Read by QxMD icon Read

bioresorbable implant

Susmita Bose, Naboneeta Sarkar, Dishary Banerjee
Calcium phosphate materials are widely used as bone-like scaffolds or coating for metallic hip and knee implants due to their excellent biocompatibility, compositional similarity to natural bone and controllable bioresorbability. Local delivery of drugs or osteogenic factors from scaffolds and implants are required over a desired period of time for an effectual treatment of various musculoskeletal disorders. Curcumin, an antioxidant and anti-inflammatory molecule, enhances osteoblastc activity in addition to its anti-osteoclastic activity...
June 2018: Materials today. Chemistry
Vic Velanovich, Paul Rider, Kenneth Deck, Harold S Minkowitz, David Leiman, Nigel Jones, Gwendolyn Niebler
INTRODUCTION: Surgical site infiltration with bupivacaine results in short-lived analgesia. The MATRIX-1 and MATRIX-2 studies examined the efficacy and safety of the bioresorbable bupivacaine HCl collagen-matrix implant (INL-001) for postsurgical pain after open inguinal hernia repair. INL-001, designed to provide early and extended delivery of bupivacaine, provides prolonged duration of perioperative analgesia. METHODS: In two phase 3 double-blind studies [MATRIX-1 (ClinicalTrials...
November 22, 2018: Advances in Therapy
Peng-Fei Wei, Zuo-Ying Yuan, Wei Jing, Bin-Bin Guan, Zi-Hao Liu, Xu Zhang, Jian-Ping Mao, Da-Fu Chen, Qing Cai, Xiao-Ping Yang
Treatment of infected bone defects still remains a formidable clinical challenge, and the design of bone implants with both anti-bacterial activity and -osteogenesis effects is nowadays regarded as a powerful strategy for infection control and bone healing. In the present study, bioresorbable porous-structured microspheres were fabricated from an amphiphilic block copolymer composed of poly(l-lactide) and poly(ethyl glycol) blocks. After being surface coated with mussel-inspired polydopamine, the microspheres were loaded with nanosilver via the reduction of silver nitrate and apatite via biomineralization in sequence...
November 23, 2018: Biomaterials Science
Satoru Mitomo, Ozan M Demir, Francesco Giannini, Azeem Latib, Antonio Colombo
No abstract text is available yet for this article.
November 20, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
Joan Combie, Ebru Toksoy Öner
Levan is a fructose homopolysaccharide which gained attention recently for its unusual combination of properties distinguishing it from other natural biodegradable polysaccharides like chitosan, cellulose or starch. Among the strongest bioadhesives, film-forming levan is garnering interest for its role in some simple solutions to difficult problems. One of these is illustrated by the elegant research using laser-based techniques to construct levan films for healing wounds and burned tissue. Another is the development of bioresorbable electronic implants...
November 20, 2018: Bioinspiration & Biomimetics
Hyun-Seung Kim, Seung Min Yang, Tae-Min Jang, Nuri Oh, Hee-Soo Kim, Suk-Won Hwang
A strategy of materials synthesis, characteristic evaluations, and manufacturing process for a mechanically elastic, biologically safe silicon-based dopamine detector that is designed to be completely transient, i.e., dissolved in water and/or biofluids, potentially in the brain after a desired period of operation, is introduced. Use of inexpensive, bioresorbable iron (Fe)-based nanoparticles (NPs) is one of the attractive choices for efficient catalytic oxidation of dopamine as an alternative for noble, nontransient platinum (Pt) nanoparticles, based on extensive studies of synthesized materials and catalytic reactions...
November 19, 2018: Advanced Healthcare Materials
Jenny E Zablah, Gareth J Morgan
Stent implantation for pulmonary artery stenosis has advanced. Newer generations of stents allow confidence in long-term results, even in pediatric interventions. Primary intravascular stent implantation is recommended in significant branch pulmonary artery stenosis when the vessel or patient is large enough to accommodate a stent that can be dilated to an adult diameter. A variety of specialized stents are now available, improving applicability despite complex vessel size characteristics. Developments in bioresorbable stents and patient-specific rapid prototyping are anticipated...
