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Sepsis and renal function

Liujing Chen, Tu Huang, Yini Qiao, Fulin Jiang, Jingxiang Lan, Yimei Zhou, Cai Yang, Shanyu Yan, Kaihui Luo, Liping Su, Juan Li
Stem cells are promising candidates for cell-based therapies in diverse conditions including regenerating damaged tissues, treating inflammation in virtue of sepsis, acute renal failure, and cardiovascular disease. Advancement of these therapies relies on the ability to guide stem cells to migrate directly and differentiate towards specific cell phenotypes. During the past decade, many researchers have demonstrated that exogenous applied forces could significantly affect the migration and lineage differentiation of stem cells...
December 9, 2018: Journal of Cellular Biochemistry
Tomoko Fujii, Tosiya Sato, Shigehiko Uchino, Kent Doi, Taku Iwami, Takashi Kawamura
PURPOSE: Acute kidney injury (AKI) is common in the intensive care unit (ICU). Selected clinical studies have implied human atrial natriuretic peptide (hANP) improves renal function; however, the treatment effects for AKI are unclear. METHODS: A multicenter prospective observational study in 13 Japanese ICUs. The effects of hANP were estimated by the standardized mortality ratio weighted analyses of generalized linear models using propensity scores. The primary outcome was renal replacement therapy (RRT) or death in the ICU...
December 1, 2018: Journal of Critical Care
Tim Rahmel, Hartmuth Nowak, Katharina Rump, Winfried Siffert, Jürgen Peters, Michael Adamzik
BACKGROUND: Aquaporin 5 (AQP5) expression impacts on cellular water transport, renal function but also on key mechanisms of inflammation and immune cell migration that prevail in sepsis and ARDS. Thus, the functionally relevant AQP5 -1364A/C promoter single nucleotide polymorphism could impact on the development and resolution of acute kidney injury (AKI). Accordingly, we tested the hypothesis that the AQP5 promoter -1364A/C polymorphism is associated with AKI in patients suffering from pneumonia evoked ARDS...
2018: PloS One
Lecticia Barbosa Jorge, Fernanda Oliveira Coelho, Talita Rojas Sanches, Denise M A C Malheiros, Leandro Ezaquiel de Souza, Fernando Dos Santos, Larissa de Sá Lima, Cristóforo Scavone, Maria Claudia Irigoyen, Makoto Kuro-O, Lucia Andrade
Sepsis-induced organ failure is characterized by a massive inflammatory response and oxidative stress. Acute kidney injury (AKI) occurs in approximately half of patients in septic shock, and the mortality associated with sepsis-induced AKI is unacceptably high. Klotho is a protein expressed by renal cells and has anti-senescence properties. Klotho has also been shown to protect the kidneys in ischemia-reperfusion injury and to have antioxidant properties. To analyze the role of Klotho in sepsis-related organ dysfunction and AKI, we used a cecal ligation and puncture (CLP) model of sepsis in heterozygous Klotho-haploinsufficient mice and their wild-type littermates (CLP-Kl+/- and CLP-WT mice, respectively)...
December 5, 2018: American Journal of Physiology. Renal Physiology
Lee Ann MacMillan-Crow, Philip R Mayeux
Given the inherent heterogeneity of the septic patient population and possible comorbid conditions, it is not surprising that the influence of gender on incidence and outcomes are still unclear. The goal of this study was to use a clinically relevant murine model of sepsis, cecal ligation and puncture (CLP) in CD1 mice, with and without uniphrectomy as a comorbid condition to investigate possible gender differences in renal mitochondrial function and dynamics. High resolution respirometry on fresh kidney biopsies was used to measure renal respiratory complex activities...
