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infantile hypertrophic pyloric stenosis

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https://www.readbyqxmd.com/read/30470884/association-between-exposure-to-macrolides-and-the-development-of-infantile-hypertrophic-pyloric-stenosis-a-systematic-review-and-meta-analysis
#1
Mohammed Abdellatif, Sherief Ghozy, Mohamed Gomaa Kamel, Sameh Samir Elawady, Mohamed Mohy Eldeen Ghorab, Andrew Wassef Attia, Truong Thi Le Huyen, Diep Trong Vien Duy, Kenji Hirayama, Nguyen Tien Huy
Macrolides are bacteriostatic antibiotics with a broad spectrum of activity against Gram-positive bacteria. The aim of this study was to systematically review and meta-analyze the association between infantile hypertrophic pyloric stenosis (IHPS) and macrolides. Nine databases were searched systematically for studies with information on the association between macrolides and IHPS. We combined findings using random effects models. Our study revealed 18 articles investigating the association between macrolides and IHPS...
November 23, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/30419040/safety-of-azithromycin-in-infants-under-six-months-of-age-in-niger-a-community-randomized-trial
#2
Catherine E Oldenburg, Ahmed M Arzika, Ramatou Maliki, Mohamed Salissou Kane, Elodie Lebas, Kathryn J Ray, Catherine Cook, Sun Y Cotter, Zhaoxia Zhou, Sheila K West, Robin Bailey, Travis C Porco, Jeremy D Keenan, Thomas M Lietman
BACKGROUND: Mass azithromycin distribution reduces under-5 child mortality. Trachoma control programs currently treat infants aged 6 months and older. Here, we report findings from an infant adverse event survey in 1-5 month olds who received azithromycin as part of a large community-randomized trial in Niger. METHODS AND PRINCIPAL FINDINGS: Active surveillance of infants aged 1-5 months at the time of treatment was conducted in 30 randomly selected communities from within a large cluster randomized trial of biannual mass azithromycin distribution compared to placebo to assess the potential impact on child mortality...
November 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/30402682/developmental-outcome-at-3-years-of-age-of-infants-following-surgery-for-infantile-hypertrophic-pyloric-stenosis
#3
Alison Loughran-Fowlds, Dermot T McDowell, Claire Galea, Robert Halliday, Karen Walker, Nadia Badawi, Andrew J A Holland
PURPOSE: The study compared neurodevelopmental outcome at 3 years of age of infants with infantile hypertrophic pyloric stenosis (IHPS) who underwent pyloromyotomy with healthy control infants in New South Wales, Australia. METHODS: Infants with IHPS as well as controls were recruited between August 2006 and July 2008. Developmental assessments were performed using the Bayley scales of infant and toddler development (version III) (BSITD-III) at 1 and 3 years of age...
November 7, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/30281099/genome-wide-meta-analysis-identifies-barx1-and-eml4-mta3-as-new-loci-associated-with-infantile-hypertrophic-pyloric-stenosis
#4
João Fadista, Line Skotte, Frank Geller, Jonas Bybjerg-Grauholm, Sanne Gørtz, Paul A Romitti, Michele Caggana, Denise M Kay, Hans Matsson, Heather A Boyd, David M Hougaard, Agneta Nordenskjöld, James L Mills, Mads Melbye, Bjarke Feenstra
Infantile hypertrophic pyloric stenosis (IHPS) is a disorder of young infants with a population incidence of ~2/1000 live births, caused by hypertrophy of the pyloric sphincter smooth muscle. Reported genetic loci associated with IHPS explain only a minor proportion of IHPS risk. To identify new risk loci, we carried out a genome-wide meta-analysis on 1395 surgery-confirmed cases and 4438 controls, with replication in a set of 2427 cases and 2524 controls. We identified and replicated six independent genomic loci associated with IHPS risk at genome wide significance (P<5x10-8), including novel associations with two SNPs...
