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https://www.readbyqxmd.com/read/30119965/imaging-the-heart-to-detect-cardiomyopathy-in-duchenne-muscular-dystrophy-a-review
#1
REVIEW
Lisa C Power, Gina L O'Grady, Tim S Hornung, Craig Jefferies, Silmara Gusso, Paul L Hofman
Duchenne Muscular Dystrophy is the most common paediatric neuromuscular disorder. Mutations in the DMD gene on the X-chromosome result in progressive skeletal muscle weakness as the main clinical manifestation. However, cardiac muscle is also affected, with cardiomyopathy becoming an increasingly recognised cause of morbidity, and now the leading cause of mortality in this group. The diagnosis of cardiomyopathy has often been made late due to technical limitations in transthoracic echocardiograms and delayed symptomatology in less mobile patients...
June 6, 2018: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/30118624/the-impact-of-lsvt-big-therapy-on-postural-control-for-individuals-with-parkinson-disease-a-case-series
#2
Sarah C Fishel, Megan E Hotchkiss, Samantha A Brown
BACKGROUND AND PURPOSE: LSVT BIG therapy may improve motor function and gait in those with early Parkinson disease (PD), but its impact on postural control for those with moderate PD has not been investigated. The purpose of this case series is to describe the impact of LSVT BIG therapy on postural control and gait in three individuals with moderate PD. INTERVENTION: Three individuals with moderate PD, classified as stage 3 on the Hoehn and Yahr Scale, participated in the LSVT BIG therapy program...
August 17, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/30116746/exercise-training-induced-cardioprotection-with-moderate-hyperglycemia-versus-sedentary-intensive-glycemic-control-in-type-1-diabetic-rats
#3
Matthew W McDonald, Michelle S Dotzert, Mao Jiang, Michael R Murray, Earl G Noble, C W James Melling
Intensive insulin therapy (IIT; 4-7 mmol/L) is the preferred treatment for type 1 diabetes mellitus (T1DM) patients to reduce the risk of cardiovascular disease (CVD). However, this treatment strategy has been questioned as it is accompanied with a sedentary lifestyle leading to weight gain and insulin resistance. T1DM patients who partake in high-intensity aerobic training (AThigh ) to reduce CVD often utilize conventional insulin therapy (CIT; 9-15 mmol/L) to offset the risk of hypoglycemia. Moreover, exercise modalities incorporating resistance training (RT) have been shown to further reduce this risk...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/30116319/gsh-levels-affect-weight-loss-in-individuals-with-metabolic-syndrome-and-obesity-following-dietary-therapy
#4
Nikolaos Goutzourelas, Marina Orfanou, Ioannis Charizanis, George Leon, Demetrios A Spandidos, Demetrios Kouretas
This study examined the effects of redox status markers on metabolic syndrome (MetS) and obesity before and after dietary intervention and exercise for weight loss. A total of 103 adults suffering from MetS and obesity participated in this study and followed a personalized diet plan for 6 months. Body weight, body fat (BF) percentage (BF%), respiratory quotient (RQ) and the redox status markers, reduced glutathione (GSH), thiobarbituric acid reactive substances (TBARS) and protein carbonyls (CARB), were measured twice in each individual, before and after intervention...
August 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30116121/efficacy-of-exercise-therapy-in-persons-with-burnout-a-systematic-review-and-meta-analysis
#5
REVIEW
Oliver Ochentel, Crystal Humphrey, Klaus Pfeifer
An increasing amount of scientific work suggests positive effects of exercise-related interventions in patients with burnout. Exercise therapy could therefore be a useful intervention procedure in the treatment of burnout. The aim of this meta-analysis is to examine empirical findings for exercise therapy used to treat burnout in the occupational setting, including the variety of the application and variety of the exercise modality itself. Electronic databases (PubMed, Cochrane Library, Scopus, PubPsych, PsycInfo) were searched (January 2018) for randomized controlled trials reporting on exercise therapy intervention studies in persons with burnout...
