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Yoko Momose-Sato, Katsushige Sato
Facial motor neurons of the rat embryo are first generated in rhombomere 4 and then migrate in the caudo-ventral direction. This migration forms a unique axonal trajectory called the genu, a loop of facial motor axons around the abducens nucleus. It is still unclear when and how this unique structure is functionally established during ontogenesis. Using voltage-sensitive dye (VSD) recording and the DiI staining method, we identified neural responses evoked by facial nerve (N.VII) stimulation and examined developmental processes of the facial motor nucleus in E12-E17 rat brainstems...
August 17, 2018: European Journal of Neuroscience
Hyeonjeong Jang, Min Sung Chung, Shin Sook Kang, Yongsoon Park
The dietary inflammatory index (DII) has been associated with breast cancer incidence and survival. However, the association between DII and cancer recurrence and mortality among patients with breast cancer has not been investigated. Therefore, the present study aimed to investigate whether DII was positively associated with risk for cancer recurrence and overall mortality among patients with breast cancer. Among 511 women (51.9 ± 10.7 years; stage 0⁻3) who underwent breast cancer surgery, 88 had cancer recurrence, and 44 died during follow⁻up until 213 months (average disease free survival of 84...
August 15, 2018: Nutrients
Catherine M Phillips, Nitin Shivappa, James R Hébert, Ivan J Perry
Accumulating evidence identifies diet and inflammation as potential mechanisms contributing to cardiometabolic risk. However, inconsistent reports regarding dietary inflammatory potential, biomarkers of cardiometabolic health and metabolic syndrome (MetS) risk exist. Our objective was to examine the relationships between a food frequency questionnaire (FFQ)-derived dietary inflammatory index (DII® ), biomarkers of lipoprotein metabolism, inflammation and glucose homeostasis and MetS risk in a cross-sectional sample of 1992 adults...
August 8, 2018: Nutrients
Irene Esteban-Cornejo, Jorge Mota, Sandra Abreu, Andreia N Pizarro, Maria Paula Santos
OBJECTIVE: The main aim of the present study was to examine the association between the Dietary Inflammatory Index (DII®) and academic performance in children. DESIGN: School-based cross-sectional study. The DII was calculated based on dietary information obtained from a single 24h dietary recall. Academic performance was assessed by school records provided by the administrative services (i.e. Maths and Language). SETTING: Porto area (Portugal)...
August 8, 2018: Public Health Nutrition
Sajjad Moradi, Amos Issah, Hamed Mohammadi, Khadijeh Mirzaei
OBJECTIVES: Dietary inflammatory index (DII) scores have been inconsistently linked to cancer risks. Therefore, a systematic review and meta-analysis was performed to examine the associations between the DII and the risks of breast and prostate cancer among men and women. METHODS: Relevant studies were identified by searching PubMed and EMBASE databases up to March 2018. Data were available from 13 studies; of these, four studies used a prospective cohort design and nine studies were case-control studies...
May 25, 2018: Nutrition
Leila Nikniaz, Zeinab Nikniaz, Nitin Shivappa, James R Hébert
AIMS: Investigating the association between the dietary inflammatory index (DII® ) and metabolic syndrome (MetS) components and liver enzymes in Iranian population. METHODS: The present cross-sectional study consist of 606 participants from East-Azarbaijan-Iran. The MetS status was determined using ATPIII NCEP criteria. Moreover, liver enzymes including alanine aminotransferase and aspartate aminotransferase were measured. The DII was calculated according to Shivappa et al...
August 1, 2018: Primary Care Diabetes
Greta Carmona-Antoñanzas, Kari O Helgesen, Joseph L Humble, Claudia Tschesche, Marit J Bakke, Louise Gamble, Michaël Bekaert, David I Bassett, Tor E Horsberg, James E Bron, Armin Sturm
BACKGROUND: Parasitic salmon lice (Lepeophtheirus salmonis) cause high economic losses in Atlantic salmon farming. Pyrethroids, which block arthropod voltage-gated sodium channels (Nav 1), are used for salmon delousing. However, pyrethroid resistance is common in L. salmonis. The present study characterised Nav 1 homologues in L. salmonis in order to identify channel mutations associated to resistance, called kdr (knockdown) mutations. RESULTS: Genome scans identified three L...
