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Evidenced based

Carlos Mesak, Douglas Marcel Dos Reis Sampaio, Raíssa de Oliveira Ferreira, Bruna de Oliveira Mendes, Aline Sueli de Lima Rodrigues, Guilherme Malafaia
The toxicity of ZnO nanoparticles (NPs) has been the subject of several investigations; however, concentrations much higher than the ones potentially found in the environment are often tested. In addition, groups of animals such as birds have not been used as model in studies in this field, fact that creates an important ecotoxicological gap in them. The aim of the present study is to investigate the effects of the exposure to environmentally relevant concentrations of ZnO nanoparticles on the anti-predatory behavior of chicks (Gallus gallus domesticus)...
August 9, 2018: Environmental Pollution
Rebecca J Hirst, Jemaine E Stacey, Lucy Cragg, Paula C Stacey, Harriet A Allen
Across development, vision increasingly influences audio-visual perception. This is evidenced in illusions such as the McGurk effect, in which a seen mouth movement changes the perceived sound. The current paper assessed the effects of manipulating the clarity of the heard and seen signal upon the McGurk effect in children aged 3-6 (n = 29), 7-9 (n = 32) and 10-12 (n = 29) years, and adults aged 20-35 years (n = 32). Auditory noise increased, and visual blur decreased, the likelihood of vision changing auditory perception...
August 17, 2018: Scientific Reports
Aaron B Caughey, Stephen L Wood, George A Macones, Ian J Wrench, Jeffrey Huang, Mikael Norman, Karin Pettersson, William J Fawcett, Medhat M Shalabi, Amy Metcalfe, Leah Gramlich, Gregg Nelson, R Douglas Wilson
OBJECTIVE: This ERAS Guideline for intraoperative care in Cesarean Delivery (CD) will provide best practice, evidenced-based, recommendations for intra-operative care with primarily, a maternal focus. The 'focused' pathway process for scheduled and unscheduled CD, for this ERAS CD guideline will consider, from decision to operate (starting with the 30 - 60 minutes prior to skin incision) through the conduct of the surgery. METHODS: The literature search (1966-2017) used Embase and PubMed to search medical subject headings including "Cesarean Section", "Cesarean Section", "Cesarean Section Delivery" and all pre- and intra-operative ERAS® items...
August 14, 2018: American Journal of Obstetrics and Gynecology
Hongrong Wu, Xiaocheng Zhou, Jidong Li, Xuemei Li, Baowen Li, Wenwen Fei, Jianxin Zhou, Jun Yin, Wanlin Guo
Metal oxides have advantages over the traditional noble metals to be used as substrate materials for surface-enhanced Raman spectroscopy (SERS) with low cost, versatility, and biocompatibility, but their enhancement factors are generally quite low with a poor limit of detection. Here, ultrathin molybdenum dioxide (MoO2 ) nanosheets synthesized by chemical vapor deposition demonstrated in large area are used as SERS substrates with superior signal uniformity in the whole area with a limit of detectable concentration down to 4 × 10-8 m and enhancement factor up to 2...
August 16, 2018: Small
Karen Yasmim Pereira Dos Santos Avelino, Isaac Aarón Morales Frías, Norma Lucena-Silva, César Augusto Souza de Andrade, Maria Danielly Lima de Oliveira
A label-free impedimetric biosensor was developed for determination of BCR/ABL transcripts. Specific DNA primers were covalently immobilized on a gold electrode modified with carboxylated multiwalled carbon nanotubes (cMWCNTs) and zinc oxide nanoparticles (ZnO-NPs). Aggregation of the ZnO-NPs is prevented by the introduction of an amino-modified silica coating, which also allows a subsequent covalent linkage to cMWCNTs. The impedimetric biosensor was typically operated at a working voltage of +10 mV vs. Ag/AgCl, in a frequency range from 100 mHz to 100 kHz...
August 16, 2018: Mikrochimica Acta
Saeid Komasi, Ali Soroush, Mozhgan Saeidi, Agostino Brugnera, Massimo Rabboni, Mario Fulcheri, Danilo Carrozzino, Paolo Marchettini, Angelo Compare
Introduction: The causal attributions and perceived risk factors can affect patients' health behaviors. Therefore, the present study aimed to assess (i) the effect of an outpatient cardiac rehabilitation (CR) program on perceived heart risk factors (PHRFs) and on psychological stress, and (ii) the role of changes of PHRFs at pre-post CR in predicting changes in psychological stress. Methods: In this longitudinal study, 110 CR patients were assessed from June to November 2016 in a hospital in Iran. Perceived heart risk factors and perceived stress were investigated using the PHRFs scale and the Depression, Anxiety, Stress Scale-21, respectively...
2018: Journal of Cardiovascular and Thoracic Research
E Galavan
The collaborative assessment and management of suicide (CAMS) model has been developed over 25 years providing mental health clinicians with a flexible, evidenced-based, collaborative and ethically informed way of addressing suicidality with service users. This paper briefly overviews the CAMS model and its advantages and advocates for its use in mental health services both nationally and internationally.
