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bioresorbable implant

Sila Cagri Isler, Fatma Soysal, Tugce Ceyhanlı, Batuhan Bakırarar, Berrin Unsal
BACKGROUND: Platelet concentration based membranes, as well as collagen membranes in combination with bone substitutes, have demonstrated successful outcomes in regeneration of peri-implant bone defects (PBD). PURPOSE: The aim of this study was to evaluate the clinical and radiographic outcomes of regenerative surgical treatment (RST) of peri-implantitis using a bone substitute combined with two different bioresorbable barrier membranes, either collagen membrane (CM) or concentrated growth factor (CGF), during 12-month follow-up...
August 17, 2018: Clinical Implant Dentistry and related Research
Moritz Baquet, Petra Hoppmann, David Grundmann, Wolfgang Schmidt, Sebastian Kufner, Hans D Theiss, Stefan Brunner, Jens Wiebe, Madeleine Eickhoff, David Jochheim, Robert A Byrne, Karl-Ludwig Laugwitz, Heribert Schunkert, Steffen Massberg, Adnan Kastrati, Julinda Mehilli
AIMS: Women and men suffering of coronary artery disease differ in their risk profile. We sought to investigate the impact of sex on 2-year outcomes after BVS implantation in routine clinical practice. METHODS AND RESULTS: Sex-based analysis of clinical outcomes was done by pooling the individual patient data of ISAR-ABSORB and KUM-ABSORB registries performed in 4 high-volume tertiary centers in Munich. Of the total of 1032 patients, 259 (25.1%) were women. The primary composite endpoint of death, target-vessel myocardial infarction (TV-MI) and target lesion revascularization (TLR) through 2 years occurred in 13...
August 14, 2018: EuroIntervention
David B Jessup, Matthew M Grove, Susan Marks, Alex Kirby
Bioresorbable Vascular Scaffolds (BVS) have the potential for adaptive vessel remodeling, restoration of vasomotion, and late luminal enlargement, thus allowing them to circumvent target lesion failures associated with bare metal stents (BMS) and drug-eluting stents (DES). However, recent data has shown a concerning increase in BVS-associated scaffold thrombosis (ScT) compared to DES. Upfront administration of GP IIb/IIIa inhibitors (GPIs) has shown to reduce early stent thrombosis (ST) compared to standard of care in BMS and DES...
August 3, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Florian Blachutzik, Stephan Achenbach, Mohamed Marwan, Jens Röther, Monique Tröbs, Reinhard Schneider, Holger Nef, Melissa Weissner, Christian Schlundt
BACKGROUND: Coronary evaginations can occur after implantation of bioresorbable vascular scaffolds (BRS) and may be associated with scaffold thrombosis. Aim of this study was to clarify the clinical manifestation, extent and time course of coronary artery remodeling in vessel segments that develop angiographically detectable evaginations following BRS implantation through optical coherence tomography (OCT) analysis. METHODS: In 8 patients, 10 BRS (Absorb, Abbott Vascular, Santa Clara, CA, USA) which displayed coronary evaginations in clinically driven late invasive coronary angiograms were identified and findings were compared to 10 BRS in 8 patients without coronary evaginations...
August 4, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Bo Xu, Yuejin Yang, Yaling Han, Yong Huo, Lefeng Wang, Xiangqian Qi, Jifu Li, Yundai Chen, Hai-Chien Kuo, Shih-Wa Ying, Wai-Fung Cheong, Yunlong Zhang, Xiaolu Su, Jeffrey J Popma, Runlin Gao, Gregg W Stone
AIMS: Absorb bioresorbable vascular scaffolds (BVS) and XIENCE cobalt-chromium everolimus-eluting stents (CoCr-EES) had comparable angiographic and clinical outcomes up to one year in patients enrolled in the ABSORB China randomised trial. Whether these favourable results with BVS continue beyond one year up to three years is unknown. In this study we sought to analyse the outcomes from the trial up to three-year follow-up. METHODS AND RESULTS: ABSORB China was a prospective, open-label, multicentre trial in which 480 patients with one or two native coronary artery lesions were randomised 1:1 to BVS (N=241) vs...
