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Faecal Microbiota Transplant

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https://www.readbyqxmd.com/read/30341117/protocol-for-faecal-microbiota-transplantation-in-ulcerative-colitis-fmtuc-a-randomised-feasibility-study
#1
Maki Jitsumura, Andrew Laurence Cunningham, Matthew David Hitchings, Saiful Islam, Angharad P Davies, Paula E Row, Andrew D Riddell, James Kinross, Tom S Wilkinson, G J Jenkins, John G Williams, Dean Anthony Harris
BACKGROUND: The interaction of the gut microbiota with the human host is implicated in the pathogenesis of inflammatory and immunological diseases including ulcerative colitis (UC). Faecal microbiota transplantation (FMT) as a method of restoring gut microbial diversity is of increasing interest as a therapeutic approach in the management of UC. The current literature lacks consensus about the dose of FMT, route of administration and duration of response. METHODS AND ANALYSIS: This single-blinded randomised trial will explore the feasibility of FMT in 30 treatment-naïve patients with histologically confirmed distal UC limited to the recto-sigmoid region (up to 40 cm from the anal verge)...
October 18, 2018: BMJ Open
https://www.readbyqxmd.com/read/30335629/irritable-bowel-syndrome-following-clostridium-difficile-infection
#2
Pete Dayananda, Mark H Wilcox
PURPOSE OF REVIEW: The aim of this review was to provide an overview of the current understanding of the diagnosis, pathophysiology, and the role of the gut microbiome in Clostridium difficile infection (CDI)-related postinfectious irritable bowel syndrome (PI-IBS). RECENT FINDINGS: PI-IBS is a recognized pathological entity and was estimated to affect 1 in 10 patients with infectious enteritis. CDI remains a major healthcare burden worldwide with a one in four chance of recurrence of symptoms following treatment...
October 17, 2018: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/30317530/an-insight-into-gut-microbiota-and-its-functionalities
#3
REVIEW
Atanu Adak, Mojibur R Khan
Gut microbiota has evolved along with their hosts and is an integral part of the human body. Microbiota acquired at birth develops in parallel as the host develops and maintains its temporal stability and diversity through adulthood until death. Recent developments in genome sequencing technologies, bioinformatics and culturomics have enabled researchers to explore the microbiota and in particular their functions at more detailed level than before. The accumulated evidences suggest that though a part of the microbiota is conserved, the dynamic members vary along the gastrointestinal tract, from infants to elderly, primitive tribes to modern societies and in different health conditions...
October 13, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/30298433/the-microgenderome-revealed-sex-differences-in-bidirectional-interactions-between-the-microbiota-hormones-immunity-and-disease-susceptibility
#4
REVIEW
Ravichandra Vemuri, Kristyn E Sylvia, Sabra L Klein, Samuel C Forster, Magdalena Plebanski, Raj Eri, Katie L Flanagan
Sex differences in immunity are well described in the literature and thought to be mainly driven by sex hormones and sex-linked immune response genes. The gastrointestinal tract (GIT) is one of the largest immune organs in the body and contains multiple immune cells in the GIT-associated lymphoid tissue, Peyer's patches and elsewhere, which together have profound effects on local and systemic inflammation. The GIT is colonised with microbial communities composed of bacteria, fungi and viruses, collectively known as the GIT microbiota...
October 8, 2018: Seminars in Immunopathology
https://www.readbyqxmd.com/read/30288286/efficacy-of-different-faecal-microbiota-transplantation-protocols-for-clostridium-difficile-infection-a-systematic-review-and-meta-analysis
#5
Gianluca Ianiro, Marcello Maida, Johan Burisch, Claudia Simonelli, Georgina Hold, Marco Ventimiglia, Antonio Gasbarrini, Giovanni Cammarota
Background: Protocols for treating recurrent Clostridium difficile infection (rCDI) through faecal microbiota transplantation (FMT) are still not standardised. Our aim was to evaluate the efficacy of different FMT protocols for rCDI according to routes, number of infusions and infused material. Methods: MEDLINE, Embase, SCOPUS, Web of Science and the Cochrane Library were searched through 31 May 2017. Studies offering multiple infusions if a single infusion failed to cure rCDI were included...
