a rare genitourinary tumor. Pre-operative lymphocyte-to-monocyte ratio (LMR) is associated with worse outcome in several malignancies. The aim of this study was to determine the prognostic value of pre-operative LMR in UUTUC. MATERIALS AND METHODS: A historical cohort of 100 UUTUC patients was recruited from January 1990 to June 2011. The counts of peripheral lymphocyte and monocyte were retrieved, and the LMR was calculated by dividing lymphocyte count by monocyte count...
July 23, 2018: Urology Journal
Siva P Raman, Elliot K Fishman
Computed tomography (CT) urography is the best noninvasive method of evaluating the upper urinary tract for urothelial malignancies. However, the utility of CT urography is heavily contingent on the use of proper image acquisition protocols. This article focuses on the appropriate protocols for optimizing CT urography acquisitions, including contrast administration and the timing of imaging acquisitions, as well as the use of ancillary techniques to increase collecting system distention. In addition, imaging findings are discussed that should raise concern for urothelial carcinoma at each of the 3 segments of the urinary tract: the intrarenal collecting systems, ureters, and bladder...
August 2018: Urologic Clinics of North America
Li-Jen Wang, Wen-Chi Chou, See-Tong Pang, Chih-Wei Yang, Cheng-Keng Chuang, Ying-Hsu Chang, Ming-Li Hsieh, Yon-Cheong Wong
Purpose: To stratify upper urinary tract urothelial carcinoma (UTUC) patients into risk groups in terms of 5-year survival. Methods and materials: All potential UTUC patients recorded in our cancer registry database from 1997 to 2011 were evaluated for authentic presence of UTUC. Age at diagnosis, sex, organ involvement, dialysis, renal transplantation status, clinical stage, survival to the last follow-up, and the cause of death of each patient were recorded. All patients were randomized into a developmental set or a validation set at a 1:1 ratio...
2018: Journal of Cancer
Jeffrey A Farnum, Raghunandan Vikram, Arvind Rao, Deepak G Bedi, Colin P Dinney, Surena F Matin
INTRODUCTION: staging of upper tract urothelial carcinoma remains a dilemma due to imaging and biopsy limitations leading to understaging. We seek to determine the accuracy of endoluminal ultrasound (ELUS) for clinical staging of UTUC. MATERIALS AND METHODS: Patients evaluated for UTUC underwent retrograde pyelography, ureteroscopy and ELUS. ELUS was performed using mechanical radial scanning at 20 MHz in B-mode with a 5F probe. Cine clips were evaluated by 2 radiologists blinded to ureteroscopic and pathology findings...
July 17, 2018: Journal of Endourology
Wei Shen Tan, Rachael Sarpong, Pramit Khetrapal, Simon Rodney, Hugh Mostafid, Joanne Cresswell, Dawn Watson, Abhay Rane, James Hicks, Giles Hellawell, Melissa Davies, Shalom J Srirangam, Louise Dawson, David Payne, Norman Williams, Chris Brew-Graves, Andrew Feber, John D Kelly
OBJECTIVES: To determine the diagnostic accuracy of urinary cytology to diagnose bladder cancer and upper tract urothelial cancer (UTUC) as well as the outcome of patients with a positive urine cytology and normal haematuria investigations in patients in a multicentre prospective observational study of patients investigated for haematuria. PATIENT AND METHODS: The DETECT I study (clinicaltrials. gov NCT02676180) recruited patients presenting with haematuria following referral to secondary case at 40 hospitals...
July 12, 2018: BJU International
Hsiang-Ying Lee, Hsin-Chih Yeh, Wen-Jeng Wu, Jiun-Shiuan He, Chun-Nung Huang, Hung-Lung Ke, Wei-Ming Li, Chien-Feng Li, Ching-Chia Li
BACKGROUND: To clarify if diagnostic ureteroscopy (URS) before radical nephroureterectomy for patients with upper tract urothelial carcinoma (UTUC) will increase the risk of intravesical recurrence. METHODS: From retrospective review of cohort at our institution, 502 patients with UTUC who underwent radical nephroureterectomy with bladder cuff excision were enrolled from 1990 to 2013. Cox proportional hazards model was used to analyze the overall survival (OS), disease-free survival (DFS), metastasis-free survival (MFS), and intravesical recurrence-free survival (IVRFS)...
July 9, 2018: World Journal of Surgical Oncology
Hang Xu, Ping Tan, Jianzhong Ai, Yu Huang, Tianhai Lin, Lu Yang, Qiang Wei
PURPOSE: To identify the impact of albumin-globulin ratio (AGR) on pathologic and survival outcomes in patients with upper tract urothelial carcinoma (UTUC) after radical nephroureterectomy (RNU). PATIENTS AND METHODS: We retrospectively reviewed medical records of 620 patients treated with RNU for UTUC at our institution. Logistic regression analysis was used to evaluate the relation between low AGR (<1.45) and adverse pathologic features. Kaplan-Meier curves were used to estimate recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS) probabilities between 2 groups...
