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Zhenzhen Jia, Joni Zhang, Dulce Trindade, Tanja Sobko
Objectives Many obesity-related chronic diseases originate from unhealthy childhood habits. The aim of this study was to describe 9-month-old infants' physical activity levels and patterns and to examine the correlates. Understanding these factors is necessary for improving the effectiveness of physical activity intervention programs for infants. Methods In total, 143 infant-mother dyads from Macau, SAR China, participated in this study. Physical activity (PA) was assessed by using the Actigraph GT3X+ accelerometer and the demographic variables were collected by questionnaires...
August 9, 2018: Maternal and Child Health Journal
Johanne Dubail, Céline Huber, Sandrine Chantepie, Stephan Sonntag, Beyhan Tüysüz, Ercan Mihci, Christopher T Gordon, Elisabeth Steichen-Gersdorf, Jeanne Amiel, Banu Nur, Irene Stolte-Dijkstra, Albertien M van Eerde, Koen L van Gassen, Corstiaan C Breugem, Alexander Stegmann, Caroline Lekszas, Reza Maroofian, Ehsan Ghayoor Karimiani, Arnaud Bruneel, Nathalie Seta, Arnold Munnich, Dulce Papy-Garcia, Muriel De La Dure-Molla, Valérie Cormier-Daire
Skeletal dysplasia with multiple dislocations are severe disorders characterized by dislocations of large joints and short stature. The majority of them have been linked to pathogenic variants in genes encoding glycosyltransferases, sulfotransferases or epimerases required for glycosaminoglycan synthesis. Using exome sequencing, we identify homozygous mutations in SLC10A7 in six individuals with skeletal dysplasia with multiple dislocations and amelogenesis imperfecta. SLC10A7 encodes a 10-transmembrane-domain transporter located at the plasma membrane...
August 6, 2018: Nature Communications
André Ferreira, João P Castro, José P Andrade, M Dulce Madeira, Armando Cardoso
Early life, covering childhood and adolescence in humans, is an important period of brain development and maturation. Experimental works in rodents have shown that high-caloric diets are particularly detrimental to young rats, affecting cognition. We studied the effects of two different high-caloric diets, prevalent in human adolescents, on male Wistar rats aged 4 weeks at the beginning of the experiment. Rats were randomly allocated to control (C, n=10), high-sugar diet (HS, n=10) and cafeteria diet (CAF, n=10) groups and fed accordingly for 8 weeks...
July 31, 2018: Neurobiology of Learning and Memory
Neil E Rowland, Deniz Atalayer, Melissa R Cervantez, Dulce M Minaya, Emily C Splane
Anorexia nervosa (AN) is an eating disorder that is thought to emerge through biological predisposition(s) within sociocultural context(s). Practical and ethical concerns limit study of the etiology of this disorder in humans, and in particular the biological aspects. Laboratory animal models have a pivotal role in advancing our understanding of the neurobiological, physiological and behavioral aspects of this disorder, and developing new treatment strategies. One shortcoming of animal models, including activity based anorexia (ABA) in rodents, is that they cannot fully capture the contextual aspects of AN...
July 31, 2018: Appetite
Milton N Schroth, John J Cho, Sylvia K Green, Spyros D Kominos, Microbiology Society Publishing
A prevailing opinion is that the strains of Pseudomonas aeruginosa that infects both plants and humans are two separate species. This study strongly disputes that notion until the modern molecular technology proves otherwise. This paper examines a spectrum of strains occurring in nature, their habitats, dissemination, their relationship to clinical strains, and the environmental conditions that favor their colonization of plants. The isolates were obtained from clinical specimens, plants, soil, and water. The identity of these strains was confirmed using pyocin typing and biochemical assays...
August 2018: Journal of Medical Microbiology
Cynara Maria Pereira, Rodolfo Carvalho Pacagnella, Mary Angela Parpinelli, Carla Betina Andreucci, Dulce Maria Zanardi, Renato Souza, Carina Robles Angelini, Carla Silveira, José Guilherme Cecatti
OBJECTIVE:  To assess the relationship between the use of psychoactive substances during pregnancy and the occurrence of severe maternal morbidity (SMM), perinatal outcomes and repercussions on the neuropsychomotor development of exposed children. METHODS:  A case-control study nested within a cohort of severe maternal morbidity (COMMAG) was performed. Women with SMM were considered cases. Controls were those with low-risk pregnancy, without SMM and admitted during the same time period as the cases...