October 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/30257633/the-gut-microbiota-cause-and-cure-of-gut-diseases
#6
Lauren S White, Johan Van den Bogaerde, Michael Kamm
The gastrointestinal microbiota is emerging as a central factor in the pathogenesis of a range of gastrointestinal and hepatic disorders. Epidemiological studies, and experimental studies in animals and humans, have highlighted a likely causative role of this microbial community in the modern global epidemics of inflammatory bowel disease, non-alcoholic fatty liver disease, non-alcoholic steato-hepatitis, obesity and metabolic syndrome. New techniques for microbial culture and gene sequencing are enabling the identification of specific pathogens and protective organisms in these conditions...
September 1, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/30245786/faecal-microbiota-transplantation-as-a-treatment-for-inflammatory-bowel-disease-a-national-survey-of-adult-and-paediatric-gastroenterologists-in-the-uk
#7
James Roger Mcilroy, Niharika Nalagatla, Richard Hansen, Ailsa Hart, Georgina Louise Hold
Background: Interest in the use of faecal microbiota transplantation (FMT) in inflammatory bowel disease (IBD) has increased following outcomes in patients with Clostridioides difficile infection (CDI). While research exploring clinician awareness and attitude towards the use of FMT in CDI has been carried out, data for IBD are currently lacking. Objective: To assess the perceptions of gastroenterologists and current practice relating to FMT as a treatment for IBD in the UK...
October 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30241676/introduction-to-the-joint-british-society-of-gastroenterology-bsg-and-healthcare-infection-society-his-faecal-microbiota-transplant-guidelines
#8
EDITORIAL
B H Mullish, M N Quraishi, J P Segal, H R T Williams, S D Goldenberg
No abstract text is available yet for this article.
October 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/30209919/a-comprehensive-approach-for-the-patient-with-clostridium-difficile-infection
#9
REVIEW
J Cobo
During the last decade there have been many changes and advances in the research on Clostridium difficile infection (CDI). We have improved diagnostic and therapeutic tools and, at the same time, we have learned that the CDI implies, especially in the most vulnerable patients, an important morbidity. CDI has traditionally been undervalued and it is widely dispersed in hospitals. Surely, there is inertness in its management and there are also broad areas of improvement. If we add to this the high cost of the new drugs and the practical difficulties to implement the faecal microbiota transplant, we realize that we may not be taking full advantage of all the opportunities to improve patient's outcomes...
September 2018: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/30173851/the-use-of-faecal-microbiota-transplant-as-treatment-for-recurrent-or-refractory-clostridium-difficile-infection-and-other-potential-indications-joint-british-society-of-gastroenterology-bsg-and-healthcare-infection-society-his-guidelines
#10
Benjamin H Mullish, Mohammed Nabil Quraishi, Jonathan P Segal, Victoria L McCune, Melissa Baxter, Gemma L Marsden, David Moore, Alaric Colville, Neeraj Bhala, Tariq H Iqbal, Christopher Settle, Graziella Kontkowski, Ailsa L Hart, Peter M Hawkey, Horace Rt Williams, Simon D Goldenberg
No abstract text is available yet for this article.
