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https://www.readbyqxmd.com/read/30095360/cardioplegia-practice-in-paediatric-cardiac-surgery-a-uk-ireland-survey
#1
Nigel E Drury, Angela Horsburgh, Rehana Bi, Robert G Willetts, Timothy J Jones
INTRODUCTION: Many techniques are available for cardioplegic arrest in children, but there is a lack of late phase clinical trials to guide practice. We surveyed paediatric cardiac surgeons and perfusionists to establish current practice and willingness to change within a clinical trial. METHODS: An online survey was sent to all consultant paediatric cardiac surgeons and chief perfusionists in paediatric centres in the UK and Ireland. Information was sought on cardioplegia type, composition, temperature, topical cooling, dosing for induction and maintenance, interval between doses, whether practice changed with patient age or complexity and whether respondents would be willing and able to use different cardioplegia solutions within a randomised trial...
August 10, 2018: Perfusion
https://www.readbyqxmd.com/read/30089762/comparison-of-del-nido-and-intermittent-warm-blood-cardioplegia-in-coronary-artery-bypass-grafting-surgery
#2
Haci Ali Ucak, Hasan Uncu
PURPOSE: In this study, we aim to investigate the efficacy and clinical results of using Del Nido solution (DNS) in coronary artery bypass grafting (CABG) surgery by comparing with intermittent warm blood cardioplegia (IWBC). METHODS: Between March 2017 and February 2018, 297 adult patients who underwent primary isolated CABG surgery with cardiopulmonary bypass (CPB) were included in the study. We used DNS in 112 patients and IWBC was used in 185 patients. We compared both the clinical and the laboratory results...
August 9, 2018: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/30043912/lidocaine-and-pinacidil-added-to-blood-versus-crystalloid-cardioplegic-solutions-study-in-isolated-hearts
#3
Helison Pereira do Carmo, Karla Reichert, Daniela Diógenes de Carvalho, Lindemberg da Mota Silveira-Filho, Karlos Vilarinho, Pedro Oliveira, Orlando Petrucci
OBJECTIVE: The present study aimed the functional recovery evaluation after long term of cardiac arrest induced by Custodiol (crystalloid-based) versus del Nido (blood-based) solutions, both added lidocaine and pinacidil as cardioplegic agents. Experiments were performed in isolated rat heart perfusion models. METHODS: Male rat heart perfusions, according to Langendorff technique, were induced to cause 3 hours of cardiac arrest with a single dose. The hearts were assigned to one of the following three groups: (I) control; (II) Custodiol-LP; and (III) del Nido-LP...
May 2018: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29909772/impact-of-surgical-pulmonary-valve-replacement-on-ventricular-strain-and-synchrony-in-patients-with-repaired-tetralogy-of-fallot-a-cardiovascular-magnetic-resonance-feature-tracking-study
#4
Sowmya Balasubramanian, David M Harrild, Basavaraj Kerur, Edward Marcus, Pedro Del Nido, Tal Geva, Andrew J Powell
BACKGROUND: In patients with repaired tetralogy of Fallot (TOF), a better understanding of the impact of surgical pulmonary valve replacement (PVR) on ventricular mechanics may lead to improved indications and outcomes. Therefore, we used cardiovascular magnetic resonance (CMR) feature tracking analysis to quantify ventricular strain and synchrony in repaired TOF patients before and after PVR. METHODS: Thirty-six repaired TOF patients (median age 22.4 years) prospectively underwent CMR a mean of 4...
June 18, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29874956/does-the-type-of-cardioplegia-used-during-valve-surgery-influence-operative-nadir-hematocrit-and-transfusion-requirements
#5
Alfred H Stammers, Eric A Tesdahl, Linda B Mongero, Andrew Stasko
INTRODUCTION: Myocardial protection is performed using diverse cardioplegic (CP) solutions with various combinations of chemical and blood constituents. Newer CP formulations that extend ischemic intervals may require greater asanguineous volume, contributing to hemodilution. METHODS: We evaluated intraoperative hemodilution and red blood cell (RBC) transfusion rates among three common CP solutions during cardiac valve surgery. Data from 5,830 adult cardiac primary valve procedures where either four-to-one blood CP (4:1), del Nido solution (DN) or microplegia (MP) was used at 173 United States surgical centers...
June 1, 2018: Perfusion
https://www.readbyqxmd.com/read/29804663/dehiscence-of-patch-augmentation-of-a-left-sided-atrioventricular-valve-related-to-strenuous-isometric-exercise-case-report-and-failure-analysis
#6
Peter E Hammer, Christopher W Baird, Pedro J Del Nido, Gerald R Marx
No abstract text is available yet for this article.