October 2018: Internal Medicine Review (Washington, D.C.: Online)
M F van den Berg, J P Schoeman, P Defauw, Z Whitehead, A Breemersch, K Goethals, S Daminet, E Meyer
Dogs with naturally occurring canine parvovirus (CPV) infection are at risk of developing acute kidney injury (AKI) due to several factors, including severe dehydration, hypotension and sepsis. Serum creatinine (sCr) and serum urea are insensitive markers for the assessment of early kidney injury. Therefore, the aim of this study was to investigate potential kidney injury in dogs with CPV infection using both routine renal functional parameters and several kidney injury biomarkers. Twenty-two dogs with CPV infection were prospectively enrolled and compared with eight clinically healthy control dogs...
December 2018: Veterinary Journal
Ivan Ye, Ray Tang, Samuel J White, Zoe B Cheung, Samuel K Cho
OBJECTIVE: The purpose of this study was to identify predictors of 30-day postoperative pulmonary complications following open reduction and internal fixation (ORIF) of vertebral fractures. METHODS: We performed a retrospective study using the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database from 2010 to 2014. Adult patients who underwent ORIF of vertebral fractures were included and divided into 2 groups based on the occurrence of 30-day postoperative pulmonary complications...
November 26, 2018: World Neurosurgery
Alexandros T Oratis, John J Subasic, Natalia Hernandez, James C Bird, Brian H Eisner
Ureteroscopy is an endoscopic kidney stone removal procedure which increases the internal pressure in the renal pelvis, the kidney's urinary collecting system. Elevated renal pelvic pressure may result in systemic absorption of irrigation fluid and urine, which can increase the risk of postoperative fever and sepsis. Urologists have investigated the effects of various surgical parameters on the renal pelvic pressure. However, it still remains unknown which surgical parameter has the most dominant effect on the renal pelvic pressure over time...
2018: PloS One
Wenyu Zhao, Lei Zhang, Rui Chen, Hanlan Lu, Mingxing Sui, Youhua Zhu, Li Zeng
Acute kidney injury (AKI), which involves the loss of kidney function caused by damage to renal tubular cells, is an important public health concern. We previously showed that sirtuin (SIRT)3 protects the kidneys against mitochondrial damage by inhibiting the nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome, attenuating oxidative stress, and downregulating proinflammatory cytokines. In this article, we investigated the role of autophagy, mediated by a mammalian target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK), in the protective effect of SIRT3, against sepsis-induced AKI, in a mouse model of cecal ligation and puncture (CLP)...
2018: Frontiers in Physiology
Yu-Feng Lin, Tao-Min Huang, Shuei-Liong Lin, Vin-Cent Wu, Kwan-Dun Wu
Objective: Prompt assessment of perioperative complications is critical for the comprehensive care of surgical patients. Acute kidney injury requiring dialysis (AKI-D) is associated with high mortality, yet little is known about how long-term outcomes of patients have evolved. The association of AKI-D with postsurgical outcomes has not been well studied. Methods: We investigated patients from the National Health Insurance Research Database and validated by the multicenter Clinical Trial Consortium for Renal Diseases cohort...
2018: Clinical Epidemiology
Alexa Hollinger, Xavier Wittebole, Bruno François, Peter Pickkers, Massimo Antonelli, Etienne Gayat, Benjamin Glen Chousterman, Jean-Baptiste Lascarrou, Thierry Dugernier, Salvatore Di Somma, Joachim Struck, Andreas Bergmann, Albertus Beishuizen, Jean-Michel Constatin, Charles Damoisel, Nicolas Deye, Stéphane Gaudry, Vincent Huberlant, Gernot Marx, Emanuelle Mercier, Haikel Oueslati, Oliver Hartmann, Romain Sonneville, Pierre-François Laterre, Alexandre Mebazaa, Matthieu Legrand
Introduction: Sepsis is the leading cause of acute kidney injury (AKI) in critically ill patients. The Kidney in Sepsis and Septic Shock (Kid-SSS) study evaluated the value of proenkephalin A 119-159 (penkid)-a sensitive biomarker of glomerular function, drawn within 24 hours upon intensive care unit (ICU) admission and analyzed using a chemiluminescence immunoassay-for kidney events in sepsis and septic shock. Methods: The Kid-SSS study was a substudy of Adrenomedullin and Outcome in Severe Sepsis and Septic Shock (AdrenOSS) (NCT02393781), a prospective, observational, multinational study including 583 patients admitted to the intensive care unit with sepsis or septic shock and a validation cohort of 525 patients from the French and euRopean Outcome reGistry in Intensive Care Units (FROG-ICU) study...
