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Evidenced based

F Marra, C Petronio, P Ceruleo, G Di Stefano, F Florindo, M Gatta, M La Rosa, M F Rolfo, L Salari
We present a combined geomorphological and biochronological study aimed at providing age constraints to the deposits forming a wide paleo-surface in the coastal area of the Tyrrhenian Sea, south of Anzio promontory (central Italy). We review the faunal assemblage recovered in Campoverde, evidencing the occurrence of the modern fallow deer subspecies Dama dama dama, which in peninsular Italy is not present before MIS 5e, providing a post-quem terminus of 125 ka for the deposit hosting the fossil remains. The geomorphological reconstruction shows that Campoverde is located within the highest of three paleosurfaces progressively declining towards the present coast, at average elevations of 36, 26 and 15 m a...
December 13, 2018: Scientific Reports
Andrea Chiappini, Laura Pasquardini, Somayeh Nodehi, Cristina Armellini, Nicola Bazzanella, Lorenzo Lunelli, Stefano Pelli, Maurizio Ferrari, Silvia M Pietralunga
In this paper, we described a versatile two steps approach for the realization of silica inverse opals functionalized with DNA-aptamers labelled with Cy3 fluorophore. The co-assembly method was successfully employed for the realization of high quality inverse silica opal, whilst the inverse network was functionalized via epoxy chemistry. Morphological and optical assessment revealed the presence of large ordered domains with a transmission band gap depth of 32%, after the functionalization procedure. Finite Difference Time-Domain (FDTD) simulations confirmed the high optical quality of the inverse opal realized...
December 7, 2018: Sensors
Seonung Lim, Wonwoo Lee, Doo Suk Lee, In-Jeong Nam, Nayoung Yun, Yoonseon Jeong, Taewoong Rho, Sunyoung Kim
Benign prostatic hyperplasia (BPH) is a common disease in the elderly male population throughout the world. Among other factors, androgen dysregulation has been known to play major roles in its pathogenesis. HX109 is a botanical formulation prepared from a mixture of Taraxacum officinale , Cuscuta australis , and Nelumbo nucifera , which have traditionally been used-usually along with other plants-to treat urinary diseases. An ethanol extract was prepared from a mixture of these three plants, and its quality was controlled through cell-based bioassays and by quantification of several marker compounds by high-performance liquid chromatography (HPLC)...
December 7, 2018: Nutrients
Diego Valenzuela-Miranda, Cristian Gallardo-Escárate
High-throughput sequencing technologies have offered the possibility to understand the complexity of the transcriptomic responses of an organism during a wide variety of biological scenarios, such as the case of pathogenic infections. Recently, the simultaneous sequencing of both pathogen and host transcriptomes (dual RNA-seq) during the infection has become a promising approach to uncover the complexity of the host-pathogen interactions. In this study, through a double rRNA depletion and RNA sequencing protocols, we simultaneously analyzed the transcriptome of the intracellular bacterium Piscirickettsia salmonis and its host the Atlantic salmon ( Salmo salar ) during the course of the infection...
2018: Frontiers in Microbiology
Zidong Jia, Ye Zhang, Qiang Li, Zhenzhen Ye, Yuqi Liu, Changzhu Fu, Xiaohui Cang, Meng Wang, Min-Xin Guan
The tissue specificity of mitochondrial tRNA mutations remains largely elusive. In this study, we demonstrated the deleterious effects of tRNAThr 15927G>A mutation that contributed to pathogenesis of coronary artery disease. The m.15927G>A mutation abolished the highly conserved base-pairing (28C-42G) of anticodon stem of tRNAThr. Using molecular dynamics simulations, we showed that the m.15927G>A mutation caused unstable tRNAThr structure, supported by decreased melting temperature and slower electrophoretic mobility of mutated tRNA...
December 12, 2018: Nucleic Acids Research
Federico Montanarella, Darius Urbonas, Luke Chadwick, Pepijn G Moerman, Patrick J Baesjou, Rainer F Mahrt, Alfons van Blaaderen, Thilo Stöferle, Daniël Vanmaekelbergh
One of the most attractive foreseen commercial applications of semiconductor nanocrystals (NCs) is their use in lasers. Thanks to their high quantum yield, tunable optical properties, photostability and wet-chemical processability, NCs have arisen as promising gain material. Most of these applications, however, rely on incorporation of NCs in lasing cavities separately produced using sophisticated fabrication methods and often difficult to manipulate. Here, we present whispering gallery mode lasing in supraparticles (SPs) of self-assembled NCs...
