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Keywords Incidence of Neonatal status e...

Incidence of Neonatal status epilepticus

https://read.qxmd.com/read/38488877/neonatal-seizures-during-extra-corporeal-membrane-oxygenation-support
#1
JOURNAL ARTICLE
Maria Chalia, Davinder Singh, Stewart G Boyd, Simon Hannam, Aparna Hoskote, Ronit Pressler
To evaluate EEG monitoring during neonatal ECMO and to identify any correlations between seizure detection to abnormal neuroimaging. Eight-year, service evaluation of neonates who received at least one continuous EEG (cEEG) whilst on ECMO at Great Ormond Street Hospital. Pearson's chi-square test and multivariate logistic regression analysis were used to assess clinical and EEG variables association with seizures and neuroimaging findings. Fifty-seven neonates were studied; 57 cEEG recordings were reviewed...
March 15, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38367369/neurological-outcomes-and-mortality-after-neonatal-seizures-with-electroencephalographical-verification-a-systematic-review
#2
JOURNAL ARTICLE
Hanna Westergren, Mikael Finder, Helena Marell-Hesla, Ronny Wickström
AIM: To conduct a systematic review of post-neonatal neurological outcomes and mortality following neonatal seizures with electroencephalographical verification. METHODS: The databases Medline, Embase and Web of Science were searched for eligible studies. All abstracts were screened in a blinded fashion between research team members and reports found eligible were obtained and screened in full text by two members each. From studies included, outcome results for post-neonatal epilepsy, cerebral palsy, intellectual disability, developmental delay, mortality during and after the neonatal period and composite outcomes were extracted...
February 12, 2024: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/38170290/three-year-incidence-and-acute-setting-predictors-of-epilepsy-after-neonatal-and-childhood-arterial-ischaemic-stroke-a-disease-based-cohort-study
#3
JOURNAL ARTICLE
Mauricio Lopez-Espejo, Ilona Skorin, Tomas Mesa, Marta I Hernandez-Chavez
UNLABELLED: To assess the association between clinical and MRI characteristics of arterial ischaemic stroke (AIS) and the 3-year risk of post-stroke epilepsy (PSE) in paediatric patients. Retrospective cohort study. Database from a single tertiary referral centre for paediatric stroke in Chile. Two hundred seven neonates and children (1 day to 18 years) with a first-ever supratentorial AIS diagnosed between January 2003 and December 2019 were evaluated. Diagnosis of PSE and explanatory variables were consecutively recorded from hospital inpatient and annual outpatient records in a predesigned database...
January 3, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/37977810/-a-pediatric-rat-model-of-organophosphate-induced-refractory-status-epilepticus-characterization-of-long-term-epileptic-seizure-activity-neurological-dysfunction-and-neurodegeneration
#4
JOURNAL ARTICLE
Tanveer Singh, Sreevidhya Ramakrishnan, Xin Wu, Doodipala Samba Reddy
Children are highly vulnerable to the neurotoxic effects of organophosphates (OP), which can cause neuronal developmental defects, including intellectual disability, autism, epilepsy, and related comorbidities. Unfortunately, no specific pediatric OP neurotoxicity model currently exists. In this study, we developed and characterized a pediatric rat model of status epilepticus (SE) induced by the OP diisopropylfluorophosphate (DFP) and examined its impact on long-term neurological outcomes. Postnatal day 21rats were exposed to a DFP regimen with standard antidotes...
November 17, 2023: Journal of Pharmacology and Experimental Therapeutics
https://read.qxmd.com/read/35526330/landscape-of-childhood-epilepsies-a-multi-ethnic-population-based-study
#5
JOURNAL ARTICLE
Ruba Benini, Nadine Asir, Ahmad Yasin, Ali M Mohamedzain, Faisal Hadid, Dhanya M Vasudeva, Amira Saeed, Khaled Zamel, Husam Kayyali, Sami Elestwani
OBJECTIVE: To describe the clinical features of childhood epilepsy in Qatar. METHODS: A retrospective cross-sectional chart review analysis was conducted at the only tertiary pediatric hospital in Qatar in 1422 patients with epilepsy followed between November 2016 and October 2019. RESULTS: 55% (781) were males and 70% were non-Qatari. Age of epilepsy onset was in the neonatal period in 9% (114/1207 patients). In the non-neonatal cohort, mean age of onset was 4 yrs 9mos ( ± 1...
