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Faecal Microbiota Transplant

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https://www.readbyqxmd.com/read/30089902/neonatal-selection-by-toll-like-receptor-5-influences-long-term-gut-microbiota-composition
#1
Marcus Fulde, Felix Sommer, Benoit Chassaing, Kira van Vorst, Aline Dupont, Michael Hensel, Marijana Basic, Robert Klopfleisch, Philip Rosenstiel, André Bleich, Fredrik Bäckhed, Andrew T Gewirtz, Mathias W Hornef
Alterations in enteric microbiota are associated with several highly prevalent immune-mediated and metabolic diseases1-3 , and experiments involving faecal transplants have indicated that such alterations have a causal role in at least some such conditions4-6 . The postnatal period is particularly critical for the development of microbiota composition, host-microbe interactions and immune homeostasis7-9 . However, the underlying molecular mechanisms of this neonatal priming period have not been defined. Here we report the identification of a host-mediated regulatory circuit of bacterial colonization that acts solely during the early neonatal period but influences life-long microbiota composition...
August 8, 2018: Nature
https://www.readbyqxmd.com/read/30064988/treatment-with-camu-camu-myrciaria-dubia-prevents-obesity-by-altering-the-gut-microbiota-and-increasing-energy-expenditure-in-diet-induced-obese-mice
#2
Fernando F Anhê, Renato T Nachbar, Thibault V Varin, Jocelyn Trottier, Stéphanie Dudonné, Mélanie Le Barz, Perrine Feutry, Geneviève Pilon, Olivier Barbier, Yves Desjardins, Denis Roy, André Marette
OBJECTIVE: The consumption of fruits is strongly associated with better health and higher bacterial diversity in the gut microbiota (GM). Camu camu ( Myrciaria dubia ) is an Amazonian fruit with a unique phytochemical profile, strong antioxidant potential and purported anti-inflammatory potential. DESIGN: By using metabolic tests coupled with 16S rRNA gene-based taxonomic profiling and faecal microbial transplantation (FMT), we have assessed the effect of a crude extract of camu camu (CC) on obesity and associated immunometabolic disorders in high fat/high sucrose (HFHS)-fed mice...
July 31, 2018: Gut
https://www.readbyqxmd.com/read/30007918/gut-commensal-parabacteroides-goldsteinii-plays-a-predominant-role-in-the-anti-obesity-effects-of-polysaccharides-isolated-from-hirsutella-sinensis
#3
Tsung-Ru Wu, Chuan-Sheng Lin, Chih-Jung Chang, Tzu-Lung Lin, Jan Martel, Yun-Fei Ko, David M Ojcius, Chia-Chen Lu, John D Young, Hsin-Chih Lai
OBJECTIVE: The medicinal fungus Ophiocordyceps sinensis and its anamorph Hirsutella sinensis have a long history of use in traditional Chinese medicine for their immunomodulatory properties. Alterations of the gut microbiota have been described in obesity and type 2 diabetes. We examined the possibility that H. sinensis mycelium (HSM) and isolated fractions containing polysaccharides may prevent diet-induced obesity and type 2 diabetes by modulating the composition of the gut microbiota...
July 14, 2018: Gut
https://www.readbyqxmd.com/read/29983136/early-intervention-with-faecal-microbiota-transplantation-an-effective-means-to-improve-growth-performance-and-the-intestinal-development-of-suckling-piglets
#4
C S Cheng, H K Wei, P Wang, H C Yu, X M Zhang, S W Jiang, J Peng
Recent studies indicate that early postnatal period is a critical window for gut microbiota manipulation to optimise the immunity and body growth. This study investigated the effects of maternal faecal microbiota orally administered to neonatal piglets after birth on growth performance, selected microbial populations, intestinal permeability and the development of intestinal mucosal immune system. In total, 12 litters of crossbred newborn piglets were selected in this study. Litter size was standardised to 10 piglets...