August 3, 2018: EuroIntervention
Konrad Stępień, Karolina Połetek, Michał Komornik, Zbigniew Siudak, Tomasz Tokarek, Dariusz Dudek
INTRODUCTION: Interventional cardiology (IC) is a rapidly expanding field of medicine. Medical studies should provide students the necessary level of knowledge about new techniques in IC. The aim of the study was to assess the medical students' knowledge about various new areas of IC. MATERIAL AND METHODS: Self-designed questionnaire was used to assess student's knowledge. It contained 31 questions. The initial 3 questions concerned general information, the remaining ones were related to different IC techniques: Transcatheter Aortic Valve Implantation (TAVI), Bioresorbable Vascular Scaffold (BVS), percutaneous mitral regurgitation repair methods, Left Atrial Appendage Occlusion (LAAO), Renal DeNervation (RDN), Balloon Aortic Valvuloplasty (BAV) and Atrial Septal Defect/Persistent Foramen Ovale (ASD/PFO)...
2018: Folia Medica Cracoviensia
Yujia Zhang, Zhitao Zhou, Zhen Fan, Shaoqing Zhang, Faming Zheng, Keyin Liu, Yulong Zhang, Zhifeng Shi, Liang Chen, Xinxin Li, Ying Mao, Fei Wang, Yun-Lu Sun, Tiger H Tao
Controllable degradation and excellent biocompatibility during/after a lifetime endow emerging transient electronics with special superiority in implantable biomedical applications. Currently, most of these devices need external power sources, limiting their real-world utilizations. Optimizing existing bioresorbable electronic devices requires natural-material-based construction and, more importantly, diverse or even all-in-one multifunctionalization. Herein, silk-based implantable, biodegradable, and multifunctional systems, self-powered with transient triboelectric nanogenerators (T2 ENGs), for real-time in vivo monitoring and therapeutic treatments of epileptic seizures, are reported...
August 5, 2018: Small
Fabien Picard, Robert Avram, Guillaume Marquis-Gravel, Victor-Xavier Tadros, Hung Q Ly, Jean-François Dorval, Serge Doucet, Gilbert Gosselin, Anita W Asgar, Reda Ibrahim, Raoul Bonan, Quentin de Hemptinne, Mohamed Nosair, Philippe L-L'Allier, Jean-François Tanguay
BACKGROUND: Scaffold thromboses (ST) and adverse events and have been associated with bioresorbable vascular scaffolds (BVS) at long-term, but their mechanism remains unclear. We sought to evaluate patient and lesion characteristics associated with mid- to long-term outcomes in patients treated with BVS. METHODS: This is an observational single-center, single-arm, retrospective study evaluating the performance of BVS in an all-comer population, including complex lesions (chronic total occlusions, long lesions), small vessels, and acute coronary syndromes (ACS)...
July 4, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Łukasz Rzeszutko, Michał Węgiel, Paweł Kleczyński, Wojciech Zasada, Rafał Depukat, Tomasz Rakowski, Jacek Legutko, Andrzej Surdacki, Dariusz Dudek, Stanisław Bartuś
BACKGROUND: Direct stent implantation is a preferred technique for primary percutaneous coronary intervention (PCI). For bioresorbable vascular scaffold (BVS) deployment current guidelines recommend aggressive predilatation. Data about direct BVS implantation in acute coronary syndrome (ACS) patients are scarce. AIMS: The aim of the study was to assess procedural characteristics and immediate outcomes of direct Absorb BVS implantation in ACS patients. METHODS: Ninety-one patients with acute myocardial infarction and requiring urgent coronary revascularization were enrolled...
