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Iron AND Transferrin

Philip Crispin, Benjamin Stephens, Evelyn McArthur, Farah Sethna
OBJECTIVES: To determine the optimum approach and timing to screen for iron deficiency in pregnancy. BACKGROUND: There is a lack of consensus on identifying and treating iron deficiency during pregnancy. Patient blood management programs may be refined by evaluating outcomes. METHODS: Retrospective data collection on women delivering prior to and following implementation of patient blood management interventions. Ferritin, transferrin saturation and haemoglobin levels were evaluated in first and second trimesters as predictors of pre-delivery anaemia...
December 5, 2018: Transfusion and Apheresis Science
Juan Mielgo-Ayuso, Julio Calleja-González, Aritz Urdampilleta, Patxi León-Guereño, Alfredo Córdova, Alberto Caballero-García, Diego Fernandez-Lázaro
INTRODUCTION: Deficient levels of 25-hydroxyvitamin D (25(OH)D) (<30 ng/mL) may compromise health and athletic performance. Supplementation with oral vitamin D can favor the state of iron metabolism, and testosterone and cortisol as an indicator of muscle recovery of the athlete with a deficiency. The main aim of this study was to evaluate the influence of eight weeks of supplementation with 3000 IU/day of vitamin D on the hematological and iron metabolism profile, as well as on the analytical values of testosterone and cortisol on elite male traditional rowers...
December 12, 2018: Nutrients
Carine Fillebeen, Edouard Charlebois, John Wagner, Angeliki Katsarou, Jeannie Mui, Hojatollah Vali, Daniel Garcia-Santos, Prem Ponka, John Presley, Kostas Pantopoulos
Transferrin receptor 1 (Tfr1) mediates uptake of circulating transferrin-bound iron to developing erythroid cells and other cell types. Its critical physiological function is highlighted by the embryonic lethal phenotype of Tfr1 knockout (Tfrc-/-) mice and the pathologies of several tissue-specific knockouts. We generated TfrcAlb-Cre mice bearing hepatocyte-specific ablation of Tfr1 to explore implications in hepatocellular and systemic iron homeostasis. TfrcAlb-Cre mice are viable and do not display any apparent liver pathology...
December 11, 2018: Blood
Paulina Krawiec, Elżbieta Pac-Kożuchowska
BACKGROUND: There is no single reliable marker of iron homeostasis in inflammatory bowel disease. AIMS: To determine diagnostic usefulness of soluble transferrin receptor and soluble transferrin receptor/log ferritin index in iron deficiency anemia in children with inflammatory bowel disease. METHODS: We assessed soluble transferrin receptor in serum and calculated soluble transferrin receptor/log ferritin index in 75 children with inflammatory bowel disease...
November 22, 2018: Digestive and Liver Disease
Erik Sørensen, Andreas S Rigas, Maria Didriksen, Kristoffer S Burgdorf, Lise W Thørner, Ole B Pedersen, Henrik Hjalgrim, Mikkel S Petersen, Christian Erikstrup, Henrik Ullum
BACKGROUND: Blood donors have an increased risk of low hemoglobin (Hb) levels due to iron deficiency. Therefore, knowledge of genetic variants associated with low Hb could facilitate individualized donation intervals. We have previously reported three specific single-nucleotide polymorphisms that were associated with ferritin levels in blood donors. In this study, we investigated the effect of these single-nucleotide polymorphisms on Hb levels in 15,567 Danish blood donors. STUDY DESIGN AND METHODS: We studied 15,567 participants in the Danish Blood Donor Study...
December 7, 2018: Transfusion
Kaman Singh, Ajay Kumar
Kinetic study on the complexation of caffeic acid with ferric chloride was performed in aqueous solution at pH 9.0. The complex was characterized by IR, UV-Vis spectroscopy and FE-SEM techniques. Kinetic data were obtained and used to model the reaction kinetics for the disappearance of the caffeic acid. The operational variables have been studied in the temperature range from 25 to 45 °C, initial iron and caffeic acid concentration from 0.6 mg/100 ml (ranging from 2.0 ml to 8 ml/100 ml). The complexation reaction was found to be a first-order with rate constants for k1 (formation) 4...
November 29, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Mohammad Golam Sabbir
Ca2+ /calmodulin-dependent protein kinase kinase 2 (CaMKK2) is a serine/threonine kinase that is activated following an increase in the intracellular Ca2+ concentration and activates multiple signaling cascades that control physiologically important neuronal processes. CaMKK2 has been implicated in schizophrenia, bipolar disease, neurodegeneration, and cancer. Using isoelectric focusing (IEF) and mass spectrometry-based proteomic analysis, it was found that knockdown (KD) of CaMKK2 in cultured adult primary dorsal root ganglion (DRG) neurons resulted in the reduction of transferrin (TF) phosphorylation at multiple functionally relevant residues which corresponded to loss of an acidic fraction (pH~3-4) of TF...