January 2019: Interventional Cardiology Clinics
Georgia S Karanasiou, George A Rigas, Savvas K Kyriakidis, Nikolaos S Tachos, Antonis I Sakellarios, Dimitrios I Fotiadis
Coronary artery disease (CAD) is the leading cause of mortality in Europe and worldwide. Atherosclerosis is the most common pathologic process that is highly related with CAD, while the implantation of drug-eluting Bioresorbable Vascular Scaffolds (BVS) is the most promising procedure for treating patients with CAD. InSilc is an textbfin silico clinical trial (ISCT) platform for the development and assessment of drugeluting BVS. The InSilc platform provides insight in the performance of drug-eluting BVS in their short term and medium/long term through the Mechanical Modelling Module, the Deployment Module, the Fluid Dynamics Module, the Myocardial Perfusion Module, the Drug-delivery Module and the Degradation Module...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Xianjing Qin, Linlin Yao, Qinhua Jin, Jing Jing, Yundai Chen, Yihui Cao, Jianan Li, Rui Zhu
Bioresorbable Vascular scaffold (BVS) is a promising type of stent in percutaneous coronary intervention. Struts apposition assessment is important to ensure the safety of implanted BVS. Currently, BVS struts apposition analysis in IVOCT images still depends on manual delineation of struts, which is labor intensive and time consuming. Automatic struts segmentation is highly desired to simplify and speed up quantitative analysis. However, it is difficult to segment struts accurately based on the contour, due to the influence of fractures inside strut and blood artifacts around strut...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Erhan Tenekecioglu, Ryo Torii, Yuki Katagiri, Ply Chichareon, Taku Asano, Yosuke Miyazaki, Kuniaki Takahashi, Rodrigo Modolo, Rasha Al-Lamee, Kadem Al-Lamee, Carlos Colet, Johan H C Reiber, Kerem Pekkan, Robert van Geuns, Christos V Bourantas, Yoshinobu Onuma, Patrick W Serruys
Optical coherence tomography based computational flow dynamic (CFD) modeling provides detailed information about the local flow behavior in stented/scaffolded vessel segments. Our aim is to investigate the in-vivo effect of strut thickness and strut protrusion on endothelial wall shear stress (ESS) distribution in ArterioSorb Absorbable Drug-Eluting Scaffold (ArterioSorb) and Absorb everolimus-eluting Bioresorbable Vascular Scaffold (Absorb) devices that struts with similar morphology (quadratic structure) but different thickness...
November 13, 2018: International Journal of Cardiovascular Imaging
Fan Zhao, Laijun Liu, Yang Yang, Fujun Wang, Lu Wang
A bstract: Polymeric bioresorbable stents (PBRSs) are considered the most promising devices to treat cardiovascular diseases. However, the mechanical weakness still hampers their application. In general, PBRSs are crimped into small sheathes and re-expanded to support narrowed vessels during angioplasty. Accordingly, one of the most significant requirements of PBRSs is to maintain mechanical efficacy after implantation. Although a little research has focused on commercial balloon-expanding PBRSs, a near-total lack has appeared on self-expanding PBRSs and their deformation mechanisms...
November 4, 2018: Materials
Hirofumi Hioki, Salvatore Brugaletta, Kohki Ishida, Gianluca Campo, Simone Biscaglia, Luis Ortega-Paz, Bernardo Cortese, Attilio Varricchio, Azeem Latib, Manel Sabaté, Maurizio Tespili, Alfonso Ielasi
AIMS: To evaluate the impact of bioresorbable vascular scaffold (BRS) implantation technique on post-procedural quantitative coronary angiography (QCA) parameters in ST-elevation myocardial infarction (STEMI). METHODS AND RESULTS: We assessed 442 STEMI patients who underwent BRS implantation in the BVS STEMI STRATEGY-IT study. Optimal BRS implantation was assessed using PSP-score, developed and validated in the GHOST-EU registry. We analyzed post-implantation QCA parameters, including minimum lumen diameter (MLD) and maximum footprint, in patients with and without optimal BRS implantation, coded as maximum PSP score...
November 6, 2018: EuroIntervention
Takeru Tsujimoto, Hideki Sudo, Masahiro Todoh, Katsuhisa Yamada, Koji Iwasaki, Takashi Ohnishi, Naoki Hirohama, Takayuki Nonoyama, Daisuke Ukeba, Katsuro Ura, Yoichi M Ito, Norimasa Iwasaki
BACKGROUND: The current surgical procedure of choice for lumbar intervertebral disc (IVD) herniation is discectomy. However, defects within IVD produced upon discectomy may impair tissue healing and predispose patients to subsequent IVD degeneration. This study aimed to investigate whether the use of an acellular bioresorbable ultra-purified alginate (UPAL) gel implantation system is safe and effective as a reparative therapeutic strategy after lumbar discectomy. METHODS: Human IVD cells were cultured in a three-dimensional system in UPAL gel...