April 28, 2022: Epilepsy Research
https://read.qxmd.com/read/35370554/sulforaphane-ameliorates-metabolic-changes-associated-with-status-epilepticus-in-immature-rats
#6
JOURNAL ARTICLE
Jan Daněk, Šárka Danačíková, David Kala, Jan Svoboda, Sonam Kapoor, Antonín Pošusta, Jaroslava Folbergrová, Kateřina Tauchmannová, Tomáš Mráček, Jakub Otáhal
Status epilepticus (SE) is a common paediatric emergency with the highest incidence in the neonatal period and is a well-known epileptogenic insult. As previously established in various experimental and human studies, SE induces long-term alterations to brain metabolism, alterations that directly contribute to the development of epilepsy. To influence these changes, organic isothiocyanate compound sulforaphane (SFN) has been used in the present study for its known effect of enhancing antioxidative, cytoprotective, and metabolic cellular properties via the Nrf2 pathway...
2022: Frontiers in Cellular Neuroscience
https://read.qxmd.com/read/32684487/seizures-severity-during-rewarming-can-predict-seizure-outcomes-of-infants-with-neonatal-hypoxic-ischemic-encephalopathy-following-therapeutic-hypothermia
#7
JOURNAL ARTICLE
Yun-Ju Chen, Ming-Chou Chiang, Jainn-Jim Lin, I-Jun Chou, Yi-Shan Wang, Shu-Sing Kong, I-Chen Su, Elaine Chen, Tze Yee Diane Mok, Reyin Lien, Kuang-Lin Lin
BACKGROUND: The aim of this study was to examine the predictive value of amplitude-integrated electroencephalography (aEEG) on 12-month seizure outcomes of infants with neonatal hypoxic-ischemic encephalopathy (HIE) treated with therapeutic hypothermia. METHODS: We conducted this retrospective cohort study in a tertiary neonatal intensive care unit between May 2012 and September 2017. Neonates with HIE who received both therapeutic hypothermia (TH) and aEEG were enrolled...
June 2020: Biomedical Journal
https://read.qxmd.com/read/31388319/epilepsy-diagnosis-and-management-of-children-in-kenya-review-of-current-literature
#8
JOURNAL ARTICLE
Pauline Samia, Jane Hassell, Jessica-Anne Hudson, Maureen Kanana Murithi, Symon M Kariuki, Charles R Newton, Jo M Wilmshurst
Introduction: The growing impact of non-communicable diseases in low- to middle-income countries makes epilepsy a key research priority. We evaluated peer-reviewed published literature on childhood epilepsy specific to Kenya to identify knowledge gaps and inform future priorities. Methodology: A literature search utilizing the terms "epilepsy" OR "seizure" as exploded subject headings AND "Kenya" was conducted. Relevant databases were searched, generating 908 articles. After initial screening to remove duplications, irrelevant articles, and publications older than 15 years, 154 papers remained for full-article review, which identified 35 publications containing relevant information...
2019: Research and Reports in Tropical Medicine
https://read.qxmd.com/read/31278022/therapeutic-hypothermia-in-children-which-indications-remain-in-2018
#9
REVIEW
F Thabet, B Tabarki
Experimental studies on therapeutic hypothermia in acute brain injury reported positive outcomes and identified two potential benefits, namely, reduction in seizure incidence and in intracranial pressure. Translating this evidence to humans is challenging, especially for conditions in pediatric patients, such as cardiac arrest, traumatic brain injury, and status epilepticus, among others. This narrative review aimed to discuss the current indications and benefits of therapeutic hypothermia in acute brain injury in the pediatric population (i...
July 2019: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://read.qxmd.com/read/30132843/incidence-of-neonatal-seizures-perinatal-risk-factors-for-epilepsy-and-mortality-after-neonatal-seizures-in-the-province-of-parma-italy
#10
JOURNAL ARTICLE
Francesco Pisani, Carlotta Facini, Elisa Bianchi, Giorgia Giussani, Benedetta Piccolo, Ettore Beghi
OBJECTIVE: Information about the incidence of neonatal seizures (NS) is scarce. Previous studies relied primarily on a clinical diagnosis of seizures. This population-based, retrospective study evaluated the incidence of electroencephalography (EEG)-confirmed seizures in neonates born in the province of Parma and the perinatal risk factors for mortality and epilepsy. METHODS: All neonates with suspected seizures or with medical conditions at high risk for seizures from the study area were recorded in the neonatal intensive care unit (NICU) of the Parma University Hospital...
