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Tumor AND imaging

Ludmilla Emilia Martins Costa, Rafael Freire de Castro, Fabiolla Maria Martins Costa, Mônica Alcântara de Oliveira Santos
Facial nerve hemangioma is a rare and benign vascular tumor, and accounts for 0.7% of intratemporal tumors. We report the second case described in the literature of a facial nerve hemangioma in its tympanic segment. A 14-year-old male patient presented with a history of progressive right ear hearing loss with preserved facial mimicry. Pure tone audiometry showed a right ear moderate conductive hearing loss. Magnetic resonance imaging demonstrated an expansive lesion involving the tympanic segment of the right facial nerve, suggestive of hemangioma...
November 29, 2018: Einstein
Zhengming Yang, Huimin Tao, Zhaoming Ye, Xin Huang, Nong Lin, Minfei Yang
OBJECTIVES: To investigate the diagnosis and treatment of tibial intercondylar chondroblastoma. METHODS: We retrospectively analyzed the diagnosis and treatment of 12 patients with tibial intercondylar chondroblastoma admitted to the orthopedics department from May 2011 to February 2016; among them were 4 males and 3 females aged 10-19 years, with an average age of 15.7 years. Tibial intercondylar chondroblastoma was on the left and right side in 7 and 5 cases, respectively...
November 29, 2018: Clinics
Arzu Antal Donmez, Davut Cekmecelioglu, Taylan Adademir, Ekrem Yilmaz, Hizir Mete Alp
Primary angiosarcoma is a rare clinical entity, it's typically located within the right atrium and known to be rapidly fatal. A 37-year-old female was presented with a history of recurrent facial paralysis and left hemiparesis. A cranial mass was identified at cranial magnetic resonance imaging and she underwent neurosurgery operation. The immunohistochemical examination was determined as metastatic cardiac angiosarcoma. The tumor, as well as part of the right pericardium, were resected. A piece of bovine pericardium was used to reconstruct the right atrial wall...
September 2018: Brazilian Journal of Cardiovascular Surgery
Yi Liu, Zhengjie Wang, Xiang Li, Xiaowei Ma, Shuailiang Wang, Fei Kang, Weidong Yang, Wenhui Ma, Jing Wang
The complete excision of glioblastomas with maximal retention of surrounding normal tissues can significantly improve patient prognosis. Near-infrared fluorescence (NIRF) optical imaging of the tumor vasculature offers a non-invasive method for detection of early-stage glioblastoma and efficient monitoring of therapeutic responses. The aim of this study was to develop a novel NIRF imaging probe as a visualization tool for image-guided surgical resection of orthotopic glioblastoma. In this study, Cy5.5-RKL, Cy5...
December 5, 2018: Molecular Pharmaceutics
Duc H T Le, Eduardo Méndez-López, Chao Wang, Ulrich Commandeur, Miguel A Aranda, Nicole F Steinmetz
Nanoparticles with high aspect ratios have favorable attributes for drug delivery and bio-imaging applications based on their enhanced tissue penetration and tumor homing properties. Here, we investigated a novel filamentous viral nanoparticle (VNP) based on Pepino mosaic virus (PepMV), a relative of the established platform Potato virus X (PVX). We studied the chemical reactivity of PepMV, produced fluorescent versions of PepMV and PVX, and then evaluated their biodistribution in mouse tumor models. We found that PepMV can be conjugated to various small chemical modifiers including fluorescent probes via the amine groups of surface-exposed lysine residues, yielding VNPs carrying payloads of up to 1600 modifiers per particle...
December 5, 2018: Biomacromolecules
Jae Heon Kim, Shufeng Li, Yash Khandwala, Kyung Jin Chung, Hyung Keun Park, Benjamin I Chung
Importance: Although the intent of nephron-sparing surgery is to eradicate malignant tumors found on preoperative imaging, benign masses often cannot be differentiated from malignant tumors. However, in the past there have been discrepancies in the reported percentages of benign masses removed by partial nephrectomy (PNx). Objective: To investigate the annual trend of prevalence of benign pathologic findings after PNx and to investigate what potential factors are associated with this prevalence...
December 5, 2018: JAMA Surgery
Guilherme de Souza E Cassia, César Augusto Pinheiro Ferreira Alves, Ajay Taranath, Nicolás Sgarbi López, Ozgur Oztekin, Fabrício Guimarães Gonçalves, Zoltan Patay
Medulloblastoma is the most common malignant solid tumor in childhood and the most common embryonal neuroepithelial tumor of the central nervous system. Several morphological variants are recognized: classic medulloblastoma, large cell/anaplastic medulloblastoma, desmoplastic/nodular medulloblastoma, and medulloblastoma with extensive nodularity. Recent advances in transcriptome and methylome profiling of these tumors led to a molecular classification that includes 4 major genetically defined groups. Accordingly, the 2016 revision of the World Health Organization's Classification of Tumors of the Central Nervous System recognizes the following medulloblastoma entities: Wingless (WNT)-activated, Sonic hedgehog (SHH)-activated, Group 3, and Group 4...