July 9, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29980607/faecal-microbiota-transplantation-alters-gut-microbiota-in-patients-with-irritable-bowel-syndrome-results-from-a-randomised-double-blind-placebo-controlled-study
#5
Sofie Ingdam Halkjær, Alice Højer Christensen, Bobby Zhao Sheng Lo, Patrick Denis Browne, Stig Günther, Lars Hestbjerg Hansen, Andreas Munk Petersen
OBJECTIVE: IBS is associated with an intestinal dysbiosis and faecal microbiota transplantation (FMT) has been hypothesised to have a positive effect in patients with IBS. We performed a randomised, double-blind placebo-controlled trial to investigate if FMT resulted in an altered gut microbiota and improvement in clinical outcome in patients with IBS. DESIGN: We performed this study in 52 adult patients with moderate-to-severe IBS. At the screening visit, clinical history and symptoms were assessed and faecal samples were collected...
July 6, 2018: Gut
https://www.readbyqxmd.com/read/29851107/randomised-clinical-trial-faecal-microbiota-transplantation-by-colonoscopy-plus-vancomycin-for-the-treatment-of-severe-refractory-clostridium-difficile-infection-single-versus-multiple-infusions
#6
G Ianiro, L Masucci, G Quaranta, C Simonelli, L R Lopetuso, M Sanguinetti, A Gasbarrini, G Cammarota
BACKGROUND: Faecal microbiota transplantation (FMT) is a highly effective treatment against recurrent Clostridium difficile infection. Far less evidence exists on the efficacy of FMT in treating severe Clostridium difficile infection refractory to antibiotics. AIM: To compare the efficacy of two FMT-based protocols associated with vancomycin in curing subjects with severe Clostridium difficile infection refractory to antibiotics. METHODS: Subjects with severe Clostridium difficile infection refractory to antibiotics were randomly assigned to one of the two following treatment arms: (1) FMT-S, including a single faecal infusion via colonoscopy followed by a 14-day vancomycin course, (2) FMT-M, including multiple faecal infusions plus a 14-day vancomycin course...
July 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29843854/the-ins-and-outs-of-faecal-microbiota-transplant-for-recurrent-clostridium-difficile-diarrhoea-at-wits-donald-gordon-medical-centre-johannesburg-south-africa
#7
S Lee, K Drennan, G Simons, A Hepple, K Karlsson, W Lowman, P C Gaylard, L McNamara, J Fabian
BACKGROUND: Clostridium difficile-associated diarrhoea (CDAD) is a potentially life-threatening condition that is becoming increasingly common. A persistent burden of this infectious illness has been demonstrated over the past 4 years at Wits Donald Gordon Medical Centre (WDGMC), Johannesburg, South Africa, through implementation of active surveillance of hospital-acquired infections as part of the infection prevention and control programme. Oral treatment with metronidazole or vancomycin is recommended, but there is a major problem with symptomatic recurrence after treatment...
April 25, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29750050/does-the-internet-promote-the-unregulated-use-of-fecal-microbiota-transplantation-a-potential-public-health-issue
#8
Jonathan Philip Segal, Faisal Abbasi, Cynthia Kanagasundaram, Ailsa Hart
Introduction: The Internet has become an increasingly popular resource for medical information. Fecal microbiota transplantation (FMT) has changed the treatment of Clostridium difficile with cure rates of 81% following one infusion of FMT, further studies have since validated these findings. The Medicines and Health care Products Regulatory Agency has classified FMT as a medicine and hence should be only utilized in strict clinical settings. Methods: We searched Facebook, Twitter, Google, and YouTube using the words "Faecal Microbiota Transplantation" and "FMT"...
2018: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/29746938/microbial-taxonomic-and-metabolic-alterations-during-faecal-microbiota-transplantation-to-treat-clostridium-difficile-infection
#9
Lee Kellingray, Gwénaëlle Le Gall, Marianne Defernez, Ian L P Beales, Ngozi Franslem-Elumogo, Arjan Narbad
OBJECTIVES: This study aimed to examine changes to the microbiota composition and metabolic profiles of seven patients with recurrent Clostridium difficile infection (rCDI), following treatment with faecal microbiota transplant (FMT). METHODS: 16S rDNA sequencing and 1 H NMR were performed on faecal samples from the patients (pre-, post-FMT, and follow-up) and the associated donor samples. Sparse partial-least-square analysis was used to identify correlations between the two datasets...