July 31, 2018: Revista Brasileira de Ginecologia e Obstetrícia
Vicente Villanueva, Javier Montoya, Ascension Castillo, José Á Mauri-Llerda, Pau Giner, Francisco J López-González, Anna Piera, Pedro Villanueva-Hernández, Vicente Bertol, Alejandro Garcia-Escrivá, Juan J Garcia-Peñas, Iñigo Garamendi, Patricia Esteve-Belloch, Juan J Baiges-Octavio, Júlia Miró, Mercè Falip, Mercedes Garcés, Asier Gómez, Francisco J Gil-López, Mar Carreño, Juan J Rodriguez-Uranga, Dulce Campos, Macarena Bonet, Rosa Querol, Albert Molins, Diego Tortosa, Javier Salas-Puig
OBJECTIVE: To analyze the effectiveness and tolerability of perampanel across different seizure types in routine clinical care of patients with idiopathic generalized epilepsy (IGE). METHODS: This multicenter, retrospective, 1-year observational study collected data from patient records at 21 specialist epilepsy units in Spain. All patients who were aged ≥12 years, prescribed perampanel before December 2016, and had a confirmed diagnosis of IGE were included. RESULTS: The population comprised 149 patients with IGE (60 with juvenile myoclonic epilepsy, 51 generalized tonic-clonic seizures [GTCS] only, 21 juvenile absence epilepsy, 10 childhood absence epilepsy, 6 adulthood absence epilepsy, and one Jeavons syndrome)...
July 31, 2018: Epilepsia
Eliana Miura Zucchi, Alexandre Grangeiro, Dulce Ferraz, Thiago Félix Pinheiro, Tatianna Alencar, Laura Ferguson, Denize Lotufo Estevam, Rosemeire Munhoz
Pre-exposure prophylaxis (PrEP) has been considered a promising strategy for controlling the global HIV epidemic. However, it is necessary to translate the knowledge accumulated from clinical trials and demosntration studies to the reality of health services and the groups most vulnerable to infection in order to achieve broad coverage with PrEP. The article proposes a reflection on this challenge, focusing on three dimensions: users of prophylaxis, with an emphasis on the contexts of sexual practices and the potential exposures to HIV; the advantages of prophylaxis as compared to other methods and the challenges for protective and safe use; and health services, considering the organizational principles to ensure greater success in the supply and incorporation of PrEP as part of combination prevention strategies...
July 23, 2018: Cadernos de Saúde Pública
Elena Navarro, Pascual González, Víctor López-Jaquero, Francisco Montero, José P Molina, Dulce Romero-Ayuso
Some people require special treatments for rehabilitating physical, cognitive or even social capabilities after an accident or degenerative illness. However, the ever-increasing costs of looking after an aging population, many of whom suffer chronic diseases, is straining the finances of healthcare systems around Europe. This situation has given rise to a great deal of attention being paid to the development of telerehabilitation (TR) systems, which have been designed to take rehabilitation beyond hospitals and care centers...
2018: Frontiers in Neuroinformatics
Júlia d'A Francisquini, Leandra No Neves, Jansen Kf Torres, Antônio F Carvalho, Italo T Perrone, Paulo Henrique F da Silva
This Research Paper addresses the hypothesis that the type of dulce de leche formula affects formation of 5-hydroxymethylfurfural (HMF) during production and storage. Milk and sweetened condensed milk are products in which the Maillard reaction (MR) defines important characteristics such as colour and taste. There are few studies on the effects of pH, time, concentration, and sugar type on the formation of HMF or other MR markers in DL. Four formulas (varying in the addition of sodium bicarbonate and the type of sugar) were analysed for moisture, lipid, protein, ash, carbohydrate, water activity (Aw), and soluble solids...