September 2018: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/30115856/muscle-and-bone-health-in-postmenopausal-women-role-of-protein-and-vitamin-d-supplementation-combined-with-exercise-training
#6
REVIEW
Deborah Agostini, Sabrina Donati Zeppa, Francesco Lucertini, Giosuè Annibalini, Marco Gervasi, Carlo Ferri Marini, Giovanni Piccoli, Vilberto Stocchi, Elena Barbieri, Piero Sestili
Menopause is an age-dependent physiological condition associated with a natural decline in oestrogen levels, which causes a progressive decrease of muscle mass and strength and bone density. Sarcopenia and osteoporosis often coexist in elderly people, with a prevalence of the latter in elderly women. The profound interaction between muscle and bone induces a negative resonance between the two tissues affected by these disorders worsening the quality of life in the postmenopausal period. It has been estimated that at least 1 in 3 women over age 50 will experience osteoporotic fractures, often requiring hospitalisation and long-term care, causing a large financial burden to health insurance systems...
August 16, 2018: Nutrients
https://www.readbyqxmd.com/read/30114983/non-pharmacologic-treatments-for-symptoms-of-diabetic-peripheral-neuropathy-a-systematic-review
#7
Suzanne Amato Nesbit, Ritu Sharma, Julie M Waldfogel, Allen Zhang, Wendy L Bennett, Hsin-Chieh Yeh, Yohalakshmi Chelladurai, Dorianne Feldman, Karen A Robinson, Sydney M Dy
OBJECTIVE: To systematically assess benefits and harm of non-pharmacologic interventions for diabetic peripheral neuropathy (DPN) symptoms. METHODS: MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials were searched from 1966 to May 24, 2016 for randomized controlled trials. Two reviewers evaluated studies for eligibility, serially abstracted data, evaluated risk of bias, and graded strength of evidence (SOE) for critical outcomes (pain and quality-of-life)...
August 17, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/30114965/structure-based-virtual-screening-3d-qsar-molecular-dynamics-and-admet-studies-for-selection-of-natural-inhibitors-against-structural-and-non-structural-targets-of-chikungunya
#8
Jaykant Vora, Shivani Patel, Sonam Sinha, Sonal Sharma, Anshu Srivastava, Mahesh Chhabria, Neeta Shrivastava
The transmission of mosquito-borne Chikungunya virus (CHIKV) has large epidemics worldwide. Till date, there are neither anti-viral drugs nor vaccines available for the treatment of Chikungunya. Accumulated evidences suggest that some natural compounds i.e. Epigallocatechin gallate, Harringtonine, Apigenin, Chrysin, Silybin etc. have the capability to inhibit CHIKV replication in vitro. Natural compounds are known to possess less or no side effects. Therefore, natural compound in its purified or crude extracts form could be the preeminent and safe mode of therapies for Chikungunya...
August 16, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/30114688/associated-pulmonary-hypertension-is-an-independent-contributor-to-exercise-intolerance-in-chronic-fibrosing-interstitial-pneumonias
#9
David K Yoo, Maurizio Zompatori, Annapina Barrile, Giorgia Rossi, Dejanira D'Amato, Gianluigi Sergiacomi, Paola Rogliani, Marco Mura
BACKGROUND: Associated pulmonary hypertension (APH) is frequently observed in fibrosing interstitial pneumonias (FIP), such as idiopathic pulmonary fibrosis (IPF). APH is associated with worse prognosis, but it remains unclear whether it is associated with greater functional impairment. Six-minute walk distance (6MWD) is widely used to assess functional capacity in pulmonary hypertension and FIP. OBJECTIVES: To investigate if APH independently contributes to exercise intolerance in FIP, irrespective of the extent of underlying fibrosis...
August 16, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/30112586/update-on-devices-for-diastolic-dysfunction-options-for-a-no-option-condition
#10
REVIEW
Ahmit Gupta, Steven R Bailey
PURPOSE OF REVIEW: This article provides an update on percutaneous devices to treat diastolic dysfunction, current clinical experience, and actively enrolling trials. We also discuss potential complications and limitations of devices. RECENT FINDINGS: Exertional symptoms including exertional dyspnea and exercise intolerance are common features of heart failure that are driven by left ventricular and left atrial non-compliance that results in pulmonary vascular congestion...