July 31, 2018: Pest Management Science
Samira Khan, Michael D Wirth, Andrew Ortaglia, Christian R Alvarado, Nitin Shivappa, Thomas G Hurley, James R Hebert
OBJECTIVE: To design and validate a literature-derived, population-based Children's Dietary Inflammatory Index (C-DII)TM . DESIGN: The C-DII was developed based on a review of literature through 2010. Dietary data obtained from children in 16 different countries were used to create a reference database for computing C-DII scores based on consumption of macronutrients, vitamins, minerals, and whole foods. Construct validation was performed using quantile regression to assess the association between C-reactive protein (CRP) concentrations and C-DII scores...
July 30, 2018: Nutrients
Nilda G Medina, Loggina S Báez, Loyda B Méndez
Aim/Purpose: In this paper, we discuss how a Transdisciplinary (TD) and a Community Based Participatory Research (CBPR) initiative was conceptualized, developed, implemented, and sustained at a small academic institution with limited research infrastructure, emphasizing die role of capacity building. Background: Most examples of die implementation of TD research come from large-scale initiatives in research-intensive institutions or centers widi multiple resources to establish collaborations among experts from different disciplines...
2018: Informing science
Nitin Shivappa, James R Hébert, Susan E Steck, Akram Safari, Fatemeh Sedaghat, Bahram Rashidkhani
Background: In Iran, colorectal cancer (CRC) is the third and fourth leading cause of cancer incidence among men and women, respectively. Diet and inflammation have been suggested as important risk factors for CRC. We examined the association between dietary inflammatory index (DII) scores and CRC in a case-control study conducted in Iran. Methods: This study included 71 CRC cases and 142 controls hospitalized for acute non-neoplastic diseases. DII scores were computed from dietary intake assessed by a previously validated food frequency questionnaire...
July 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Alireza Mohammadi, Ali Maleki-Jamshid, Peiman Brouki Milan, Kaveh Ebrahimzadeh, Faezeh Faghihi, Mohammad Taghi Joghataei
BACKGROUND AND OBJECTIVE: Alzheimer's disease (AD) is a progressive neurodegenerative disorder with consequent cognitive impairment and behavioral deficits. AD is characterized by loss of cholinergic neurons and the presence of beta-amyloid protein deposits. Stem cell transplantation seems to be a promising strategy for regeneration of defects in brain. METHOD: One of suitable type of stem cells originated from fetal membrane is Chorion-derived Mesenchymal Stem Cells (C-MSCs)...
July 22, 2018: Current Stem Cell Research & Therapy
Ahmad Jayedi, Alireza Emadi, Sakineh Shab-Bidar
Existing evidence suggests a link between the inflammatory potential of diet and risk of cancer. This study aimed to test the linear and potential nonlinear dose-response associations of the Dietary Inflammatory Index (DII), as being representative of inflammatory features of the diet, and site-specific cancer risk. A systematic search was conducted with the use of PubMed and Scopus from 2014 to November 2017. Prospective cohort or case-control studies reporting the risk estimates of any cancer type for ≥3 categories of the DII were selected...
July 1, 2018: Advances in Nutrition
C M Nagle, T Ibiebele, N Shivappa, J R Hébert, A DeFazio, P M Webb
PURPOSE: Inflammation has been implicated in ovarian carcinogenesis. This study evaluated two dietary indices: the Dietary Inflammatory Index (DII®) and the Empirical Dietary Inflammatory Pattern (EDIP), in relation to risk of developing, and survival following, a diagnosis of ovarian cancer. METHODS: Data came from the Australian Ovarian Cancer Study (1375 cases, 1415 population controls). DII and EDIP scores were computed from dietary information obtained using a semiquantitative food-frequency questionnaire...
July 19, 2018: European Journal of Nutrition
Yakup Ergül, Ahmet İrdem, Osman Esen, Alper Güzeltaş
A 15-year-old female patient presented at the clinic with heart failure (HF). A 12-lead electrocardiogram showed a heart rate of 170 bpm; negative P waves in leads DII, DIII, aVF; and long RP tachycardia (LRPT). Echocardiography demonstrated a shortening fraction (SF) of 20%. An electrophysiology study during tachycardia revealed an atrial-His time of 52 milliseconds and a His-atrial interval of 295 milliseconds. During ventricular entrainment, the postpacing interval-tachycardia cycle length was measured at 225 milliseconds...
July 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
Nitin Shivappa, Camila Niclis, Julia Becaria Coquet, María D Román, James R Hébert, María Del Pilar Diaz
PURPOSE: Various aspects of diet, including specific food items and nutrients, have been shown to modulate inflammation and have been implicated in the etiology of prostate cancer (PrCA). No study examining the role of diet-associated inflammation in PrCA has been conducted in Latin America. METHOD: We examined the association between the Dietary Inflammatory Index (DII® ) and PrCA in a population-based case-control study in Córdoba, Argentina. A total of 153 incident cases of PrCA and 309 controls frequency matched on sex, age (± 5 years), and place of residence were recruited from 2008 to 2015...
