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Seungho Ryu, Nitin Shivappa, Nicola Veronese, Minsoo Kang, Joshua R Mann, James R Hébert, Michael D Wirth, Paul D Loprinzi
OBJECTIVE: The objective of this study was to evaluate secular trends in Dietary Inflammatory Index (DII) scores in the United States between 1999 and 2014. METHODS: Data from adults over 19 years from the 1999 to 2014 National Health and Nutrition Examination Survey (N = 39,191) were used. DII scores, at each 2-year cycle, were evaluated from a 24-h recall, including 26 food parameters for DII calculation. Analyses were conducted in 2018. RESULTS: For the entire sample, there was a quadratic trend (Ptrend  < 0...
December 12, 2018: European Journal of Clinical Nutrition
Yasutake Tomata, Nitin Shivappa, Shu Zhang, Dieta Nurrika, Fumiya Tanji, Yumi Sugawara, James R Hébert, Ichiro Tsuji
Background: Previous studies have reported that a higher dietary inflammatory index (DII® ) score is related to a higher risk of mortality and conditions that result in functional disability, such as cardiovascular disease, dementia, and fractures. Although these findings suggest that higher DII scores would affect disability-free survival, this has never been investigated directly. The present study investigated the association between the DII score and disability-free survival. Methods: We analyzed follow-up data covering a 12-year period for 793 older adults (≥70 years) participating in a Japanese community-based cohort study...
December 3, 2018: Nutrients
Song-Yi Park, Minji Kang, Lynne R Wilkens, Yurii B Shvetsov, Brook E Harmon, Nitin Shivappa, Michael D Wirth, James R Hébert, Christopher A Haiman, Loïc Le Marchand, Carol J Boushey
Diet quality based on inflammatory potential, assessed by the Dietary Inflammatory Index (DII® ), has been related to mortality, but studies from racially/ethnically diverse populations are scarce. Using data from the Multiethnic Cohort Study in Hawaii and California, we investigated the association of the DII with all-cause, cardiovascular disease (CVD) and cancer mortality, both overall and by race/ethnicity. The analysis included 150,405 African Americans, Native Hawaiians, Japanese Americans, Latinos, and Whites aged 45⁻75 years, with 47,436 deaths during an average follow-up of 18...
December 1, 2018: Nutrients
Zahra Aslani, Mostafa Qorbani, James R Hébert, Nitin Shivappa, Mohammad Esmaeil Motlagh, Hamid Asayesh, Armita Mahdavi-Gorabi, Roya Kelishadi
This study aimed to assess the relationship between the Dietary Inflammatory Index (DII®), a validated tool for evaluating diet-associated inflammation, and anthropometric indices in children and adolescents. This multicentre survey was conducted on 5427 school students selected via multistage cluster sampling from thirty provinces of Iran. This survey was conducted under the framework of the weight disorders survey, which is part of a national surveillance programme entitled Childhood and Adolescence Surveillance and Prevention of Adult Non-communicable Diseases-IV...
December 3, 2018: British Journal of Nutrition
Eun-Shil Lee, Jea-Young Lee, Gil Hyun Kim, Chang-Jin Jeon
In mice, retinal ganglion cells (RGCs), which consist of around 30 subtypes, exclusively transmit retinal information to the relevant brain systems through parallel visual pathways. The superior colliculus (SC) receives the vast majority of this information from several RGC subtypes. The objective of the current study is to identify the types of calretinin (CR)-expressing RGCs that project to the SC in mice. To label RGCs, we performed CR immunoreactivity in the mouse retina after injections of fluorescent dye, dextran into mouse SC...
December 3, 2018: Cell and Tissue Research
Carolina A Carvalho, Antônio Augusto M Silva, Maria Cecília F Assunção, Poliana Cristina A Fonseca, Marco Antonio Barbieri, Heloisa Bettiol, Nitin Shivappa, James R Hébert
OBJECTIVE: The aim of this study was to assess the association between the inflammatory potential of diet, as measured by the dietary inflammatory index (DII) and insulin resistance (IR) or metabolic syndrome (MetS). METHODS: A cross-sectional study (nested within a cohort) was conducted on 2017 adults 23 to 25 y of age in Ribeirão Preto, Brazil. Food consumption was assessed using a validated food frequency questionnaire. DII scores were calculated from 35 available food parameters...
August 23, 2018: Nutrition
Viacheslav Viatchenko-Karpinski, Ferhat Erol, Jennifer Ling, William Reed, Jianguo G Gu
Orofacial muscle pain is a significant clinical problem because it affects eating, speaking, and other orofacial functions in patients. However, mechanisms underlying orofacial muscle pain are not fully understood. In the present study we induced orofacial muscle pain by injecting Complete Freund's Adjuvant (CFA) into masseter muscle of rats and assessed pain by the orofacial operant test. In comparison with the control group, CFA-injected animals (CFA group) showed decreases in operant behaviors, suggesting the presence of orofacial pain...