September 2017: Irish Journal of Psychological Medicine
Xin Yu, Maofu Pang, Shengnan Zhang, Xinlong Hu, Chen-Ho Tung, Wenguang Wang
To determine the reaction pathways at a metal-ligand site in enzymes, we incorporated a terminal thiolate site into a diiron bridging hydride. Trithiolato diiron hydride, (-H)Fe2(pdt)(dppbz)(CO)2(SR) (1(-H)) [pdt2- = 1,3-(CH2)3S22-, dppbz = 1,2-C6H4(PPh2)2, RS- = 1,2-Cy2PC6H4S-)] was synthesized directly by photo-assisted oxidative addition of 1,2-Cy2PC6H4SH to Fe2(pdt)(dppbz)(CO)4. The terminal thiolate in 1(-H) undergoes protonation, affording a thiol-hydride complex [1(-H)H]+. Placing an acidic SH site adjacent to the Fe-H-Fe site allows intramolecular thiol-hydride coupling, and releases H2 from [1(-H)H]+...
August 16, 2018: Journal of the American Chemical Society
Yuanyuan Zhang, Xuan Zhang, Jiafei Lyu, Ken-Ichi Otake, Xingjie Wang, Louis R Redfern, Christos D Malliakas, Zhanyong Li, Timur Islamoglu, Bo Wang, Omar K Farha
Zr-based metal-organic frameworks (MOFs) have been known for their excellent stability, however, due to the high connectivity of the Zr6 nodes, it is challenging to introduce flexibility into Zr-MOFs. Here we present a flexible Zr-MOF named NU-1400 comprising 4-connected Zr6 nodes and tetratopic linkers. It exhibits guest-dependent structural flexibility with up to 48% contraction in the unit cell volume as evidenced by single-crystal X-ray studies. The expanded or contracted conformations of NU-1400 showed drastically different reactivity toward the hydrolysis of a nerve agent simulant owing to the size-selective effect toward the reactant...
August 16, 2018: Journal of the American Chemical Society
Sien Hu, Jaime S Ide, Herta H Chao, Brittney Castagna, Kimberly A Fischer, Sheng Zhang, Chiang-Shan R Li
Inhibitory control or the ability to refrain from incorrect responses is a critical executive function known to diminish during aging. Imaging studies have elucidated cerebral changes that may underlie the age-related deficits. However, it remains unclear whether the structural and functional changes occur in the same brain regions and whether reduced gray matter volumes (GMV) mediate decreased activation during inhibition. Here, in a sample of 149 participants, we addressed the issues using structural and functional magnetic resonance imaging...
August 16, 2018: Human Brain Mapping
Sandra Mrozińska, Joanna Cieślik, Elżbieta Broniatowska, Anetta Undas
Introduction The HERDOO2 rule can help identify patients in whom anticoagulation therapy can be safely discontinued. Unfavorably altered fibrin clot properties predicted recurrent venous thromboembolism (VTE). Objectives We aimed to assess whether there is an association between fibrin clot properties and the HERDOO2 rule in women after unprovoked VTE. Patients and methods Eighty women below 70 years after the first-ever unprovoked VTE separately and combined with 32 women after hormone-related VTE were followed up for a median 48...
August 16, 2018: Polish Archives of Internal Medicine
Emin Semih Perdahcıoğlu, Celal Soyarslan, Emin Erkan Aşık, Ton van den Boogaard, Swantje Bargmann
As the characteristic scale of products and production processes decreases, the plasticity phenomena observed start to deviate from those evidenced at the macroscale. The current research aims at investigating this gap using a lower-order gradient enhanced approach both using phenomenological continuum level as well as crystal plasticity models. In the phenomenological approach, a physically based hardening model relates the flow stress to the density of dislocations where it is assumed that the sources of immobile dislocations are both statistically stored (SSDs) as well as geometrically necessary dislocations (GNDs)...
August 14, 2018: Materials
Eric A Wold, Jianping Chen, Kathryn A Cunningham, Jia Zhou
G protein-coupled receptors (GPCRs) have been tractable drug targets for decades with over one-third of currently marketed drugs targeting GPCRs. Of these, the class A GPCR superfamily is highly represented and continued drug discovery for this family of receptors may provide novel therapeutics for a vast range of diseases. GPCR allosteric modulation is an innovative targeting approach that broadens the available small molecule toolbox and is proving to be a viable drug discovery strategy, as evidenced by recent FDA approvals and clinical trials...
August 14, 2018: Journal of Medicinal Chemistry
Magdalena Szaryńska, Agata Olejniczak, Jarosław Kobiela, Dariusz Łaski, Zbigniew Śledziński, Zbigniew Kmieć
The therapy of colorectal cancer (CRC) patients is often unsuccessful because of the presence of cancer stem cells (CSCs) resistant to conventional approaches. Dendritic cells (DC)-based protocols are believed to effectively supplement CRC therapy. Our study was aimed to assess how the number and properties of CSCs isolated from tumor tissue of CRC patients will affect the biological characteristics of in vitro modified DCs. Similar procedures were conducted with the using of CRC HCT116 and HT29 cell lines...