October 2, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/30234537/retrospective-cohort-study-on-the-optimal-timing-of-orogastric-tube-nasogastric-tube-insertion-in-infants-with-pyloric-stenosis
#5
Lisa K Lee, Rebekah A Burns, Rajvinder S Dhamrait, Harmony F Carter, Marissa G Vadi, Tristan R Grogan, David A Elashoff, Richard L Applegate, Marc Iravani
BACKGROUND: Hypertrophic pyloric stenosis in infants can cause a buildup of gastric contents. Orogastric tubes (OGTs) or nasogastric tubes (NGTs) are often placed in patients with pyloric stenosis before surgical management to prevent aspiration. However, exacerbation of gastric losses may lead to electrolyte abnormalities that can delay surgery, and placement has been associated with increased risk of postoperative emesis. Currently, there are no evidence-based guidelines regarding OGT/NGT placement in these patients...
September 18, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/30176827/hypertrophic-pyloric-stenosis-following-persistent-pulmonary-hypertension-of-the-newborn-a-case-report-and-literature-review
#6
Shigeo Iijima, Daizo Ueno, Toru Baba, Akira Ohishi
BACKGROUND: Although persistent pulmonary hypertension of the newborn (PPHN) and infantile hypertrophic pyloric stenosis (HPS) are both well-known diseases that occur in early infancy, PPHN complicated by HPS is rare. As nitric oxide (NO) is an important mediator of biological functions, on both the vascular endothelium and smooth muscle cells, the decreased production of NO might play a role in the pathogenesis of both PPHN and HPS. We present the case of a neonate who developed HPS following PPHN, including a detailed review on research published to date, and we discuss the pathogenesis of PPHN and HPS...
September 3, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29582798/our-experience-of-laparoscopic-pyloromyotomy-with-ultrasound-guided-parameters
#7
Aboli Hukeri, Abhaya Gupta, Paras Kothari, Vishesh Dikshit, Geeta Kekre, Prashant Patil, Apoorva Kulkarni, Arjun Pawar
Traditional management of infantile Hypertrophic Pyloric Stenosis is open pyloromyotomy after initial adequate resuscitation of the patient. From 1991, laparoscopic approach is considered feasible and safe. Today, diagnosis of hypertrophic pyloric stenosis is made most often made by ultrasound. With use of ultrasound-guided parameters (length of pyloric tumour and thickness of pyloric tumour), we could avoid 'incomplete pyloromyotomy' and 'mucosal perforation' (most common complications in laparoscopic approach) to achieve 100% adequacy and safety in laparoscopic pyloromyotomy...
March 23, 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29338765/infantile-hypertrophic-pyloric-stenosis-a-4-year-experience-from-two-tertiary-care-centres-in-cameroon
#8
MULTICENTER STUDY
Rene Ndongo, Paul Nkemtendong Tolefac, Faustin Félicien Mouafo Tambo, Matin Hongieh Abanda, Marcelin Ngowe Ngowe, Olivier Fola, Bonaventure Dzekem, Patrick Eroyl Weledji, Maurice Aurelien Sosso, Jacqueline Ze Minkande
OBJECTIVE: This study aimed to describe the clinical characteristics of patients with infantile hypertrophic stenosis, management and its outcome in two tertiary care centres in Cameroon. RESULTS: A total of 21 patients were included from the two centres. The mean age at presentation was 5.2 ± 1.2 weeks, predominantly male with a male-to-female ratio of 4.25:1. The triad of vomiting, visible peristalsis and palpable mass was present in only 7 (33.3%) of the participants...
January 16, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29236645/caterpillar-sign-in-infantile-hypertrophic-pyloric-stenosis
#9
Bruno Martinez-Leo, Luis M Garcia-Cabello
A 23-day-old male infant was brought to the emergency department because of nonbilious vomiting that had increased in frequency over a period of 5 days. Findings from the clinical examination were notable for mild dehydration and a possible olive-sized mass, approximately 2 cm in diameter, that was..
December 14, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29099348/transient-neonatal-myasthenia-gravis-with-infantile-hypertrophic-pyloric-stenosis-coincidence-or-causation
#10
Aakash Pandita, Deepak Sharma, Srinivas Murki, Tejo Pratap Oleti, Vallamsetty Leelakumar
No abstract text is available yet for this article.