November 2018: KI Reports
Jing Ma, Yu-Tao Li, Shi-Xiong Zhang, Shou-Zhi Fu, Xian-Zhi Ye
Previous studies have been indicated that tumor necrosis factor receptor-associated factor 6 (TRAF6)-induced inflammation leads to acute kidney injury (AKI). How microRNA (miR) contributes to this process is poorly defined. The aim of this study was to investigate whether miR-590-3p regulated lipopolysaccharide (LPS)-induced inflammatory response by inhibiting TRAF6. LPS-induced septic mice were treated with adenovirus expressing miR-590-3p (ad-miR-590-3p) via tail-vein injection. AKI was evaluated by examining serum cystatin C (CysC), serum β2-microglobulin (β2-MG), and blood urea nitrogen (BUN)...
November 3, 2018: Inflammation
Arun Karat Anandan, Pradeep Balachandran, Arpitha Chowksey, Gomathy Sankaranarayanan, Usha Samuel
Acute renal cortical necrosis is a rare cause of intrinsic acute kidney injury (AKI) which is commonly associated with obstetric complications such as placental abruption and some serious systemic disorders such as hemolytic-uremic syndrome, sepsis, severe burns, and snake bite. Acute pancreatitis is an extremely rare cause of renal cortical necrosis, and only less than 10 cases are reported in the literature. Here, we present a 24-year-old male presented with features of acute pancreatitis and oliguric AKI...
September 2018: Saudi Journal of Kidney Diseases and Transplantation
Christopher Antonio Febres Aldana, Robert J Poppiti
INTRODUCTION: Inadequate perfusion and abnormal cellular metabolism are among the mechanisms of organ dysfunction in sepsis. Concomitant hepatorenal failure during the late phase of sepsis is poorly understood. CASE REPORT: The autopsy of a child who developed sepsis-induced hepatorenal failure revealed bile cast nephropathy, hepatic centrilobular necrosis and cholangitis lenta, a type of sepsis-induced cholestasis, with no biliary obstruction, fibrosis or cirrhosis...
October 23, 2018: Fetal and Pediatric Pathology
Sumin Yang, Changhun Lee, Bong-Seon Lee, Eui Kyun Park, Kyung-Min Kim, Jong-Sup Bae
BACKGROUND: Aspalathin (Aspt) and nothofagin (Not) were reported to have antioxidant activity and are the two major active dihydrochalcones in green rooibos. This study was conducted to determine whether Asp and Not can modulate renal functional damage in a mouse model of sepsis and to elucidate the underlying mechanisms. METHODS: The potential of Aspt and Not treatment to reduce renal damage induced by cecal ligation and puncture (CLP) surgery in mice was measured by assessing blood urea nitrogen (BUN), serum creatinine, total urine protein, levels of lactate dehydrogenase (LDH), nitric oxide (NO), tumour necrosis factor (TNF)-α, interleukin (IL)-6, and myeloperoxidase (MPO), lipid peroxidation, total glutathione, glutathione peroxidase activity, catalase activity, and superoxide dismutase activity...