May 3, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29754124/predictors-of-postoperative-rehabilitation-therapy-following-congenital-heart-surgery
#7
Ana Ubeda Tikkanen, Meena Nathan, Lynn A Sleeper, Marisa Flavin, Ana Lewis, Donna Nimec, John E Mayer, Pedro Del Nido
BACKGROUND: Patients with congenital heart disease are at risk of motor, cognitive, speech, and feeding difficulties after cardiac surgery. Rehabilitation therapy could improve functional outcomes in this population if applied in the acute postcardiac surgical in-hospital stay. However, information on the types of acute postcardiac surgery therapy needs in children is scarce. Our goal was to describe rehabilitation therapy following congenital heart surgery and pre/intraoperative factors associated with need for therapy...
May 12, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29709363/staged-ventricular-recruitment-in-patients-with-borderline-ventricles-and-large-ventricular-septal-defects
#8
Olubunmi O Oladunjoye, Breanna Piekarski, Puja Banka, Gerald Marx, Roger E Breitbart, Pedro J Del Nido, Sitaram M Emani
OBJECTIVES: Patients with borderline ventricles and ventricular septal defects (VSDs) who have previously undergone single ventricle palliation might be candidates for staged ventricular recruitment with the ultimate goal of biventricular conversion. This study aimed to determine the effect of atrial septal defect (ASD) restriction without VSD closure on ventricular growth in patients with borderline right or left ventricles and VSDs. METHODS: Patients with borderline ventricles and VSD who underwent a staged ventricular recruitment procedure with strategies to increase blood flow through hypoplastic ventricle via ASD restriction without VSD closure after single ventricle palliation were retrospectively reviewed...
July 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29667902/myocardial-protection-following-del-nido-cardioplegia-in-pediatric-cardiac-surgery
#9
Debasish Panigrahi, Saibal Roychowdhury, Rahul Guhabiswas, Emmanuel Rupert, Mrinalendu Das, Pradeep Narayan
Background This study was designed to compare myocardial protection with del Nido cardioplegia and conventional blood cardioplegia in children undergoing cardiac surgery in Risk Adjustment for Congenital Heart Surgery categories 1 and 2. Methods Sixty patients were randomized into 2 groups receiving del Nido cardioplegia solution or conventional blood cardioplegia. Myocardial injury was assessed using biochemical markers (troponin I and creatine kinase-MB). Vasoactive-inotropic scores were calculated to compare inotropic requirements...
May 2018: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/29615331/a-novel-wall-water-system-for-cardiopulmonary-bypass-may-reduce-the-risk-of-aerosolized-infection
#10
Gregory S Matte, Thomas J Sandora, Robert J Howe, William L Regan, Gail Potter-Bynoe, James R Neal, Pedro J Del Nido
OBJECTIVE: Oxygenators for cardiopulmonary bypass require water flow for their integral heat exchanger. Heater-cooler units are nearly universally used for this requirement. Heater-cooler units pose the risk of aerosolized infection. The Centers for Disease Control and Prevention recommended discontinuing use of Stöckert 3T heater-cooler units (LivaNova PLC, London, United Kingdom) in October 2016 because of this risk. We aimed to reduce the risk of aerosolized infection posed by heater-cooler units by eliminating those devices from our operating rooms...
July 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29599273/cell-based-therapy-with-cardiosphere-derived-cardiocytes-a-new-hope-for-pediatric-patients-with-single-ventricle-congenital-heart-disease
#11
EDITORIAL
Sitaram M Emani, Pedro J Del Nido
No abstract text is available yet for this article.
March 30, 2018: Circulation Research
https://www.readbyqxmd.com/read/29588218/alloreactivity-and-allorecognition-of-syngeneic-and-allogeneic-mitochondria
#12
Giovanna Ramirez-Barbieri, Kamila Moskowitzova, Borami Shin, David Blitzer, Arzoo Orfany, Alvise Guariento, Khadija Iken, Ingeborg Friehs, David Zurakowski, Pedro J Del Nido, James D McCully
Previously, we have demonstrated that the transplantation of autologous mitochondria is cardioprotective. No immune or autoimmune response was detectable following the single injection of autologous mitochondria. To expand the therapeutic potential and safety of mitochondrial transplantation, we now investigate the immune response to single and serial injections of syngeneic and allogeneic mitochondria delivered by intraperitoneal injection. Our results demonstrate that there is no direct or indirect, acute or chronic alloreactivity, allorecognition or damage-associated molecular pattern molecules (DAMPs) reaction to single or serial injections of either syngeneic or allogeneic mitochondria...