2018: Frontiers in Molecular Biosciences
Xinbing Sui, Ruonan Zhang, Shuiping Liu, Ting Duan, Lijuan Zhai, Mingming Zhang, Xuemeng Han, Yu Xiang, Xingxing Huang, Haoming Lin, Tian Xie
Ferroptosis is an iron-dependent, oxidative cell death, and is characterized by iron-dependent accumulation of reactive oxygen species (ROS) within the cell. It has been implicated in various human diseases, including cancer. Recently, ferroptosis, as a non-apoptotic form of cell death, is emerging in specific cancer types; however, its relevance in colorectal cancer (CRC) is unexplored and remains unclear. Here, we showed that ferroptosis inducer RSL3 initiated cell death and ROS accumulation in HCT116, LoVo, and HT29 CRC cells over a 24 h time course...
2018: Frontiers in Pharmacology
Elizabeth A Lundeen, Jennifer N Lind, Kristie E N Clarke, Nancy J Aburto, Cholpon Imanalieva, Tursun Mamyrbaeva, Asel Ismailova, Arnold Timmer, Ralph D Whitehead, Larissa Praslova, Galina Samohleb, Muktar Minbaev, O Yaw Addo, Mary K Serdula
BACKGROUND/OBJECTIVES: In 2009, the Ministry of Health of Kyrgyzstan launched a national Infant and Young Child Nutrition (IYCN) program which included point-of-use fortification of foods with micronutrient powders (MNP) containing iron, vitamin A, and other micronutrients. Caretakers of children aged 6-23 months were given 30 sachets of MNP every 2 months. Micronutrient surveys were conducted in 2009 and 2013. The objective of the study was to compare the prevalence of anemia and deficiencies of iron and vitamin A among children aged 6-29 months prior to the MNP program (2009) with those after full implementation (2013)...
December 6, 2018: European Journal of Clinical Nutrition
Brian Dean, Andrew Tsatsanis, Linh Q Lam, Elizabeth Scarr, James A Duce
OBJECTIVES: The objective of this study was to determine whether a breakdown in proteins regulating cortical iron homeostasis could be involved in the pathophysiology of mood disorders. METHODS: Levels of select proteins responsible for cortical iron transport were quantitated by Western blotting of Brodmann's (BA) areas 6 and 10 from patients with major depressive disorder (n = 13), bipolar disorder (n = 12) and age/sex matched controls (n = 13). RESULTS: We found the inactive form of ceruloplasmin was lower in BA 6 from males compared to females...
December 4, 2018: World Journal of Biological Psychiatry
Harry G Sherman, Carolyn Jovanovic, Snow Stolnik, Kim Baronian, Alison J Downard, Frankie J Rawson
All eukaryotic organisms require iron to function. Malfunctions within iron homeostasis have a range of physiological consequences, and can lead to the development of pathological conditions that can result in an excess of non-transferrin bound iron (NTBI). Despite extensive understanding of iron homeostasis, the links between the "macroscopic" transport of iron across biological barriers (cellular membranes) and the chemistry of redox changes that drive these processes still needs elucidating. This review draws conclusions from the current literature, and describes some of the underlying biophysical and biochemical processes that occur in iron homeostasis...
2018: Frontiers in Molecular Biosciences
Stefanie Kulnigg-Dabsch, Maximilian Resch, Georg Oberhuber, Florian Klinglmueller, Anke Gasche, Christoph Gasche
Iron deficiency (ID) workup is a common challenge for gastrointestinal endoscopy. In premenopausal women current guidelines recommend serologic evaluation of coeliac disease only. Here we systematically tested serologic screening for autoimmune gastritis (AIG) in a large cohort of patients with ID. This is a retrospective analysis of patients who attended an out-patient clinic specialized for ID. Patients with ferritin <50 µg/L or transferrin saturation <15% were included. Laboratory workup included endomysial antibodies and parietal-cell antibodies (PCA)...
October 2018: Seminars in Hematology
Ding-Ding Han, Cong Ma, Ling Zhao, Yu-Juan Gao, Yan-Hua Su
OBJECTIVE: To investigate the relationship between iron metabolism and thrombocytosis. METHODS: iron metabolism indexes , erythrocyte and platelet parameters of iron deficiency anemia patients with thrombocytosis were collected, the correlation of platelet parameters with iron metabolism indexes and erythrocyte parameters was analysed; the difference in erythrocyte,platelet and iron parameters between severe anemia group (hemoglobin<60 g / L) and mild and moderate anemia group (hemoglobin≥60 g / L) were compared; the changes of platelet count before and after treatment were observed...
December 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
Wei Zhang, Anjian Xu, Yanmeng Li, Suxian Zhao, Donghu Zhou, Lina Wu, Bei Zhang, Xinyan Zhao, Yu Wang, Xiaoming Wang, Weijia Duan, Qianyi Wang, Yuemin Nan, Hong You, Jidong Jia, Xiaojuan Ou, Jian Huang
BACKGROUND & AIMS: Hemochromatosis type 4, also known as ferroportin disease, is an autosomal dominant genetic disorder caused by pathogenic mutations in the SLC40A1 gene, which encodes ferroportin 1 (FPN1). We have identified a novel SCL40A1 p.Y333H mutation in our previous study. In the present study, we tried to investigate the frequency and pathogenicity of the SCL40A1 p.Y333H mutation in hemochromatosis in China. METHODS: Patients were analyzed for SCL40A1 p...