July 27, 2018: Pharmacological Reports: PR
Juan Du, Osama Abdel-Razek, Qiao Shi, Fengqi Hu, Guohua Ding, Robert N Cooney, Guirong Wang
Pneumonia and sepsis are major risk factors for acute kidney injury (AKI). Patients with pneumonia and AKI are at increased risk for morbidity and mortality. Surfactant protein D (SP-D) expressed in lung and kidney plays important roles in innate immunity. However, little is known about the role of organ-specific SP-D in the sepsis. The current study uses wild type (WT), SP-D knockout (KO), and humanized SP-D transgenic (hTG, lung-specific SP-D expression) mice to study organ-specific role of SP-D in pneumonia-induced sepsis...
October 18, 2018: Scientific Reports
Valentine de A C de Castro Lima, Ana Luisa Figueira Gouvêa, Paulo Menezes, Jacqueline da F Santos, Mayra Carrijo Rochael, Fabiana Rabe Carvalho, Jorge Reis Almeida, Jocemir Ronaldo Lugon
Hemophagocytic lymphohistiocytosis (HLH) is an uncommon and life-threating condition characterized by major immune activation and massive cytokine production by mononuclear inflammatory cells, due to defects in cytotoxic lymphocyte function. It is even more unusual in renal transplant recipients, in which it is often associated with uncontrolled infection. The mortality is high in HLH and differential diagnosis with sepsis is a challenge. The approach and management depend on the underlying trigger and comorbidities...
October 11, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Raphaël Burger, Monia Guidi, Valérie Calpini, Frédéric Lamoth, Laurent Decosterd, Corinne Robatel, Thierry Buclin, Chantal Csajka, Oscar Marchetti
Background: Meropenem plasma concentration above a pathogen's MIC over the whole dosing interval (100% ƒT>MIC) is a determinant of outcome in severe infections. Significant variability of meropenem pharmacokinetics is reported in ICU patients. Objectives: To characterize meropenem pharmacokinetics in variable CLCR or renal replacement therapy and assess the appropriateness of recommended regimens for MIC coverage. Methods: A pharmacokinetic analysis (NONMEM) was conducted with external model validation...
December 1, 2018: Journal of Antimicrobial Chemotherapy
Sooghee Chang, Youn-Hee Kim, Young-Joo Kim, Young-Woo Kim, Sungyoon Moon, Yong Yook Lee, Jin Sun Jung, Youngsoo Kim, Hi-Eun Jung, Tae-Joo Kim, Taek-Chin Cheong, Hye-Jung Moon, Jung-Ah Cho, Hang-Rae Kim, Dohyun Han, Yirang Na, Seung-Hyeok Seok, Nam-Hyuk Cho, Hai-Chon Lee, Eun-Hee Nam, Hyosuk Cho, Murim Choi, Nagahiro Minato, Seung-Yong Seong
Bile acids (BAs) control metabolism and inflammation by interacting with several receptors. Here, we report that intravenous infusion of taurodeoxycholate (TDCA) decreases serum pro-inflammatory cytokines, normalizes hypotension, protects against renal injury, and prolongs mouse survival during sepsis. TDCA increases the number of granulocytic myeloid-derived suppressor cells (MDSCLT ) distinctive from MDSCs obtained without TDCA treatment (MDSCL ) in the spleen of septic mice. FACS-sorted MDSCLT cells suppress T-cell proliferation and confer protection against sepsis when adoptively transferred better than MDSCL ...
2018: Frontiers in Immunology
D J Gross, E H Chang, P L Rosen, V Roudnitsky, M Muthusamy, G Sugiyama, P J Chung
BACKGROUND: Most thoracic surgical procedures in the United States are being performed by general surgeons (GSs) without any advanced training. With the recent approval of computed tomography screening for lung malignancy in high-risk populations, the number of thoracic oncologic resections is expected to rise. Previous literature has demonstrated consistently worsened outcomes for patients undergoing thoracic surgical procedure when done by nonthoracic fellowship-trained surgeons. Using the American College of Surgeons National Surgical Quality Improvement Project database, we examined short-term outcomes in patients undergoing video-assisted thoracoscopic surgery (VATS) lobectomy for malignancy...
November 2018: Journal of Surgical Research
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