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https://www.readbyqxmd.com/read/30517259/comparison-of-del-nido-cardioplegia-with-blood-cardioplegia-in-coronary-artery-bypass-grafting-combined-with-mitral-valve-replacement
#1
Ali Aycan Kavala, Saygin Turkyilmaz
OBJECTIVE: To compare del Nido cardioplegia (DNC) with blood cardioplegia (BC) in coronary artery bypass grafting (CABG) combined with mitral valve replacement. METHODS: A 3-year single-center retrospective cohort study was carried out. Subjects who underwent CABG (up to triple bypass) combined with mitral valve replacement were divided into DNC and BC groups. Each group had thirty subjects. RESULTS: Both groups demonstrated similar baseline characteristics, including age, gender, cardiac/non-cardiac comorbidity, and preoperative echocardiographic parameters...
September 2018: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/30391192/mitochondrial-transplantation-prolongs-cold-ischemia-time-in-murine-heart-transplantation
#2
Kamila Moskowitzova, Borami Shin, Kaifeng Liu, Giovanna Ramirez-Barbieri, Alvise Guariento, David Blitzer, Jerusha K Thedsanamoorthy, Rouan Yao, Erin R Snay, James A H Inkster, Arzoo Orfany, David Zurakowski, Douglas B Cowan, Alan B Packard, Gary A Visner, Pedro J Del Nido, James D McCully
BACKGROUND: Cold ischemia time (CIT) causes ischemia‒reperfusion injury to the mitochondria and detrimentally effects myocardial function and tissue viability. Mitochondrial transplantation replaces damaged mitochondria and enhances myocardial function and tissue viability. Herein we investigated the efficacy of mitochondrial transplantation in enhancing graft function and viability after prolonged CIT. METHODS: Heterotopic heart transplantation was performed in C57BL/6J mice...
September 28, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/30370123/new-insights-on-the-use-of-del-nido-cardioplegia-in-the-adult-cardiac-surgery
#3
EDITORIAL
Paolo Nardi, Calogera Pisano, Fabio Bertoldo, Giovanni Ruvolo
No abstract text is available yet for this article.
September 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/30250347/asanguinous-del-nido-cardioplegia-for-an-aortic-valve-replacement-patient-with-cold-agglutinins
#4
Michael Rosenbloom, Michael Hancock, Perry Weinstock, Allyson Paterek, Richard Highbloom, Frank Bowen, Kinjal Patel
A patient with known cold agglutinins requiring an aortic valve replacement was referred for surgery. Asanguinous, Del Nido cardioplegia was used for myocardial protection. Warm induction followed by cold infusion prevented any agglutination and eliminated the need for subsequent cardioplegia doses. Following the cross-clamp period, the heart returned to normal sinus rhythm without need for defibrillation. Postoperative ejection fraction and systolic function were normal.
September 2018: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/30250339/incidence-of-cerebral-microemboli-in-single-dose-vs-multidose-cardioplegia-in-adult-cardiac-surgery
#5
Laith Mukdad, William Toppen, Yas Sanaiha, Aditya Mantha, Stephanie Bland, Richard Shemin, Peyman Benharash
Cerebral microemboli have been associated with neurocognitive deficits after cardiac operations using cardiopulmonary bypass (CPB). Interventions by the perfusionist and alterations in blood flow account for a large proportion of previously unexplained microemboli. This study compared the incidence of microemboli during cardiac operations using conventional (multidose) and del Nido (single-dose) cardioplegia delivery. Transcranial Doppler ultrasonography was used to detect microemboli in bilateral middle cerebral arteries of 30 adult patients undergoing cardiac operations using CPB and aortic clamping...
September 2018: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/30217422/patient-specific-in-vivo-right-ventricle-material-parameter-estimation-for-patients-with-tetralogy-of-fallot-using-mri-based-models-with-different-zero-load-diastole-and-systole-morphologies
#6
Han Yu, Pedro J Del Nido, Tal Geva, Chun Yang, Alexander Tang, Zheyang Wu, Rahul H Rathod, Xueying Huang, Kristen L Billiar, Dalin Tang
Patient-specific in vivo ventricle material parameter determination is important for cardiovascular investigations. A new cardiac magnetic image (CMR)-based modeling approach with different zero-load diastole and systole geometries was adopted to estimate right ventricle material parameter values for healthy and patients with Tetralogy of Fallot (TOF) and seeking potential clinical applications. CMR data were obtained from 6 healthy volunteers and 16 TOF patients with consent obtained. CMR-based RV/LV models were constructed using two zero-load geometries (diastole and systole, 2G model)...
September 10, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30187516/safety-and-benefits-of-new-techniques-and-technologies-in-less-invasive-mitral-valve-repair
#7
Joseph F Sabik, Sajjad Raza, Kenneth D Chavin
OBJECTIVE: To assess the safety and benefits of new techniques and technologies such as single-dose (del Nido) cardioplegia and suture fasteners (COR-KNOT) in patients undergoing mini-thoracotomy for degenerative mitral valve repair (MVR). METHODS: From 2009 to 2016, 252 patients underwent primary isolated degenerative MVR by mini-thoracotomy by a single surgeon. Del Nido cardioplegia was used in 153 patients (61%) and COR-KNOT in 168 (67%). Patient outcomes were compared using propensity-matching separately for del Nido versus Buckberg cardioplegia and COR-KNOT versus knot-pusher...
