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Incidence of Neonatal status epilepticus

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https://www.readbyqxmd.com/read/28271640/neuroprotective-effect-of-lacosamide-on-hypoxic-ischemic-brain-injury-in-neonatal-rats
#1
Gun Ha Kim, Jung Hye Byeon, Baik Lin Eun
BACKGROUND AND PURPOSE: Lacosamide (LCM) is an antiepileptic drug that enhances the slow inactivation of sodium channels and modulates collapsin response mediator protein-2. LCM was recently demonstrated to exert a neuroprotective effect in a murine model of traumatic brain injury and status epilepticus. Assuming the same underlying excitotoxicity-related brain injury mechanism, we hypothesized that LCM would have a neuroprotective effect in hypoxic-ischemic brain injury. METHODS: We divided rats into three groups at each testing session: pre- or postfed with LCM, fed with normal saline, and sham...
April 2017: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/25957454/subclinical-seizures-identified-by-postoperative-electroencephalographic-monitoring-are-common-after-neonatal-cardiac-surgery
#2
Maryam Y Naim, J William Gaynor, Jodi Chen, Susan C Nicolson, Stephanie Fuller, Thomas L Spray, Dennis J Dlugos, Robert R Clancy, Livia Vianez Costa, Daniel J Licht, Rui Xiao, Heather Meldrum, Nicholas S Abend
OBJECTIVES: The American Clinical Neurophysiology Society recommends continuous electroencephalographic monitoring after neonatal cardiac surgery because seizures are common, often subclinical, and associated with worse neurocognitive outcomes. We performed a quality improvement project to monitor for postoperative seizures in neonates with congenital heart disease after surgery with cardiopulmonary bypass. METHODS: We implemented routine continuous electroencephalographic monitoring and reviewed the results for an 18-month period...
July 2015: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/25145506/seizures-and-epilepsy-in-hypoglycaemia-caused-by-inborn-errors-of-metabolism
#3
Svetlana Gataullina, Pascale Delonlay, Eric Lemaire, Nathalie Boddaert, Christine Bulteau, Christine Soufflet, Gemma Aznar Laín, Rima Nabbout, Catherine Chiron, Olivier Dulac
AIM: The aim of the study was to characterize seizures and epilepsy related to hypoglycaemia. METHOD: We analyzed the files of 170 consecutive patients referred for hypoglycaemia (onset 1h to 4y) caused by inborn errors of metabolism (glycogen storage disease type I, fatty acid β-oxidation disorders, and hyperinsulinism). RESULTS: Ninety patients (42 males and 48 females; 38 neonates and 52 infants/children) had brief hypoglycaemic seizures (68%) or status epilepticus (32%)...
February 2015: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/24099053/treatment-of-convulsive-status-epilepticus-in-childhood-recommendations-of-the-italian-league-against-epilepsy
#4
REVIEW
Giuseppe Capovilla, Francesca Beccaria, Ettore Beghi, Fabio Minicucci, Stefano Sartori, Marilena Vecchi
The Italian League Against Epilepsy Commission Guidelines Subcommittee on Status Epilepticus (SE) has published an article on the management of SE in adults, and now presents a report on the management of convulsive status epilepticus (CSE) in children, excluding the neonatal period. Children's greater susceptibility than adults to epileptic seizures results from many factors. Earlier maturation of excitatory than inhibitory synapses, increased susceptibility and concentration of receptors for excitatory neurotransmitters, peculiar composition of the receptor subunits resulting in slower and less effective inhibitory responses, all cause the high incidence of SE in the pediatric population...