July 17, 2018: Cancer Causes & Control: CCC
Mohsen Mazidi, Nitin Shivappa, Michael D Wirth, James R Hebert, Dimitri P Mikhailidis, Andre Pascal Kengne, Maciej Banach
BACKGROUND AND AIMS: We investigated the association between Dietary Inflammatory Index (DII® ) scores and cardio-metabolic risk factors singly and in combination as metabolic syndrome (MetS). METHODS: We used data from participants selected from the US National Health and Nutrition Examination Survey (NHANES). Analyses were restricted to participants with data available on dietary intake, biochemical data, and anthropometric measurements from 2005 to 2012. Statistical analyses used the SPSS® Complex Samples v22...
February 15, 2018: Atherosclerosis
Chau-Zen Wang, Rajalakshmanan Eswaramoorthy, Tzu-Hsiang Lin, Chung-Hwan Chen, Yin-Chih Fu, Chih-Kuang Wang, Shun-Cheng Wu, Gwo-Jaw Wang, Je-Ken Chang, Mei-Ling Ho
Injectable thermoresponsive hydrogels have the advantages of effective cell delivery and minimal invasion for tissue engineering applications. In this study, we investigated the chondroinductive potential of newly developed hyaluronic acid (HA)-modified thermoresponsive poly(N-isopropylacrylamide) (HA-PNIPAAm-CL) hydrogels on enhancing rabbit ADSC (rADSC) chondrogenesis in vitro and in the synovial cavity of rabbit. The HA-mixed PNIPAAm (HA-PNIPAAm-CP) and HA-cross-linked PNIPAAm (HA-PNIPAAm-CL) were fabricated using physical interaction and chemical cross-linking methods, respectively...
July 12, 2018: Scientific Reports
Gabriele Domschke, Fabian Linden, Lukas Pawig, Anna Hafner, Mohammadreza Akhavanpoor, Jürgen Reymann, Andreas O Doesch, Christian Erbel, Christian Weber, Hugo A Katus, Heidi Noels, Holger Erfle, Christian A Gleissner, Heiko Runz
Macrophage-derived foam cells are key regulators of atherogenesis. They accumulate in atherosclerotic plaques and support inflammatory processes by producing cytokines and chemokines. Identifying factors that regulate macrophage lipid uptake may reveal therapeutic targets for coronary artery disease (CAD). Here, we establish a high-throughput screening workflow to systematically identify genes that impact the uptake of DiI-labeled low-density lipoprotein (LDL) into monocyte-derived primary human macrophages...
July 12, 2018: Scientific Reports
Guangpeng Liu, Caihe Liao, Xi Chen, Yipin Xu, Jian Tan, Fang Han, Xinhai Ye
Skeletal muscle stem cell (SMSC) transplantation has shown great therapeutical potential in repairing muscle loss and dysfunction, but the muscle acquisition is usually a traumatic procedure causing pain and morbidity to the donor. In the present study, we investigated the feasibility of isolating SMSCs from human orbicularis oculi muscle (OOM), which is routinely discarded during ophthalmic cosmetic surgeries. OOM fragments were harvested from 18 female healthy donors undergoing upper eyelid blepharoplasties...
July 11, 2018: Tissue Engineering. Part C, Methods
Ryotaro Yamada, Keiichiro Murai, Naoyuki Uchida, Koji Takahashi, Rie Iwasaki, Yasuomi Tada, Toshinori Kinoshita, Kenichiro Itami, Keiko U Torii, Shinya Hagihara
Auxin regulates diverse aspects of plant growth and development through induction of the interaction between TRANSPORT INHIBITOR RESPONSE 1/AUXIN SIGNALING F-BOX proteins (TIR1/AFBs) and AUXIN/INDOLE-3-ACETIC ACID (Aux/IAA) co-receptor proteins and the subsequent transcriptional regulation. The artificial control of endogenous auxin signaling should enable the precise delineation of auxin-mediated biological events as well as the agricultural application of auxin. To this end, we previously developed synthetic auxin-receptor pair that consists of 5-(3-methoxyphenyl)-IAA (convexIAA, cvxIAA) and the engineered TIR1 whose Phe at the position of 79 in the auxin binding pocket is substituted to Gly (TIR1F79G) (concaveTIR1, ccvTIR1)...
July 7, 2018: Plant & Cell Physiology
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