July 23, 2018: Journal of Dairy Research
Angélica Barili, Vanessa da Silva Corralo, Andréia Machado Cardoso, Aline Mânica, Beatriz da Silva Rosa Bonadiman, Margarete Dulce Bagatini, Marzo Edir Da Silva-Grigoletto, Gabriela Gonçalves de Oliveira, Clodoaldo Antônio De Sá
Systemic arterial hypertension has been associated with the majority deaths from cardiovascular disease, especially among the elderly population, and the imbalance between antioxidant and pro-oxidants has been associated with hypertension. This study analyzed the acute responses of cardiorespiratory and oxidative stress parameters to low intensity aerobic exercise (LIAE) with blood flow restriction (BFR) in hypertensive elderly women. The experimental group consisted of 16 hypertensive women (67.2 ± 3...
July 20, 2018: Molecular Biology Reports
Ricado Salgado, Dulce Brito, Joao P Noronha, Barbara Almeida, Maria R Bronze, Adrian Oehmen, Gilda Carvalho, Maria T Barreto Crespo
Ibuprofen (IBU) is a non-steroidal anti-inflammatory drug that is becoming increasingly recognized as an important micropollutant to be monitored in wastewater treatment plants (WWTP), since it has been detected in effluents at the µg L-1 level. The IBU metabolites from biological degradation are not completely understood and can represent a threat to natural aquatic systems. P. medicamentivorans was previously isolated from WWTP sludge and found to be capable of IBU degradation. The aerobic biodegradation of ibuprofen by this organism was investigated in a batch lab-scale reactor for the identification of the metabolites formed...
July 27, 2018: Environmental Technology
Ana Priscila Gomes Silva, Marcella da Silva Araujo Santiago, Luciane Alves Maranho, Rodolpho Pereira de Oliveira, Dulce Helena Jardim Constantino, Camilo Dias Seabra Pereira, Regina Cláudia Barbosa da Silva, Juliana Elaine Perobelli
Manganese (Mn) is one of the most common chemical elements on Earth and an essential micronutrient in animal organism. However, in supraphysiological levels and long-term exposures, it is a potential toxicant. Although nervous system is the most studied in relation to Mn toxicity, other tissues can have their function impaired by Mn in high doses. The present study investigated the possible adverse effects of subchronic exposure to supraphysiologic level of Mn (5 mg/kg or 15 mg/kg, intraperitoneally) on reproductive, neurobehavioral, renal and hepatic parameters of male rats...
July 7, 2018: Toxicology
Stefan Barwe, Jonas Weidner, Steffen Cychy, Dulce M Morales, Stefan Dieckhöfer, Dennis Hiltrop, Justus Masa, Martin Muhler, Wolfgang Schuhmann
The electrochemical oxidation of the biorefinery product 5-(hydroxymethyl)furfural (HMF) to 2,5-furandicarboxylic acid (FDCA), an important platform chemical for the polymer industry, is receiving increasing interest. FDCA-based polymers such as polyethylene 2,5-furandicarboxylate (PEF) are sustainable candidates for replacing polyethylene terephthalate (PET). Herein, we report the highly efficient electrocatalytic oxidation of HMF to FDCA, using Ni foam modified with high-surface-area nickel boride (Nix B) as the electrode...
July 9, 2018: Angewandte Chemie
João Luiz Grandi, Mariana Cabrera Grell, Kelsy Catherina Nema Areco, Dulce Aparecida Barbosa
OBJECTIVE: To describe the occurrence of immediate transfusion reactions received by the Risk Management Department of Hospital São Paulo. METHOD: Cross-sectional and retrospective study which analyzed the notification sheets of transfusion reactions that occurred between May 2002 and December 2016 and were included in the Hemovigilance National System. RESULTS: One thousand five hundred and forty-eight transfusion reaction notification sheets were analyzed, all of which concerned immediate reactions associated with packed red blood cells (72...