September 2018: Epilepsia
https://read.qxmd.com/read/28271640/neuroprotective-effect-of-lacosamide-on-hypoxic-ischemic-brain-injury-in-neonatal-rats
#11
JOURNAL ARTICLE
Gun Ha Kim, Jung Hye Byeon, Baik Lin Eun
BACKGROUND AND PURPOSE: Lacosamide (LCM) is an antiepileptic drug that enhances the slow inactivation of sodium channels and modulates collapsin response mediator protein-2. LCM was recently demonstrated to exert a neuroprotective effect in a murine model of traumatic brain injury and status epilepticus. Assuming the same underlying excitotoxicity-related brain injury mechanism, we hypothesized that LCM would have a neuroprotective effect in hypoxic-ischemic brain injury. METHODS: We divided rats into three groups at each testing session: pre- or postfed with LCM, fed with normal saline, and sham...
April 2017: Journal of Clinical Neurology
https://read.qxmd.com/read/25957454/subclinical-seizures-identified-by-postoperative-electroencephalographic-monitoring-are-common-after-neonatal-cardiac-surgery
#12
JOURNAL ARTICLE
Maryam Y Naim, J William Gaynor, Jodi Chen, Susan C Nicolson, Stephanie Fuller, Thomas L Spray, Dennis J Dlugos, Robert R Clancy, Livia Vianez Costa, Daniel J Licht, Rui Xiao, Heather Meldrum, Nicholas S Abend
OBJECTIVES: The American Clinical Neurophysiology Society recommends continuous electroencephalographic monitoring after neonatal cardiac surgery because seizures are common, often subclinical, and associated with worse neurocognitive outcomes. We performed a quality improvement project to monitor for postoperative seizures in neonates with congenital heart disease after surgery with cardiopulmonary bypass. METHODS: We implemented routine continuous electroencephalographic monitoring and reviewed the results for an 18-month period...
July 2015: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/25145506/seizures-and-epilepsy-in-hypoglycaemia-caused-by-inborn-errors-of-metabolism
#13
JOURNAL ARTICLE
Svetlana Gataullina, Pascale Delonlay, Eric Lemaire, Nathalie Boddaert, Christine Bulteau, Christine Soufflet, Gemma Aznar Laín, Rima Nabbout, Catherine Chiron, Olivier Dulac
AIM: The aim of the study was to characterize seizures and epilepsy related to hypoglycaemia. METHOD: We analyzed the files of 170 consecutive patients referred for hypoglycaemia (onset 1h to 4y) caused by inborn errors of metabolism (glycogen storage disease type I, fatty acid β-oxidation disorders, and hyperinsulinism). RESULTS: Ninety patients (42 males and 48 females; 38 neonates and 52 infants/children) had brief hypoglycaemic seizures (68%) or status epilepticus (32%)...
February 2015: Developmental Medicine and Child Neurology
https://read.qxmd.com/read/24099053/treatment-of-convulsive-status-epilepticus-in-childhood-recommendations-of-the-italian-league-against-epilepsy
#14
REVIEW
Giuseppe Capovilla, Francesca Beccaria, Ettore Beghi, Fabio Minicucci, Stefano Sartori, Marilena Vecchi
The Italian League Against Epilepsy Commission Guidelines Subcommittee on Status Epilepticus (SE) has published an article on the management of SE in adults, and now presents a report on the management of convulsive status epilepticus (CSE) in children, excluding the neonatal period. Children's greater susceptibility than adults to epileptic seizures results from many factors. Earlier maturation of excitatory than inhibitory synapses, increased susceptibility and concentration of receptors for excitatory neurotransmitters, peculiar composition of the receptor subunits resulting in slower and less effective inhibitory responses, all cause the high incidence of SE in the pediatric population...
October 2013: Epilepsia
https://read.qxmd.com/read/22883283/evaluation-of-etiologic-and-prognostic-factors-in-neonatal-convulsions
#15
JOURNAL ARTICLE
Edibe Pembegul Yıldız, Burak Tatlı, Barış Ekici, Emine Eraslan, Nur Aydınlı, Mine Calışkan, Meral Ozmen
This study evaluated etiologic and risk factors affecting long-term prognoses of neurologic outcomes in newborns with neonatal seizures. We enrolled patients at chronologic ages of 23-44 months, referred to the Department of Pediatric Neurology, Istanbul Medical Faculty, from January 1, 2007-December 31, 2009, after manifesting seizures in their first postnatal 28 days. Of 112 newborns, 41 were female, 71 were male, 33 were preterm, and 79 were full-term. Perinatal asphyxia (28.6%) and intracranial hemorrhage (17%) were the most common causes of neonatal seizures...