August 15, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/30112217/beyond-statins-emerging-evidence-for-hdl-increasing-therapies-and-diet-in-treating-cardiovascular-disease
#11
REVIEW
Sterling Farrer
Coronary heart disease continues to be the leading cause of death in the United States. Current attempts to treat atherosclerosis and coronary artery disease often involve pharmaceutical and surgical treatments. While these treatments are successful in managing the pain from coronary heart disease, they do little to prevent or stop it. There are a number of clinical strategies that are currently being researched to treat atherosclerosis through HDL-increasing therapies. These clinical studies have shown positive effects through nutritional intervention, exercise, stress reduction, and tobacco and alcohol cessation...
2018: Advances in Preventive Medicine
https://www.readbyqxmd.com/read/30112056/study-on-the-clinical-efficacy-of-specific-phosphodiesterase-inhibitor-in-patients-with-pulmonary-hypertension-due-to-left-heart-disease
#12
Bing Han, Qingli Wang
Pulmonary hypertension due to left heart disease (PH-LHD) is caused by left ventricular (LV) systolic and/or diastolic dysfunction and left heart valve disease. LV diseases lead to left ventricular filling pressure increases, pulmonary venous obstruction and pulmonary venous pressure increases, and thus to secondary PH. Exercise tolerance is lower and fatality rates are higher in patients with PH-LHD than those in subjects with normal pulmonary arterial pressure. In spite of the progress in the study of the mechanisms of PH-LHD in recent years, no specific treatment is currently available...
August 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30109950/assessment-of-right-ventricular-function-in-the-research-setting-knowledge-gaps-and-pathways-forward-an-official-american-thoracic-society-research-statement
#13
Tim Lahm, Ivor S Douglas, Stephen L Archer, Harm J Bogaard, Naomi C Chesler, Francois Haddad, Anna R Hemnes, Steven M Kawut, Jeffrey A Kline, Todd M Kolb, Stephen C Mathai, Olaf Mercier, Evangelos D Michelakis, Robert Naeije, Rubin M Tuder, Corey E Ventetuolo, Antoine Vieillard-Baron, Norbert F Voelkel, Anton Vonk-Noordegraaf, Paul M Hassoun
BACKGROUND: Right ventricular (RV) adaptation to acute and chronic pulmonary hypertensive syndromes is a significant determinant of short- and long-term outcomes. Although remarkable progress has been made in the understanding of RV function and failure since the meeting of the NIH Working Group on Cellular and Molecular Mechanisms of Right Heart Failure in 2005, significant gaps remain at many levels in the understanding of cellular and molecular mechanisms of RV responses to pressure and volume overload, in the validation of diagnostic modalities, and in the development of evidence-based therapies...
August 15, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30109735/short-medium-long-term-efficacy-of-interdisciplinary-intervention-against-overweight-and-obesity-randomized-controlled-clinical-trial
#14
Virginia E Fernández-Ruiz, David Armero-Barranco, José Antonio Paniagua-Urbano, Maria Sole-Agusti, Alfonso Ruiz-Sánchez, José Gómez-Marín
AIM: The aim of the study is to evaluate the efficacy of a nurse-led interdisciplinary programme based on healthy eating, physical exercise, and cognitive behavioural therapy applied to anthropometric and cardiovascular measures, which are related to obesity in short, medium, and long term. METHODS: We conducted a randomised controlled clinical trial with 74 obese and overweight participants (experimental group, n = 37; control group, n = 37). An interdisciplinary programme of 12 months was applied and coordinated by a nurse...
August 14, 2018: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/30108618/depression-and-chronic-heart-failure-in-the-elderly-an-intriguing-relationship
#15
REVIEW
Ilaria Liguori, Gennaro Russo, Francesco Curcio, Giuseppe Sasso, David Della-Morte, Gaetano Gargiulo, Flora Pirozzi, Francesco Cacciatore, Domenico Bonaduce, Pasquale Abete, Gianluca Testa
Chronic heart failure and depressive disorders have a high prevalence and incidence in the elderly. Several studies have shown how depression tends to exacerbate coexisting chronic heart failure and its clinical outcomes and vice versa, especially in the elderly. The negative synergism between chronic heart failure and depression in the elderly may be approached only taking into account the multifaceted pathophysiological characteristics underlying both these conditions, such as behavioural factors, neurohormonal activation, inflammatory mediators, hypercoagulability and vascular damage...