August 1, 2018: Kardiologia Polska
N G Grün, P Holweg, S Tangl, J Eichler, L Berger, J J J P van den Beucken, J F Löffler, T Klestil, A M Weinberg
Fracture treatment in children needs new implant materials to overcome disadvantages associated with removal surgery. Magnesium-based implants constitute a biocompatible and bioresorbable alternative. In adults and especially in children, implant safety needs to be evaluated. In children the bone turnover rate is higher and implant material might influence growth capacity, and the long-term effect of accumulated particles or ions is more critical due to the host's prolonged post-surgery lifespan. In this study we aimed to investigate the degradation behavior of ZX00 (Mg-0...
July 29, 2018: Acta Biomaterialia
Alberto Polimeni, Remzi Anadol, Thomas Münzel, Salvatore De Rosa, Ciro Indolfi, Tommaso Gori
BACKGROUND: Little data are available on the long-term outcomes of bioresorbable scaffold (BRS) in the setting of ST-segment elevation myocardial infarction (STEMI). The aim of this study is to investigate three-years outcomes and predictors of BRS failure in patients presenting with STEMI. METHODS AND RESULTS: Two prospective, single-arm registries were pooled. Incidence and predictors of clinical outcome were assessed with Kaplan-Meier and Cox regression analyses...
October 1, 2018: International Journal of Cardiology
Kenji Yaginuma, Hiller Moehlis, Matthias Koch, Karlheinz Tischer, Juliane Werner, Gerald S Werner
PURPOSE: This analysis of a consecutive series of bioresorbable vascular scaffolds (BVS) implanted for complex chronic total occlusions (CTOs) was done to evaluate the potential of this device to avoid a permanent full metal jacket with drug-eluting stents. PATIENTS: We analyzed 52 young patients (50.8 ± 8.3 years) for the BVS group, and additionally we followed a subgroup of 17 patients where DES were combined with BVS mainly because severe calcification at the lesion site (hybrid group)...
June 21, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Isabel Wustrow, Nikolaus Sarafoff, Bernhard Haller, Lisa Rössner, Dirk Sibbing, Stefanie Schüpke, Tareq Ibrahim, Aida Anetsberger, Heribert Schunkert, Karl-Ludwig Laugwitz, Adnan Kastrati, Isabell Bernlochner
OBJECTIVES: We aimed to assess the impact of omitting aspirin on clinical outcomes in a real-world collective of patients receiving oral anticoagulation (OAC) therapy who were treated with a current-generation drug-eluting stent (DES) or an everolimus-eluting bioresorbable vascular scaffold (BVS). BACKGROUND: Limited data are available regarding the clinical benefit of triple antithrombotic therapy (TAT) with aspirin compared with dual antithrombotic therapy (DAT) without aspirin in patients undergoing percutaneous coronary intervention (PCI) and requiring OAC...
July 18, 2018: Catheterization and Cardiovascular Interventions
Gaoke Feng, Chaoshi Qin, Xin Yi, Jinggang Xia, Jingjing Chen, Xiyu Chen, Tao Chen, Xuejun Jiang
To study the effect of novel bioresorbable scaffold composed of poly-L-lactic acid (PLLA) and amorphous calcium phosphate (ACP) nanoparticles on inflammation and calcification of surrounding tissues after implantation. Ninety six PLLA/ACP scaffolds and 96 PLLA scaffolds were randomly implanted in the back muscle tissue of 48 SD rats. At the 1st, 2nd, 4th, and 12th weeks after implantation, the calcium, phosphorus, and alkaline phosphatase levels in the blood serum and the contents of calcium and alkaline phosphatase in the tissue surrounding the scaffolds were measured...
July 17, 2018: Journal of Materials Science. Materials in Medicine
Natalia Dorosz, Marzena Dominiak
Reconstruction can be very problematic in the case of mandibular alveolar bone loss, which can also hinder the implant restorative treatment. The aim of the study was to present current views on reconstructing the alveolar part of mandibular bone, which allows the insertion of implants and then the placement of denture. Based on the available literature, the efficacy of various techniques of filling of mandibular bone losses was described and compared. Reconstruction with autogenous bone block graft had been used as a gold standard...