December 2018: Topics in Magnetic Resonance Imaging: TMRI
Cihan Gündoğan, Aytül Hande Yardimci, Burçak Yilmaz Güneş, Tevfik Fikret Çermik
A 68-year-old woman with colon carcinoma was referred to F-FDG PET/CT imaging for staging. In addition to primary tumor involvement, PET/CT demonstrated focal FDG uptake in the right temporal lobe suggestive of primary brain tumor or metastasis. To delineate the lesion, a brain MRI scan showed sigmoid sinus thrombosis and vasogenic edema in the right temporal lobe. The patient presented a history of right-sided headache that began 1 week before the PET/CT. Neurological examination and MRI findings were concluded as subacute venous infarct due to sigmoid sinus thrombosis and that is a potential cause for false-positive FDG uptake on PET/CT...
December 3, 2018: Clinical Nuclear Medicine
Ana María García Vicente, María José Rodriguez Muñoz, Francisco José Pena Pardo, Milton Miguel Martinez Madrigal, Angel Soriano Castrejón
Ischemic complications after resection of high-grade glioma are frequent and may constitute potential cause of false-positive results in postsurgical evaluation using F-fluorocholine PET/CT. On the other hand, hypoxia caused by ischemia promotes invasive glioma growth. We present 3 cases of patients with different grades of ischemic injury after resection of high-grade glioma. The combined interpretation of diffusion-weighted imaging and apparent diffusion coefficient map on MRI, in this clinical setting, is mandatory to avoid PET/CT misinterpretations...
December 3, 2018: Clinical Nuclear Medicine
Marc-Antoine Hubaut, Alice Jaillard, Capucine Eloy, Gregory Petyt
We report the case of a 31-year-old woman with left foot bones located epithelioid hemangioendothelioma. It is a rare type of vascular tumor, locally aggressive with metastatic potential. It was revealed by a chronic isolated left foot pain. Conventional imaging showed multiple osteolytic lesions of the bones, appearing aggressive. Both bone scintigraphy and F-FDG PET showed an increased uptake of these lesions and confirmed the limited extent to distal extremity of the left lower limb. Final diagnosis was given on a surgical biopsy...
December 3, 2018: Clinical Nuclear Medicine
Sied Kebir, Manuel Weber, Lazaros Lazaridis, Cornelius Deuschl, Teresa Schmidt, Christoph Mönninghoff, Kathy Keyvani, Lale Umutlu, Daniela Pierscianek, Michael Forsting, Ulrich Sure, Martin Stuschke, Christoph Kleinschnitz, Björn Scheffler, Patrick M Colletti, Domenico Rubello, Christoph Rischpler, Martin Glas
PURPOSE: With the advent of the revised WHO classification from 2016, molecular features, including isocitrate dehydrogenase (IDH) mutation have become important in glioma subtyping. This pilot trial analyzed the potential for C-methionine (MET) PET/MRI in classifying glioma according to the revised WHO classification using a machine learning model. METHODS: Patients with newly diagnosed WHO grade II-IV glioma underwent preoperative MET-PET/MRI imaging. Patients were retrospectively divided into four groups: IDH wild-type glioblastoma (GBM), IDH wild-type grade II/III glioma (GII/III-IDHwt), IDH mutant grade II/III glioma with codeletion of 1p19q (GII/III-IDHmut1p19qcod) or without 1p19q-codeletion (GII/III-IDHmut1p19qnc)...
December 3, 2018: Clinical Nuclear Medicine
Jason H Peragallo
PURPOSE OF REVIEW: To review the recent advances in understanding how primary brain tumors affect vision in children. RECENT FINDINGS: Children with primary brain tumors may have vision loss due to involvement of their afferent visual pathways or from papilledema. These vision deficits may go unrecognized until later in life, years after treatment of the primary lesion. Strabismus and cranial nerve palsies may occur as a result of brain tumors. Ophthalmologists can monitor and treat young children at risk for vision loss from amblyopia as a result of effects from their underlying lesion...
December 3, 2018: Current Opinion in Neurology
Noriaki Iizuka, Yoshihiro Ikura, Yasunori Fukuoka, Takashi Shibata, Masashi Okamoto, Akio Kamiya, Tetsuya Oishi, Fumikazu Kotsuji, Yasuhiro Iwai
Primary ovarian lymphomas are rare, but can potentially evoke diagnostic problems. We present a case of ovarian lymphoma, in which an ambiguous intraoperative pathologic report led to overtreatment (unnecessary surgery). A 73-yr-old woman with fatigue and low-grade fever was diagnosed as having a left ovarian tumor by imaging modalities. Exploratory laparotomy was carried out to confirm the diagnosis. The frozen tissue sections of the ovarian tumor showed condensed proliferation of atypical round cells accompanied with a few small lymphocytes...
