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Tissue Heart Valve

Pablo Elpidio García-Granja, Javier López, Isidre Vilacosta, Cristina Sarriá, Raquel Ladrón, Carmen Olmos, Carmen Sáez, Luis Maroto, Salvatore Di Stefano, Itziar Gómez, J Alberto San Román
Background: The culture of removed cardiac tissues during cardiac surgery of left-sided infective endocarditis (LSIE) helps guiding antibiotic treatment. Nevertheless, the prognostic information of a positive valve culture has never been explored. Methods: Among 1078 cases of LSIE consecutively diagnosed in three tertiary centres we selected those with positive blood cultures, who underwent surgery during the active period of infection and in whom surgical biological tissues were cultured (n=429)...
August 11, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Cyril Seillet, Elysa Carr, Derek Lacey, Michael D Stutz, Marc Pellegrini, Lachlan Whitehead, Joel Rimes, Edwin D Hawkins, Ben Roediger, Gabrielle T Belz, Philippe Bouillet
BPSM1 (Bone phenotype spontaneous mutant 1) mice develop severe polyarthritis and heart valve disease as a result of a spontaneous mutation in the Tnf gene. In these mice, the insertion of a retrotransposon in the 3' untranslated region of Tnf causes a large increase in the expression of the cytokine. We have found that these mice also develop inducible bronchus-associated lymphoid tissue (iBALT), as well as nodular lymphoid hyperplasia (NLH) in the bone marrow. Loss of TNFR1 prevents the development of both types of follicles, but deficiency of TNFR1 in the hematopoietic compartment only prevents the iBALT and not the NLH phenotype...
August 14, 2018: Immunology and Cell Biology
V Lintas, E S Fioretta, S E Motta, P E Dijkman, M Pensalfini, E Mazza, E Caliskan, H Rodriguez, M Lipiski, M Sauer, N Cesarovic, S P Hoerstrup, M Y Emmert
Transcatheter aortic valve replacement (TAVR) is being extended to younger patients. However, TAVR-compatible bioprostheses are based on xenogeneic materials with limited durability. Off-the-shelf tissue-engineered heart valves (TEHVs) with remodeling capacity may overcome the shortcomings of current TAVR devices. Here, we develop for the first time a TEHV for TAVR, based on human cell-derived extracellular matrix and integrated into a state-of-the-art stent for TAVR. The TEHVs, characterized by a dense acellular collagenous matrix, demonstrated in vitro functionality under aortic pressure conditions (n = 4)...
August 13, 2018: Journal of Cardiovascular Translational Research
Douglas Bell, Sudesh Prabhu, Kim Betts, Robert Justo, Prem Venugopal, Tom R Karl, Nelson Alphonso
OBJECTIVES: This study aims to assess the performance of tissue-engineered bovine pericardium (CardioCel®) at 24 months and beyond when used for the repair of congenital heart defects. METHODS: Between October 2012 and November 2014, CardioCel was implanted in 135 patients (140 procedures and 195 implants). Applications included the closure of septal defects (98, 50.3%), repair of pulmonary arteries (63, 32.3%), intra-atrial/intraventricular baffles (10, 5.1%), repair of systemic arteries (15, 7...
August 7, 2018: Interactive Cardiovascular and Thoracic Surgery
Hamidreza Pouraliakbar, Maryam Pourmojib, Yousef Rezaei, Saeid Hosseini
Pericardial patch has been used to repair cardiac defects; however, its strength as an aortoplasty patch to tolerate systemic pressure is a matter of debate. We report an aneurysmal dilatation of pericardial patch in aortoplasty. Our patient was a 56-year-old female known case of rheumatic heart disease that underwent redoes mitral and aortic valve replacements along with Manouguian aortoplasty at the age of 44 years old. After 2 months, she was readmitted with a diagnosis of endocarditis. Echocardiography revealed a small cavity in the posterior wall of the aorta...
October 2018: Journal of the Saudi Heart Association
Elyssa Cannaerts, Anju Shukla, Mensuda Hasanhodzic, Maaike Alaerts, Dorien Schepers, Lut Van Laer, Katta M Girisha, Iva Hojsak, Bart Loeys, Aline Verstraeten
BACKGROUND: Mutations in the X-linked gene filamin A (FLNA), encoding the actin-binding protein FLNA, cause a wide spectrum of connective tissue, skeletal, cardiovascular and/or gastrointestinal manifestations. Males are typically more severely affected than females with common pre- or perinatal death. CASE PRESENTATION: We provide a genotype- and phenotype-oriented literature overview of FLNA hemizygous mutations and report on two live-born male FLNA mutation carriers...