September 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/30171064/population-level-analysis-of-blastocystis-subtype-prevalence-and-variation-in-the-human-gut-microbiota
#11
Raul Y Tito, Samuel Chaffron, Clara Caenepeel, Gipsi Lima-Mendez, Jun Wang, Sara Vieira-Silva, Gwen Falony, Falk Hildebrand, Youssef Darzi, Leen Rymenans, Chloë Verspecht, Peer Bork, Severine Vermeire, Marie Joossens, Jeroen Raes
OBJECTIVE: Human gut microbiome studies are mainly bacteria- and archaea-oriented, overlooking the presence of single-cell eukaryotes such as Blastocystis, an enteric stramenopiles with worldwide distribution. Here, we surveyed the prevalence and subtype variation of Blastocystis in faecal samples collected as part of the Flemish Gut Flora Project (FGFP), a Western population cohort. We assessed potential links between Blastocystis subtypes and identified microbiota-host covariates and quantified microbiota differentiation relative to subtype abundances...
August 31, 2018: Gut
https://www.readbyqxmd.com/read/30158252/-primum-non-nocere-is-faecal-microbiota-transplantation-doing-harm-to-patients-with-ibs
#12
Paul Enck
No abstract text is available yet for this article.
August 29, 2018: Gut
https://www.readbyqxmd.com/read/30126889/fifty-years-of-faecal-microbiota-transplant-in-central-australia
#13
Eliza Jane Temple Milliken
No abstract text is available yet for this article.
August 20, 2018: Gut
https://www.readbyqxmd.com/read/30089902/neonatal-selection-by-toll-like-receptor-5-influences-long-term-gut-microbiota-composition
#14
Marcus Fulde, Felix Sommer, Benoit Chassaing, Kira van Vorst, Aline Dupont, Michael Hensel, Marijana Basic, Robert Klopfleisch, Philip Rosenstiel, André Bleich, Fredrik Bäckhed, Andrew T Gewirtz, Mathias W Hornef
Alterations in enteric microbiota are associated with several highly prevalent immune-mediated and metabolic diseases1-3 , and experiments involving faecal transplants have indicated that such alterations have a causal role in at least some such conditions4-6 . The postnatal period is particularly critical for the development of microbiota composition, host-microbe interactions and immune homeostasis7-9 . However, the underlying molecular mechanisms of this neonatal priming period have not been defined. Here we report the identification of a host-mediated regulatory circuit of bacterial colonization that acts solely during the early neonatal period but influences life-long microbiota composition...
August 2018: Nature
https://www.readbyqxmd.com/read/30064988/treatment-with-camu-camu-myrciaria-dubia-prevents-obesity-by-altering-the-gut-microbiota-and-increasing-energy-expenditure-in-diet-induced-obese-mice
#15
Fernando F Anhê, Renato T Nachbar, Thibault V Varin, Jocelyn Trottier, Stéphanie Dudonné, Mélanie Le Barz, Perrine Feutry, Geneviève Pilon, Olivier Barbier, Yves Desjardins, Denis Roy, André Marette
OBJECTIVE: The consumption of fruits is strongly associated with better health and higher bacterial diversity in the gut microbiota (GM). Camu camu ( Myrciaria dubia ) is an Amazonian fruit with a unique phytochemical profile, strong antioxidant potential and purported anti-inflammatory potential. DESIGN: By using metabolic tests coupled with 16S rRNA gene-based taxonomic profiling and faecal microbial transplantation (FMT), we have assessed the effect of a crude extract of camu camu (CC) on obesity and associated immunometabolic disorders in high fat/high sucrose (HFHS)-fed mice...
July 31, 2018: Gut
https://www.readbyqxmd.com/read/30007918/gut-commensal-parabacteroides-goldsteinii-plays-a-predominant-role-in-the-anti-obesity-effects-of-polysaccharides-isolated-from-hirsutella-sinensis
#16
Tsung-Ru Wu, Chuan-Sheng Lin, Chih-Jung Chang, Tzu-Lung Lin, Jan Martel, Yun-Fei Ko, David M Ojcius, Chia-Chen Lu, John D Young, Hsin-Chih Lai
OBJECTIVE: The medicinal fungus Ophiocordyceps sinensis and its anamorph Hirsutella sinensis have a long history of use in traditional Chinese medicine for their immunomodulatory properties. Alterations of the gut microbiota have been described in obesity and type 2 diabetes. We examined the possibility that H. sinensis mycelium (HSM) and isolated fractions containing polysaccharides may prevent diet-induced obesity and type 2 diabetes by modulating the composition of the gut microbiota...