August 2018: Journal of Infection
https://www.readbyqxmd.com/read/29743833/why-is-it-so-difficult-to-evaluate-faecal-microbiota-transplantation-as-a-treatment-for-ulcerative-colitis
#10
REVIEW
Natalie Grace Fairhurst, Simon P L Travis
Faecal microbiota transplantation (FMT) has recently re-emerged as a viable therapeutic option for colonic disorders. Its efficacy has been proved in the treatment of Clostridium difficile infection which has encouraged research into the use of FMT for other disorders involving gut dysbiosis, such as ulcerative colitis (UC), a chronic inflammatory disease characterized by relapsing and remitting colonic inflammation. Although the FMT protocol for C. difficile treatment is well established, there are numerous additional factors to consider when applying FMT to treat inflammatory diseases...
April 2018: Intestinal Research
https://www.readbyqxmd.com/read/29703851/efficacy-and-safety-of-faecal-microbiota-transplantation-in-patients-with-psoriatic-arthritis-protocol-for-a-6-month-double-blind-randomised-placebo-controlled-trial
#11
Maja Skov Kragsnaes, Jens Kjeldsen, Hans Christian Horn, Heidi Lausten Munk, Finn Moeller Pedersen, Hanne Marie Holt, Jens Kristian Pedersen, Dorte Kinggaard Holm, Henning Glerup, Vibeke Andersen, Ulrich Fredberg, Karsten Kristiansen, Robin Christensen, Torkell Ellingsen
INTRODUCTION: An unbalanced intestinal microbiota may mediate activation of the inflammatory pathways seen in psoriatic arthritis (PsA). A randomised, placebo-controlled trial of faecal microbiota transplantation (FMT) infused into the small intestine of patients with PsA with active peripheral disease who are non-responsive to methotrexate (MTX) treatment will be conducted. The objective is to explore clinical aspects associated with FMT performed in patients with PsA. METHODS AND ANALYSIS: This trial is a randomised, two-centre stratified, double-blind (patient, care provider and outcome assessor), placebo-controlled, parallel-group study...
April 27, 2018: BMJ Open
https://www.readbyqxmd.com/read/29682542/gut-microbial-changes-interactions-and-their-implications-on-human-lifecycle-an-ageing-perspective
#12
REVIEW
Ravichandra Vemuri, Rohit Gundamaraju, Madhur D Shastri, Shakti Dhar Shukla, Krishnakumar Kalpurath, Madeleine Ball, Stephen Tristram, Esaki M Shankar, Kiran Ahuja, Rajaraman Eri
Gut microbiota is established during birth and evolves with age, mostly maintaining the commensal relationship with the host. A growing body of clinical evidence suggests an intricate relationship between the gut microbiota and the immune system. With ageing, the gut microbiota develops significant imbalances in the major phyla such as the anaerobic Firmicutes and Bacteroidetes as well as a diverse range of facultative organisms, resulting in impaired immune responses. Antimicrobial therapy is commonly used for the treatment of infections; however, this may also result in the loss of normal gut flora...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29670863/commentary-bacteriophage-transfer-during-faecal-microbiota-transplantation-in-clostridium-difficile-infection-is-associated-with-treatment-outcome
#13
COMMENT
Blessing O Anonye
No abstract text is available yet for this article.