October 2013: Epilepsia
https://www.readbyqxmd.com/read/22883283/evaluation-of-etiologic-and-prognostic-factors-in-neonatal-convulsions
#5
Edibe Pembegul Yıldız, Burak Tatlı, Barış Ekici, Emine Eraslan, Nur Aydınlı, Mine Calışkan, Meral Ozmen
This study evaluated etiologic and risk factors affecting long-term prognoses of neurologic outcomes in newborns with neonatal seizures. We enrolled patients at chronologic ages of 23-44 months, referred to the Department of Pediatric Neurology, Istanbul Medical Faculty, from January 1, 2007-December 31, 2009, after manifesting seizures in their first postnatal 28 days. Of 112 newborns, 41 were female, 71 were male, 33 were preterm, and 79 were full-term. Perinatal asphyxia (28.6%) and intracranial hemorrhage (17%) were the most common causes of neonatal seizures...
September 2012: Pediatric Neurology
https://www.readbyqxmd.com/read/22331332/nonconvulsive-status-epilepticus-the-encephalopathic-pediatric-patient
#6
COMPARATIVE STUDY
Hansel M Greiner, Katherine Holland, James L Leach, Paul S Horn, Andrew D Hershey, Douglas F Rose
OBJECTIVE: A high prevalence of nonconvulsive status epilepticus (NCSE) has been reported in critically ill adults and neonates. Recent prospective pediatric studies focus on critically ill children and show wide variability in the frequency of NCSE. This study examines prevalence of pediatric NCSE regardless of inpatient setting and retrospectively identifies risk factors indicating a need for urgent continuous EEG. METHODS: Medical records from patients aged 3 months to 21 years were identified either by (1) searching a clinical EEG database (n = 18) or (2) consecutive inpatient EEG referrals for NCSE over an 8-month period (n = 57)...
March 2012: Pediatrics
https://www.readbyqxmd.com/read/21796017/risk-factors-for-epilepsy-in-children-with-neonatal-encephalopathy
#7
Hannah C Glass, Karen J Hong, Elizabeth E Rogers, Rita J Jeremy, Sonia L Bonifacio, Joseph E Sullivan, A James Barkovich, Donna M Ferriero
We examined neonatal predictors of epilepsy in term newborns with neonatal encephalopathy (NE) by studying children enrolled in a longitudinal, single center cohort study. Clinical data were obtained through chart review, and MRI was performed in the neonatal period. We administered a seizure questionnaire to parents of children aged ≥ 12 mo (range, 12 mo to 16.5 y) to determine the outcome of epilepsy. The association between clinical predictors and time to onset of epilepsy was assessed using Cox proportional hazards regression...
November 2011: Pediatric Research
https://www.readbyqxmd.com/read/21447810/electrographic-seizures-during-therapeutic-hypothermia-for-neonatal-hypoxic-ischemic-encephalopathy
#8
Courtney J Wusthoff, Dennis J Dlugos, Ana Gutierrez-Colina, Anne Wang, Noah Cook, Maureen Donnelly, Robert Clancy, Nicholas S Abend
Electrographic seizures are common in neonates with hypoxic-ischemic encephalopathy, but detailed data are not available regarding seizure incidence during therapeutic hypothermia. The objective of this prospective study was to determine the incidence and timing of electrographic seizures in term neonates undergoing whole-body therapeutic hypothermia for hypoxic-ischemic encephalopathy as detected by conventional full-array electroencephalography for 72 hours of therapeutic hypothermia and 24 hours of normothermia...
June 2011: Journal of Child Neurology
https://www.readbyqxmd.com/read/21307352/nonconvulsive-seizures-are-common-in-critically-ill-children
#9
N S Abend, A M Gutierrez-Colina, A A Topjian, H Zhao, R Guo, M Donnelly, R R Clancy, D J Dlugos
BACKGROUND: Retrospective studies have reported the occurrence of nonconvulsive seizures in critically ill children. We aimed to prospectively determine the incidence and risk factors of nonconvulsive seizures in critically ill children using predetermined EEG monitoring indications and EEG interpretation terminology. METHODS: Critically ill children (non-neonates) with acute encephalopathy underwent continuous EEG monitoring if they met institutional clinical practice criteria...