December 12, 2018: ACS Nano
Júlia Mayans, Queralt Saez, Mercè Font-Bardia, Albert Escuer
Employing the chiral bi-compartmental Schiff-base ligand H2L obtained from the condensation of (RR) or (SS)-1,2-diphenyl-ethylenediamine and o-vanillin, we report the structural characterization of the discrete dinuclear pairs of enantiomers [NiIIEuIII] 1RR, 1SS and [ZnIIEuIII] 2RR, 2SS and the magnetic properties for the series of complexes [NiIILnIII], Ln = Ce, 3RR; Nd, 4RR; Dy, 5RR; Er, 6RR, Yb, 7SS and [ZnIILnIII], Ln = Ce, 8RR; Nd, 9RR; Dy, 10SS; Er, 11SS and Yb, 12RR in which MII is diamagnetic and LnIII is a Kramers lanthanide...
December 12, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Cesar Mauricio Rodríguez Barrero, Lyle Alberto Romero Gabalan, Edgar Eduardo Roa Guerrero
In the field of medicine, the analysis of blood is one of the most important exams to determine the physiological state of a patient. In the analysis of the blood sample, an important process is the counting and classification of white blood cells, which is done manually, being an exhaustive, subjective, and error-prone activity due to the physical fatigue that generates the professional because it is a method that consumes long laxes of time. The purpose of the research was to develop a system to identify and classify blood cells, by the implementation of the networks of Gaussian radial base functions (RBFN) for the extraction of its nucleus and subsequently their classification through the morphological characteristics, its color, and the distance between objects...
2018: Advances in Hematology
Jill Manthorpe, Steve Iliffe
There is growing interest in the social geography of dementia, with the development of dementia-friendly communities, localities and cities in the developed world. This paper considers the claims being made for cities to be risky spaces for people with dementia. It debates this through an analysis based on Bacchi's 'representation of problems' framework, evidencing this with policy documents and research findings. This reveals that the city is often seen as problematic for people with dementia, despite evidence to the contrary, and that local politicians are making claims for cities to be responsive dementia communities...
December 11, 2018: Dementia
Jiayong Dong, Fei Teng, Wenyuan Guo, Jinghui Yang, Guoshan Ding, Zhiren Fu
BACKGROUND/AIMS: Long noncoding RNAs (lncRNAs) are aberrantly expressed in multiple malignant tumors involved in tumor growth and metastasis. Accumulating data show that small nucleolar RNA host gene (SNHG) 1/12/20 plays a key role in the progression of hepatocellular carcinoma (HCC). However, the molecular mechanisms by which SNHG8 contributes to HCC remain elusive and merit exploration. METHODS: The association between SNHG8 expression and the clinicopathological characteristics and prognoses in HCC patients was analysed by using qRT-PCR analysis and the data from The Cancer Genome Atlas...
2018: Cellular Physiology and Biochemistry
Sandra D Reid, Rhoda Reddock, Tisha Nickenig
BACKGROUND: Child sexual abuse (CSA) is a multi-dimensional problem. The search for best practice must consider the complexities surrounding CSA and its management in any particular society. OBJECTIVE: Data previously gathered from service providers on CSA service provision in Trinidad and Tobago identified key deficient issues in policy and practice. In this paper, researchers aimed to bridge the gaps identified, and effect changes to improve services for CSA using an action research methodology...
December 8, 2018: Child Abuse & Neglect
Yuhang Li, Zhiwei Qiao, Yonghai Cao, Hongjuan Wang, Hong Liang, Hao Yu, Feng Peng
The superoxide decay behavior is evaluated by contrastive potential energy surface analyses from theoretical calculations. The presence of carbon surface enhances the superoxide decay via disproportionation instead of electroreduction, which is a non-electrochemical reaction impeding the increase in energy efficiency for relevant energy conversion applications. Nitrogen doping in carbon effectively retards the disproportionation by influencing the oxygen stretching vibration and changing the proton coupled electron transfer trend...
December 11, 2018: ChemSusChem
Trina Pyron, Jamila Fonseka, Monique Young, LaTisha Zimmerman, Angela R Moore, Nikki Hayes
The National Comprehensive Cancer Control Program has experienced exponential growth over the past 20 years due to the coordination and collaboration of many stakeholders to sustain multisector coalitions, develop and execute data-driven plans, and successfully implement evidenced-based interventions across the United States. These stakeholders have worked tirelessly to address the burden of cancer by employing strategies that promote healthy behaviors to reduce cancer risk, facilitate screening, and address the needs of cancer survivors...
December 8, 2018: Cancer Causes & Control: CCC
Filippo Migliorini, Markus Tingart, Marc Niewiera, Björn Rath, Jörg Eschweiler
PURPOSE: In the last couple of years, a significant amount of studies comparing the UKA and TKA for unicompartmental knee osteoarthritis have been published. However, there is a lack of recent meta-analysis comparing the two implants. Since the number of performed UKAs is currently increasing and the indications are obsolete, it becomes important to update current evidences and outcomes. With these premises, a meta-analysis of clinical trials comparing UKA versus TKA was conducted. METHODS: In October 2018, the following databases were accessed: Cochrane Systematic Reviews, Scopus, PubMed and Google Scholar...