November 29, 2018: Neuroscience Letters
Daria M McMahon, James B Burch, James R Hébert, James W Hardin, Jiajia Zhang, Michael D Wirth, Shawn D Youngstedt, Nitin Shivappa, Steven J Jacobsen, Bette Caan, Stephen K Van Den Eeden
PURPOSE: The purpose of the study was to examine the relationship between proinflammatory diet and prostate cancer risk. METHODS: Energy-adjusted Dietary Inflammatory Index (E-DII) scores were computed among 40,161 participants in the California Men's Health Study. Over 9.7 ± 3.8 years of follow-up, 2707 incident prostate cancer cases were diagnosed and categorized as low-, intermediate-, or high-risk, based on disease grade and stage. Accelerated failure-time models assessed time to diagnosis of prostate cancer...
November 2, 2018: Annals of Epidemiology
Jiang Du, Xinxing Zhu, Rui Guo, Zhihao Xu, Fang Fang Cheng, Qing Liu, Fen Yang, Lihong Guan, Yanli Liu, Juntang Lin
BACKGROUND/AIMS: Menstrual blood-derived endometrial stem cells (MenSCs) emerge as an ideal source for cell-based treatment in regenerative medicine and immunotherapy. However, the major obstacle is the low survival rate in tissues and the limited expansion number. Autophagy is an intracellular metabolic self-degradative process which plays important roles in normal cellular division and survival, and the present study aimed to explore the related mechanisms between autophagy and survival of MenSCs in vitro and in vivo...
November 28, 2018: Stem Cell Research & Therapy
William Kwame Amakye, Zheqing Zhang, Yuanhuan Wei, Nitin Shivappa, James R Hebert, Jue Wang, Yixiang Su, Limei Mao
BACKGROUND AND OBJECTIVES: The dietary inflammatory index (DII®) is a measure of the overall inflammatory potential of a person's diet. However, there have been no studies looking at the effect of DII on measures of muscle mass and strength. We aimed to examine the association between DII and skeletal muscle mass and strength in Chinese children. METHODS AND STUDY DESIGN: A total of 466 children aged 6-9 years completed the study. Total body skeletal muscle mass (TSM), appendicular skeletal mass (ASM) and appendicular lean mass (ALM) were determined using Dual-energy X-ray absorptiometry...
2018: Asia Pacific Journal of Clinical Nutrition
Zimin Chen, Fei Ye, Sheng Lin, Fanli Yang, Yanwei Cheng, Yu Cao, Zhujun Chen, Guangwen Lu
BACKGROUND: Usutu virus (USUV) is a mosquito-born flavivirus that can infect multiple avian and mammalian species. The viral surface envelope (E) protein functions to initiate the viral infection by recognizing cellular receptors and mediating the subsequent membrane fusion, and is therefore a key virulence factor involved in the pathogenesis of USUV. The structural features of USUV-E, however, remains un-investigated thus far. FINDINGS: Using the crystallographic method, we determined the structure of USUV-E in the pre-fusion state at 2...
November 26, 2018: Virology Journal
Mohsen Mazidi, Nitin Shivappa, Michael D Wirth, James R Hebert, Andre Pascal Kengne
The prevalence of non-alcoholic fatty liver disease (NAFLD) is rising-caused, at least in part, by unhealthy lifestyles including poor dietary choices. We examined the link between the inflammatory potential of diet as measured by the Dietary Inflammatory Index (DII® ) and liver function tests [summarised by the fatty liver index (FLI)]. Of 20,643 US NHANES participants, 48.7% were men and the mean age was 47.3 years. Significant associations were apparent between increasing DII score and prevalent fatty liver...
November 19, 2018: European Journal of Clinical Nutrition
Chang Hyun Kim, Cheol-Ki Sa, Min Su Goh, Eun Seok Lee, Tae Hoon Kang, Ho Yub Yoon, Gantumur Battogtokh, Young Tag Ko, Young Wook Choi
Background: RIPL peptide (IPLVVPLRRRRRRRRC)-conjugated nanostructured lipid carriers (RIPL-NLCs) can facilitate selective drug delivery to hepsin (Hpn)-expressing cancer cells, but they exhibit low stability in the blood. Generally, biocompatible and nontoxic poly(ethylene glycol) surface modification (PEGylation) can enhance NLC stability, although this may impair drug delivery and NLC clearance. To attain RIPL-NLC steric stabilization without impairing function, pH-sensitive cleavable PEG (cPEG) was grafted onto RIPL-NLCs (cPEG-RIPL-NLCs)...