March 26, 2018: Mitochondrion
https://www.readbyqxmd.com/read/29559754/does-the-type-of-cardioplegia-solution-affect-intraoperative-glucose-levels-a-propensity-matched-analysis
#13
Linda B Mongero, Eric A Tesdahl, Alfred H Stammers, Andrew J Stasko, Samuel Weinstein
Myocardial protection during cardiac surgery is a multifaceted process that is structured to limit injury and preserve function. Evolving techniques use solutions with varying constituents that enter the systemic circulation and alter intrinsic systemic concentrations. This study compared two distinct cardioplegia solutions on affecting intraoperative glucose levels. Data were abstracted from a multi-institutional perfusion registry, including a total of 1,188 propensity-matched cases performed from January through October 2016, at 17 cardiac surgical centers across the United States in which both del Nido and 4:1 cardioplegia were used during the study period...
March 2018: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/29525190/pro-in-favor-of-more-generalized-use-of-del-nido-cardioplegia-in-adult-patients-undergoing-cardiac-surgery
#14
Jessica Spellman
No abstract text is available yet for this article.
January 31, 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29460374/del-nido-cardioplegia-for-minimally-invasive-aortic-valve-replacement
#15
Michael S Koeckert, Deane E Smith, Patrick F Vining, Neel K Ranganath, Thomas Beaulieu, Didier F Loulmet, Elias Zias, Aubrey C Galloway, Eugene A Grossi
BACKGROUND: We analyzed the impact and safety of del Nido Cardioplegia (DNC) in patients undergoing minimally invasive aortic valve replacement (MIAVR). METHODS: We analyzed all isolated MIAVR replacements from 5/2013-6/2015 excluding re-operative patients. The approach was a hemi-median sternotomy in all patients. Patients were divided into two cohorts, those who received 4:1 crystalloid:blood DNC solution and those in whom standard 1:4 Buckberg-based cardioplegia (WBC) was used...
February 2018: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29452357/del-nido-cardioplegia-in-adult-cardiac-surgery-beyond-single-valve-surgery
#16
Wan Kee Kim, Hong Rae Kim, Joon Bum Kim, Sung-Ho Jung, Suk Jung Choo, Cheol Hyun Chung, Jae Won Lee
OBJECTIVES: In recent years, the use of del Nido (DN) cardioplegia has been reported in single-valve surgery or isolated coronary artery bypass surgery with acceptable outcomes. The reports of its use in more complex adult cardiac procedures, however, have been scarce. METHODS: We enrolled a total of 149 adult patients who underwent heart valve surgery with the use of DN cardioplegia between May 2014 and December 2016. For a benchmark comparison, 892 patients who underwent cardiac valve surgery with blood cardioplegia during the same period served as controls...
July 1, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29444545/bretschneider-and-del-nido-solutions-are-they-safe-for-coronary-artery-bypass-grafting-if-so-how-should-we-use-them
#17
Shirin Siddiqi, Eugene H Blackstone, Faisal G Bakaeen
A variety of cardioplegic solutions are being used widely today to arrest the heart during coronary artery bypass grafting (CABG) and other cardiac operations. To minimize interruptions during the surgery for intermittent dosing of the cardioplegia and to facilitate less invasive cardiac procedures, single-shot solutions, including Bretschneider and del Nido solutions, have been introduced. This review examines the evidence regarding the safety and efficacy of Bretschneider and del Nido cardioplegia during CABG...
May 2018: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29428622/targeted-increase-in-pulmonary-blood-flow-in-a-bidirectional-glenn-circulation
#18
Samuel L Casella, Aditya Kaza, Pedro Del Nido, James E Lock, Audrey C Marshall
In patients with a Glenn shunt and unilateral pulmonary vascular abnormalities, supplemental pulmonary blood flow may improve antegrade flow in the target lung and may permit eventual Fontan completion, while mitigating the risks of uncontrolled additional flow to the contralateral lung. We attempted this by inserting a small aortopulmonary shunt into the affected pulmonary artery and banding the central pulmonary artery. We performed a retrospective review of all patients who underwent this procedure from 2000 to 2015...
2018: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29365088/reply-to-buratto-et-al
#19
Meena Nathan, Sitaram Emani, Pedro J Del Nido
No abstract text is available yet for this article.
June 1, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29356304/fast-image-based-mitral-valve-simulation-from-individualized-geometry
#20
Pierre-Frederic Villard, Peter E Hammer, Douglas P Perrin, Pedro J Del Nido, Robert D Howe
BACKGROUND: Common surgical procedures on the mitral valve of the heart include modifications to the chordae tendineae. Such interventions are used when there is extensive leaflet prolapse caused by chordae rupture or elongation. Understanding the role of individual chordae tendineae before operating could be helpful to predict whether the mitral valve will be competent at peak systole. Biomechanical modelling and simulation can achieve this goal. METHODS: We present a method to semi-automatically build a computational model of a mitral valve from micro CT (computed tomography) scans: after manually picking chordae fiducial points, the leaflets are segmented and the boundary conditions as well as the loading conditions are automatically defined...
April 2018: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
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