December 3, 2018: International Journal of Gynecological Pathology
David A Talan, Darin J Saltzman, Daniel A DeUgarte, Gregory J Moran
BACKGROUND: Meta-analyses and a recent guideline acknowledge that conservative management of uncomplicated appendicitis with antibiotics can be successful for patients who wish to avoid surgery. However, guidance as to specific management does not exist. METHODS: PUBMED and EMBASE search of trials describing methods of conservative treatment was conducted according to PRISMA guidelines. RESULTS: Thirty-four studies involving 2944 antibiotic-treated participants were identified...
December 3, 2018: Journal of Trauma and Acute Care Surgery
Xiaowei Qiu, Hang Yuan, Bin Sima
BACKGROUND: The aim of this study was to investigate the relationship between EGFR mutation and computed tomography (CT) features in patients with adenocarcinoma of the lung. METHODS: One hundred and ninety two lung adenocarcinoma patients who underwent surgery were retrospectively included in this study. Examination of EGFR gene mutation was performed on all resected tumor samples. The 192 recruited lung adenocarcinoma patients were divided into groups according to EGFR mutation status: patients with mutations in exons 18-21 (effective mutated, n = 61) and non-mutated (n = 131)...
December 5, 2018: Thoracic Cancer
Carol H Yan, Charles C L Tong, Mrudula Penta, Vishal S Patel, James N Palmer, Nithin D Adappa, Jayakar V Nayak, Peter H Hwang, Zara M Patel
OBJECTIVES/HYPOTHESIS: Inverted papillomas (IPs) are benign tumors of the sinonasal tract with a malignant transformation potential. Predicting the transformation propensity of IPs and corresponding risk factors has long been a challenge. In this study, we aimed to use radiographic findings on magnetic resonance imaging (MRI) and computed tomography (CT) to help differentiate IP from IP-transformed squamous cell carcinomas (IP-SCC). STUDY DESIGN: Retrospective cohort study...
December 4, 2018: Laryngoscope
Linjue Shangguan, Shengwei Fang, Peipei Zhang, Suyang Han, Xiaodong Shen, Yawen Geng, Dingcun Luo, Chunlei Zhao
OBJECTIVE: To investigate the impact factors of the outcome of the first 131 I treatment in patients with papillary thyroid carcinoma (PTC) after total thyroidectomy. METHODS: Three hundred and fifty-three patients [256 females, 97 males, average age (43.58 ± 12.33 years)] with PTC after total thyroidectomy who underwent 131 I treatment from July 2014 to August 2017 were retrospectively analyzed. Curative efficacy of 131 I treatment was assessed 6 months afterward...
December 4, 2018: Annals of Nuclear Medicine
Amy Inji Chang, Young Kon Kim, Ji Hye Min, Jisun Lee, Honsoul Kim, Soon Jin Lee
PURPOSE: To determine the differential features of inflammatory myofibroblastic tumor (IMT) and intrahepatic cholangiocarcinoma (ICC) manifesting as target appearance on gadoxetic acid-enhanced MRI. METHODS: Twenty-seven patients with 36 IMTs (1.2-6.0 cm) and 34 patients with 34 ICCs (1.5-6.0 cm) who underwent gadoxetic acid-enhanced MRI were enrolled in this study. Two reviewers evaluated morphology, signal intensity, and enhancement features of tumors on T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and gadoxetic acid-enhanced imaging...
December 4, 2018: Abdominal Radiology
Vu-Long Tran, Vivek Thakare, Marco Natuzzi, Mathieu Moreau, Alexandra Oudot, Jean-Marc Vrigneaud, Alan Courteau, Cédric Louis, Stéphane Roux, Frédéric Boschetti, Franck Denat, Olivier Tillement, François Lux
Multimodal nanoprobes are highly demanded for biomedical imaging applications to enhance the reliability of the diagnostic results. Among different types of nano-objects, ultrasmall silica gadolinium nanoparticle (SiGdNP) appears as a safe, effective, and versatile platform for this purpose. In this study, a new method to functionalize SiGdNP based on silane chemistry has been reported. Two types of chelating silanes (APTES-DOTAGA and APTES-NODAGA) have been synthesized and grafted on SiGdNP by a simple one-step protocol...
2018: Contrast Media & Molecular Imaging
Noémi Kovács, Krisztián Szigeti, Nikolett Hegedűs, Ildikó Horváth, Dániel S Veres, Michael Bachmann, Ralf Bergmann, Domokos Máthé
Radiotherapy is one of the most frequently applied treatments in oncology. Tissue-absorbed ionizing radiation damages not only targeted cells but the surrounding cells too. The consequent long-term induced oxidative stress, irreversible tissue damage, or second malignancies draw attention to the urgent need of a follow-up medical method by which personalized treatment could be attained and the actually dose-limiting organ could be monitored in the clinical practice. We worked out a special hemisphere irradiation technique for mice which mimics the radiation exposure during radiotherapy...
2018: Contrast Media & Molecular Imaging
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