Mayumi Oishi, Keiko Shinjo, Keisuke Takanari, Ayako Muraoka, Miho M Suzuki, Miki Kanbe, Shinichi Higuchi, Katsumi Ebisawa, Kazunobu Hashikawa, Yuzuru Kamei, Yutaka Kondo
Keloids are characterized by abnormal wound healing with excessive accumulation of extracellular matrix. Myofibroblasts are the primary contributor to extracellular matrix secretion, playing an essential role in the wound healing process. However, the differences between myofibroblasts involved in keloid formation and normal wound healing remain unclear. To identify the specific characteristics of keloid myofibroblasts, we initially assessed the expression levels of well-established myofibroblast markers, α-smooth muscle actin (α-SMA) and transgelin (TAGLN), in scar and keloid tissues (n = 63 and 51, respectively)...
April 16, 2024: Scientific Reports