August 13, 2018: Scientific Reports
Taisuke Kanaji, My-Nuong Vo, Sachiko Kanaji, Alessandro Zarpellon, Ryan Shapiro, Yosuke Morodomi, Akinori Yuzuriha, Koji Eto, Rajesh Belani, Minh-Ha Do, Xiang-Lei Yang, Zaverio M Ruggeri, Paul Schimmel
New mechanisms behind blood cell formation continue to be uncovered, with therapeutic approaches for hematological diseases being of great interest. Here we report an enzyme in protein synthesis, known for cell-based activities beyond translation, is a factor inducing megakaryocyte-biased hematopoiesis, most likely under stress conditions. We show an activated form of tyrosyl-tRNA synthetase (YRSACT ), prepared either by rationally designed mutagenesis or alternative splicing, induces expansion of a previously unrecognized high-ploidy Sca-1+ megakaryocyte population capable of accelerating platelet replenishment after depletion...
August 13, 2018: Proceedings of the National Academy of Sciences of the United States of America
Pucharee Songprakhon, Thawornchai Limjindaporn, Guey Chuen Perng, Chunya Puttikhunt, Thanawat Thaingtamtanha, Thanyaporn Dechtawewat, Sawanan Saitornuang, Chairat Uthaipibull, Sissades Thongsima, Pa-Thai Yenchitsomanus, Prida Malasit, Sansanee Noisakran
Virus-host interactions play important roles in virus infection and host cellular response. Several viruses, including dengue virus (DENV), usurp host chaperones to support their amplification and survival in the host cell. We investigated the interaction of nonstructural protein 1 (NS1) of DENV with three endoplasmic reticulum-resident chaperones (i.e. GRP78, calnexin and calreticulin) to delineate their functional roles and potential binding sites for protein complex formation. GRP78 protein showed prominent association with DENV NS1 in virus-infected Huh7 cells as evidenced by co-localization and co-immunoprecipitation assays...
August 10, 2018: Journal of General Virology
Amie R Newins, Susan W White
Sexual victimization among college women is a common problem, necessitating the development of risk reduction programs that are both effective and acceptable to this population. Computer-based programs may be a cost- and time-effective option. This pilot study sought to examine the feasibility, acceptability, and preliminary efficacy of a computer-based risk reduction program. A total of 136 collegiate women were randomly assigned to receive either a computer-based risk reduction program or an educational program about campus resources (active control condition)...
August 13, 2018: Journal of Interpersonal Violence
Carlos Diezma-Díaz, Alejandro Jiménez-Meléndez, Michela Tatiana Re, Ignacio Ferre, Maria Del Carmen Ferreras, Daniel Gutiérrez-Expósito, Silvia Rojo-Montejo, Alicia Román-Trufero, Julio Benavides-Silván, Paula García-Lunar, Lydia Calleja-Bueno, Javier Blanco-Murcia, Koldo Osoro, Luis-Miguel Ortega-Mora, Gema Álvarez-García
Bovine besnoitiosis is continuing to spread in Europe. Therefore, the development of ruminant animal models of infection is urgently needed to evaluate therapeutic and prophylactic tools. Herein, we studied the effect of parasite dose and host age on the infection dynamics with Besnoitia besnoiti tachyzoites in cattle in two independent experimental infections. In experiment A, twelve 3-month-old male calves were inoculated intravenously with either three different doses of tachyzoites (G1: 108 ; G2: 107 ; G3: 106 ) or with PBS (G4)...
August 12, 2018: Transboundary and Emerging Diseases
Akos Banyasz, Lara Martínez-Fernández, Roberto Improta, Tiia-Maaria Ketola, Clémence Balty, Dimitra Markovitsi
Recent studies have evidenced that oxidatively damaged DNA, which potentially leads to carcinogenic mutations and aging, may result from the direct absorption of low-energy photons (>250 nm). Herein, the primary species, i.e., ejected electrons and base radicals associated with such damage in duplexes with an alternating guanine-cytosine sequence are quantified by nanosecond transient absorption spectroscopy. The one-photon ionization quantum yield at 266 nm is 1.2 × 10-3, which is similar to those reported previously for adenine-thymine duplexes...
August 13, 2018: Physical Chemistry Chemical Physics: PCCP
András Gyovai, Renáta Minorics, Anita Kiss, Erzsébet Mernyák, Gyula Schneider, András Szekeres, Erika Kerekes, Imre Ocsovszki, István Zupkó
19-Nortestosterone C-17 epimers with prominent antiproliferative properties have been previously described. In our present study, five novel 17α-19-nortestosterones ( 3-7 ) were synthesized to increase their beneficial biological activities with no associated undesired hormonal effects. The compounds were screened by a viability assay against a panel of human adherent gynecological cancer cell lines. Three of the tested derivatives ( 3 - 5 ) exhibited a remarkable inhibitory effect on the proliferation of HeLa cells with IC50 values lower than that of our reference agent cisplatin (CIS)...
2018: Frontiers in Pharmacology
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