October 2018: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/30179626/rates-of-interventions-in-isolated-coarctation-repair-in-neonates-versus-infants-does-age-matter
#8
Rinske Ijsselhof, Hua Liu, Frank Pigula, Kimberlee Gauvreau, John E Mayer, Pedro Del Nido, Meena Nathan
BACKGROUND: In the current era, coarctation repair is usually performed as soon as diagnosis is established. We sought to determine if neonatal isolated coarctation repair had a higher rate of interventions post-discharge when compared to older infants. METHODS: Retrospective review of neonates (≤30 days) and infants(1-6 months) undergoing isolated coarctation repair between 1/1/2000-3/31/2016. Preoperative/postoperative Z scores of arch, aortic valve and isthmus, rates of reintervention and length of stay were compared between groups...
September 1, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/30141453/comparative-study-between-the-use-of-multidose-standard-cardioplegia-and-long-acting-del-nido-cardioplegia-during-intracardiac-repair-for-tetralogy-of-fallot-in-pediatric-patients
#9
K Z Rushel, A Hoque, M K Alamgir, M Z Islam, K A Hasan, M R Rahman, R Sarkar, M K Hasan, A B Adhikary
Pediatric myocardium is unique from mature myocardium; thus, the use of adult cardioplegia for pediatric cardiac operations may provide suboptimal myocardial protection. It is found that children undergoing heart surgery show evidence of less myocardial damage when del Nido cardioplegia is used instead of a standard cardioplegic solution. Del Nido cardioplegia solution provides a depolarized hyperkalaemic arrest lasting up to 60 minutes, reduces spontaneous and inducible activity during arrest, and prevents hyper contraction during early reperfusion...
July 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/30095360/cardioplegia-practice-in-paediatric-cardiac-surgery-a-uk-ireland-survey
#10
Nigel E Drury, Angela Horsburgh, Rehana Bi, Robert G Willetts, Timothy J Jones
INTRODUCTION: Many techniques are available for cardioplegic arrest in children, but there is a lack of late phase clinical trials to guide practice. We surveyed paediatric cardiac surgeons and perfusionists to establish current practice and willingness to change within a clinical trial. METHODS: An online survey was sent to all consultant paediatric cardiac surgeons and chief perfusionists in paediatric centres in the UK and Ireland. Information was sought on cardioplegia type, composition, temperature, topical cooling, dosing for induction and maintenance, interval between doses, whether practice changed with patient age or complexity and whether respondents would be willing and able to use different cardioplegia solutions within a randomised trial...
August 10, 2018: Perfusion
https://www.readbyqxmd.com/read/30089762/comparison-of-del-nido-and-intermittent-warm-blood-cardioplegia-in-coronary-artery-bypass-grafting-surgery
#11
Haci Ali Ucak, Hasan Uncu
PURPOSE: In this study, we aim to investigate the efficacy and clinical results of using Del Nido solution (DNS) in coronary artery bypass grafting (CABG) surgery by comparing with intermittent warm blood cardioplegia (IWBC). METHODS: Between March 2017 and February 2018, 297 adult patients who underwent primary isolated CABG surgery with cardiopulmonary bypass (CPB) were included in the study. We used DNS in 112 patients and IWBC was used in 185 patients. We compared both the clinical and the laboratory results...
August 9, 2018: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/30043912/lidocaine-and-pinacidil-added-to-blood-versus-crystalloid-cardioplegic-solutions-study-in-isolated-hearts
#12
Helison Pereira do Carmo, Karla Reichert, Daniela Diógenes de Carvalho, Lindemberg da Mota Silveira-Filho, Karlos Vilarinho, Pedro Oliveira, Orlando Petrucci
OBJECTIVE: The present study aimed the functional recovery evaluation after long term of cardiac arrest induced by Custodiol (crystalloid-based) versus del Nido (blood-based) solutions, both added lidocaine and pinacidil as cardioplegic agents. Experiments were performed in isolated rat heart perfusion models. METHODS: Male rat heart perfusions, according to Langendorff technique, were induced to cause 3 hours of cardiac arrest with a single dose. The hearts were assigned to one of the following three groups: (I) control; (II) Custodiol-LP; and (III) del Nido-LP...
May 2018: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29909772/impact-of-surgical-pulmonary-valve-replacement-on-ventricular-strain-and-synchrony-in-patients-with-repaired-tetralogy-of-fallot-a-cardiovascular-magnetic-resonance-feature-tracking-study
#13
Sowmya Balasubramanian, David M Harrild, Basavaraj Kerur, Edward Marcus, Pedro Del Nido, Tal Geva, Andrew J Powell
BACKGROUND: In patients with repaired tetralogy of Fallot (TOF), a better understanding of the impact of surgical pulmonary valve replacement (PVR) on ventricular mechanics may lead to improved indications and outcomes. Therefore, we used cardiovascular magnetic resonance (CMR) feature tracking analysis to quantify ventricular strain and synchrony in repaired TOF patients before and after PVR. METHODS: Thirty-six repaired TOF patients (median age 22.4 years) prospectively underwent CMR a mean of 4...