November 30, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
Gianluca Abbati, Federica Incerti, Chiara Boarini, Francesca Pileri, Davide Bocchi, Paolo Ventura, Elena Buzzetti, Antonello Pietrangelo
Iron deficiency anemia (IDA) is one of the most common complications of inflammatory bowel disease (IBD). We planned a prospective study to address tolerability and efficacy of sucrosomial iron, a new oral formulation of ferric pyrophosphate, in IBD patients. Thirty patients with a confirmed diagnosis of Crohn's Disease (CD) or ulcerative colitis (UC) and mild IDA were enrolled. Patients with severe IBD were excluded. All patients underwent 12 weeks of oral treatment with 30 mg/day of sucrosomial iron. Treatment compliance and adverse events were investigated every 4 weeks...
November 29, 2018: Internal and Emergency Medicine
Tyler J Loftus, Juan C Mira, Julie A Stortz, Tezcan Ozrazgat-Baslanti, Gabriella L Ghita, Zhongkai Wang, Babette A Brumback, Ricardo F Ungaro, Azra Bihorac, Christiaan Leeuwenburgh, Frederick A Moore, Lyle L Moldawer, Scott C Brakenridge, Philip A Efron, Alicia M Mohr
BACKGROUND: Associations among inflammatory cytokines, erythropoietin, and anemia in critically ill septic patients remain unclear. This study tested the hypothesis that elevated inflammatory cytokines and decreased erythropoietin would be associated with iron-restricted anemia while accounting for operative blood loss, phlebotomy blood loss, and red blood cell (RBC) transfusion volume. METHODS: Prospective observational cohort study of 42 critically ill septic patients...
November 27, 2018: Journal of Trauma and Acute Care Surgery
Olivier Loréal, Thibault Cavey, François Robin, Moussa Kenawi, Pascal Guggenbuhl, Pierre Brissot
Genetic hemochromatosis is an iron overload disease that is mainly related to the C282Y mutation in the HFE gene. This gene controls the expression of hepcidin, a peptide secreted in plasma by the liver and regulates systemic iron distribution. Homozygous C282Y mutation induces hepcidin deficiency, leading to increased circulating transferrin saturation, and ultimately, iron accumulation in organs such as the liver, pancreas, heart, and bone. Iron in excess may induce or favor the development of complications such as cirrhosis, liver cancer, diabetes, heart failure, hypogonadism, but also complaints such as asthenia and disabling arthritis...
November 26, 2018: Pharmaceuticals
Gunnar Birgegard, Jan Samuelsson, Erik Ahlstrand, Elisabeth Ejerblad, Christian Enevold, Waleed Ghanima, Hans Hasselbalch, Claus H Nielsen, Håvar Knutsen, Ole B Pedersen, Anders Sørensen, Björn Andreasson
OBJECTIVES: The study investigates the hypothesis that inflammation in myelofibrosis (MF) like in myeloma and lymphoma, may disturb iron distribution and contribute to anaemia. METHODS: A cross-sectional study of 80 MF and 23 ET patients was performed. RESULTS: Thirtyfive % of anaemic MF patients had functional iron deficiency (FID) with transferrin saturation <20 and normal or elevated S-ferritin (<500 μg/L). In ET, FID was rare. In MF patients with FID, 70...
November 25, 2018: European Journal of Haematology
D Pluta, G Franik, Ł Blukacz, K Kowalczyk, A Witkowska, M Wysocka, P Madej
OBJECTIVE: Scarce clinical and experimental studies suggest that hepcidin can be a protein participating in the development of metabolic disorders, while its synthesis and concentration in the circulation outside of the iron metabolism parameters can be influenced by hormones. The aim of the present study was to determine the correlation between the concentration of hepcidin in serum and the occurrence of insulin resistance and hyperandrogenemia in women with PCOS. PATIENTS AND METHODS: Five groups of women with PCOS were divided based on: correct body mass (17 without hyperandrogenemia and insulin resistance - G1; 17 with hyperandrogenemia and without insulin resistance - G2; 11 without hyperandrogenemia and with insulin resistance - G3; 10 with hyperandrogenemia and insulin resistance - G4), metabolic and hormonal parameters and selected markers of iron metabolism...
November 2018: European Review for Medical and Pharmacological Sciences
Dylan L Petkus, Laura E Murray-Kolb, Samuel P Scott, Emily A Southmayd, Mary Jane De Souza
OBJECTIVES: Although exercising women are at high risk of poor iron status, it is unknown how non-pathological, physiological menstrual function affects iron status. As such, this study investigates the association between menstrual function and iron status in exercising women with amenorrhea and exercising women with ovulatory, eumenorrheic menstrual cycles. DESIGN: Cross-sectional analysis of iron depletion prevalence, iron status indices, exercise parameters, and diet composition...
January 2019: Journal of Trace Elements in Medicine and Biology
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