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29564058/faecal-microbiota-transplantation-looking-beyond-clostridium-difficile-infection-at-inflammatory-bowel-disease
#14
REVIEW
Krish Patel, Amee Patel, David Hawes, Janki Shah, Krishna Shah
Gastrointestinal (GI) microbiota are known to play paramount role in inflammatory bowel disease (IBD). Innovative sequencing methods have radically expanded our ability to analyze the intestinal microbiome. However, alterations of the GI microbiome in IBD have not yet been fully evaluated. Irregular colonization of the gut has been implicated in chronic intestinal inflammation. Faecal microbiota transplantation (FMT) is a procedure which aims to restore microbial disturbances to the individual's gut microbiome...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29535482/faecal-microbiota-transplantation-for-clostridium-difficile-a-local-perspective
#15
C Diamond, T McNeilly
Clostridium Difficile represents one of the major challenges of the antimicrobial era with associated significant morbidity. Treatment options are limited to a number of specific antibiotics with significant failure rates. Faecal Microbiota Transplantation has been recognised as a possible treatment option when standard therapy fails. We report a local case of Clostridium Difficile Infection ultimately requiring Faecal Microbiota Transplantation with good success. While no formal service providing the treatment is available within Northern Ireland it is a feasible treatment option for Clostridium Difficile Infection...
May 2017: Ulster Medical Journal
https://www.readbyqxmd.com/read/29528385/effect-of-faecal-microbiota-transplantation-for-treatment-of-clostridium-difficile-infection-in-patients-with-inflammatory-bowel-disease-a-systematic-review-and-meta-analysis-of-cohort-studies
#16
Tuo Chen, Qun Zhou, Dan Zhang, Feng Jiang, Jing Wu, Jin-Yong Zhou, Xiao Zheng, Yu-Gen Chen
Background: Evidence concerning the effect of faecal microbiota transplantation [FMT] in Clostridium difficile infection [CDI] patients with inflammatory bowel disease [IBD] has not been firmly established. Therefore, we performed a systematic review and meta-analysis to evaluate FMT treatment outcomes in patients with IBD treated for CDI. Methods: An electronic search of four databases was conducted until November 1, 2017. Cohort studies of FMT efficacy and safety in CDI patients with IBD were included...
May 25, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29507020/successful-faecal-microbiota-transplant-for-recurrent-clostridium-difficile-infection-delivered-by-colonoscopy-through-a-diverted-ileostomy-in-a-patient-with-severe-perianal-crohn-s-disease
#17
Jonathan Digby-Bell, Andrew Williams, Peter Irving, Simon Goldenberg
We present the first reported case of successful treatment of recurrent Clostridium difficile infection with faecal microbiota transplantation delivered antegrade with a colonoscope through a diverting ileostomy.
March 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29484160/meeting-update-faecal-microbiota-transplantation-bench-bedside-courtroom
#18
Nik Sheng Ding, Benjamin H Mullish, John McLaughlin, Ailsa Hart, Julian R Marchesi
No abstract text is available yet for this article.
January 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/29428498/the-role-of-gut-microbiota-in-clostridium-difficile-infection
#19
REVIEW
Michael Samarkos, Elpida Mastrogianni, Olga Kampouropoulou
Clostridium difficile infection has emerged as a major health problem. Because it is a spore-forming microorganism, C. difficile is difficult to eradicate and recurrences of the infection are frequent. The strong association of CDI with prior use of antibiotics led to the recognition that disturbances in the gut microbiota apparently plays a central role in CDI. Except for antibiotics, several other risk factors for CDI have been recognised, such as advanced age and use of proton pump inhibitors. The common characteristic of these factors is that they are associated with changes in the composition of gut microbiota...
April 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29397391/gut-microbiome-and-depression-what-we-know-and-what-we-need-to-know
#20
Gal Winter, Robert A Hart, Richard P G Charlesworth, Christopher F Sharpley
Gut microbiome diversity has been strongly associated with mood-relating behaviours, including major depressive disorder (MDD). This association stems from the recently characterised bi-directional communication system between the gut and the brain, mediated by neuroimmune, neuroendocrine and sensory neural pathways. While the link between gut microbiome and depression is well supported by research, a major question needing to be addressed is the causality in the connection between the two, which will support the understanding of the role that the gut microbiota play in depression...
February 5, 2018: Reviews in the Neurosciences
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