August 8, 2018: BMC Medical Genetics
Deepanshu Sodhani, Stefanie Reese, Andrey Aksenov, Sinan Soğanci, Stefan Jockenhövel, Petra Mela, Scott E Stapleton
Prosthetic heart valves deployed in the left heart (aortic and mitral) are subjected to harsh hemodynamical conditions. Most of the tissue engineered heart valves have been developed for the low pressure pulmonary position because of the difficulties in fabricating a mechanically strong valve, able to withstand the systemic circulation. This necessitates the use of reinforcing scaffolds, resulting in a tissue-engineered textile reinforced tubular aortic heart valve. Therefore, to better design these implants, material behaviour of the composite, valve kinematics and its hemodynamical response need to be evaluated...
July 20, 2018: Journal of Biomechanics
Chadi Ayoub, Gautam Kumar, Carin Y Smith, Sandra C Bryant, Diane M Jech, Filip Ionescu, Ioana Petrescu, Fletcher A Miller, Peter C Spittell
We sought to characterize mid-ascending aorta diameter reference values by age, sex, and body surface area (BSA) in a large echocardiography laboratory practice-based cohort. All subjects with transthoracic echocardiograms with mid-ascending aorta diameter measure from January 2004 to December 2009 were identified, and medical records were reviewed for medical history and anthropometric data. Those with aortic valve disease or replacement, congenital heart disease, any connective tissue or inflammatory disease that may affect the aorta, or known aortic aneurysm (>55 mm) were excluded...
June 27, 2018: American Journal of Cardiology
Miriam Nightingale, Michel R Labrosse
The ability to accurately model soft tissue behavior, such as that of heart valve tissue, is essential for developing reliable numerical simulations and determining patient-specific care options. Although several material models can predict soft tissue behavior, complications may arise when these models are implemented into finite element (FE) programs, due to the addition of an arbitrary penalty parameter for numerically enforcing material incompressibility. Herein, an inverse methodology was developed in MATLAB to use previously published stress-strain data from experimental planar equibiaxial testing of five biomaterials used in heart valve cusp replacements, in conjunction with commercial explicit FE solver LS-DYNA, to optimize the material parameters and the penalty parameter for an anisotropic hyperelastic strain energy function...
July 24, 2018: Journal of Biomechanics
Ying Tang, Shanliang Zhu, Jun Chen, Lichun Hua
BACKGROUND The aim of this study was to evaluate the feasibility of an R-wave modified tissue Doppler imaging (TDI) myocardial performance index (MPI), or MPI TDI-R, for the assessment of cardiac function in children with congestive heart failure (CHF). MATERIAL AND METHODS Forty children with CHF and 40 normal children were evaluated using the modified pediatric Ross heart failure grading system. TDI recorded the spectrum of diastolic function at the mitral valve annulus to measure the MPI. Twelve-lead electrocardiogram (ECG) measured the R-wave in the QRS complex, resulting in the modified MPI TDI-R...
July 28, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Klaas Loger, Georg Lutter, Katharina Huenges, Derk Frank, Justus Groß, Jochen Cremer, Tim Attmann, Michael Morlock, Saskia Pokorny
OBJECTIVES: Transcatheter mitral valved stent implantation provides an off-pump treatment option for mitral valve regurgitation, especially for secondary mitral valve regurgitation. The aim of this study was to evaluate novel fixation strategies: direct fixation (SUPRA) and subvalvular fixation (sub-VALV) to successfully implement alternative fixation methods at the mitral annulus and to reduce radial stent and apical tether forces. METHODS: Specific concepts were developed for the supra-annular hook-shaped fixation (SUPRA) and the subvalvular fixation (sub-VALV)...
July 19, 2018: European Journal of Cardio-thoracic Surgery
Julia Segert, Isabelle Schneider, Ina M Berger, Wolfgang Rottbauer, Steffen Just
The molecular mechanism essential for the formation of heart valves involves complex interactions of signaling molecules and transcription factors. The Mediator Complex (MC) functions as multi-subunit machinery to orchestrate gene transcription, especially for tissue-specific fine-tuning of transcriptional processes during development, also in the heart. Here, we analyzed the role of the MC subunit Med12 during atrioventricular canal (AVC) development and endocardial cushion formation, using the Med12-deficient zebrafish mutant trapped (tpd)...
July 20, 2018: Progress in Biophysics and Molecular Biology
Bashir M Matata, Maqsood M Elahi
BACKGROUND: Left ventricular hypertrophy and myocardial remodelling occur with aortic valve disease and may lead to heart failure. Although increased oxidative stress and inflammatory factors have been implicated in heart failure, their role in the progression of valve disease remains unclear. OBJECTIVES: We investigated the role of oxidative stress and inflammatory factors in valve disease whether this relates to cell death. METHODS: Blood samples were taken from 24 patients with valve disease before surgery and the results were compared with those from blood samples from 30 control healthy subjects...