October 30, 2018: EBioMedicine
Alexander N Kharlamov
AIM: To statistically examine the released clinical trials and meta-analyses of polymeric bioresorbable scaffolds resuming the main accomplishments in the field with a translation to the routine clinical practice. METHODS: The statistical power in clinical trials such as ABSORB Japan, ABSORB China, EVERBIO II, AIDA, and few meta-analyses by the post hoc odds ratio-based sample size calculation, and the patterns of artery remodeling published in papers from ABSORB A and B trials were evaluated...
October 26, 2018: World Journal of Cardiology
Adriano Caixeta, Carlos M Campos, Cordula Felix, Alaide Chieffo, Piera Capranzano, Hiroyoshi Kawamoto, Claudia Tamburino, Roberto Diletti, José de Ribamar Costa, Yoshinobu Onuma, Robert-Jan van Geuns, Antonio L Bartorelli, Antonio Colombo, Corrado Tamburino, Patrick W Serruys, Alexandre Abizaid
AIMS: To investigate the predictors of long-term adverse clinical events after implantation of the everolimus-eluting Absorb bioresorbable vascular scaffold (BVS). METHODS AND RESULTS: We pooled patient-level databases derived from the large-scale ABSORB EXTEND study and five high-volume international centers. Between November 2011 and November 2015, 1,933 patients underwent PCI with a total of 2,372 Absorb BVS implanted. The median age was 61.0 (IQR 53.0 to 68...
October 30, 2018: EuroIntervention
Vincent Floré, Adam J Brown, Joel P Giblett, Kevin Liou, James Cranley, Stephen P Hoole, Nick E J West
AIMS: We investigated the effects of an initial learning period with mandatory optical coherence tomography (OCT) guidance for the implantation of everolimus-eluting bioresorbable vascular scaffolds (BVS). METHODS AND RESULTS: We analyzed procedural and clinical outcomes of all BVS implantations at a single center where OCT guidance was mandatory in the initial rollout (OCT-mandatory) phase. We compared these data with the later phase where use of OCT was at operator discretion (OCT-selective or angiography)...
October 30, 2018: EuroIntervention
Belay Tesfamariam
Bioresorbable scaffolds have emerged as a potential alternative to non-erodible metal implants to alleviate the long-term risk of permanent device vascular implant-related adverse events. Bioresorbable scaffolds provide a temporary mechanical support function until the vessel reaches complete healing, and the implant progressively disappears and vasomotion resumes. A polymer matrix with embedded drugs coated onto the scaffold surface degrades slowly, reducing the size from the exterior toward the interior, and this allows controlled drug release to a local vascular segment...
October 26, 2018: Journal of Cardiovascular Translational Research
Valeria Paradies, Georgios J Vlachojannis, Kees-Jan Royaards, Jochem Wassing, Martin van der Ent, Pieter C Smits
Data on the angiographic and clinical performance of bioresorbable vascular scaffolds (BVS) for bifurcation lesions treatment are still limited. Data were examined of 107 patients with at least 1 coronary bifurcation lesion involving a side branch ≥2mm. Angiographic and clinical outcomes were collected. Optical coherence tomography analysis was performed in a subgroup of patients. Between July 2009 and December 2015, 423 patients underwent PCI with Absorb BVS. A total of 110 lesions were identified as bifurcations, of which 24...
September 13, 2018: American Journal of Cardiology
In Woong Um
A bone graft and bone graft substitute should have at least one of the following properties: it should be (1) osteogenic, (2) osteoinductive and/or (3) osteoconductive. In addition, bone graft substitutes should be biocompatible and bioresorbable as well as easy to use and cost effective. Autologous cancellous bone is the clinical gold standard in bone grafting procedures1, 4 and it has osteogenic, osteoinductive, and osteoconductive properties. Because of disadvantages associated with harvesting autologous bone graft material, such as requiring an additional operation and possible donor site morbidity, there is a need for an alternative in terms of enhancing the bone healing for the treatment of large bony defects...
2018: Advances in Experimental Medicine and Biology
Patrick Rider, Željka Perić Kačarević, Said Alkildani, Sujith Retnasingh, Reinhard Schnettler, Mike Barbeck
Three-dimensional (3D) printing has become an important tool in the field of tissue engineering and its further development will lead to completely new clinical possibilities. The ability to create tissue scaffolds with controllable characteristics, such as internal architecture, porosity, and interconnectivity make it highly desirable in comparison to conventional techniques, which lack a defined structure and repeatability between scaffolds. Furthermore, 3D printing allows for the production of scaffolds with patient-specific dimensions using computer-aided design...
October 24, 2018: International Journal of Molecular Sciences
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"