December 7, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
Brian M Inouye, Francis M Hughes, Huixia Jin, Robin Lütolf, Kunal C Potnis, Jonathan C Routh, Douglas C Rouse, Wen-Chi Foo, J Todd Purves
Purpose: Diabetes is a grave and progressive condition characterized by debilitating complications. Diabetic bladder dysfunction (DBD) is a very common complication with no specific treatments currently available. Unlike other tissues affected by this disease, the bladder is subjected to two independent insults; 1) polyuria, created by the osmotic effects of glucose in the urine, and 2) hyperglycemia itself. Based on our understanding of inflammation as a major contributor to the underlying organ damage in several other diabetic complications, its presence in the bladder during DBD and the contribution of polyuria and hyperglycemia to its development were assessed...
2018: Research and Reports in Urology
Nathalie Guriec, Frédérick Bussy, Christelle Gouin, Olivier Mathiaud, Benoit Quero, Matthieu Le Goff, Pi Nyvall Collén
Responsiveness to invasive pathogens, clearance via the inflammatory response, and activation of appropriate acquired responses are all coordinated by innate host defenses. Toll-like receptor (TLR) ligands are potent immune-modulators with profound effects on the generation of adaptive immune responses. This property is being exploited in TLR-based vaccines and therapeutic agents in chickens. However, for administering the TLR agonist, all previous studies used in ovo , intra-muscular or intra-venous routes that cannot be performed in usual farming conditions, thus highlighting the need for TLR ligands that display systemic immune effects when given orally ( per os )...
2018: Frontiers in Immunology
Joshua M Smyth, Jillian A Johnson, Brandon J Auer, Erik Lehman, Giampaolo Talamo, Christopher N Sciamanna
BACKGROUND: Positive affect journaling (PAJ), an emotion-focused self-regulation intervention, has been associated with positive outcomes among medical populations. It may be adapted for Web-based dissemination to address a need for scalable, evidence-based psychosocial interventions among distressed patients with medical conditions. OBJECTIVE: This study aimed to examine the impact of a 12-week Web-based PAJ intervention on psychological distress and quality of life in general medical patients...
December 10, 2018: JMIR Mental Health
Mariana Botelho Barbosa, Estefânia Mara do Nascimento Martins, Thayana Furtado Teixeira, Regina Duque Estrada Carvalho, João Paulo Coelho, Rodrigo Ribeiro Resende, Ester Figueiredo Oliveira, Adelina Pinheiro Santos, Antero Silva Ribeiro de Andrade, Clascídia Aparecida Furtado
The interaction between carbon nanotubes (CNTs) and biological molecules of diagnostic and therapeutic interest, as well as the internalization of the CNTs-biomolecules complexes in different types of cell, has been extensively studied due to the potential use of these nanocomplexes as multifunctional nanoplatforms in a great variety of biomedical applications. The effective use of these nanobiotechnologies requires broad multidisciplinary studies of biocompatibility, regarding, for example, the in vitro and in vivo nanotoxicological assays, the capacity to target specific cells and the evaluation of their biomedical potential...
November 27, 2018: Colloids and Surfaces. B, Biointerfaces
Maddalena Grimaldi, Veronica Dal Bo, Beatrice Ferrari, Elisa Roda, Fabrizio De Luca, Paola Veneroni, Sergio Barni, Manuela Verri, Sandra A De Pascali, Franco P Fanizzi, Graziella Bernocchi, Maria G Bottone
Cisplatin (cisPt), among the best known components of multi-drug front-line therapies used for the treatments of solid tumors, such as the childhood neuroblastoma, acts through DNA linking. Nevertheless, the cisPt effectiveness is compromised by the onset of severe side effects, including neurotoxicity that results in neurodegeneration, cell death, and drug-resistance. In the field of experimental oncology, aimed at overcoming cytotoxicity and chemoresistance, great efforts are devoted to the synthesis of new platinum-based drugs, such as [Pt(O,O'-acac)(γ-acac)(DMS)] (PtAcacDMS), which shows a specific reactivity with sulfur residues of enzymes involved in apoptosis...
December 6, 2018: Toxicology and Applied Pharmacology
Meng Wang, Shuhui Duan, Zhicheng Zhou, Shibao Chen, Duo Wang
Melatonin is a multifunctional signaling molecule that regulates broad aspects of responses to environmental stresses in plants. Cadmium (Cd) is a persistent soil contaminant that is toxic to all living organisms. Recent reports have uncovered the protective role of melatonin in alleviating Cd phytotoxicity, but little is known about its regulatory mechanisms in plants. In this study, we found that foliar application of melatonin (in particular 100 μmol L-1 ) remarkably enhanced Cd tolerance of tobacco (Nicotiana tabacum L...
December 4, 2018: Ecotoxicology and Environmental Safety
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