June 14, 2018: Clinical Genitourinary Cancer
Kymora B Scotland, Nir Kleinmann, Dillon Cason, Logan Hubbard, Ryuta Tanimoto, Kelly A Healy, Scott G Hubosky, Demetrius H Bagley
OBJECTIVES: To evaluate the effectiveness of ureteroscopy (URS) with laser ablation as an alternative treatment for UTUC lesions larger than 2 cm. Traditionally, patients with large upper tract urothelial carcinoma (UTUC) are treated with radical nephroureterectomy (RNU). However, in patients with pre-existing renal disease, a solitary kidney, or those who decline RNU, management of UTUC may prove challenging METHODS: An institutional database review identified 80 patients with biopsy proven low grade UTUC who had at least one lesion larger than 2 cm...
June 29, 2018: Urology
Joanna Wang, Scott Greenberg, Jennifer Yates
No abstract text is available yet for this article.
June 26, 2018: Urology
Richard W Gregg, Francisco E Vera-Badillo, Christopher M Booth, Aamer Mahmud, Michael Brundage, Michael J Leveridge, Timothy P Hanna
INTRODUCTION: Upper tract urothelial carcinomas are rare malignancies with differences in anatomy and biology requiring therapeutic strategies that differ from bladder cancer. The role of perioperative systemic therapy in this disease remains uncertain with limited data to support its use. A systematic review of the literature and meta-analysis was therefore undertaken to provide more information and guide clinical practice. METHODS: A literature search was performed using Embase and Medline databases with additional searches performed manually using terms associated with upper tract urothelial malignancies...
August 2018: Critical Reviews in Oncology/hematology
Ning Lin, Yu-Peng Wu, Yun-Zhi Lin, Xuan Tao, Shao-Hao Chen, Zhi-Bin Ke, Yong Wei, Qing-Shui Zheng, Xue-Yi Xue, Ning Xu
The mechanism of upper tract recurrence after local excision of bladder cancer remains unknown. This study was designed to identify risk factors for upper tract urothelial recurrence following local tumor excision of bladder cancer. To identify 76 597 bladder cancer patients, comprising 76 537 nonrecurrence and 60 recurrence patients, the Surveillance, Epidemiology, and End Results database was used. Kaplan-Meier analysis and univariate and multivariate Cox proportional hazards regression models were used to determine the risk factors...
June 28, 2018: Cancer Medicine
Matthew B Clements, Tracey L Krupski, Stephen H Culp
BACKGROUND: We performed a comparative survival analysis of patients undergoing robotic-assisted versus laparoscopic or open surgery for upper tract urothelial carcinoma (UTUC). MATERIALS AND METHODS: Patients diagnosed with non-metastatic UTUC undergoing removal of the kidney and/or ureter were identified using Medicare-linked Surveillance, Epidemiology, and End Results Program data (2004-2013). Patients aged 65-85 years were categorized based on surgical approach (open, laparoscopic, or robotic-assisted)...
June 14, 2018: Annals of Surgical Oncology
Chawawat Gosrisirikul, Dong Hoon Koh, Koon Ho Rha
No abstract text is available yet for this article.
June 26, 2018: Annals of Surgical Oncology
Deepak Batura, Tumaj Hashemzehi, Wade Gayed
PURPOSE: Elderly patients with upper tract urothelial cancer (UTUC) may present with colic and microscopic haematuria, mimicking urolithiasis. Patients presenting to emergency departments with acute ureteric colic are investigated with a CT KUB. CT urography (CTU) identifies UTUC better than a CT KUB. Thus, there is a possibility that a CT KUB may miss UTUC. METHODS: We studied patients aged 65 years or over presenting to the emergency department with ureteric colic and microscopic haematuria who had a CT KUB between January 2014 and October 2016...
June 27, 2018: Emergency Radiology
Takuji Yasuda, Yasuyoshi Miyata, Yuichiro Nakamura, Yuji Sagara, Tomohiro Matsuo, Kojiro Ohba, Hideki Sakai
BACKGROUND/AIM: Smoking is a risk factor for carcinogenesis and progression of urothelial cancer (UC). Green tea polyphenol inhibits these malignant behaviors and suppresses human antigen R (HuR) expression, which is associated with malignant aggressiveness. This study aimed to clarify the anti-cancer effects of green tea based on the smoking status of UC patients. PATIENTS AND METHODS: Three hundred and sixty (260 with bladder cancer, BC and 100 with upper tract UC) patients were divided into three groups based on consumption of green tea: low (<1 cup/day, n=119), middle (1-4 cup/day, n=160), and high (>5 cup/day, n=81)...
July 2018: In Vivo
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