April 2018: Tropical Doctor
https://www.readbyqxmd.com/read/29043691/-analysis-of-hypertrophic-pyloric-stenosis-size-does-matter
#11
Y González Ruiz, A Siles Hinojosa, N Álvarez García, R Fernández Atuán, P Bragagnini Rodríguez, J Elías Pollina
OBJECTIVES: To analyze the correlation between pyloric size and evolution of patients surgically treated for infantile hypertrophic pyloric stenosis (IHPS). PATIENTS AND METHODS: We realized a retrospective study of 109 patients undergoing IHPS in 5 years. We analyzed by χ2 test if a correlation between evolution time, age and postoperative vomiting and gastroesophageal reflux disease (GERD), and pyloric muscle thickness (group A > 4.5 mm and group B ≤ 4...
July 20, 2017: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/28701060/epidemiological-and-clinical-characteristics-of-304-patients-with-infantile-hypertrophic-pyloric-stenosis-in-anhui-province-of-east-china-2012-2015
#12
Jing Li, Wei Gao, Ji-Min Zhu, Wei Zuo, Xiang Liu
OBJECTIVE: To analyze the clinical and epidemiological features of patients with infantile hypertrophic pyloric stenosis (IHPS) so as to provide scientific evidence for diagnosis and prevention of IHPS. METHODS: We performed a retrospective study of infants with IHPS diagnosed from 2012 to 2015 at Anhui Provincial Children's Hospital. Demographic characteristics and clinical data were collected. RESULTS: Three hundred four patients (264 males and 40 females) were studied, of which 94...
October 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28576429/population-level-surgical-outcomes-for-infantile-hypertrophic-pyloric-stenosis
#13
Nick Lansdale, Nadeem Al-Khafaji, Patrick Green, Simon E Kenny
OBJECTIVES: Determine national outcomes for pyloromyotomy; how these are affected by: (i) surgical approach (open/laparoscopic), or (ii) centre type/volume and establish potential benchmarks of quality. METHODS: Hospital Episode Statistics data were analysed for admissions 2002-2011. Data presented as median (IQR). RESULTS: 9686 infants underwent pyloromyotomy (83% male). Surgery was performed in 22 specialist (SpCen) and 39 nonspecialist centres (NonSpCen)...
March 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28550912/does-metabolic-alkalosis-influence-cerebral-oxygenation-in-infantile-hypertrophic-pyloric-stenosis
#14
Matthias Nissen, Grigore Cernaianu, Rene Thränhardt, Mohammad R Vahdad, Karin Barenberg, Ralf-Bodo Tröbs
BACKGROUND: This pilot study focuses on regional tissue oxygenation (rSO2 ) in patients with infantile hypertrophic pyloric stenosis in a perioperative setting. To investigate the influence of enhanced metabolic alkalosis (MA) on cerebral (c-rSO2 ) and renal (r-rSO2 ) tissue oxygenation, two-site near-infrared spectroscopy (NIRS) technology was applied. MATERIALS AND METHODS: Perioperative c-rSO2 , r-rSO2 , capillary blood gases, and electrolytes from 12 infants were retrospectively compared before and after correction of MA at admission (T1), before surgery (T2), and after surgery (T3)...
May 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28318599/perinatal-risk-factors-for-infantile-hypertrophic-pyloric-stenosis-a-meta-analysis
#15
REVIEW
Jianghu Zhu, Tingting Zhu, Zhenlang Lin, Yi Qu, Dezhi Mu
BACKGROUND: Infantile hypertrophic pyloric stenosis (IHPS) is the most common surgical cause of nonbilious vomiting in infancy. The etiology of IHPS is not completely understood. Hence, we performed a meta-analysis to investigate the association between perinatal factors and IHPS onset. METHODS: The MEDLINE, EMBASE, PubMed and Cochrane Library databases were searched for studies published in English before December 2016. The combined odd ratios (ORs) and 95% confidence intervals (CIs) were calculated using random-effects models...