June 18, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29874956/does-the-type-of-cardioplegia-used-during-valve-surgery-influence-operative-nadir-hematocrit-and-transfusion-requirements
#14
Alfred H Stammers, Eric A Tesdahl, Linda B Mongero, Andrew Stasko
INTRODUCTION: Myocardial protection is performed using diverse cardioplegic (CP) solutions with various combinations of chemical and blood constituents. Newer CP formulations that extend ischemic intervals may require greater asanguineous volume, contributing to hemodilution. METHODS: We evaluated intraoperative hemodilution and red blood cell (RBC) transfusion rates among three common CP solutions during cardiac valve surgery. Data from 5,830 adult cardiac primary valve procedures where either four-to-one blood CP (4:1), del Nido solution (DN) or microplegia (MP) was used at 173 United States surgical centers...
June 1, 2018: Perfusion
https://www.readbyqxmd.com/read/29804663/dehiscence-of-patch-augmentation-of-a-left-sided-atrioventricular-valve-related-to-strenuous-isometric-exercise-case-report-and-failure-analysis
#15
Peter E Hammer, Christopher W Baird, Pedro J Del Nido, Gerald R Marx
No abstract text is available yet for this article.
October 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29754124/predictors-of-postoperative-rehabilitation-therapy-following-congenital-heart-surgery
#16
Ana Ubeda Tikkanen, Meena Nathan, Lynn A Sleeper, Marisa Flavin, Ana Lewis, Donna Nimec, John E Mayer, Pedro Del Nido
BACKGROUND: Patients with congenital heart disease are at risk of motor, cognitive, speech, and feeding difficulties after cardiac surgery. Rehabilitation therapy could improve functional outcomes in this population if applied in the acute postcardiac surgical in-hospital stay. However, information on the types of acute postcardiac surgery therapy needs in children is scarce. Our goal was to describe rehabilitation therapy following congenital heart surgery and pre/intraoperative factors associated with need for therapy...
May 12, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29709363/staged-ventricular-recruitment-in-patients-with-borderline-ventricles-and-large-ventricular-septal-defects
#17
Olubunmi O Oladunjoye, Breanna Piekarski, Puja Banka, Gerald Marx, Roger E Breitbart, Pedro J Del Nido, Sitaram M Emani
OBJECTIVES: Patients with borderline ventricles and ventricular septal defects (VSDs) who have previously undergone single ventricle palliation might be candidates for staged ventricular recruitment with the ultimate goal of biventricular conversion. This study aimed to determine the effect of atrial septal defect (ASD) restriction without VSD closure on ventricular growth in patients with borderline right or left ventricles and VSDs. METHODS: Patients with borderline ventricles and VSD who underwent a staged ventricular recruitment procedure with strategies to increase blood flow through hypoplastic ventricle via ASD restriction without VSD closure after single ventricle palliation were retrospectively reviewed...
July 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29667902/myocardial-protection-following-del-nido-cardioplegia-in-pediatric-cardiac-surgery
#18
RANDOMIZED CONTROLLED TRIAL
Debasish Panigrahi, Saibal Roychowdhury, Rahul Guhabiswas, Emmanuel Rupert, Mrinalendu Das, Pradeep Narayan
Background This study was designed to compare myocardial protection with del Nido cardioplegia and conventional blood cardioplegia in children undergoing cardiac surgery in Risk Adjustment for Congenital Heart Surgery categories 1 and 2. Methods Sixty patients were randomized into 2 groups receiving del Nido cardioplegia solution or conventional blood cardioplegia. Myocardial injury was assessed using biochemical markers (troponin I and creatine kinase-MB). Vasoactive-inotropic scores were calculated to compare inotropic requirements...
May 2018: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/29615331/a-novel-wall-water-system-for-cardiopulmonary-bypass-may-reduce-the-risk-of-aerosolized-infection
#19
Gregory S Matte, Thomas J Sandora, Robert J Howe, William L Regan, Gail Potter-Bynoe, James R Neal, Pedro J Del Nido
OBJECTIVE: Oxygenators for cardiopulmonary bypass require water flow for their integral heat exchanger. Heater-cooler units are nearly universally used for this requirement. Heater-cooler units pose the risk of aerosolized infection. The Centers for Disease Control and Prevention recommended discontinuing use of Stöckert 3T heater-cooler units (LivaNova PLC, London, United Kingdom) in October 2016 because of this risk. We aimed to reduce the risk of aerosolized infection posed by heater-cooler units by eliminating those devices from our operating rooms...
July 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29599273/cell-based-therapy-with-cardiosphere-derived-cardiocytes-a-new-hope-for-pediatric-patients-with-single-ventricle-congenital-heart-disease
#20
EDITORIAL
Sitaram M Emani, Pedro J Del Nido
No abstract text is available yet for this article.
March 30, 2018: Circulation Research
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