July 22, 2018: Cardiovascular & Hematological Disorders Drug Targets
Batur Gonenc Kanar, Kursat Tigen, Halil Atas, Altug Cincin, Beste Ozben
A prosthetic valve thrombosis (PVT), which is a potentially fatal complication, refers to the presence of non-infective thrombotic material on a prosthetic valve apparatus, interfering with its function. Possible complications of a PVT include transient neurologic embolic events, cardiac arrest due to a stuck valve prosthesis, and cardio-embolic myocardial infarction (MI). The choice of treatments, including a redo surgery, a percutaneous coronary intervention (PCI), and a fibrinolysis with PVT or MI dosages, depends on the patient's clinical and hemodynamic status and thrombotic burden involving the prosthetic valve and surrounding tissues...
June 19, 2018: American Journal of Emergency Medicine
Daneish Selvakumar, Karan Sian, Stuart Sugito, Taranpreet Singh
Ochronosis is the bluish-black discolouration of connective tissue, including heart valves, joints, kidney and the skin. It is due to the deposition of homogentisic acid (HGA) commonly found in alkaptonuria. Ochronosis in the aortic valve is a rare occurrence and there is limited data available on the most appropriate choice of valve prosthesis in these patients. This case involves a 72-year-old male with symptomatic aortic stenosis and on echocardiogram a severe calcific trileaflet aortic stenosis with normal ejection fraction...
May 2018: Journal of Thoracic Disease
Jing Wang, Hang Zhao, Yue Wang, Howard C Herrmann, Walter R T Witschey, Yuchi Han
Background: Pulmonary arterial hypertension (PAH) and severe aortic valve stenosis (AS) are diseases characterized by increased afterload of the right and left heart, respectively. Our study aims to investigate the differences of myocardial tissue characteristics in the pressure overloaded left and right hearts, especially in the shared interventricular septum, as detected by native T1 and T2 relaxation times. Methods: Eighteen patients with PAH and 19 patients with severe AS in addition to 5 healthy volunteers underwent 1...
May 2018: Journal of Thoracic Disease
Jianyi Zhang, Wuqiang Zhu, Milica Radisic, Gordana Vunjak-Novakovic
Some of the most significant leaps in the history of modern civilization-the development of article in China, the steam engine, which led to the European industrial revolution, and the era of computers-have occurred when science converged with engineering. Recently, the convergence of human pluripotent stem cell technology with biomaterials and bioengineering have launched a new medical innovation: functional human engineered tissue, which promises to revolutionize the treatment of failing organs including most critically, the heart...
July 6, 2018: Circulation Research
Tobias Schmidt, Martin B Leon, Roxana Mehran, Karl-Heinz Kuck, Maria C Alu, Ryan E Braumann, Susheel Kodali, Samir R Kapadia, Axel Linke, Raj Makkar, Christoph Naber, Maria E Romero, Renu Virmani, Christian Frerker
OBJECTIVES: This study investigated differences between transcatheter heart valve (THV) types and regarding debris captured by a cerebral embolic protection system (Claret Medical Sentinel, Santa Rosa, California). BACKGROUND: Differences of THV types and cerebral injury after transcatheter aortic valve replacement (TAVR) are not well understood. METHODS: A total of 246 patients pooled from 2 prospective studies (SENTINEL [Cerebral Protection in Transcatheter Aortic Valve Replacement] trial, N = 100; SENTINEL-H [Histopathology of Embolic Debris Captured During Transcatheter Aortic Valve Replacement] trial, N = 146) were included in the analysis...
July 9, 2018: JACC. Cardiovascular Interventions
Piotr Wilczek, Gach Paulina, Jendryczko Karolina, Marcisz Martyna, Wilczek Grazyna, Major Roman, Mzyk Aldona, Sypien Anna, Samotus Aneta
Currently available bioprosthetic heart valves have been successfully used clinically; however, they have several limitations. Alternatively, tissue-engineering techniques can be used. However, there are limited data concerning the impact of storage conditions of scaffolds on their biomechanics and morphology. The aim of this study was to determine the effect of different storage conditions on the biomechanics and morphology of pulmonary valve dedicated for the acellular scaffold preparation to achieve optimal conditions to obtain stable heart valve prostheses...
July 3, 2018: Journal of Materials Science. Materials in Medicine
Mahmut Yesin, Süleyman Karakoyun, Macit Kalçık, Mustafa Ozan Gürsoy, Sabahattin Gündüz, Mehmet Ali Astarcıoğlu, Emrah Bayam, Sinan Cerşit, Ahmet Güner, Mehmet Özkan
Coronary thromboembolism (CE) is a rare cause of prosthetic valve derived complications. This study investigates the diagnosis and treatment strategies for non-ST elevation acute coronary syndrome (NSTEACS) in patients with prosthetic heart valves. Forty-eight NSTEACS patients with prosthetic heart valves (mitral:27; aortic:14; mitral+aortic:7) were included in this study. All patients underwent transthoracic and transesophageal echocardiographic examination and coronary angiography. Normal coronary angiographic findings, or visible trombus in one of the coronary arteries, international normalized ratio <2, concomitant prosthetic valve thrombosis (PVT) and absence of multivessel atherosclerotic disease favored CE rather than atherothrombosis...
May 11, 2018: American Journal of Cardiology
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