September 2012: Pediatric Neurology
https://read.qxmd.com/read/22331332/nonconvulsive-status-epilepticus-the-encephalopathic-pediatric-patient
#16
COMPARATIVE STUDY
Hansel M Greiner, Katherine Holland, James L Leach, Paul S Horn, Andrew D Hershey, Douglas F Rose
OBJECTIVE: A high prevalence of nonconvulsive status epilepticus (NCSE) has been reported in critically ill adults and neonates. Recent prospective pediatric studies focus on critically ill children and show wide variability in the frequency of NCSE. This study examines prevalence of pediatric NCSE regardless of inpatient setting and retrospectively identifies risk factors indicating a need for urgent continuous EEG. METHODS: Medical records from patients aged 3 months to 21 years were identified either by (1) searching a clinical EEG database (n = 18) or (2) consecutive inpatient EEG referrals for NCSE over an 8-month period (n = 57)...
March 2012: Pediatrics
https://read.qxmd.com/read/21796017/risk-factors-for-epilepsy-in-children-with-neonatal-encephalopathy
#17
JOURNAL ARTICLE
Hannah C Glass, Karen J Hong, Elizabeth E Rogers, Rita J Jeremy, Sonia L Bonifacio, Joseph E Sullivan, A James Barkovich, Donna M Ferriero
We examined neonatal predictors of epilepsy in term newborns with neonatal encephalopathy (NE) by studying children enrolled in a longitudinal, single center cohort study. Clinical data were obtained through chart review, and MRI was performed in the neonatal period. We administered a seizure questionnaire to parents of children aged ≥ 12 mo (range, 12 mo to 16.5 y) to determine the outcome of epilepsy. The association between clinical predictors and time to onset of epilepsy was assessed using Cox proportional hazards regression...
November 2011: Pediatric Research
https://read.qxmd.com/read/21447810/electrographic-seizures-during-therapeutic-hypothermia-for-neonatal-hypoxic-ischemic-encephalopathy
#18
JOURNAL ARTICLE
Courtney J Wusthoff, Dennis J Dlugos, Ana Gutierrez-Colina, Anne Wang, Noah Cook, Maureen Donnelly, Robert Clancy, Nicholas S Abend
Electrographic seizures are common in neonates with hypoxic-ischemic encephalopathy, but detailed data are not available regarding seizure incidence during therapeutic hypothermia. The objective of this prospective study was to determine the incidence and timing of electrographic seizures in term neonates undergoing whole-body therapeutic hypothermia for hypoxic-ischemic encephalopathy as detected by conventional full-array electroencephalography for 72 hours of therapeutic hypothermia and 24 hours of normothermia...
June 2011: Journal of Child Neurology
https://read.qxmd.com/read/21307352/nonconvulsive-seizures-are-common-in-critically-ill-children
#19
JOURNAL ARTICLE
N S Abend, A M Gutierrez-Colina, A A Topjian, H Zhao, R Guo, M Donnelly, R R Clancy, D J Dlugos
BACKGROUND: Retrospective studies have reported the occurrence of nonconvulsive seizures in critically ill children. We aimed to prospectively determine the incidence and risk factors of nonconvulsive seizures in critically ill children using predetermined EEG monitoring indications and EEG interpretation terminology. METHODS: Critically ill children (non-neonates) with acute encephalopathy underwent continuous EEG monitoring if they met institutional clinical practice criteria...
March 22, 2011: Neurology
https://read.qxmd.com/read/18261215/the-incidence-aetiology-and-outcome-of-acute-seizures-in-children-admitted-to-a-rural-kenyan-district-hospital
#20
COMPARATIVE STUDY
Richard Idro, Samson Gwer, Michael Kahindi, Hellen Gatakaa, Tony Kazungu, Moses Ndiritu, Kathryn Maitland, Brian Gr Neville, Piet A Kager, Charles Rjc Newton
BACKGROUND: Acute seizures are a common cause of paediatric admissions to hospitals in resource poor countries and a risk factor for neurological and cognitive impairment and epilepsy. We determined the incidence, aetiological factors and the immediate outcome of seizures in a rural malaria endemic area in coastal Kenya. METHODS: We recruited all children with and without seizures, aged 0-13 years and admitted to Kilifi District hospital over 2 years from 1st December 2004 to 30th November 2006...
February 8, 2008: BMC Pediatrics
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