July 17, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Yaping Zhao, Zhong Chen, Wayne W Zhang, Sheng Wang, Yaoguo Yang, Liao Yang
OBJECTIVE: This study aimed to compare, using optical coherence tomography (OCT), the outcomes of bioabsorbable drug-eluting stent with those of bare metal stent (BMS) following implantation in porcine iliac artery. METHODS: After the placement of BMS and bioabsorbable drug-eluting stents, we used OCT and digital subtraction angiography to investigate stent appositions, arterial neointima, evagination, and restenosis at 1 and 3 months. RESULTS: At 1 and 3 months after stent implantation, OCT study was performed to investigate 32 stents and 21 788 struts...
January 1, 2018: Vascular and Endovascular Surgery
Ieva Briede, Inga Narbute, Indulis Kumsars, Dace Sondore, Karlis Trushinskis, Sanda Jegere, Gustavs Latkovskis, Karlis Strenge, Ainars Rudzitis, Andrejs Erglis
Aim: The aim of this long-term registry data was to evaluate 2-year clinical and angiographic outcomes after implantation of everolimus-eluting bioresorbable scaffolds (Absorb) from the Latvian Centre of Cardiology Real-life Registry. Material and methods: Between November 2012 and December 2014 in the Centre of Cardiology Real-life Bioresorbable Vascular Scaffold Registry, 187 patients with stable angina or acute coronary syndrome and available 2-year follow-up were selected...
2018: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
Thai Minh Duy Le, Huu Thuy Trang Duong, Thavasyappan Thambi, V H Giang Phan, Ji Hoon Jeong, Doo Sung Lee
Despite great potential, the delivery of genetic materials into cells or tissues of interest remains challenging owing to their susceptibility to nuclease degradation, lack of permeability to the cell membrane, and short in vivo half-life, which severely restrict their widespread use in therapeutics. To surmount these shortcomings, we developed a bioinspired in situ-forming pH- and temperature-sensitive injectable hydrogel depot that could control the delivery of DNA-bearing polyplexes for versatile biomedical applications...
July 27, 2018: Biomacromolecules
Damiano Regazzoli, Azeem Latib, Babu Ezhumalai, Akihito Tanaka, Pier Pasquale Leone, Sara Khan, Vijay Kumar, Vishal Rastogi, Marco Bruno Ancona, Antonio Mangieri, Francesco Giannini, Satoru Mitomo, Ashok Seth, Antonio Colombo
OBJECTIVES: The aim of this study was to evaluate the impact of a consistent and dedicated implantation strategy on long-term outcomes after implantation of bioresorbable vascular scaffold (BVS) in a real-world cohort of patients with a high prevalence of complex lesions. BACKGROUND: Bioresorbable vascular scaffolds may result in a reduced incidence of late and very-late scaffold thrombosis (ScT) after the complete reabsorption of the scaffold, but this hypothesis is hampered by data from RCTs that showed a higher than expected incidence of late events...
June 25, 2018: International Journal of Cardiology
Ki Yoon Kwon, Ju Seung Lee, Gwan-Jin Ko, Sung Hyuk Sunwoo, Sori Lee, Young Jin Jo, Chul Hee Choi, Suk-Won Hwang, Tae-Il Kim
New options in the material context of transient electronics are essential to create or expand potential applications and to progress in the face of technological challenges. A soft, transparent, and cost-effective polymer of levan polysaccharide that is capable of complete, programmable dissolution is described when immersed in water and implanted in an animal model. The results include chemical analysis, the kinetics of hydrolysis, and adjustable dissolution rates of levan, and a simple theoretical model of reactive diffusion governed by temperature...
July 4, 2018: Small
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