2018: International Journal of Nanomedicine
Asma Salari-Moghaddam, Ammar Hassanzadeh Keshteli, Hamid Afshar, Ahmad Esmaillzadeh, Peyman Adibi
BACKGROUND & AIMS: Limited data are available on the association of inflammatory potential of the diet and odds of psychological disorders. We investigated the association between adherence to a pro-inflammatory diet, as measured by Dietary Inflammatory Index (DII), and odds of psychological disorders. METHODS: In this cross-sectional study, dietary intakes of 3363 Iranian adult participants were collected using a validated Dish-based 106-item Semi-quantitative Food Frequency Questionnaire (DS-FFQ)...
October 27, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Alexander Glassmann, Carmen Carrillo Garcia, Viktor Janzen, Dominik Kraus, Nadine Veit, Jochen Winter, Rainer Probstmeier
Cultivation of A549 non-small-cell lung carcinoma (NSCLC) cells in the presence of staurosporine (SSP) leads to a reduction or a lack of proliferation in a concentration-dependent manner. This inhibition of proliferation is accompanied by the generation of polyploid giant cancer cells (PGCCs) that are characterized by cell flattening, increased cell size, polyploidy, and polynucleation as determined by crystal violet staining, BrdU and DiI labelling, and flow cytometry as well as video time-lapse analysis. Continuous SSP treatment of A549 cells can preserve PGCCs for at least two months in a resting state...
2018: Analytical Cellular Pathology (Amsterdam)
Ahmed A Abdurahman, Leila Azadbakhat, Mahkameh Rasouli, Maryam Chamari, Mostafa Qorbani, Ahmed R Dorosty
AIM: Obesity is an emerging public health problem, with its incidence on the rise. An abnormal metabolic profile is a risk factor for developing obesity. Dietary factors play a central role in the regulation of inflammation and obesity. The aim of the present study was to determine the prevalence of metabolically healthy obese and metabolically unhealthy obese (MUO) phenotypes, and their association with dietary inflammatory index (DII) among obese Iranian people. METHODS: A cross-sectional study was conducted from July to October 2017 among 300 obese participants in southern Tehran...
November 7, 2018: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
Jin-Eon Han, Jin-Hwa Cho, Michiko Nakamura, Maan-Gee Lee, Il-Sung Jang
Migraine is a neurological disorder characterized by recurrent and disabling severe headaches. Although several anticonvulsant drugs that block voltage-dependent Na+ channels are widely used for migraine, far less is known about the therapeutic actions of carbamazepine on migraine. In the present study, therefore, we characterized the effects of carbamazepine on tetrodotoxin-resistant (TTX-R) Na+ channels in acutely isolated rat dural afferent neurons, which were identified by the fluorescent dye DiI. The TTX-R Na+ currents were measured in medium-sized DiIpositive neurons using the whole-cell patch clamp technique in the voltage-clamp mode...
November 2018: Korean Journal of Physiology & Pharmacology
João R C Fernandes, Lucas Bleicher, Paulo S L Beirão
Voltage-gated sodium channels play important roles in human physiology. However, their complexity hinders the understanding of their physiology and pathology at atomic level. We took advantage of the structural reports of similar channels obtained by cryo-EM (EeNav1.4, and NavPaS), and constructed models of human Nav1.4 channels at closed and open states. The open-state model is very similar to the recently published cryo-EM structure of hNav1.4. The comparison of both models shows shifts of the voltage sensors (VS) of DIII and DIV...
October 30, 2018: Biochemical and Biophysical Research Communications
Omprakash Singh, Dipti R Pradhan, B Nagalakashmi, Santosh Kumar, Saptarsi Mitra, Sneha Sagarkar, Amul J Sakharkar, Ronald M Lechan, Praful S Singru
Thyrotropin-releasing hormone (TRH) regulates the hypothalamic-pituitary-thyroid axis in mammals and also regulates prolactin secretion, directly or indirectly via tuberoinfundibular-dopamine neurons. Although TRH is abundantly expressed in teleost brain and believed to mediate neuronal communication, empirical evidence is lacking. We analyzed pro-TRH-mRNA expression, mapped TRH-immunoreactive elements in the brain and pituitary, and explored its role in regulation of hypophysiotropic-dopamine (DA) neurons in the catfish, Clarias batrachus...
October 29, 2018: Journal of Comparative Neurology
Xiao-Yan Wang, Ai-Ping Fang, Pei-Yan Chen, Gong-Cheng Liao, Yao-Jun Zhang, Nitin Shivappa, James R Hébert, Yu-Ming Chen, Hui-Lian Zhu
Chronic inflammation and diet play crucial roles in the development of hepatocellular carcinoma (HCC); yet the association between dietary inflammatory potential and risk of HCC has rarely been investigated. This study aimed to examine whether a higher dietary inflammatory index (DII®) score (indicating a pro-inflammatory diet) is associated with an increased risk of HCC in a matched case-control study conducted between September 2013 and October 2017 in South China. A total of 659 cases with newly diagnosed, previously untreated HCC and 659 controls individually matched on age (±3 years) and sex were included in this study...
November 14, 2018: Food & Function
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