September 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27855150/a-novel-missense-mutation-in-the-transcription-factor-foxf1-cosegregating-with-infantile-hypertrophic-pyloric-stenosis-in-the-extended-pedigree-linked-to-ihps5-on-chromosome-16q24
#16
Kate V Everett, Paris Ataliotis, Barry A Chioza, Charles Shaw-Smith, Eddie M K Chung
BACKGROUND: The aim was to identify susceptibility alleles for infantile hypertrophic pyloric stenosis (IHPS) in a pedigree previously linked to IHPS5 on chromosome 16q24. METHODS: We screened the positional and functional candidate gene FOXF1 by Sanger sequencing in a single affected individual. All family members for whom DNA was available were genotyped to determine cosegregation status of the putative causal variant. Immunofluorescence studies were performed to compare the cellular localization of wildtype and mutant form of the protein...
April 2017: Pediatric Research
https://www.readbyqxmd.com/read/27775311/-infantile-hypertrofic-pyloric-stenosis-or-gastric-adenomyoma-differential-diagnosis-of-gastric-outlet-obstruction-in-children
#17
M Oviedo Gutiérrez, S Amat Valero, A Gómez Farpón, C Montalvo Ávalos, L Fernández García, D C Lara Cárdenas, S Barnes Marañón, C Granell Suárez, N Vega Mata, A J López López, M González Guerrero, V Álvarez Muñoz
PURPOSE: Gastrointestinal adenomyoma is a rare benign tumor most frequently located in the stomach. The differential diagnosis is wide because of its large clinical spectrum and unspecific radiological findings. Surgical excision is both diagnostic and therapeutic. CASE REPORT: A 49-days old girl presented with nonbilious vomiting of 48 hours of evolution. Infantile hypertrofic pyloric stenosis was suspected. Ultrasound showed a nonobstructive nodular lesion in the anterior pyloric wall...
July 20, 2015: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/27655365/post-natal-erythromycin-exposure-and-risk-of-infantile-hypertrophic-pyloric-stenosis-a-systematic-review-and-meta-analysis
#18
REVIEW
L Murchison, P De Coppi, S Eaton
PURPOSE: Macrolide antibiotics, erythromycin, in particular, have been linked to the development of infantile hypertrophic pyloric stenosis (IHPS). Our aim was to conduct a systematic review of the evidence of whether post-natal erythromycin exposure is associated with subsequent development of IHPS. METHODS: A systematic review of postnatal erythromycin administration and IHPS was performed. Papers were included if data were available on development (yes/no) of IHPS in infants exposed/unexposed to erythromycin...
December 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27642452/infantile-hypertrophic-pyloric-stenosis-with-unusual-presentations-in-sagamu-nigeria-a-case-report-and-review-of-the-literature
#19
REVIEW
Tinuade Adetutu Ogunlesi, Opeyemi Temitola Kuponiyi, Collins Chigbundu Nwokoro, Ibukunolu Olufemi Ogundele, Gbenga Fakunle Abe, Olusoga Babatunde Ogunfowora
A 24-day old female Nigerian neonate presented with protracted vomiting, fever and dehydration but without palpable abdominal tumour or visible gastric peristalsis. There was no derangement of serum electrolytes. The initial working diagnosis was Late-Onset Sepsis but abdominal ultrasonography showed features consistent with the diagnosis of IHPS. This case report highlights the atypical presentation of this surgical condition and the need to investigate cases of protracted vomiting in the newborn with at least, ultrasonography to minimize complications and reduce the risk of mortality in a resource-poor setting...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27528563/operative-outcomes-of-infantile-hypertrophic-pyloric-stenosis-in-patients-with-congenital-heart-disease
#20
Shin Miyata, Jayun Cho, Kazuhide Matsushima, Aaron Fowler, David W Bliss
PURPOSE: This study aims to compare the outcomes of pyloromyotomy for infantile hypertrophic pyloric stenosis (IHPS) in children with and without congenital heart disease (CHD). METHODS: A retrospective, single pediatric center, case-control, matched cohort study was performed over 10years. A case of IHPS with CHD was paired with control patients of IHPS without CHD, matched by age and gender. Perioperative morbidity, 30-day mortality, length of hospital stay, and hospital cost were compared...
November 2016: Journal of Pediatric Surgery
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