March 22, 2011: Neurology
https://www.readbyqxmd.com/read/18261215/the-incidence-aetiology-and-outcome-of-acute-seizures-in-children-admitted-to-a-rural-kenyan-district-hospital
#10
COMPARATIVE STUDY
Richard Idro, Samson Gwer, Michael Kahindi, Hellen Gatakaa, Tony Kazungu, Moses Ndiritu, Kathryn Maitland, Brian Gr Neville, Piet A Kager, Charles Rjc Newton
BACKGROUND: Acute seizures are a common cause of paediatric admissions to hospitals in resource poor countries and a risk factor for neurological and cognitive impairment and epilepsy. We determined the incidence, aetiological factors and the immediate outcome of seizures in a rural malaria endemic area in coastal Kenya. METHODS: We recruited all children with and without seizures, aged 0-13 years and admitted to Kilifi District hospital over 2 years from 1st December 2004 to 30th November 2006...
February 8, 2008: BMC Pediatrics
https://www.readbyqxmd.com/read/15264692/-questions-of-epileptogenesis-and-prevention-in-symptomatic-epilepsies
#11
REVIEW
János Nikl
Symptomatic epilepsies usually report themselves after a longer period of time after brain injury, after the so-called latent period. During this period progressive functional and structural changes occur which finally cause an increased excitatory condition. The process of epileptogenesis may be examined in animal models, such as in the kindling, status epilepticus, hypoxicischaemic models. Data gained from such sources support the hypothesis that the first injury results in a lower seizure threshold, but genetical and environmental factors also contribute to the development of epilepsy and most probably further insults may be needed...
May 20, 2004: Ideggyógyászati Szemle
https://www.readbyqxmd.com/read/12915079/analysis-of-clinical-characteristics-and-risk-factors-for-mortality-in-human-status-epilepticus
#12
Eliana Garzon, Regina Maria França Fernandes, Américo Ceiki Sakamoto
PURPOSE: To analyse clinical data including aetiology, age, antecedents, classification and mortality in human status epilepticus (SE), and to assess prognostic factors for mortality. METHODS: A prospective study was performed, including detailed analysis of clinical and laboratorial data of SE in individuals of any age, except neonates. RESULTS: One hundred and eleven SE were included, with patients' age ranging from 3 months to 98 years...
September 2003: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/12566235/epilepsy-in-children-with-cerebral-palsy
#13
COMPARATIVE STUDY
A K Gururaj, L Sztriha, A Bener, A Dawodu, V Eapen
OBJECTIVES: To study the occurrence, associated factors, nature and prognosis of seizures in children with cerebral palsy (CP). DESIGN: A prospective, descriptive, hospital-based, case-control study. SETTING: Tertiary level University Teaching Hospitals in the Al Ain Medical District, United Arab Emirates. PATIENTS: Fifty-six children with CP and seizures seen in the neurodevelopmental clinics at Al Ain and Tawam University Hospitals during the period of 1997-1999 were studied (group 1)...
March 2003: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/12143353/seizure-induced-neuronal-death-in-the-immature-brain
#14
REVIEW
Claude G Wasterlain, Jerome Niquet, Kerry W Thompson, Roger Baldwin, Hanato Liu, R Sankar, Andrey M Mazarati, David Naylor, Hiroshi Katsumori, Lucie Suchomelova, Yukioyoshi Shirasaka
The response of the developing brain to epileptic seizures and to status epilepticus is highly age-specific. Neonates with their low cerebral metabolic rate and fragmentary neuronal networks can tolerate relatively prolonged seizures without suffering massive cell death, but severe seizures in experimental animals inhibit brain growth, modify neuronal circuits, and can lead to behavioral deficits and to increases in neuronal excitability. Past infancy, the developing brain is characterized by high metabolic rate, exuberant neuronal and synaptic networks and overexpression of receptors and enzymes involved in excitotxic mechanisms...