June 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/30108224/exercise-induced-bronchoconstriction-prevalence-pathophysiology-patient-impact-diagnosis-and-management
#16
REVIEW
Bhumika Aggarwal, Aruni Mulgirigama, Norbert Berend
Exercise-induced bronchoconstriction (EIB) can occur in individuals with and without asthma, and is prevalent among athletes of all levels. In patients with asthma, symptoms of EIB significantly increase the proportion reporting feelings of fearfulness, frustration, isolation, depression and embarrassment compared with those without symptoms. EIB can also prevent patients with asthma from participating in exercise and negatively impact their quality of life. Diagnosis of EIB is based on symptoms and spirometry or bronchial provocation tests; owing to low awareness of EIB and lack of simple, standardised diagnostic methods, under-diagnosis and mis-diagnosis of EIB are common...
August 14, 2018: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/30105656/anti-anginal-effectiveness-and-tolerability-of-trimetazidine-modified-release-80-mg-once-daily-in-stable-angina-patients-in-real-world-practice
#17
Maria G Glezer, Vladimir A Vygodin
INTRODUCTION: Trimetazidine (TMZ) was shown to reduce angina symptoms and increase the exercise capacity in stable angina (SA) patients. A new formulation allowing a once-daily (od) dosage could improve patients' satisfaction and adherence. METHODS: ODA was a 3-month, observational, multicenter, prospective Russian study in SA patients with persistent symptoms despite therapy. Angina attack frequency, short-acting nitrate (SAN) consumption, adherence to antianginal medications, and overall efficacy and tolerability of TMZ 80 mg od were assessed in a real-world setting...
August 13, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/30103263/treatments-for-women-with-gestational-diabetes-mellitus-an-overview-of-cochrane-systematic-reviews
#18
REVIEW
Ruth Martis, Caroline A Crowther, Emily Shepherd, Jane Alsweiler, Michelle R Downie, Julie Brown
BACKGROUND: Successful treatments for gestational diabetes mellitus (GDM) have the potential to improve health outcomes for women with GDM and their babies. OBJECTIVES: To provide a comprehensive synthesis of evidence from Cochrane systematic reviews of the benefits and harms associated with interventions for treating GDM on women and their babies. METHODS: We searched the Cochrane Database of Systematic Reviews (5 January 2018) for reviews of treatment/management for women with GDM...
August 14, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30100313/a-12-week-supervised-exercise-therapy-program-for-young-adults-with-a-meniscal-tear-program-development-and-feasibility-study
#19
Søren T Skou, Jonas B Thorlund
OBJECTIVE: To describe the development and feasibility of an exercise therapy program for treatment of young adults (18-40 years of age) with a meniscal tear. METHODS: Researchers and experienced physical therapists developed a 12-week supervised neuromuscular and strengthening exercise therapy program based on clinical expertise and available evidence. Six patients (age range 22-39 years) considered eligible for meniscal surgery by an orthopedic surgeon underwent the program...
July 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/30100096/variables-describing-individuals-with-improved-pain-and-function-with-a-primary-complaint-of-low-back-pain-a-secondary-analysis
#20
Scott A Burns, Joshua A Cleland, Chad E Cook, Michael Bade, Darren A Rivett, Suzanne Snodgrass
OBJECTIVES: The purpose of this study was to identify descriptive factors in individuals with a primary complaint of low back pain (LBP) associated with improved pain and function after receiving physical therapy for LBP with or without manual therapy and exercise directed at the femoroacetabular joints. METHODS: Participants were enrolled in a randomized clinical trial investigating physical therapy interventions for their LBP, with or without interventions directed at the femoroacetabular joints (hips)...
August 9, 2018: Journal of Manipulative and Physiological Therapeutics
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