Dimitrios Pollalis, Alejandra Gonzalez Calle, Juan Carlos Martinez-Camarillo, Kabir Ahluwalia, Cassidy Hinman, Debbie Mitra, Jane Lebkowski, Sun Young Lee, Biju B Thomas, Faizah Ahmed, Victoria Chan, Jason A Junge, Scott Fraser, Stan Louie, Mark Humayun
Age-related macular degeneration (AMD), a leading cause of vision loss, primarily arises from the degeneration of retinal pigment epithelium (RPE) and photoreceptors. Current therapeutic options for dry AMD are limited. Encouragingly, cultured RPE cells on parylene-based biomimetic Bruch's membrane demonstrate characteristics akin to the native RPE layer. In this study, we cultivated human embryonic stem cell-derived polarized RPE (hESC-PRPE) cells on parylene membranes at both small- and large-scale settings, collecting conditioned supernatant, denoted as PRPE-SF...
January 17, 2024: Experimental Eye Research