Jekaterina Aid, Ajime Tom Tanjeko, Jef Serré, Moritz Eggelbusch, Wendy Noort, Gerard M J de Wit, Michel van Weeghel, Marju Puurand, Kersti Tepp, Ghislaine Gayan-Ramirez, Hans Degens, Tuuli Käämbre, Rob C I Wüst
AIMS: Active cigarette smoking is a major risk factor for chronic obstructive pulmonary disease that remains elevated after cessation. Skeletal muscle dysfunction has been well documented after smoking, but little is known about cardiac adaptations to cigarette smoking. The underlying cellular and molecular cardiac adaptations, independent of confounding lifestyle factors, and time course of reversibility by smoking cessation remain unclear. We hypothesized that smoking negatively affects cardiac metabolism and induces local inflammation in mice, which do not readily reverse upon 2-week smoking cessation...
April 22, 2024: Acta Physiologica