2002: Progress in Brain Research
https://www.readbyqxmd.com/read/10778481/-epileptic-signs-in-alterations-of-neuronal-migration
#15
REVIEW
J Campos-Castelló, A López-Lafuente, R Ramírez-Segura, C Martínez-Hernández, M T de Santos-Moreno
INTRODUCTION: A wide range of conditions are due to alterations in neurone migration (ANM). Mental retardation, motor disorders and epilepsy are seen in all these disorders. Anomalies included with the ANM are those produced at the time of neuronal migration in the phase prior to neurone proliferation and during the time following cortical organization. All these have a common characteristic, namely an anomalous cerebral cortex (cerebral dysplasias). DEVELOPMENT: There is a high incidence of epilepsy in ANM (60%), appearing early (10% neonatal, 42% before 1 year old)...
January 1999: Revista de Neurologia
https://www.readbyqxmd.com/read/10726833/electroclinical-correlation-in-neonatal-seizures
#16
E Biagioni, F Ferrari, A Boldrini, M F Roversi, G Cioni
A dissociation between clinical and electroencephalographic phenomena is often observable in neonatal seizures. This finding raises important questions, including those related to the management of these patients. Another characteristic of neonatal convulsions is represented by their increased tendency towards status epilepticus. In order to examine the electroclinical correlation and its possible relationship to the occurrence of status epilepticus, recorded video-electroencephalograms of 17 newborns were submitted to detailed analysis...
1998: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/10519720/epidemiology-of-pyridoxine-dependent-and-pyridoxine-responsive-seizures-in-the-uk
#17
P Baxter
OBJECTIVE: To study the epidemiology of pyridoxine dependent seizures and other forms of pyridoxine responsive seizures. DESIGN: Monthly notifications to the British Paediatric Surveillance Unit over two years. Questionnaire follow up. SETTING: UK and the Republic of Ireland. PATIENTS: Children aged 15 years or younger whose seizures respond to pyridoxine. INTERVENTIONS: None. MAIN OUTCOME MEASURES: Numbers of children with definite, probable, and possible pyridoxine dependent seizures or other seizures responsive to pyridoxine...
November 1999: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/10421560/acute-and-chronic-effects-of-seizures-in-the-developing-brain-lessons-from-clinical-experience
#18
REVIEW
E M Mizrahi
Seizures in the neonate are often considered a form of status epilepticus (SE) because they are relatively prolonged, difficult to control with antiepileptic drugs (AEDs), and may be associated with significant morbidity and mortality. Despite their clinical importance, there is still no clear understanding of how seizures may affect the developing brain. Although both basic neuroscience and clinical research have addressed these issues, there are difficulties in the design and analysis of each type of investigation...
1999: Epilepsia
https://www.readbyqxmd.com/read/9952271/referral-patterns-of-family-physicians-may-allow-population-based-incidence-studies-of-childhood-epilepsy
#19
K Nixon Speechley, S D Levin, S Wiebe, W T Blume
PURPOSE: To evaluate the burden of illness of childhood epilepsy on patient, care giver, and society, representative incidence cohorts must be followed longitudinally. Case ascertainment through pediatricians and neurologists would be a valid method if family physicians refered all new cases of childhood epilepsy. The study objective was to determine whether family physicians' referral patterns in Southwestern Ontario make it possible to conduct a population-based incidence study of childhood epilepsy by sampling only from specialists' practices...
February 1999: Epilepsia
https://www.readbyqxmd.com/read/9682882/epilepsy-in-children-with-cerebral-palsy
#20
K L Kwong, S N Wong, K T So
Epilepsy occurs in 15-60% of children with cerebral palsy; however, its clinical course is not well defined. This retrospective study reviewed the prevalence, nature, and prognosis of epilepsy in cerebral palsy. Thirty-two of 85 children with cerebral palsy seen in the Neurodevelopmental Clinic in Tuen Mun Hospital between 1990 and 1995 had epilepsy. A control group of 59 epileptic children with normal neurodevelopment status was seen during the same period. Epilepsy most commonly affected patients with spastic tetraplegia and those with mental subnormality...
July 1998: Pediatric Neurology
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