July 14, 2018: Gut
https://www.readbyqxmd.com/read/29983136/early-intervention-with-faecal-microbiota-transplantation-an-effective-means-to-improve-growth-performance-and-the-intestinal-development-of-suckling-piglets
#17
C S Cheng, H K Wei, P Wang, H C Yu, X M Zhang, S W Jiang, J Peng
Recent studies indicate that early postnatal period is a critical window for gut microbiota manipulation to optimise the immunity and body growth. This study investigated the effects of maternal faecal microbiota orally administered to neonatal piglets after birth on growth performance, selected microbial populations, intestinal permeability and the development of intestinal mucosal immune system. In total, 12 litters of crossbred newborn piglets were selected in this study. Litter size was standardised to 10 piglets...
July 9, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29980607/faecal-microbiota-transplantation-alters-gut-microbiota-in-patients-with-irritable-bowel-syndrome-results-from-a-randomised-double-blind-placebo-controlled-study
#18
Sofie Ingdam Halkjær, Alice Højer Christensen, Bobby Zhao Sheng Lo, Patrick Denis Browne, Stig Günther, Lars Hestbjerg Hansen, Andreas Munk Petersen
OBJECTIVE: IBS is associated with an intestinal dysbiosis and faecal microbiota transplantation (FMT) has been hypothesised to have a positive effect in patients with IBS. We performed a randomised, double-blind placebo-controlled trial to investigate if FMT resulted in an altered gut microbiota and improvement in clinical outcome in patients with IBS. DESIGN: We performed this study in 52 adult patients with moderate-to-severe IBS. At the screening visit, clinical history and symptoms were assessed and faecal samples were collected...
July 6, 2018: Gut
https://www.readbyqxmd.com/read/29851107/randomised-clinical-trial-faecal-microbiota-transplantation-by-colonoscopy-plus-vancomycin-for-the-treatment-of-severe-refractory-clostridium-difficile-infection-single-versus-multiple-infusions
#19
G Ianiro, L Masucci, G Quaranta, C Simonelli, L R Lopetuso, M Sanguinetti, A Gasbarrini, G Cammarota
BACKGROUND: Faecal microbiota transplantation (FMT) is a highly effective treatment against recurrent Clostridium difficile infection. Far less evidence exists on the efficacy of FMT in treating severe Clostridium difficile infection refractory to antibiotics. AIM: To compare the efficacy of two FMT-based protocols associated with vancomycin in curing subjects with severe Clostridium difficile infection refractory to antibiotics. METHODS: Subjects with severe Clostridium difficile infection refractory to antibiotics were randomly assigned to one of the two following treatment arms: (1) FMT-S, including a single faecal infusion via colonoscopy followed by a 14-day vancomycin course, (2) FMT-M, including multiple faecal infusions plus a 14-day vancomycin course...
July 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29843854/the-ins-and-outs-of-faecal-microbiota-transplant-for-recurrent-clostridium-difficile-diarrhoea-at-wits-donald-gordon-medical-centre-johannesburg-south-africa
#20
S Lee, K Drennan, G Simons, A Hepple, K Karlsson, W Lowman, P C Gaylard, L McNamara, J Fabian
BACKGROUND: Clostridium difficile-associated diarrhoea (CDAD) is a potentially life-threatening condition that is becoming increasingly common. A persistent burden of this infectious illness has been demonstrated over the past 4 years at Wits Donald Gordon Medical Centre (WDGMC), Johannesburg, South Africa, through implementation of active surveillance of hospital-acquired infections as part of the infection prevention and control programme. Oral treatment with metronidazole or vancomycin is recommended, but there is a major problem with symptomatic recurrence after treatment...
April 25, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
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