June 28, 2018: Revista da Escola de Enfermagem da U S P
Raul Peralta, Paola Garcia, Alejandra Valdivia, Arianna Lopez, Teresa Apresa, Dulce M Hernandez, Francisco Gallegos, Isabel Alvarado-Cabrero, Cruz Vargas-De-Leon, Sonia Davila, Pablo Romero, Mauricio Salcedo
Introduction: In Head and Neck (HN) cancer, the High-Risk Human Papillomavirus (hr HPV) infection has been associated in about 40% of these tumors. The hr HPV infection is one of the etiological factors of several epithelial tumors; however, its association with the prognosis has not yet been established for patients with Laryngeal Squamous Cell Carcinoma (LSCC). On the other hand, Epidermal Growth Factor Receptor (EGFR) is a molecular marker widely studied in cancer and its overexpression has been associated with poor prognosis in some types of cancer, including the HN cancer...
June 25, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Dominic P Byrne, Yong Li, Krithika Ramakrishnan, Igor L Barsukov, Edwin A Yates, Claire E Eyers, Dulcé Papy-Garcia, Sandrine Chantepie, Vijayakanth Pagadala, Jian Lu, Carrow Wells, David H Drewry, William J Zuercher, Neil G Berry, David G Fernig, Patrick A Eyers
Sulphation of carbohydrate residues occurs on a variety of glycans destined for secretion, and this modification is essential for efficient matrix-based signal transduction. Heparan sulphate (HS) glycosaminoglycans control physiological functions ranging from blood coagulation to cell proliferation. HS biosynthesis involves membrane-bound Golgi sulphotransferases, including heparan sulphate 2- O -sulphotransferase (HS2ST), which transfers sulphate from the co-factor PAPS (3'-phosphoadenosine 5'-phosphosulphate) to the 2- O  position of a-L-iduronate in the maturing polysaccharide chain...
June 22, 2018: Biochemical Journal
Maria Graça Miguel, Custódia Gago, Maria Dulce Antunes, Soraia Lagoas, Maria Leonor Faleiro, Cristina Megías, Isabel Cortés-Giraldo, Javier Vioque, Ana Cristina Figueiredo
Background: Essential oils (EOs) have shown antimicrobial, antioxidant, and antiproliferative activity, which may, alone or in combination with other substances, potentially be used for the development of new drugs. However, their chemical variability, depending on the species, varieties, or geographical origin (among other factors) determines different bioactivities that need to be evaluated. Methods: The antioxidant activity of Corymbia citriodora and eight Eucalyptus species EOs was determined using two different methods: the scavenging ability of 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS+• ) and peroxyl free radicals or oxygen radical absorbance capacity (ORAC)...
June 21, 2018: Medicines (Basel, Switzerland)
Anne-Catherine Pouleur, Stefan Anker, Dulce Brito, Oana Brosteanu, Dirk Hasenclever, Barbara Casadei, Frank Edelmann, Gerasimos Filippatos, Damien Gruson, Ignatios Ikonomidis, Renaud Lhommel, Masliza Mahmod, Stefan Neubauer, Alexandre Persu, Bernhard L Gerber, Stefan Piechnik, Burkert Pieske, Elisabeth Pieske-Kraigher, Fausto Pinto, Piotr Ponikowski, Michele Senni, Jean-Noël Trochu, Nancy Van Overstraeten, Rolf Wachter, Jean-Luc Balligand
AIMS: Progressive left ventricular (LV) remodelling with cardiac myocyte hypertrophy, myocardial fibrosis, and endothelial dysfunction plays a key role in the onset and progression of heart failure with preserved ejection fraction. The Beta3-LVH trial will test the hypothesis that the β3 adrenergic receptor agonist mirabegron will improve LV hypertrophy and diastolic function in patients with hypertensive structural heart disease at high risk for developing heart failure with preserved ejection fraction...
June 22, 2018: ESC Heart Failure
Cara L Wallace, Dulce M Cruz-Oliver, Jennifer E Ohs, Leslie Hinyard
BACKGROUND: Although practitioners overwhelmingly agree on the importance of advance care planning (ACP) and preparing for the end of life (EOL), the process is fraught with barriers. OBJECTIVE: The goal of this research was to explore potential connections between providers' own personal experiences and current professional practices in ACP and EOL care. DESIGN: A cross-sectional survey design, gathering voluntary, anonymous responses from participants between August and December 2016...
January 1, 2018: American Journal of Hospice & Palliative Care
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